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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44570962	183857	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480821	183857	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	145950336	162827	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172656	162827	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	156016416	177657	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	177657	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	94499	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251572	94499	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156014430	177223	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	177223	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016416	177657	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	177657	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	94499	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	CHEMBL251572	94499	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	44570963	183880	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481013	183880	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	156014430	177223	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	177223	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444563	154955	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401134	154955	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	156011926	177400	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	177400	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44571002	191098	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL518774	191098	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44449987	95893	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259166	95893	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	25010378	159398	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	CHEMBL410074	159398	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	44449955	159412	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410085	159412	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	156011926	177400	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	177400	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	177806	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	177806	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156015100	177572	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	177572	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	177806	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	177806	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44570960	183988	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481796	183988	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	24894012	176797	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL460680	176797	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	156015100	177572	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	177572	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437979	10327	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	10327	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44437979	10327	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	10327	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44454303	97569	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	97569	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	156020725	178105	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	178105	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44570764	184049	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482220	184049	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	24803512	89007	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364468	89007	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	156020725	178105	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	178105	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	9917957	109718	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	CHEMBL322912	109718	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	44447855	194856	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL539929	194856	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	178024	1971	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1971	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1971	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	156013414	177472	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	177472	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	177484	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	177484	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44452749	96215	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL260819	96215	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44570765	191440	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL519301	191440	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007047	88965	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364427	88965	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	178024	1971	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1971	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1971	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	25022640	97801	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	97801	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454337	155603	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	155603	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44447839	94991	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254765	94991	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156013414	177472	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	177472	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	177484	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	177484	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44447857	166876	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL428592	166876	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156019724	177991	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	177991	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888474	63464	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL179823	63464	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	11306502	63642	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63642	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	63642	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63642	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	63642	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63642	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888476	122818	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	122818	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	22888476	122818	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	122818	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	44454117	155556	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155556	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44444559	94436	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251169	94436	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	156011750	177290	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	177290	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156019724	177991	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	177991	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453123	97986	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL272753	97986	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	44570966	183569	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480037	183569	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007062	88967	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364429	88967	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	24803514	89012	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364472	89012	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	44447852	155562	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404354	155562	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156011750	177290	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	177290	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450016	160560	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411259	160560	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	44454367	95261	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	95261	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	22867441	10315	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	10315	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	16114096	79160	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113324	79160	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	22867441	10315	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	10315	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447841	155078	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL401827	155078	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	69195371	88891	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364354	88891	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44450101	159460	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410135	159460	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	44391039	131788	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369329	131788	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44449988	161101	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411697	161101	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	44447843	95020	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254973	95020	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	10280020	63092	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178900	63092	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156021297	178089	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	178089	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444571	93979	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248544	93979	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	10553921	104560	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	104560	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	139275	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	139275	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	156012122	177381	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	177381	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021297	178089	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	178089	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11584048	98029	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	CHEMBL272993	98029	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	24755624	157300	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL407706	157300	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	24755624	157300	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	CHEMBL407706	157300	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	69197353	88945	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364408	88945	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44454060	155332	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	155332	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10553921	104560	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	104560	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	139275	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	139275	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	127047525	139767	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798559	139767	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	156022162	178206	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	178206	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156012122	177381	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	177381	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	20600693	63456	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179785	63456	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44560945	179102	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL471751	179102	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	216208	9727	33	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9727	33	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	44449891	96474	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL262358	96474	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	216208	9727	33	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9727	33	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	156021478	178055	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	178055	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437955	10325	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	10325	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	9807597	183017	5	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL47938	183017	5	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	156018364	177913	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177913	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021478	178055	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	178055	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	178203	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	178203	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156022162	178206	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	178206	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	56926175	69013	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923504	69013	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926356	69019	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923512	69019	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	56926461	69036	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923609	69036	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926462	69037	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923610	69037	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	57399248	69044	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923617	69044	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	11664206	69053	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923626	69053	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926894	69064	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923638	69064	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	11526745	69068	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923642	69068	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11526696	71602	17	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	71602	17	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	71602	17	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	134130631	142373	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	CHEMBL3889512	142373	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	134137202	142826	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3893048	142826	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137257	143137	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3895776	143137	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134133518	143453	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3898348	143453	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134133352	143505	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3898794	143505	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134286	143694	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900284	143694	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134135712	144138	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	CHEMBL3903845	144138	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	11512561	144369	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3905791	144369	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134133037	144567	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3907497	144567	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132893	144863	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3909834	144863	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132152	144932	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3910300	144932	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142218	145287	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3913052	145287	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134142433	145326	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3913335	145326	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	134142839	145386	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913855	145386	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143635	145574	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3915269	145574	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	134143366	145760	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3916659	145760	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134142204	145937	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3918046	145937	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11584702	146191	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3920049	146191	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134140270	146373	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3921499	146373	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134139279	146447	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922056	146447	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134139286	146554	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922810	146554	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134141886	147118	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3927481	147118	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	117812380	147752	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3932408	147752	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138595	147755	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	CHEMBL3932434	147755	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	134138824	148014	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934402	148014	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148504	148354	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3937200	148354	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149306	148474	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3938104	148474	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145791	148786	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3940705	148786	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145564	149090	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3943086	149090	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134147441	149489	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3946348	149489	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134155239	151014	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3958460	151014	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	134155132	151092	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959108	151092	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154079	152403	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970499	152403	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	134153247	152720	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3973085	152720	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	44570763	190259	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517543	190259	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	9890504	89740	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	CHEMBL237699	89740	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	24969109	88875	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364338	88875	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11518200	88890	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364353	88890	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641108	88919	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364382	88919	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197887	88940	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364403	88940	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447856	161814	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL414394	161814	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156018364	177913	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177913	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	178203	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	178203	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10323604	10309	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	10309	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10323604	10309	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	10309	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447853	94964	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254565	94964	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	25022503	155563	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404355	155563	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44269035	27332	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13675	27332	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44269039	98341	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL275093	98341	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	145956061	162693	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162693	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44570965	189837	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL516602	189837	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	69194933	88962	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364424	88962	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	69198297	88971	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364432	88971	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447850	94935	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254363	94935	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450015	96318	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261358	96318	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	178024	1971	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	1971	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	1971	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	178024	1971	33	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	5867	1971	33	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	CHEMBL13817	1971	33	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	178024	1971	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	1971	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	1971	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	145956061	162693	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162693	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44450104	95801	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258761	95801	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	214115	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	214115	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
	22888475	63825	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180246	63825	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL500468	214115	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.040
	162653916	180545	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753794	180545	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL500468	214115	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.02.021
	CHEMBL500468	214115	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.05.100
	178024	1971	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	5867	1971	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	CHEMBL13817	1971	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	156012849	177298	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	177298	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44390996	64304	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181063	64304	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	64616	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	64616	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	64616	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	64616	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44347919	16373	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122939	16373	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	16133832	213331	18	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	CHEMBL425281	213331	18	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	145957574	162301	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	162301	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	9875705	205301	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	205301	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	156012849	177298	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	177298	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013219	177489	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	177489	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11648350	88918	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364381	88918	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007043	88921	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364384	88921	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	69197106	88964	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364426	88964	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	24803348	88969	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364430	88969	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197228	89015	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364475	89015	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	16114291	191294	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL5190973	191294	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	16114292	96934	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	CHEMBL266063	96934	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	9875705	205301	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	205301	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	44436850	91549	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240509	91549	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44447840	94992	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254766	94992	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44447854	94965	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254566	94965	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL105462	208468	38	None	12	2	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm980197u
	44447844	94877	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253965	94877	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450017	96346	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261544	96346	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	10118326	24093	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	24093	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10458218	27487	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13687	27487	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	10745618	112987	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	CHEMBL331093	112987	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	10118326	24093	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	24093	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	156010457	177054	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	177054	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	23649669	153967	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL398372	153967	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	23649669	153967	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	CHEMBL398372	153967	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	23649669	153967	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL398372	153967	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	23649669	153967	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL398372	153967	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44437955	10325	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	10325	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	10626337	101225	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	101225	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156010457	177054	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	177054	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	156012445	177335	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	177335	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015928	177581	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177581	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452750	96257	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL261030	96257	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44452932	97587	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	CHEMBL270790	97587	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	44570700	183959	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	CHEMBL481620	183959	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	69197169	88936	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364399	88936	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641478	88944	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364407	88944	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	24803350	88980	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364441	88980	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	11547664	89020	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364480	89020	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	44579802	186768	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488965	186768	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44444572	94019	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248745	94019	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145962494	162074	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	162074	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145951150	162776	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162776	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44434120	89907	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237926	89907	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	9827234	5336	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL106841	5336	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	44411718	10306	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161825	10306	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	10324	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	10324	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	44293557	101088	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL294923	101088	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL540001	101088	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	127046473	139780	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798645	139780	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	156012203	177334	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	177334	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	156016696	177630	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177630	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11525404	95381	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL256808	95381	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44571004	184046	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482203	184046	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL105462	208468	38	None	12	2	Rat	8.0	pEC50	=	8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(97)10199-8
	24969294	88880	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364343	88880	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	69194607	88895	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364358	88895	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	69197049	88896	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364359	88896	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	69195141	88914	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364377	88914	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	11682686	88927	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364390	88927	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198021	88970	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	CHEMBL2364431	88970	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	11655608	88983	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364444	88983	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194649	89017	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364477	89017	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196750	89019	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364479	89019	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	23730339	148119	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL393531	148119	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	156016696	177630	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177630	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145993528	167318	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	167318	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	156012203	177334	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	177334	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	145950201	162942	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162942	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44281466	169382	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	169382	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44452806	96683	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL263916	96683	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44452885	97814	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271948	97814	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	11633712	159335	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410013	159335	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	57390496	69055	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	69055	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	56926782	69057	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923631	69057	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926785	69060	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923634	69060	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926892	69062	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923636	69062	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926893	69063	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	CHEMBL1923637	69063	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	134131183	142468	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890296	142468	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134133488	143236	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3896536	143236	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134870	144392	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3905987	144392	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132958	144661	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	CHEMBL3908264	144661	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	134132265	144971	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	CHEMBL3910661	144971	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	76460236	145460	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3914338	145460	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134141159	146729	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3924192	146729	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149092	148453	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3937924	148453	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134146570	148780	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940653	148780	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145820	149034	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3942642	149034	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155024	151012	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3958451	151012	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155282	151342	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961108	151342	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134152627	151548	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963078	151548	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150696	152079	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967506	152079	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134150029	152115	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967783	152115	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134153608	152370	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970180	152370	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154022	152825	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3973940	152825	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134151899	153319	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3978207	153319	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134156625	153651	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981072	153651	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	16040587	179384	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	CHEMBL473921	179384	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	44576247	214222	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	CHEMBL506986	214222	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	44576247	214222	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL506986	214222	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL3578015	211766	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578018	211769	0	None	-15	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69198097	88901	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364364	88901	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	69198438	88903	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364366	88903	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	69196473	88912	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364375	88912	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197657	88913	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364376	88913	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	69195983	88934	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364397	88934	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196844	88951	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364414	88951	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647817	88955	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	CHEMBL2364418	88955	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	69196864	88973	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364434	88973	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	69198407	89002	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364463	89002	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	44579958	191342	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519171	191342	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	156020713	178088	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	178088	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	134139753	146036	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3918783	146036	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	44449923	96338	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL261497	96338	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	156020713	178088	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	178088	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	44434110	88512	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235135	88512	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578018	211769	0	None	-15	2	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44450102	95771	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL258550	95771	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	16114290	137208	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374992	137208	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11664206	69053	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923626	69053	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	71453489	209368	15	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209368	15	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	9870965	64314	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181092	64314	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44434051	89415	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237058	89415	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	44434053	146858	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	CHEMBL392522	146858	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	145988557	167260	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	167260	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL2170775	209363	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434083	90031	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL238155	90031	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	44436884	91552	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240522	91552	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	16114098	141611	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL385131	141611	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113246	94677	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252643	94677	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	22888486	64318	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL181108	64318	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	71453489	209368	15	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	CHEMBL2170781	209368	15	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	156018539	177809	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	177809	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145949755	162934	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162934	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	156013970	177240	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	177240	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156018539	177809	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	177809	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	69197178	88873	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364336	88873	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	69194396	88924	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364387	88924	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	69195258	88956	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364419	88956	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11604627	88972	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364433	88972	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197381	88990	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364451	88990	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	11576185	88997	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364458	88997	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	11633856	89023	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364483	89023	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	59007104	89026	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364486	89026	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2170779	209366	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579824	184110	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482623	184110	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44579883	186837	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489403	186837	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579861	194200	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL528332	194200	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	44579906	192619	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL521612	192619	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	145992125	166750	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	166750	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016682	177766	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	177766	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170776	209364	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	16752689	188368	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL501315	188368	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	44444557	154686	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL399704	154686	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	145957404	162049	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	162049	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	162524	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	162524	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	145950261	162729	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162729	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156014569	177232	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	177232	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452776	96328	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL261466	96328	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	69196695	88886	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364349	88886	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007058	88894	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	CHEMBL2364357	88894	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	156016682	177766	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	177766	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44579842	184751	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL485091	184751	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	145986461	167213	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	167213	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145950261	162729	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162729	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	10602593	112842	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330860	112842	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391038	64585	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181627	64585	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170783	209370	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](N)CCCCN)C(c1ccccc1)c1ccccc1)C(N)=O	10.1021/jm300414b
	CHEMBL2170779	209366	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013970	177240	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	177240	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156014569	177232	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	177232	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	56926173	69012	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923501	69012	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	134138625	148030	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3934561	148030	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	155526063	171036	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4456830	171036	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145957404	162049	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	162049	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	162524	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	162524	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	44454060	155332	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	155332	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	57399248	69044	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	69044	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	145949755	162934	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162934	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44434109	146281	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392076	146281	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	9890375	98270	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	98270	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	98270	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44436876	147019	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL392663	147019	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9890375	98270	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL274599	98270	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL558802	98270	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	9890375	98270	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	98270	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	98270	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44281466	169382	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	169382	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	162672839	183022	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4793824	183022	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	22888428	64350	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181247	64350	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	23730227	147874	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	CHEMBL393330	147874	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	44450133	160393	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL411122	160393	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44579821	184228	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL483455	184228	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	44579879	186995	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490627	186995	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44450071	96585	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263141	96585	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	16113906	137223	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL375102	137223	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	44579752	186960	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490390	186960	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	44436887	90959	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239464	90959	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44434076	89777	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	CHEMBL237717	89777	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	145952740	162501	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	162501	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	23648250	79163	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113327	79163	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16113577	84936	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL223725	84936	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	162657465	181041	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759418	181041	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	44444574	94020	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248746	94020	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145952740	162501	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	162501	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	11532288	96920	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL265950	96920	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	11576186	155225	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	CHEMBL402632	155225	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	44570964	183881	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481014	183881	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44570921	183955	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481601	183955	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	59007073	88874	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364337	88874	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	69197749	88883	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364346	88883	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11682796	88885	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364348	88885	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198460	88897	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	CHEMBL2364360	88897	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	69198360	88905	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364368	88905	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11683967	88917	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364380	88917	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	69195261	88925	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364388	88925	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11516766	88929	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364392	88929	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11525161	88986	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364447	88986	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194533	89016	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364476	89016	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197165	89028	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364488	89028	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44579777	186984	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490601	186984	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44454432	155258	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	155258	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44434112	168860	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL438154	168860	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44579908	186874	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489610	186874	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145954311	162486	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	162486	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44434124	88658	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235817	88658	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	162659161	181391	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763471	181391	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44444556	94402	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	CHEMBL250973	94402	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	145950963	162806	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162806	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952396	163003	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	163003	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	156011695	177355	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	177355	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452887	159578	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL410282	159578	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	46882522	5712	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078208	5712	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	69195349	88908	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	CHEMBL2364371	88908	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	69198352	89029	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364489	89029	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	44446188	155391	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403542	155391	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145954311	162486	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	162486	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	46882521	5711	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078207	5711	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	44445620	154678	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399651	154678	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	22862453	98459	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL275795	98459	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	10675061	96543	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL262889	96543	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	10026738	162769	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	162769	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	162769	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	56926464	69039	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	CHEMBL1923612	69039	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	155540883	172957	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172957	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	10210658	10326	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	10326	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	145952396	163003	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	163003	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL2170784	209371	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134139080	147683	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3931856	147683	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	156011695	177355	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	177355	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170697	209357	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434080	89911	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44434080	89911	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	89911	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237933	89911	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10210658	10326	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	10326	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10026738	162769	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	162769	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	162769	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	10530983	168385	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL434609	168385	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391003	123321	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL361612	123321	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170780	209367	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145950963	162806	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162806	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	127047409	139631	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797639	139631	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	10745533	140120	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	140120	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	202520	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	202520	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	16113693	138016	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376471	138016	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	11692516	69048	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923621	69048	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	155557019	174587	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174587	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	9810101	99249	17	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL281764	99249	17	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10745533	140120	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	140120	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	202520	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	202520	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44579909	186903	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489819	186903	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44436882	146016	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391859	146016	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2170698	209358	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434122	89511	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237302	89511	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	145992142	166771	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	166771	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL3578006	211760	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	145953016	162587	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162587	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	44454304	97603	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	97603	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	97649	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97649	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454338	97835	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	97835	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	22867310	30041	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	CHEMBL13891	30041	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	162653802	180531	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753592	180531	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44436886	161955	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL415674	161955	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9987037	12032	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183385	12032	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL294324	12032	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	44391008	64867	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182137	64867	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	22888379	168313	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL434152	168313	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	44444564	94472	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251366	94472	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	145961213	162163	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	162163	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145953016	162587	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162587	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145949595	162724	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162724	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	163024	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	163024	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44452929	97543	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL270573	97543	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	46882396	5844	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079187	5844	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570698	183958	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481619	183958	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	24969292	88877	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364340	88877	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	69194665	88910	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364373	88910	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	11524465	88930	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364393	88930	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11576404	88941	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364404	88941	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194865	88960	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364422	88960	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	11712498	88974	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364435	88974	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	69195296	88979	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364440	88979	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11518242	88982	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364443	88982	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	69197366	88987	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364448	88987	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11503413	89004	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	CHEMBL2364465	89004	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	11647900	89010	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364470	89010	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	11669734	89011	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364471	89011	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	44391007	64866	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182136	64866	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	145994050	167345	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	167345	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016392	177646	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177646	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL3578006	211760	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	25098836	191458	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519322	191458	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957574	162301	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	162301	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	10308	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	10308	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	10626337	101225	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	101225	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156013219	177489	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	177489	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888352	63937	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	63937	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888352	63937	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	63937	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	10649999	17106	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL125498	17106	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156015928	177581	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177581	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156012445	177335	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	177335	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44411634	10305	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	10305	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44411634	10305	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	10305	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44390986	64669	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181832	64669	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170695	209355	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156011766	177308	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	177308	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44281449	113394	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	113394	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	44281449	113394	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	113394	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	23648249	79162	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113326	79162	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	10166594	64636	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181786	64636	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391010	64874	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL182158	64874	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	23648244	92014	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241775	92014	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	155557019	174587	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174587	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44444565	94500	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251573	94500	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145957075	162279	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	162279	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	10308	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	10308	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	156013684	177265	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	177265	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156011766	177308	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	177308	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	11539642	97928	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL272540	97928	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	44570702	183836	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480639	183836	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	11683968	88916	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364379	88916	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197883	88939	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364402	88939	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69195597	88952	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	CHEMBL2364415	88952	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	59007081	88966	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364428	88966	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	11648834	89021	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364481	89021	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	44411753	10310	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	10310	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411753	10310	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	10310	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	10415000	168067	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	168067	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	71453489	209368	15	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209368	15	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013684	177265	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	177265	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10415000	168067	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	168067	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	156019457	177942	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177942	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449922	96221	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL260849	96221	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44269019	98226	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL274340	98226	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44579840	184749	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL485090	184749	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579907	187048	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491044	187048	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579805	187066	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491221	187066	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434113	88649	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235793	88649	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	127048060	139861	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799222	139861	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	57399248	69044	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923617	69044	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44268965	24062	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13383	24062	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	10675800	113794	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL332414	113794	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391002	123910	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL362798	123910	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44579857	186924	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490009	186924	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44434018	88492	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235012	88492	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44579641	186897	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489794	186897	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579996	187136	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491835	187136	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	44579919	191349	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	CHEMBL519196	191349	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	44454092	97649	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97649	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44450070	158651	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL409258	158651	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	156016392	177646	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177646	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145961213	162163	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	162163	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145949595	162724	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162724	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	163024	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	163024	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44390905	64457	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181337	64457	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391040	64461	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181352	64461	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10579444	114243	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL332987	114243	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	162645413	179726	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744051	179726	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44293091	188186	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	188186	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	16114011	138138	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL376736	138138	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	145981343	166709	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	166709	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44391048	62948	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178502	62948	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44454399	155139	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	155139	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44293091	188186	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	188186	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	155540883	172957	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172957	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44579801	187161	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL492028	187161	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	168276220	190421	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5177954	190421	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	145958774	162266	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	162266	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145950877	162995	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162995	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44450135	158703	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL409327	158703	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44454302	159380	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	159380	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	16203237	96951	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	CHEMBL266199	96951	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	56926462	69037	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923610	69037	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	162660604	181219	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761319	181219	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956753	162157	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	162157	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	71453489	209368	15	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209368	15	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44446190	94556	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL251855	94556	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44446189	155374	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403426	155374	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	10744738	16204	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122420	16204	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL2170699	209359	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44454432	155258	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	155258	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44454397	155524	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL404227	155524	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145949381	162715	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162715	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	22862431	30485	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13930	30485	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	162653781	180482	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753046	180482	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	156013764	177271	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	177271	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145958317	162313	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	162313	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145949381	162715	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162715	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950877	162995	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162995	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	156013764	177271	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	177271	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156020452	178034	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	178034	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	24969201	88881	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364344	88881	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	69197403	88906	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	CHEMBL2364369	88906	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	59007071	88920	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364383	88920	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11547135	88933	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364396	88933	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11567764	88937	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364400	88937	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11511157	88947	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	CHEMBL2364410	88947	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	11547599	88949	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364412	88949	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197133	88959	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	CHEMBL2364421	88959	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	69197849	88984	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364445	88984	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198350	88991	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364452	88991	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	156020452	178034	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	178034	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44579860	188901	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL507551	188901	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145956415	162063	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	162063	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956415	162063	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	162063	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956753	162157	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	162157	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145958774	162266	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	162266	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145955718	162535	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	162535	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952404	162736	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	162736	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	211765	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44436816	91805	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241242	91805	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44391028	64298	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181051	64298	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44390906	132103	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369571	132103	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44434052	89416	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237059	89416	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	44450169	159750	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	CHEMBL410499	159750	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	56926894	69064	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923638	69064	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	44391027	128803	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL366916	128803	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579803	186769	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488966	186769	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145952404	162736	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	162736	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	211765	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	11526696	71602	17	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1923502	71602	17	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1963249	71602	17	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	44450045	159237	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL409894	159237	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	44434012	89074	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL236513	89074	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44454398	97598	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	97598	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	11526745	69068	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923642	69068	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	44391020	63864	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180337	63864	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	162643920	181780	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4777792	181780	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155540883	172957	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172957	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145955718	162535	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	162535	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	23648236	79152	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	CHEMBL2113317	79152	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	145958317	162313	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	162313	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	162649014	179941	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4746362	179941	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	44434123	145550	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL391510	145550	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	11526696	71602	17	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923502	71602	17	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1963249	71602	17	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	122178179	121263	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	121263	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	145980382	166643	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	166643	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71453489	209368	15	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209368	15	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134149793	148605	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	CHEMBL3939196	148605	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	145980333	166581	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	166581	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44579823	184081	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482420	184081	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957075	162279	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	162279	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145951150	162776	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162776	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44449864	158830	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL409462	158830	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	10005618	10323	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	10323	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	77744	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	77744	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	99249	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	99249	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	141210	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	141210	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	208687	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	16114292	96934	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL266063	96934	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16114292	96934	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96934	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	23730225	154176	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	CHEMBL398570	154176	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	10530781	15578	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122108	15578	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10005618	10323	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	10323	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	77744	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	77744	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	99249	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	99249	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	141210	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	141210	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	208687	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	156011385	177378	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	177378	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449956	96615	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263389	96615	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44447846	94899	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254166	94899	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44444566	154767	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400124	154767	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156011385	177378	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	177378	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156019457	177942	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177942	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570961	192561	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521246	192561	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	69195095	88963	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364425	88963	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194503	88999	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364460	88999	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	59007103	89025	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	CHEMBL2364485	89025	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	69197358	89031	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364491	89031	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	44450046	95856	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	CHEMBL259016	95856	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	23730341	89742	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL237701	89742	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	71453489	209368	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209368	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44390914	63638	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180093	63638	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888424	122998	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360877	122998	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	71453489	209368	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209368	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	162671996	182831	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4791255	182831	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	23730228	89592	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237492	89592	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	71453489	209368	15	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209368	15	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444568	93978	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248542	93978	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	15481185	77261	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	77261	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	156011736	177423	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	177423	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	25022506	95267	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL256263	95267	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	24803347	155028	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401548	155028	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	46882394	5842	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079185	5842	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	46882395	5843	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079186	5843	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570699	191305	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL519121	191305	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196498	88911	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364374	88911	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	69197028	88950	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364413	88950	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198238	88961	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364423	88961	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11712867	88998	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364459	88998	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	69194471	89013	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364473	89013	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	11698505	89022	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364482	89022	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	9950632	88706	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL236038	88706	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	44579880	186835	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489401	186835	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579841	192554	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL521176	192554	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434010	88773	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL236311	88773	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	9950632	88706	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	9950632	88706	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	88706	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL236038	88706	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44434010	88773	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL236311	88773	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44437966	202093	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	202093	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	202519	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	202519	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437966	202093	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	202093	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	202519	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	202519	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44454368	95262	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL256236	95262	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145987684	167277	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	167277	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44444560	154954	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401133	154954	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	145953855	162515	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	162515	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44570923	183956	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481602	183956	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44570761	189972	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517081	189972	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	122178179	121263	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	121263	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	24969112	88876	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364339	88876	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11540248	88882	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364345	88882	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647560	88884	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364347	88884	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196005	88915	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	CHEMBL2364378	88915	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	69198434	88923	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	CHEMBL2364386	88923	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	69198286	88931	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364394	88931	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11562181	88942	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364405	88942	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196132	88953	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	CHEMBL2364416	88953	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	69197703	88954	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364417	88954	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	69194443	88975	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364436	88975	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	11503069	88978	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364439	88978	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11647941	88985	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364446	88985	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	11576203	88992	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	CHEMBL2364453	88992	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	11683891	89006	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364467	89006	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	69194380	89030	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364490	89030	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	56926783	69058	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923632	69058	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	156021183	178124	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	178124	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156017268	177650	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177650	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021183	178124	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	178124	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453070	95093	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL255401	95093	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	44453097	155093	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401891	155093	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	44570762	183428	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL479865	183428	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578013	211764	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	156017268	177650	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177650	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44434114	89418	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237060	89418	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	44450134	161892	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL415095	161892	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44446177	94647	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252448	94647	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL500468	214115	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
	44450105	95802	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL258762	95802	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44447848	94900	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254167	94900	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44580031	193070	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL522446	193070	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL3578013	211764	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44447845	94878	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253966	94878	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44434119	89906	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	CHEMBL237925	89906	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	145953855	162515	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	162515	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44434121	89908	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL237927	89908	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	162646324	179736	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744139	179736	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	10721075	15553	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121960	15553	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	145959787	162285	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162285	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16114289	98665	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL277376	98665	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	56926892	69062	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923636	69062	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145984632	166391	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	166391	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	155551597	173949	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4541252	173949	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	22862448	97178	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL268231	97178	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	22867465	97219	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	CHEMBL268518	97219	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	44301387	11264	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179088	11264	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL59572	11264	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	56926356	69019	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923512	69019	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	10143731	64328	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181156	64328	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44444558	167777	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL430398	167777	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	145959007	162257	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	162257	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145959787	162285	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162285	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156021766	178127	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	178127	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452826	95382	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL256809	95382	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452777	96220	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL260831	96220	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	11554351	96539	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL262879	96539	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	11605061	96714	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL264170	96714	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452825	155250	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL402772	155250	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL3578017	211768	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69197033	88907	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364370	88907	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197513	88922	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364385	88922	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196509	88926	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364389	88926	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11669948	88938	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364401	88938	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196071	88996	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364457	88996	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	69194899	89000	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364461	89000	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	44434055	89305	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL236858	89305	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44436889	153057	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397594	153057	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44570922	192563	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521264	192563	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196838	88887	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364350	88887	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	25211977	186902	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489818	186902	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	16113580	137879	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	CHEMBL376258	137879	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	44434111	146283	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392077	146283	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	15481185	77261	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	77261	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	127048059	139566	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797225	139566	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	16113580	137879	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376258	137879	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44450103	95772	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258551	95772	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44391032	64845	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182050	64845	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156011736	177423	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	177423	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450132	96012	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259712	96012	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	145948725	167497	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299615	167497	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	44281450	99645	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	99645	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44281450	99645	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	99645	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44411584	10303	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	10303	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	156015766	177568	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	177568	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44411584	10303	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	10303	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888433	64613	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181735	64613	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579775	187180	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL492230	187180	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	11258291	189104	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL510195	189104	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579882	193066	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL522426	193066	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44450044	161102	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411699	161102	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	56926463	69038	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923611	69038	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145981687	166577	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	166577	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44579640	186896	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489793	186896	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579686	186991	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490614	186991	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	16203238	137109	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	CHEMBL374757	137109	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	44390997	123001	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360891	123001	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL3578017	211768	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	23661656	169044	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL439560	169044	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	44434074	154673	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL399625	154673	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434009	167453	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL429799	167453	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	22867312	23870	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	CHEMBL13366	23870	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	162665952	182379	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4785149	182379	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44434056	144995	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391088	144995	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434007	88575	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235446	88575	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	156021766	178127	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	178127	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44391035	122608	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360247	122608	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	44301512	12022	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183340	12022	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL291333	12022	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	145979268	166664	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	166664	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145959007	162257	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	162257	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44580030	186970	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490422	186970	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	118718706	115379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3350011	115379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	44301462	11262	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179075	11262	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL58758	11262	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	16113800	137812	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL375972	137812	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44391015	123555	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL361802	123555	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	162677268	183573	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4800459	183573	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	10507433	16467	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL123430	16467	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	23730458	146572	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	CHEMBL392296	146572	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	44576247	214222	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL506986	214222	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	168285897	191657	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5196194	191657	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	155529391	171440	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4463042	171440	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145956659	162055	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	162055	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	155537651	172316	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4475293	172316	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145981196	166536	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	166536	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	145979819	166473	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	166473	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434016	90193	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL238228	90193	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	16113692	137236	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL375162	137236	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	24970113	69056	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923629	69056	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL2170777	209365	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCC[C@H](NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm300414b
	145956026	162662	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162662	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	10314	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	10314	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	138189	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	138189	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	139536	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	139536	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	169284	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	169284	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	11526696	71602	17	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	71602	17	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	71602	17	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	10649323	15530	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121803	15530	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10841400	16851	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL124831	16851	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156009875	177123	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	177123	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444562	94471	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251365	94471	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	145956026	162662	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162662	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	10314	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	10314	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	138189	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	138189	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	139536	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	139536	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	169284	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	169284	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	156009875	177123	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	177123	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015766	177568	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	177568	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44570967	190169	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL517391	190169	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	24969114	88879	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364342	88879	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	59007076	88902	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364365	88902	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	69197196	88904	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364367	88904	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	69197071	88943	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364406	88943	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194482	88958	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364420	88958	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	11719784	88995	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364456	88995	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	59007054	89027	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	CHEMBL2364487	89027	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	16114097	79157	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113321	79157	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	16113710	79161	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113325	79161	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	23730226	147872	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	CHEMBL393329	147872	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	71453489	209368	15	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	CHEMBL2170781	209368	15	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	44411632	10304	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	10304	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888425	62524	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178216	62524	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44411632	10304	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	10304	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL2170782	209369	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579858	186925	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490010	186925	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579778	187019	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490801	187019	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	162657606	181117	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760409	181117	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956659	162055	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	162055	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950987	162840	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	162840	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	69198313	88898	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	CHEMBL2364361	88898	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	69195692	88899	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	CHEMBL2364362	88899	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	69196612	88900	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364363	88900	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	11511158	88948	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364411	88948	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198054	89001	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364462	89001	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	69195074	89014	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364474	89014	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	69195546	89024	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364484	89024	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	44580028	193250	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL523786	193250	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	44434011	147864	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL393321	147864	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	57390496	69055	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	69055	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	145988894	167144	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	167144	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434086	148855	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL394130	148855	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	145950987	162840	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	162840	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	44449924	159945	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	CHEMBL410730	159945	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	56926785	69060	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923634	69060	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434078	89910	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237932	89910	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434008	146534	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL392268	146534	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44411913	10313	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	10313	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44268939	30447	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13926	30447	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44411913	10313	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	10313	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44434015	88491	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL235011	88491	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44411905	10312	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	10312	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10506325	101241	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	101241	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	16113371	79153	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL2113318	79153	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	162676229	183304	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797064	183304	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL3578005	211759	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	44348031	113089	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL331303	113089	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44411905	10312	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	10312	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	10324	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	10324	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	10506325	101241	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	101241	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	44436857	145656	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL391588	145656	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	156021787	178143	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	178143	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	10006735	117013	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	117013	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	10006735	117013	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	117013	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	156021787	178143	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	178143	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	11712108	161308	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL412303	161308	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	44571003	192588	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL521439	192588	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578005	211759	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	69196876	88889	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364352	88889	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11562329	88928	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364391	88928	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	69196868	88932	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364395	88932	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196990	88988	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364449	88988	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	69195880	89005	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364466	89005	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	11518463	89008	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364469	89008	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	69195024	89032	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364492	89032	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44390922	122146	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL359686	122146	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	23631026	167456	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL429817	167456	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL2170779	209366	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44447842	95019	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254972	95019	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44579804	187065	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491220	187065	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145948708	167496	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299606	167496	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	121879	2234	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	5868	2234	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	CHEMBL308716	2234	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	44268996	166463	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL427806	166463	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	122178180	121264	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	121264	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	44579959	184272	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL483865	184272	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44454117	155556	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155556	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	162677361	183509	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4799766	183509	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170700	209360	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444570	154768	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400125	154768	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156017532	177908	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177908	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11662746	97813	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271947	97813	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	122178180	121264	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	121264	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578007	211761	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	16750162	88878	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364341	88878	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	11568467	88888	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364351	88888	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197136	88989	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	CHEMBL2364450	88989	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	69195304	89003	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	CHEMBL2364464	89003	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	145949880	162791	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162791	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	16114099	137224	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375103	137224	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44269018	97348	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL269447	97348	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	145949880	162791	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162791	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	156015598	177577	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	177577	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	44452827	95426	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL257019	95426	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	46882582	5755	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078490	5755	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	145988647	167072	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	167072	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44454367	95261	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	95261	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	16113691	136719	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	CHEMBL374073	136719	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	16113691	136719	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL374073	136719	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	22867380	29420	1	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13841	29420	1	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	2098	3694	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	36511	3694	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3805	3694	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3835	3694	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	CHEMBL235363	3694	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	155561671	175664	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4581511	175664	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44434073	89600	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL237507	89600	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	145981794	166696	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	166696	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56926173	69012	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	CHEMBL1923501	69012	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	44301389	11275	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179118	11275	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL61292	11275	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	156015598	177577	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	177577	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	156017532	177908	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177908	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10100708	12034	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183387	12034	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL294408	12034	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44579756	186823	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489370	186823	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145958487	162184	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	162184	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156016840	177631	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	177631	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170779	209366	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	71453489	209368	15	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209368	15	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	10209618	63499	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179978	63499	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391041	64321	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181123	64321	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10600702	141336	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	141336	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10600702	141336	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	141336	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	9868878	96541	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL262884	96541	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	11306502	63642	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63642	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888395	63905	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180540	63905	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	156021942	178223	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	178223	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16113248	79164	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113328	79164	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	23730342	89902	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	CHEMBL237916	89902	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	145958487	162184	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	162184	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156010733	177080	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	177080	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013130	177502	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	177502	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016840	177631	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	177631	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156021942	178223	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	178223	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570920	183933	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481408	183933	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44571005	184047	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL482204	184047	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	11539144	88893	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364356	88893	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	69197315	88909	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364372	88909	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11683663	88935	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364398	88935	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	11583902	88976	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364437	88976	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	69198030	88981	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364442	88981	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197149	88993	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364454	88993	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	69196669	89018	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364478	89018	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	10032659	12051	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183505	12051	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL301259	12051	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44450137	96301	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL261234	96301	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	127046472	139694	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798056	139694	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127046472	139694	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798056	139694	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	145988286	167206	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	167206	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL3578007	211761	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	CHEMBL61663	215839	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
	24180592	97013	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	97013	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	162663868	181988	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780408	181988	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	145986080	166452	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	166452	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	168274297	190579	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5180310	190579	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	127047523	140063	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3800422	140063	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	44434118	148178	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL393570	148178	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44446187	94621	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252255	94621	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145959787	162285	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162285	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	155557019	174587	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174587	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	56926893	69063	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	CHEMBL1923637	69063	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	44437963	202092	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	202092	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44437963	202092	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	202092	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44579881	186836	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL489402	186836	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	24180646	148182	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	148182	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	24180646	148182	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL393576	148182	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	145959787	162285	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162285	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	46882520	5856	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	CHEMBL1079311	5856	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	46882458	5978	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1080046	5978	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL3578016	211767	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	59007057	88892	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364355	88892	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11597905	88946	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364409	88946	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198135	88977	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364438	88977	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	11711997	88994	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	CHEMBL2364455	88994	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	44452778	159778	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410527	159778	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	10437444	112881	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330989	112881	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	24969603	69054	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	CHEMBL1923627	69054	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	162649450	180054	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4747770	180054	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	156013130	177502	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	177502	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44450100	160655	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL411330	160655	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	44411720	10307	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	10307	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	10311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	10311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411720	10307	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	10307	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	10311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	10311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	162656896	180860	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4757313	180860	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	44436883	146153	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	CHEMBL391980	146153	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	156010733	177080	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	177080	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10745674	167954	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	167954	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44579776	193251	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL523795	193251	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	127048061	139736	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798337	139736	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	23730340	89741	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237700	89741	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	56926175	69013	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923504	69013	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	145992835	166834	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	166834	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56925343	69066	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923640	69066	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	145986870	167140	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	167140	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44434054	89304	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL236857	89304	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	44446178	155123	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL402023	155123	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3578016	211767	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	162648837	179838	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745116	179838	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44391024	64285	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180992	64285	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10745674	167954	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	167954	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391021	19453	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL129637	19453	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL2170696	209356	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	23730343	89903	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	CHEMBL237917	89903	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	22888359	63916	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180591	63916	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	16114514	79158	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	CHEMBL2113322	79158	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	44579843	184753	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL485092	184753	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44579643	186771	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488971	186771	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579822	192524	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL520953	192524	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44579755	186943	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490186	186943	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44580032	186834	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489398	186834	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	145991945	166815	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	166815	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	145992253	166928	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	166928	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL2170702	209362	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145993313	166892	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	166892	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16114008	84846	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223532	84846	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL501261	214135	23	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
	9848305	145452	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391429	145452	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	44434050	145450	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL391428	145450	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578015	211766	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL369482	212163	0	None	-	0	Rat	8.0	pED50	=	8	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cn1ccnc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/S0960-894X(01)80239-0
	44269087	98227	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	CHEMBL274341	98227	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	70691550	73200	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011825	73200	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	16114292	96934	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96934	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL509976	215580	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	25260901	113480	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319405	113480	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	71456897	81850	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164507	81850	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70691551	73201	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011826	73201	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	25261382	113441	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319215	113441	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11431274	77344	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL208424	77344	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11577349	65231	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182655	65231	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	11351838	77650	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	CHEMBL208842	77650	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	11712151	75993	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205470	75993	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	11713497	123237	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL361349	123237	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	44409757	141324	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383454	141324	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	127046807	139940	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139940	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	3676358	5534	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1076586	5534	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	122182047	122002	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	122002	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	122178603	121339	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	121339	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	11649248	66670	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185399	66670	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	44395020	124032	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL363021	124032	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	44389262	122032	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359506	122032	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	145993628	167391	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4295148	167391	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11211892	80216	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL213703	80216	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	122178611	121348	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	121348	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	11846624	77916	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209443	77916	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11846463	139242	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL378909	139242	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11430392	76724	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	CHEMBL206588	76724	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	57797614	73192	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011817	73192	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44409801	76733	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206638	76733	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11523411	75555	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	CHEMBL204511	75555	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	11537800	75567	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL204564	75567	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	71453392	81847	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164504	81847	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71456910	81901	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164823	81901	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	71460578	81908	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164830	81908	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	122178612	121349	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	121349	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL507636	214433	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	56942387	139662	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139662	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145991822	166959	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287267	166959	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11676995	66162	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184258	66162	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	127048038	139972	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139972	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	71458746	81837	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164493	81837	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	145992142	166771	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	166771	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	71460565	81839	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164495	81839	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	11538533	75001	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203280	75001	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	46880462	6267	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081648	6267	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	70693641	73203	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011828	73203	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	44409756	76767	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206820	76767	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46865987	7597	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087908	7597	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880772	5911	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079624	5911	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11538534	75014	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203373	75014	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	145986870	167140	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	167140	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	127046806	139933	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139933	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178613	121350	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	121350	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	145981196	166536	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	166536	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	46880814	6377	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082190	6377	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178616	121352	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	121352	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	145986461	167213	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	167213	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71451551	81851	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164508	81851	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	46880727	6145	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080939	6145	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122182190	122009	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	122009	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44409840	76342	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205896	76342	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127047362	139719	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139719	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145989916	166746	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4283454	166746	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	127048038	139972	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139972	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880673	6105	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080755	6105	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11455251	161314	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL412362	161314	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409611	74687	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203019	74687	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11221946	140846	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL381942	140846	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409839	76258	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205847	76258	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71460576	81905	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164828	81905	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL509976	215580	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11692087	62992	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178610	62992	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	44409758	75974	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205374	75974	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409661	75996	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205484	75996	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880724	6258	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081611	6258	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	71455105	81904	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164827	81904	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	11221946	140846	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	CHEMBL381942	140846	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	44410003	76181	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205794	76181	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880811	5998	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080162	5998	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687379	73198	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011823	73198	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	44394974	67012	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186974	67012	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	211801	6	None	-	1	Rat	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	46880567	6387	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082210	6387	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71460564	81836	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164492	81836	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	145992854	166866	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4285747	166866	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	44394833	126825	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365460	126825	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL509976	215580	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	215580	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	215580	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	127047654	139977	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139977	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	145993758	167316	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294024	167316	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145993528	167318	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	167318	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL444131	213929	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
	11476589	75988	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205451	75988	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11329138	64460	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL181350	64460	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	70681022	73207	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011833	73207	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL509976	215580	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178611	121348	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	121348	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	46880675	6143	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080927	6143	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11612155	141009	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL382375	141009	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	328912	62576	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178266	62576	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	70685218	73195	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011820	73195	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145981794	166696	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	166696	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11649239	66340	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185057	66340	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL501261	214135	23	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	1744826	62998	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178668	62998	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	11282247	165926	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL425048	165926	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11282247	165926	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL425048	165926	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	1744826	62998	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178668	62998	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409831	75698	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204776	75698	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145979268	166664	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	166664	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44409678	141217	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382853	141217	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11349789	78773	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211265	78773	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11692087	62992	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178610	62992	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11677781	125058	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL364430	125058	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	11538533	75001	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	CHEMBL203280	75001	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	11154823	76029	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205660	76029	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	56942244	125197	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	125197	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44409994	76182	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205796	76182	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	214222	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44395002	66186	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184368	66186	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	11646276	75934	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL205136	75934	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	127046807	139940	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139940	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113695	137027	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374643	137027	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	145987684	167277	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	167277	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	122178602	121338	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	121338	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	70681020	73204	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011829	73204	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	56942098	125193	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	125193	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	125195	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	125195	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	127046956	139957	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139957	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	66788278	125192	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	125192	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046956	139957	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139957	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	57797640	73226	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011892	73226	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880628	6032	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	6032	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	121342	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	121342	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880629	6058	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080556	6058	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	121342	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	121342	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	70681021	73206	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011832	73206	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70691552	73208	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011834	73208	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44576247	214222	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	122178607	121344	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	121344	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	46880631	6135	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080907	6135	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	46880726	6144	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080938	6144	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70689441	73225	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011891	73225	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145988582	167291	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4293608	167291	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	122178610	121347	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	121347	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409666	75887	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204897	75887	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	214222	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL500703	214120	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	44409802	76744	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206687	76744	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178613	121350	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	121350	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	71458747	81838	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164494	81838	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	56942244	125197	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	125197	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11537683	75527	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL204352	75527	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	71449740	81840	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164497	81840	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	122178601	121337	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	121337	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	11337482	76640	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL206399	76640	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	122178614	121351	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	121351	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	44389168	64873	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL182154	64873	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	145991389	167004	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4288108	167004	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145990051	166955	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287218	166955	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44410012	138399	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377305	138399	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71462272	81845	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164502	81845	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	71451563	81910	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164832	81910	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	145988286	167206	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	167206	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	46880813	6376	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082189	6376	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	44409761	75866	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204880	75866	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11846625	77884	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209394	77884	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	122178610	121347	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	121347	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880461	6235	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081483	6235	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	71453391	81846	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164503	81846	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	1221269	122034	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359530	122034	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389151	62505	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178138	62505	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	71451564	81912	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164834	81912	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	71449753	81902	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164825	81902	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44409871	75396	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203948	75396	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880569	6189	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081212	6189	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	70693640	73197	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011822	73197	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL449590	213962	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	44576247	214222	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	145994299	167396	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4295212	167396	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71460577	81906	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164829	81906	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	16113902	137676	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL375859	137676	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	71462274	81849	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL2164506	81849	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL509976	215580	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	70683143	73196	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011821	73196	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880495	6369	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082162	6369	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	11697618	62599	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178289	62599	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145988557	167260	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	167260	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44409771	141253	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383073	141253	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145980333	166581	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	166581	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11329138	64460	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	CHEMBL181350	64460	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	44576247	214222	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11568561	169554	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL443560	169554	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	145991945	166815	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	166815	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	44394982	66138	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184093	66138	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	66788278	125192	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	125192	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942099	125194	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	125194	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942243	125196	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	125196	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139862	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139862	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	70681018	73194	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011819	73194	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	70685225	73228	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011894	73228	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11410373	138535	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	CHEMBL377514	138535	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	11339816	76007	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205521	76007	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992253	166928	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	166928	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11503585	65204	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182542	65204	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	44409762	75886	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204884	75886	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180026	121587	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121587	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	46880846	7612	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088038	7612	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44389248	122168	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359714	122168	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	70695749	73210	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011836	73210	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178614	121351	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	121351	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	70695748	73202	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011827	73202	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	145981687	166577	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	166577	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11508639	76535	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL206091	76535	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409683	76259	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205848	76259	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11626181	124381	2	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363896	124381	2	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	11690097	76672	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL206446	76672	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	44409775	76025	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205605	76025	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	214222	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11655355	74421	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL202642	74421	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	127047654	139977	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139977	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113799	168713	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL436849	168713	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145986080	166452	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	166452	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56942385	125198	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	125198	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880771	5910	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079623	5910	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11654867	76201	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205833	76201	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	122178600	121336	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	121336	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	46880844	7596	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087907	7596	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11248021	139255	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378989	139255	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122182189	122008	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	122008	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	44409865	140718	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381759	140718	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11751384	141506	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL384524	141506	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409679	75508	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204322	75508	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409868	76742	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206673	76742	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409667	75969	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205294	75969	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	214222	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	56942388	139943	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139943	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	11166495	75550	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL204474	75550	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	145994050	167345	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	167345	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11538533	75001	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203280	75001	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880770	5909	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079622	5909	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71453390	81843	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164500	81843	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	44409763	141365	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383757	141365	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409989	165826	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL424860	165826	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44410008	141251	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383058	141251	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11178309	79901	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL212415	79901	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11517629	168338	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL434330	168338	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	127047655	139614	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139614	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	139707	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139707	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139862	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139862	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	56942098	125193	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	125193	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	139707	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139707	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	46880630	6098	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080735	6098	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70685219	73209	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011835	73209	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	121334	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	121334	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	122178607	121344	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	121344	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	11452801	139298	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL379191	139298	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	46882763	5628	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077617	5628	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44409776	77143	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207754	77143	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145991797	166916	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286597	166916	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	122178616	121352	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	121352	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	11430583	80217	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL213704	80217	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL509976	215580	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11669486	64614	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL181736	64614	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	44409946	139815	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL379887	139815	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127046806	139933	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139933	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178600	121336	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	121336	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	11605333	76725	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	CHEMBL206589	76725	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	46880845	7611	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088037	7611	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880773	6207	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081301	6207	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178604	121340	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	121340	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	56942387	139662	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139662	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	214222	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11683469	76706	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL206486	76706	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	44389216	123854	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL362595	123854	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	145979819	166473	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	166473	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880498	5995	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080155	5995	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71462273	81848	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164505	81848	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71453404	81903	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164826	81903	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44389283	62945	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178494	62945	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	11179347	77353	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL208477	77353	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44409764	77149	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207792	77149	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11606121	64576	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	CHEMBL181584	64576	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	11539587	67077	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187271	67077	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	211801	6	None	-	1	Rat	8.3	pIC50	=	8.3	Functional	Inverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	122178608	121345	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	121345	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409821	76037	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205711	76037	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11340044	141335	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL383522	141335	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70683149	73223	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011887	73223	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	71452183	83529	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	83529	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	122178602	121338	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	121338	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	11582836	62913	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178463	62913	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389192	168646	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL436275	168646	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	71455106	81913	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164835	81913	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	44409998	138536	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377515	138536	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145984632	166391	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	166391	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	10415364	126767	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126767	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	15949382	74848	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203158	74848	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145993313	166892	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	166892	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11605822	124388	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363930	124388	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11154001	79888	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL212354	79888	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	44394930	66332	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185028	66332	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	11699004	66203	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184429	66203	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11618705	166938	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL428698	166938	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	44409785	75803	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204852	75803	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409990	76517	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205995	76517	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145992125	166750	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	166750	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880568	6388	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082211	6388	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687383	73224	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011890	73224	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	121334	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	121334	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL509976	215580	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	57422817	113449	18	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319223	113449	18	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11190594	75985	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205445	75985	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	56942385	125198	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	125198	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	214222	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	16113904	137036	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374655	137036	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	44389215	63078	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178838	63078	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44576247	214222	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409809	75065	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203578	75065	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113468	141800	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL386218	141800	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	11531313	62504	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178137	62504	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389167	123858	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL362612	123858	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880674	6142	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080926	6142	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71455085	81844	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164501	81844	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	46880463	6268	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081649	6268	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	46880812	6021	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080320	6021	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880497	6371	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082164	6371	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	44409770	141368	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383766	141368	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178604	121340	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	121340	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	46880496	6370	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082163	6370	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL502208	214150	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
	145980382	166643	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	166643	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44389186	64615	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL181739	64615	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409864	75499	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204266	75499	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409975	75790	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204835	75790	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409455	75968	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL205286	75968	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	11441554	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	5871	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	CHEMBL212761	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	11340329	79602	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211454	79602	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178605	121341	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	121341	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	127047655	139614	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139614	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	46880672	6196	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081254	6196	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	66601728	81841	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164499	81841	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70689440	73193	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011818	73193	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	70693644	73227	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011893	73227	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70695747	73191	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	73191	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11225576	166037	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL425594	166037	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11225576	166037	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL425594	166037	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	122178608	121345	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	121345	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	122178609	121346	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	121346	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	56942388	139943	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139943	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139761	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139761	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11176805	77334	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	CHEMBL208374	77334	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	71453405	81911	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164833	81911	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	44394913	127173	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365721	127173	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	44409832	76410	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205955	76410	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	25190383	81909	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164831	81909	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	122178615	121304	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	121304	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44410013	77053	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207268	77053	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44389243	64583	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	CHEMBL181619	64583	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	753168	123239	40	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL361366	123239	40	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880566	6386	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082209	6386	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178603	121339	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	121339	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	44409979	140559	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381159	140559	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11256439	75379	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	CHEMBL203843	75379	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	11655578	170033	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL444277	170033	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70681019	73199	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011824	73199	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	122178612	121349	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	121349	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	11617435	75997	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL205486	75997	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	145988647	167072	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	167072	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11663710	124467	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363995	124467	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	56942099	125194	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	125194	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	125195	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	125195	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	11663710	124467	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL363995	124467	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	70695747	73191	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	73191	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70687380	73205	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011831	73205	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178605	121341	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	121341	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	145988894	167144	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	167144	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16203569	141733	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL385803	141733	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145981343	166709	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	166709	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL509976	215580	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Agonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178615	121304	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	121304	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44409810	140900	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382138	140900	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113124	121335	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581032	121335	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	44576247	214222	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214222	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409536	75509	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL204325	75509	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992835	166834	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	166834	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11327400	75372	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL203782	75372	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11539588	66913	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186540	66913	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	16113796	84681	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL222518	84681	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	11442040	78551	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211211	78551	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178601	121337	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	121337	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	56942243	125196	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	125196	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	46880725	6259	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	CHEMBL1081612	6259	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	122178609	121346	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	121346	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	11454617	141319	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383411	141319	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	46880628	6032	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	6032	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44409684	140885	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382033	140885	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409672	140487	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL380971	140487	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409673	76750	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL206741	76750	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	11453509	76178	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205784	76178	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	127047362	139719	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139719	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139761	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139761	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145990956	167021	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4288441	167021	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44394947	169223	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL440939	169223	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	44410007	76427	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205963	76427	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11583811	75987	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205450	75987	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11576960	67115	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187427	67115	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	11281346	76018	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205568	76018	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL499371	214095	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
	155540883	172957	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172957	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155540883	172957	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172957	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	174587	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174587	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	174587	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174587	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57399248	69044	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	69044	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	71452183	83529	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	83529	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	44454117	155556	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155556	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44454060	155332	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	155332	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	95261	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	95261	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454338	97835	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	97835	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44434080	89911	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	89911	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454302	159380	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	159380	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454092	97649	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97649	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454432	155258	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	155258	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	9950632	88706	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	88706	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44454399	155139	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	155139	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454432	155258	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	155258	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	25022640	97801	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	97801	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	97649	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97649	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454303	97569	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	97569	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454304	97603	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	97603	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	56926461	69036	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923609	69036	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	44454398	97598	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	97598	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	44454060	155332	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	155332	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	95261	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	95261	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454337	155603	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	155603	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454117	155556	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155556	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	1099	1787	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.	Guide to Pharmacology		None	None	None		None	29233536
	121879	2234	24	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	2234	24	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	2234	24	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5869	4080	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	121879	2234	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	5868	2234	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	CHEMBL308716	2234	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	1099	1787	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10628755
	1099	1787	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	121879	2234	24	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	2234	24	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	2234	24	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	1093	1794	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1794	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1093	1794	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1794	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	178024	1971	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	178024	1971	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	5867	1971	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	5867	1971	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	CHEMBL13817	1971	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	CHEMBL13817	1971	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	1099	1787	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1099	1787	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	5866	3624	4	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9804743	3624	4	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	CHEMBL360227	3624	4	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9734	2330	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.	Guide to Pharmacology		None	None	None		None	29233536
	11441554	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5871	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	CHEMBL212761	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5872	2124	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	74015851	2124	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	25124566	1874	8	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5870	1874	8	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	CHEMBL3358452	1874	8	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5866	3624	4	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	9804743	3624	4	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	CHEMBL360227	3624	4	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	25124566	1874	8	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	5870	1874	8	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	CHEMBL3358452	1874	8	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		2713	205271	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5353524	205271	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5360566	205271	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		88536661	205271	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		9552079	205271	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1330113	205271	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL790	205271	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		156419	938	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		3308	938	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		647	938	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL1201284	938	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB01012	938	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		5920	47275	83	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	651	5	3	4	4.0	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
		7048703	47275	83	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	651	5	3	4	4.0	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL1544	47275	83	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	651	5	3	4	4.0	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
		148192	10420	81	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704	14	5	9	4.2	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1163	10420	81	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704	14	5	9	4.2	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	10.1038/s41467-023-40064-9
		154257	178619	67	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
		CHEMBL46740	178619	67	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
		2600	3779	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	3779	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	3779	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	3779	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	3779	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		47319	26464	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1360	26464	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
		135409453	3773	41	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	3773	41	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	3773	41	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		71496458	115564	87	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL3353410	115564	87	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
		242	470	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		39186	85935	54	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	414	6	0	6	3.4	COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1	10.1038/s41467-023-40064-9
		CHEMBL23	85935	54	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	414	6	0	6	3.4	COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1	10.1038/s41467-023-40064-9
		16362	3125	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	3125	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	3125	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	3125	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	3125	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		3042	1414	35	None	-	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		355	1414	35	None	-	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		868	1414	35	None	-	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		CHEMBL1123	1414	35	None	-	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		DB00804	1414	35	None	-	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		10184665	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		4799	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		7353	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1198857	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		DB09082	3991	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		3191	102858	97	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL305660	102858	97	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
		3926	207241	40	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL92870	207241	40	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		11626560	200937	94	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
		CHEMBL601719	200937	94	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
		2267	559	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		271	559	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		7121	559	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL639	559	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB00972	559	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		135564886	14493	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		135673376	14493	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		137157436	14493	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		145948239	14493	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		71587099	14493	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		CHEMBL1201304	14493	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		2585	803	103	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		522	803	103	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		551	803	103	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		CHEMBL723	803	103	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		DB01136	803	103	None	-	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		1353	1911	93	None	-	83	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-	83	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-	83	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-	83	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-	83	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		100	3805	58	None	-	55	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		2637	3805	58	None	-	55	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		5452	3805	58	None	-	55	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL479	3805	58	None	-	55	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB00679	3805	58	None	-	55	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		202	1508	77	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		60835	1508	77	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		972	1508	77	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1175	1508	77	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		DB00476	1508	77	None	-	30	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		11976	920	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		667467	920	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		CHEMBL908	920	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		DB01239	920	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		2218	15283	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
		CHEMBL1213033	15283	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
		41684	31221	105	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
		CHEMBL1401	31221	105	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
		3025	7275	86	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	10	1	4	3.5	CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1	10.1038/s41467-023-40064-9
		CHEMBL1086	7275	86	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	10	1	4	3.5	CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1	10.1038/s41467-023-40064-9
		44112	121290	48	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
		CHEMBL357995	121290	48	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
		68617	205527	62	None	-	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1709	205527	62	None	-	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL809	205527	62	None	-	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		2726	919	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	919	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	919	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	919	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	919	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		16363	596	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		312	596	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		9215	596	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL297302	596	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB12867	596	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2291	3184	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		2561	3184	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		4932	3184	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL631	3184	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		DB01182	3184	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		24826799	10798	104	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
		CHEMBL1171837	10798	104	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
		2274	3173	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		4917	3173	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		7279	3173	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL728	3173	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00433	3173	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		2398	954	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2801	954	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		701	954	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL415	954	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB01242	954	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		4046	2483	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		4252	2483	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		CHEMBL416956	2483	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		DB00358	2483	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		3074	17958	26	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL126075	17958	26	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
		4413	98073	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
		CHEMBL273264	98073	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
		25382	9157	37	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL110094	9157	37	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
		2375	158394	106	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	430	5	2	5	2.9	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
		CHEMBL409	158394	106	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	430	5	2	5	2.9	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
		2351	4300	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1008	4300	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1257078	4300	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		448537	160250	89	None	-	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL411	160250	89	None	-	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		3393	207924	24	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	0	3	4.0	CCN(CC)CCN1C(=O)CN=C(c2ccccc2F)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
		CHEMBL968	207924	24	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	0	3	4.0	CCN(CC)CCN1C(=O)CN=C(c2ccccc2F)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
		441243	9836	58	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
		CHEMBL114	9836	58	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
		214	3860	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		2740	3860	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5566	3860	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		66064	3860	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL422	3860	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00831	3860	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		46780481	107531	20	None	-	53	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		9903970	107531	20	None	-	53	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3187365	107531	20	None	-	53	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3544974	107531	20	None	-	53	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		6436173	55116	45	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
		CHEMBL1617	55116	45	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
		8550	14424	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	578	7	1	9	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	10.1038/s41467-023-40064-9
		CHEMBL1200515	14424	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	578	7	1	9	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	10.1038/s41467-023-40064-9
		31101	729	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	729	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	729	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	729	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	729	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		104850	3330	96	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		4150	3330	96	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		743	3330	96	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL111	3330	96	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		DB06155	3330	96	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		392622	56312	95	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
		CHEMBL163	56312	95	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
		2995	204405	53	None	-	23	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1696	204405	53	None	-	23	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL72	204405	53	None	-	23	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		3947	206395	53	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL87708	206395	53	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		212	3806	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	3806	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	3806	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	3806	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	3806	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL3039583	210949	0	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
		60065	84369	6	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2218858	84369	6	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		3081361	93934	123	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
		CHEMBL24828	93934	123	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
		107771	120248	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
		CHEMBL35228	120248	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
		3151	1462	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		945	1462	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		965	1462	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL219916	1462	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01184	1462	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		3949	100614	50	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL29188	100614	50	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
		2435	3590	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		60149	3590	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		98	3590	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		CHEMBL12713	3590	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		DB06144	3590	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		25181577	78219	56	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2105695	78219	56	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
		2318	154856	29	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL400599	154856	29	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
		2407	3372	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		59227	3372	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		941	3372	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		CHEMBL1303	3372	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		DB05271	3372	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		3380	22790	34	None	-	1	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	10.1038/s41467-023-40064-9
		CHEMBL13280	22790	34	None	-	1	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	10.1038/s41467-023-40064-9
		2202	3132	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		4850	3132	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		49	3132	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		CHEMBL1371770	3132	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		DB12478	3132	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		4495	196535	92	None	-	29	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL56367	196535	92	None	-	29	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	10.1038/s41467-023-40064-9
		9801	91585	35	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL24072	91585	35	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		6729	14485	41	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	432	5	0	2	6.5	CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201271	14485	41	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	432	5	0	2	6.5	CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1038/s41467-023-40064-9
		1016	3747	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		2561	3747	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		2733526	3747	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		5384	3747	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL83	3747	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		DB00675	3747	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		9915743	63542	93	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	556	11	2	8	5.9	CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C	10.1038/s41467-023-40064-9
		CHEMBL180022	63542	93	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	556	11	2	8	5.9	CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C	10.1038/s41467-023-40064-9
		275196	125673	52	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
		CHEMBL364713	125673	52	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
		26987	949	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	949	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	949	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	949	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	949	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		11980903	14492	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		22526	14492	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		5281035	14492	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201303	14492	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		25077405	2715	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		3902	2715	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		CHEMBL1201309	2715	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		DB00666	2715	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		102	4127	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	4127	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	4127	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	4127	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	4127	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		4034	55822	55	None	-	1	Human	4.4	pAC50	=	4.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	55822	55	None	-	1	Human	4.4	pAC50	=	4.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		5328940	100216	107	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	100216	107	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		10531	1420	21	None	-	23	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	1420	21	None	-	23	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	1420	21	None	-	23	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	1420	21	None	-	23	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	1420	21	None	-	23	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		118422671	2757	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		1887	2757	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		71301	2757	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		7246	2757	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		CHEMBL434394	2757	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		DB04861	2757	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		30323	62485	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		CHEMBL1563	62485	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		CHEMBL178	62485	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		10096344	89594	85	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	10	1.1	CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C	10.1038/s41467-023-40064-9
		CHEMBL237500	89594	85	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	10	1.1	CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C	10.1038/s41467-023-40064-9
		216416	111581	48	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL328190	111581	48	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		319	1324	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		321	1324	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		444031	1324	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		784	1324	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		CHEMBL1346	1324	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		DB00496	1324	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		3149	12614	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1187011	12614	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
		4746	204891	31	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1334033	204891	31	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
		CHEMBL75880	204891	31	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
		2335	11848	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	11848	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	11848	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	11848	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		65709	59881	39	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1729803	59881	39	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
		11643449	89955	3	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	753	6	5	10	2.7	CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1	10.1038/s41467-023-40064-9
		CHEMBL238071	89955	3	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	753	6	5	10	2.7	CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1	10.1038/s41467-023-40064-9
		2448	99323	70	None	-	18	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
		CHEMBL28218	99323	70	None	-	18	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
		4452	2762	19	None	-	19	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		983	2762	19	None	-	19	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL20734	2762	19	None	-	19	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		176	398	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2157	398	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2566	398	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		CHEMBL633	398	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		DB01118	398	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		1222	1664	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		3396	1664	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		85	1664	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL46516	1664	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		DB04842	1664	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		5329102	194726	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	194726	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		72093	35061	9	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL1433361	35061	9	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL2103773	35061	9	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		42890	9425	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
		CHEMBL1117	9425	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
		1164	1630	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		1626	1630	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		3345	1630	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL596	1630	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		DB00813	1630	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		2247	505	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	505	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	505	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	505	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	505	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		5482	14420	80	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1200438	14420	80	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		1385580	29276	76	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		4615	29276	76	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL13828	29276	76	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		16722836	18985	99	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	524	10	3	8	4.8	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1	10.1038/s41467-023-40064-9
		CHEMBL1287853	18985	99	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	524	10	3	8	4.8	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1	10.1038/s41467-023-40064-9
		2794	19380	85	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1292	19380	85	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		3883	183535	112	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	369	5	1	4	3.5	Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1	10.1038/s41467-023-40064-9
		CHEMBL480	183535	112	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	369	5	1	4	3.5	Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1	10.1038/s41467-023-40064-9
		178024	1971	33	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
		5867	1971	33	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
		CHEMBL13817	1971	33	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
		22867441	10315	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161835	10315	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		67457995	91833	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
		CHEMBL2413152	91833	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
		22867441	10315	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161835	10315	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		71716660	86002	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		CHEMBL2304221	86002	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		10345516	139275	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
		CHEMBL379074	139275	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
		71716660	86002	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		CHEMBL2304221	86002	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		10345516	139275	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
		CHEMBL379074	139275	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
		9807597	183017	5	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		CHEMBL47938	183017	5	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		10323604	10309	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161828	10309	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10323604	10309	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161828	10309	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		44411920	77878	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		CHEMBL209360	77878	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		162662316	181523	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
		CHEMBL4765101	181523	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
		90666017	109300	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218890	109300	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44411920	77878	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		CHEMBL209360	77878	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		10625750	168154	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		CHEMBL433087	168154	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		10625750	168154	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		CHEMBL433087	168154	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		10626337	101225	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
		CHEMBL295984	101225	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
		44411718	10306	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161825	10306	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44293557	101088	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL294923	101088	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL540001	101088	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		16040587	179384	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
		CHEMBL473921	179384	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
		16040587	179384	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
		CHEMBL473921	179384	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
		16752689	188368	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
		CHEMBL501315	188368	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
		9890375	98270	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL274599	98270	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL558802	98270	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		9890375	98270	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL274599	98270	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL558802	98270	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		10026738	162769	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL417182	162769	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL557206	162769	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		10026738	162769	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL417182	162769	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL557206	162769	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		10745533	140120	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL380096	140120	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		10745533	140120	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL380096	140120	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		44411745	10308	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		CHEMBL1161827	10308	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		10626337	101225	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
		CHEMBL295984	101225	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
		44411634	10305	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161824	10305	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		44411634	10305	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161824	10305	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		44411745	10308	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		CHEMBL1161827	10308	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		44411753	10310	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		CHEMBL1161829	10310	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		44411753	10310	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		CHEMBL1161829	10310	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		44293091	188186	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL49884	188186	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		44293091	188186	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL49884	188186	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		46905972	10409	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
		CHEMBL1162926	10409	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
		15481181	77744	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		CHEMBL209020	77744	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		9810101	99249	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL281764	99249	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		15481188	141210	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
		CHEMBL382844	141210	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
		CHEMBL1793862	208928	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
		216208	9727	33	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
		CHEMBL113313	9727	33	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
		46905972	10409	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
		CHEMBL1162926	10409	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
		15481181	77744	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		CHEMBL209020	77744	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		9810101	99249	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL281764	99249	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		15481188	141210	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
		CHEMBL382844	141210	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
		CHEMBL1793862	208928	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
		15481185	77261	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		CHEMBL207970	77261	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		15481185	77261	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		CHEMBL207970	77261	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		44411584	10303	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161822	10303	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44411584	10303	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161822	10303	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		22862436	10314	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161834	10314	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10602640	138189	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
		CHEMBL376970	138189	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
		10791616	139536	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL379564	139536	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		10029990	169284	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL441360	169284	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		22862436	10314	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161834	10314	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10602640	138189	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
		CHEMBL376970	138189	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
		10791616	139536	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL379564	139536	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		10029990	169284	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL441360	169284	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		44411632	10304	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161823	10304	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44411632	10304	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161823	10304	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		23529194	102191	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
		CHEMBL302810	102191	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
		16041292	183611	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
		CHEMBL480219	183611	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
		44411913	10313	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161833	10313	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44411913	10313	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161833	10313	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44411905	10312	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161832	10312	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10506325	101241	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		CHEMBL296104	101241	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		44411905	10312	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161832	10312	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10506325	101241	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		CHEMBL296104	101241	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		10600702	141336	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL383526	141336	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		10600702	141336	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL383526	141336	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL335799	211564	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmc.2013.06.006
		44411720	10307	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		CHEMBL1161826	10307	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		44411902	10311	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		CHEMBL1161831	10311	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		44411720	10307	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		CHEMBL1161826	10307	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		44411902	10311	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		CHEMBL1161831	10311	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		44390849	62915	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL178475	62915	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		25227441	113443	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL3319217	113443	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL501253	214133	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCCBr)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
		44582528	193416	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
		91935097	193416	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
		CHEMBL525994	193416	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
		CHEMBL2310891	209495	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		90665845	109272	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218645	109272	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL500468	214115	0	None	-	1	Human	9.9	pIC50	=	9.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.042
		57422686	113447	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319221	113447	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL2310888	209493	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C	10.1021/jm0001727
		11340044	141335	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL383522	141335	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		44336274	108570	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
		CHEMBL320289	108570	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
		122180027	121588	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586033	121588	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		118709502	113472	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319398	113472	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		44390862	63867	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL180349	63867	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		16133832	213331	18	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		CHEMBL425281	213331	18	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		CHEMBL500468	214115	0	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
		90665847	109274	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218647	109274	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		122182190	122009	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		CHEMBL3593815	122009	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		57422687	113448	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319222	113448	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		16114292	96934	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL266063	96934	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
		16114292	96934	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		CHEMBL266063	96934	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		11225576	166037	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL425594	166037	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		122182047	122002	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593636	122002	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		11225576	166037	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL425594	166037	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		25260749	113446	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL3319220	113446	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		57422792	113471	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319397	113471	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		57422692	113445	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319219	113445	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL500468	214115	0	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
		122182043	121998	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593632	121998	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		118709506	113482	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319407	113482	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		178024	1971	33	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
		5867	1971	33	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
		CHEMBL13817	1971	33	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
		11431274	77344	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL208424	77344	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		11410373	138535	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
		CHEMBL377514	138535	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
		44582531	188722	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		91935100	188722	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		CHEMBL504776	188722	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		122182046	122001	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593635	122001	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		25260745	113475	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319400	113475	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
		122182190	122009	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		CHEMBL3593815	122009	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		57422768	113454	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
		CHEMBL3319228	113454	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
		16114096	79160	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
		CHEMBL2113324	79160	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
		178024	1971	33	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
		5867	1971	33	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
		CHEMBL13817	1971	33	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
		57422690	113453	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
		CHEMBL3319227	113453	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
		118709503	113473	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319399	113473	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		66788278	125192	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		CHEMBL3645254	125192	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		16114292	96934	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
		CHEMBL266063	96934	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
		44436850	91549	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL240509	91549	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		57422793	113470	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
		CHEMBL3319396	113470	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
		178024	1971	33	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
		5867	1971	33	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
		CHEMBL13817	1971	33	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
		57422688	113451	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319225	113451	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		57785733	113450	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319224	113450	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		16113245	121334	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581030	121334	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
		44445600	154788	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL400175	154788	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL437713	213731	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm020424z
		178024	1971	33	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		5867	1971	33	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		CHEMBL13817	1971	33	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		CHEMBL412799	213025	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(N)=O)C(C)C	10.1021/jm0001727
		57422817	113449	18	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319223	113449	18	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		11476589	75988	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205451	75988	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL526723	215697	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		44436857	145656	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		CHEMBL391588	145656	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		90666039	109322	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218912	109322	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		118709505	113481	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319406	113481	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL2310887	209492	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCC(CCC)C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		122180026	121587	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586032	121587	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		122182043	121998	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593632	121998	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL2310890	209494	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		C/C=C/C=C/C=C/C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		44409536	75509	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL204325	75509	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		44445595	94403	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL250974	94403	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		90665850	109277	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218650	109277	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
		90665851	109278	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218651	109278	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		11134880	99431	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		CHEMBL282891	99431	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		5866	3624	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
		9804743	3624	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
		CHEMBL360227	3624	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
		11712151	75993	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL205470	75993	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		56942098	125193	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		CHEMBL3645255	125193	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		25261382	113441	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319215	113441	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		57422789	113455	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
		CHEMBL3319229	113455	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
		56942244	125197	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
		CHEMBL3645259	125197	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
		90665846	109273	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218646	109273	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		11339816	76007	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205521	76007	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		44409756	76767	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL206820	76767	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		90666012	109295	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218885	109295	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		90666031	109314	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218904	109314	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44390840	123556	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL361804	123556	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		90666017	109300	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218890	109300	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		90666027	109310	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218900	109310	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		44445594	154642	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399447	154642	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		90666013	109296	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218886	109296	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44445599	94184	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL249639	94184	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		44446187	94621	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL252255	94621	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		178024	1971	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		5867	1971	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		CHEMBL13817	1971	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		23648244	92014	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		CHEMBL241775	92014	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		44409776	77143	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL207754	77143	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122178616	121352	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581048	121352	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
		16113471	84721	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		CHEMBL222789	84721	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		156021766	178127	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4648355	178127	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145959787	162285	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164107	162285	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		145953855	162515	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4167669	162515	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		16113585	137235	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL375161	137235	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		145958774	162266	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4163811	162266	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		156016073	177655	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
		CHEMBL4641503	177655	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
		162646061	179531	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
		CHEMBL4741413	179531	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
		70692600	75874	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048813	75874	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2310886	209491	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCNC(=O)CCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		156021766	178127	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4648355	178127	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		44445601	94185	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
		CHEMBL249640	94185	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
		44390901	64079	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL180755	64079	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		145959787	162285	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164107	162285	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		70694648	75872	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048811	75872	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		44445591	154641	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399446	154641	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16113468	141800	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL386218	141800	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		16113468	141800	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL386218	141800	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		46882103	5954	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079872	5954	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		72190450	92275	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426679	92275	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		11441978	130455	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
		CHEMBL368034	130455	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
		CHEMBL2310894	209497	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)c1ccccc1)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm0001727
		122180017	121578	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586023	121578	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		44445592	94183	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL249638	94183	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113577	84936	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		CHEMBL223725	84936	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		16113902	137676	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL375859	137676	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		90666041	109324	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		CHEMBL3218914	109324	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		16113902	137676	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL375859	137676	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		15945877	146939	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL392593	146939	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
		11337482	76640	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
		CHEMBL206399	76640	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
		44409775	76025	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205605	76025	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122182190	122009	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		CHEMBL3593815	122009	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		44445620	154678	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399651	154678	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		11676995	66162	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL184258	66162	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
		16203930	84335	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
		CHEMBL221674	84335	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
		11537683	75527	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
		CHEMBL204352	75527	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
		122180020	121581	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586026	121581	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		44338247	7927	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL109035	7927	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
		44445622	154679	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399653	154679	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		59446139	81601	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163449	81601	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44436812	91764	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL241033	91764	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		11731384	162720	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
		CHEMBL417092	162720	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
		44390888	64416	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL181312	64416	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		60195112	81606	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163466	81606	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2370788	209921	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
		16113904	137036	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL374655	137036	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		90665852	109279	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218652	109279	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		90666032	109315	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218905	109315	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		16113904	137036	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL374655	137036	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL500703	214120	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
		10415364	126767	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL365294	126767	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		53390181	92271	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426675	92271	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		145957075	162279	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164040	162279	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		145956026	162662	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4169979	162662	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		145956061	162693	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4170481	162693	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
		145951150	162776	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL4171914	162776	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
		11328064	160312	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
		CHEMBL411055	160312	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
		44445607	166730	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL428314	166730	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16113581	85137	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL224921	85137	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		90666022	109305	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218895	109305	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		90666028	109311	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218901	109311	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		70682036	75878	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048817	75878	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		16113796	84681	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL222518	84681	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		57422697	113461	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319276	113461	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL499371	214095	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
		59446101	81616	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163477	81616	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446101	81616	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163477	81616	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44389262	122032	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
		CHEMBL359506	122032	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
		16113796	84681	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL222518	84681	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		11576960	67115	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL187427	67115	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		11124146	99153	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL281173	99153	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		122178600	121336	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581033	121336	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
		44409679	75508	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204322	75508	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		9745	2453	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		9804938	2453	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		CHEMBL278623	2453	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		DB13074	2453	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		16113579	84937	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL223726	84937	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL3578015	211766	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		145954311	162486	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4167267	162486	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL3578015	211766	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		11373823	78503	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL211188	78503	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		145954311	162486	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4167267	162486	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		44301389	11275	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1179118	11275	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL61292	11275	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		46882236	5772	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078608	5772	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		16114514	79158	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
		CHEMBL2113322	79158	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
		11523411	75555	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
		CHEMBL204511	75555	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
		57422730	113438	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319212	113438	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		46882763	5628	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1077617	5628	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44576247	214222	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
		CHEMBL506986	214222	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
		145951150	162776	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL4171914	162776	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL433540	213642	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020424z
		1744826	62998	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
		CHEMBL178668	62998	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
		1744826	62998	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL178668	62998	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
		122178603	121339	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581036	121339	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
		16114009	137194	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL374921	137194	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
		23648246	161788	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		CHEMBL414132	161788	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		11655578	170033	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL444277	170033	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		1744826	62998	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178668	62998	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		156021336	178167	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4649089	178167	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		44446190	94556	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL251855	94556	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
		44389167	123858	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL362612	123858	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44338240	109139	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL321403	109139	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		11539587	67077	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL187271	67077	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
		11503585	65204	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL182542	65204	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
		23656300	148766	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
		CHEMBL394054	148766	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
		59446107	81619	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163480	81619	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446107	81619	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163480	81619	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44436807	148311	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		CHEMBL393692	148311	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		46882237	5780	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078677	5780	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44395002	66186	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL184368	66186	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
		44445627	154940	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL401084	154940	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113906	137223	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		CHEMBL375102	137223	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		70692601	75875	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048814	75875	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		145957075	162279	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164040	162279	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		145956026	162662	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4169979	162662	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		145956061	162693	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4170481	162693	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
		46882271	5809	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078899	5809	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		156018364	177913	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645148	177913	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		44445624	154906	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL400879	154906	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16203238	137109	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
		CHEMBL374757	137109	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
		16113694	137193	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL374920	137193	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
		16114181	141940	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL387109	141940	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		44446137	155417	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL403682	155417	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		122180017	121578	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586023	121578	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		44379072	12798	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1188124	12798	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL535353	12798	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		16113905	84697	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL222622	84697	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		11626181	124381	2	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL363896	124381	2	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
		42624369	188863	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		44582535	188863	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		91935102	188863	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		CHEMBL506930	188863	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		16113691	136719	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
		CHEMBL374073	136719	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
		90666023	109306	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218896	109306	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		16113691	136719	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
		CHEMBL374073	136719	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
		57422696	113478	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319403	113478	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		156012849	177298	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4636571	177298	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		44390860	63644	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL180096	63644	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		73347725	92270	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426674	92270	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
		156012849	177298	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4636571	177298	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156015928	177581	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4640615	177581	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156018364	177913	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645148	177913	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145949595	162724	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4171040	162724	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		1100	1608	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
		6918297	1608	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
		CHEMBL108335	1608	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
		11539588	66913	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL186540	66913	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
		122180015	121576	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586021	121576	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		122178615	121304	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3580668	121304	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
		16113798	84333	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		CHEMBL221662	84333	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		16113797	138137	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		CHEMBL376735	138137	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		16113903	168377	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
		CHEMBL434573	168377	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
		44338241	6541	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL108287	6541	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		44410012	138399	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL377305	138399	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16113122	148168	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
		CHEMBL393565	148168	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
		11556937	81622	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163484	81622	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		11556937	81622	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163484	81622	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		9956908	13096	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1190326	13096	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL540604	13096	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		11329138	64460	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
		CHEMBL181350	64460	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
		90665848	109275	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218648	109275	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
		23648245	92015	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		CHEMBL241776	92015	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		145949595	162724	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4171040	162724	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		11846625	77884	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		CHEMBL209394	77884	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		44409683	76259	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205848	76259	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		46882305	5828	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079091	5828	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		11124146	99153	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL281173	99153	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		56942855	125199	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
		CHEMBL3645261	125199	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
		11016748	98350	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL275141	98350	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		44445602	94186	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
		CHEMBL249659	94186	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
		11256439	75379	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
		CHEMBL203843	75379	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
		44390881	66103	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL183916	66103	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		44338151	109749	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL323026	109749	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		46882238	5783	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078699	5783	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		59446133	175034	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4567432	175034	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		60195284	81610	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163471	81610	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44394930	66332	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL185028	66332	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
		11016748	98350	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL275141	98350	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		59446115	174310	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4550305	174310	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		60195379	81614	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163475	81614	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		46882155	5708	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078114	5708	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		11145720	67340	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
		CHEMBL18853	67340	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
		11846628	77712	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		CHEMBL208930	77712	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		156015928	177581	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4640615	177581	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		16114012	168399	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
		CHEMBL434738	168399	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
		122180018	121579	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586024	121579	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		16113582	136639	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL373995	136639	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		46882807	5764	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078533	5764	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		16114184	150491	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
		CHEMBL395441	150491	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
		44446188	155391	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL403542	155391	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		44436817	166769	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL428383	166769	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		44445618	161898	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL415134	161898	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		44436887	90959	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL239464	90959	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		10907396	99150	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
		CHEMBL281147	99150	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
		11649239	66340	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL185057	66340	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		1100	1608	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
		6918297	1608	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
		CHEMBL108335	1608	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
		16113580	137879	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
		CHEMBL376258	137879	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
		16113580	137879	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL376258	137879	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		44436883	146153	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
		CHEMBL391980	146153	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
		44436889	153057	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL397594	153057	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		11452801	139298	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL379191	139298	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		44445625	154819	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL400381	154819	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		122180019	121580	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586025	121580	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		145957443	162089	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160928	162089	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		10864048	98388	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL275373	98388	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		44389187	64022	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL180722	64022	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44409871	75396	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL203948	75396	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		145959007	162257	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4163623	162257	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		145956659	162055	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160434	162055	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
		145959787	162285	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164107	162285	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		16113248	79164	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		CHEMBL2113328	79164	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		11282247	165926	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL425048	165926	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		11282247	165926	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL425048	165926	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		44409802	76744	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL206687	76744	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		156019457	177942	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645625	177942	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		216208	9727	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
		CHEMBL113313	9727	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
		90666037	109320	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		CHEMBL3218910	109320	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		23648236	79152	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
		CHEMBL2113317	79152	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
		44383343	120342	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
		CHEMBL353007	120342	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
		156014693	177192	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4635089	177192	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		44389151	62505	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
		CHEMBL178138	62505	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
		44409979	140559	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL381159	140559	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44395020	124032	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL363021	124032	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
		16114530	84740	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL222912	84740	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		59446130	81618	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163479	81618	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446130	81618	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163479	81618	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44409761	75866	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204880	75866	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		145956659	162055	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160434	162055	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
		145957443	162089	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160928	162089	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		145959007	162257	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4163623	162257	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		145959787	162285	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164107	162285	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		11328920	144042	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
		CHEMBL390308	144042	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
		122178606	121342	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581039	121342	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
		122178609	121346	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581042	121346	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
		178024	1971	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		5867	1971	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		CHEMBL13817	1971	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		44409821	76037	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205711	76037	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		46882307	5830	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079108	5830	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
		122182044	121999	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593633	121999	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		5866	3624	4	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
		9804743	3624	4	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
		CHEMBL360227	3624	4	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
		CHEMBL500468	214115	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
		CHEMBL500468	214115	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
		11683469	76706	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
		CHEMBL206486	76706	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
		11454617	141319	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
		CHEMBL383411	141319	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
		90666029	109312	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218902	109312	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44409672	140487	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL380971	140487	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		11154823	76029	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL205660	76029	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		11190594	75985	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205445	75985	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		11583811	75987	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205450	75987	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		25260900	113477	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319402	113477	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
		10918326	98972	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
		CHEMBL279822	98972	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
		44378981	13970	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1196773	13970	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL558181	13970	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		90666033	109316	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218906	109316	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		16113472	169006	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL439251	169006	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		66813470	76832	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
		CHEMBL2069411	76832	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
		122180022	121583	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586028	121583	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		70694649	75884	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2048823	75884	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		10100708	12034	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		CHEMBL1183387	12034	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		CHEMBL294408	12034	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		11577349	65231	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL182655	65231	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
		16114098	141611	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL385131	141611	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		11327400	75372	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL203782	75372	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		44409455	75968	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
		CHEMBL205286	75968	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
		156019457	177942	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645625	177942	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		46882306	5829	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079107	5829	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
		11731384	162720	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
		CHEMBL417092	162720	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
		118709470	113459	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319274	113459	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL507636	214433	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
		156021885	178215	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
		CHEMBL4649741	178215	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
		70688404	75867	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048807	75867	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
		11114279	98249	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
		CHEMBL274460	98249	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
		70688404	75867	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2048807	75867	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
		16113693	138016	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL376471	138016	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		216208	9727	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
		CHEMBL113313	9727	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
		11827047	99220	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
		CHEMBL281578	99220	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
		9745	2453	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		9804938	2453	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		CHEMBL278623	2453	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		DB13074	2453	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		16113124	121335	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581032	121335	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
		44445605	154981	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL401260	154981	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113578	137192	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL374919	137192	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
		16113584	137594	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
		CHEMBL375568	137594	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
		44389168	64873	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
		CHEMBL182154	64873	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
		11314908	141812	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		CHEMBL386290	141812	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		11846627	79724	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		CHEMBL211581	79724	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		10929048	68807	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL19220	68807	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		90666020	109303	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218893	109303	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		16114403	147187	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL392805	147187	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
		57422673	113466	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319282	113466	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
		70684154	75869	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048809	75869	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		122180020	121581	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586026	121581	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		16113710	79161	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
		CHEMBL2113325	79161	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
		122178611	121348	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581044	121348	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
		122178614	121351	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581047	121351	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
		16114531	84675	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL222498	84675	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		145974293	163024	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4175823	163024	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		46882197	5742	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078403	5742	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44409980	76180	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205790	76180	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		145952740	162501	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL4167481	162501	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
		44409868	76742	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL206673	76742	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		156017532	177908	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645072	177908	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		11605822	124388	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL363930	124388	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
		162651761	180209	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
		CHEMBL4749698	180209	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
		70686292	75880	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048819	75880	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		10186158	98442	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		CHEMBL275660	98442	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		122178602	121338	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581035	121338	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3586019	211801	6	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
		122180025	121586	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586031	121586	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
		156017532	177908	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645072	177908	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145952740	162501	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL4167481	162501	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
		145974293	163024	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4175823	163024	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		44436881	91588	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
		CHEMBL240746	91588	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
		122182189	122008	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593814	122008	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		122180016	121577	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586022	121577	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		46882199	5761	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078498	5761	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44301462	11262	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1179075	11262	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL58758	11262	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		90666042	109325	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		CHEMBL3218915	109325	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		25262771	113464	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319280	113464	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		42624370	188837	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		44582537	188837	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		91935104	188837	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		CHEMBL506624	188837	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		44445617	154676	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL399649	154676	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		11163070	65568	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
		CHEMBL183123	65568	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
		156012428	177310	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
		CHEMBL4636832	177310	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
		46882766	5672	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1077839	5672	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44436813	147307	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL392902	147307	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		44410013	77053	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL207268	77053	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44235473	81617	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163478	81617	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		44235473	81617	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163478	81617	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44409839	76258	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205847	76258	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16114099	137224	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL375103	137224	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		16113372	79154	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
		CHEMBL2113319	79154	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
		46882273	5818	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078982	5818	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		122182044	121999	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593633	121999	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		121879	2234	24	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		5868	2234	24	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		CHEMBL308716	2234	24	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		CHEMBL2370788	209921	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
		145950261	162729	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4171137	162729	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		44394974	67012	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL186974	67012	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
		44445615	161869	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL414929	161869	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113370	79159	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL2113323	79159	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
		145953016	162587	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4168863	162587	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		156012445	177335	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4637284	177335	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		10186158	98442	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		CHEMBL275660	98442	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		11617435	75997	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
		CHEMBL205486	75997	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
		70696689	75882	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048821	75882	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		70694647	75868	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048808	75868	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		56942242	125195	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
		CHEMBL3645257	125195	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
		122178605	121341	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581038	121341	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
		44445611	154675	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL399648	154675	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		122182189	122008	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593814	122008	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		56942385	125198	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
		CHEMBL3645260	125198	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
		CHEMBL501261	214135	23	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
		56942099	125194	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		CHEMBL3645256	125194	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		56942243	125196	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
		CHEMBL3645258	125196	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
		122178608	121345	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581041	121345	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
		44409673	76750	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
		CHEMBL206741	76750	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
		CHEMBL105462	208468	38	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		11690097	76672	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		CHEMBL206446	76672	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		57422695	113476	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319401	113476	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
		25124566	1874	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
		5870	1874	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
		CHEMBL3358452	1874	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
		156013219	177489	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4639379	177489	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145957574	162301	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164328	162301	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		46882805	5824	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079046	5824	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
		53390538	92277	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426681	92277	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		178024	1971	33	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
		5867	1971	33	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
		CHEMBL13817	1971	33	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
		44445629	161900	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL415136	161900	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16204239	136284	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		CHEMBL373393	136284	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		11508639	76535	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
		CHEMBL206091	76535	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
		216208	9727	33	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL113313	9727	33	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
		11846630	138935	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL378438	138935	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		156012445	177335	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4637284	177335	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145953016	162587	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4168863	162587	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		145949755	162934	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4174302	162934	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		16204241	84428	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
		CHEMBL221996	84428	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
		11221946	140846	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
		CHEMBL381942	140846	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
		11221946	140846	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
		CHEMBL381942	140846	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
		46882104	5955	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079873	5955	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		145956415	162063	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160541	162063	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		145950261	162729	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4171137	162729	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		11654867	76201	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205833	76201	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
		10415364	126767	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL365294	126767	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		178024	1971	33	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		5867	1971	33	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		CHEMBL13817	1971	33	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		16114404	154897	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL400814	154897	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
		90666014	109297	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218887	109297	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		44436885	146429	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
		CHEMBL392191	146429	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
		44436829	152478	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL397109	152478	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		16114404	154897	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		CHEMBL400814	154897	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		122182047	122002	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593636	122002	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		70684155	75885	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2048824	75885	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2163483	209325	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163483	209325	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44409872	75066	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL203581	75066	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44445596	154643	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399448	154643	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16113692	137236	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
		CHEMBL375162	137236	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
		118709504	113479	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL3319404	113479	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		10907396	99150	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
		CHEMBL281147	99150	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
		11677781	125058	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL364430	125058	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
		44445606	155014	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL401467	155014	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		44379034	12924	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1189120	12924	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL538068	12924	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		44378986	13095	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1190325	13095	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL540603	13095	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		11697618	62599	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178289	62599	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		145956415	162063	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160541	162063	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		44436886	161955	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		CHEMBL415674	161955	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		145949755	162934	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4174302	162934	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		23648242	79156	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
		CHEMBL2113320	79156	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
		11606121	64576	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
		CHEMBL181584	64576	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
		122180023	121584	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586029	121584	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
		44379301	13060	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1190091	13060	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL540093	13060	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
		44338300	167843	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		CHEMBL430882	167843	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		44338239	167898	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		CHEMBL431245	167898	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		44409762	75886	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204884	75886	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122180018	121579	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586024	121579	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		122182189	122008	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593814	122008	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		10032659	12051	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		CHEMBL1183505	12051	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		CHEMBL301259	12051	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		60195019	81604	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163464	81604	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		156009875	177123	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4633695	177123	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		11430583	80217	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL213704	80217	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		11517629	168338	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL434330	168338	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
		44409975	75790	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204835	75790	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		53391301	92274	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426678	92274	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		90666019	109302	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218892	109302	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
		11669486	64614	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
		CHEMBL181736	64614	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
		59446141	81620	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163481	81620	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446141	81620	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163481	81620	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44436917	90649	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL239007	90649	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		60165265	116198	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
		CHEMBL3358453	116198	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
		16113002	148313	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
		CHEMBL393693	148313	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
		44409678	141217	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL382853	141217	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122178604	121340	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581037	121340	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
		10929048	68807	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL19220	68807	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		60195018	81603	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163463	81603	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44394913	127173	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL365721	127173	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
		11649248	66670	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL185399	66670	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
		44394833	126825	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL365460	126825	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
		11827047	99220	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
		CHEMBL281578	99220	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
		42624359	193401	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		44582536	193401	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		91935103	193401	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		CHEMBL525751	193401	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		156009875	177123	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4633695	177123	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156021942	178223	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4649860	178223	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		122180021	121582	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586027	121582	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
		11134880	99431	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		CHEMBL282891	99431	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		11846629	138819	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL378118	138819	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		11114279	98249	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
		CHEMBL274460	98249	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
		145952396	163003	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
		CHEMBL4175534	163003	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
		122178607	121344	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581040	121344	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
		156013219	177489	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4639379	177489	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145957574	162301	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164328	162301	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		11846463	139242	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		CHEMBL378909	139242	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		9890863	131992	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL369533	131992	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		44409864	75499	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204266	75499	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122180027	121588	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586033	121588	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		11430392	76724	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
		CHEMBL206588	76724	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
		57785737	113442	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319216	113442	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		44390871	64842	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL182035	64842	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		70682037	75881	20	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048820	75881	20	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		156021297	178089	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4647797	178089	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		90666040	109323	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218913	109323	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		90666026	109309	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218899	109309	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		16204021	84707	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
		CHEMBL222710	84707	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
		122180014	121575	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586020	121575	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		90666016	109299	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
		CHEMBL3218889	109299	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
		44389186	64615	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL181739	64615	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44338266	110333	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
		CHEMBL323974	110333	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
		70692602	75876	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048815	75876	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
		11455251	161314	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL412362	161314	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		156021942	178223	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4649860	178223	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		16204037	137233	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL375150	137233	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		11582836	62913	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178463	62913	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44389131	63462	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL179812	63462	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
		122180025	121586	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586031	121586	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
		122178612	121349	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581045	121349	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
		16203237	96951	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
		CHEMBL266199	96951	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
		59446148	175049	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4567800	175049	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		46882152	5855	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079302	5855	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
		11655355	74421	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL202642	74421	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		145952396	163003	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
		CHEMBL4175534	163003	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
		46882764	5631	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1077716	5631	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
		16114290	137208	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL374992	137208	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		90666015	109298	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218888	109298	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
		44436831	151996	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		CHEMBL396681	151996	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		25262608	113463	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
		CHEMBL3319279	113463	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
		10918326	98972	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
		CHEMBL279822	98972	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
		16203918	84787	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		CHEMBL223239	84787	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		70696687	75873	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048812	75873	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		46882105	6351	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1082044	6351	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44446189	155374	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL403426	155374	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
		44446157	94652	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL252501	94652	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		44446148	155418	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL403683	155418	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		44410008	141251	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL383058	141251	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		59446143	81600	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
		CHEMBL2163448	81600	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
		59446143	81600	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		CHEMBL2163448	81600	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		44338221	8048	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL109094	8048	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
		60195113	81607	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
		CHEMBL2163467	81607	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
		46882804	5823	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079045	5823	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		10864048	98388	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL275373	98388	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		156016110	177698	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4642043	177698	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		156017268	177650	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641472	177650	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		59446118	174700	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4559602	174700	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		60195285	81612	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163473	81612	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44436868	146083	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
		CHEMBL391922	146083	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
		44394947	169223	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL440939	169223	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
		122180022	121583	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586028	121583	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		11751384	141506	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL384524	141506	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		122180026	121587	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586032	121587	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		122182043	121998	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593632	121998	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		16204226	84799	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL223323	84799	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		118709472	113462	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
		CHEMBL3319277	113462	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
		46882196	5741	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078402	5741	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44379303	12839	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1188529	12839	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL536706	12839	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL2310893	209496	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		44445614	169309	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL441567	169309	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		44445598	94376	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL250807	94376	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		145949381	162715	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4170865	162715	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		44436832	151998	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL396682	151998	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		44445626	97066	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL267197	97066	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		90666025	109308	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218898	109308	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		156012122	177381	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4637980	177381	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156012122	177381	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4637980	177381	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156021297	178089	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4647797	178089	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		90666024	109307	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218897	109307	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		57422776	113444	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL3319218	113444	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		162657463	181040	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
		CHEMBL4759415	181040	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
		44409990	76517	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205995	76517	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122180024	121585	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586030	121585	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		44409758	75974	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205374	75974	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122182190	122009	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		CHEMBL3593815	122009	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		44409684	140885	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL382033	140885	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16113003	94747	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
		CHEMBL253126	94747	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
		16113003	94747	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
		CHEMBL253126	94747	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
		122182047	122002	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593636	122002	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		90666030	109313	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218903	109313	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		11605333	76725	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
		CHEMBL206589	76725	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
		122182046	122001	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593635	122001	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		11281346	76018	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205568	76018	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		145949381	162715	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4170865	162715	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		16204145	136552	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
		CHEMBL373772	136552	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
		90666036	109319	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218909	109319	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44338235	109662	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL322499	109662	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
		156016392	177646	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641386	177646	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156017268	177650	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641472	177650	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145958317	162313	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164531	162313	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		145949880	162791	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4172217	162791	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		145950963	162806	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4172411	162806	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		156016392	177646	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641386	177646	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		44445608	155015	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL401468	155015	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		59446116	81598	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		CHEMBL2163439	81598	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		23631387	93266	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL244936	93266	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
		90666038	109321	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
		CHEMBL3218911	109321	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
		44421230	84791	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		CHEMBL223269	84791	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		156018460	177877	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4644587	177877	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		145950963	162806	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4172411	162806	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		11618705	166938	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL428698	166938	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
		44436842	146938	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL392592	146938	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL509976	215580	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
		CHEMBL450217	213963	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrsDisplacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrs	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300414b
		CHEMBL450217	213963	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1074/jbc.m609796200
		10984270	98507	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL276137	98507	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		44436884	91552	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL240522	91552	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL444131	213929	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
		60195020	81605	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163465	81605	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		59446112	172974	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4517723	172974	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL422461	213286	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm0001727
		16114010	136283	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		CHEMBL373392	136283	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		16203349	166290	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL427076	166290	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		11531313	62504	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178137	62504	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44389283	62945	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178494	62945	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		122180019	121580	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586025	121580	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL447282	213949	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm8014519
		145958317	162313	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164531	162313	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		16114008	84846	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL223532	84846	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		16112910	136377	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL373507	136377	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		16112910	136377	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL373507	136377	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		44436882	146016	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
		CHEMBL391859	146016	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
		145949880	162791	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4172217	162791	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		122180024	121585	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586030	121585	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		46882154	5861	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079323	5861	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		59446145	81599	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163444	81599	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446145	81599	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163444	81599	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		11699004	66203	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL184429	66203	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
		11537800	75567	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
		CHEMBL204564	75567	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
		16203236	166262	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
		CHEMBL426905	166262	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
		10207327	67071	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		CHEMBL18725	67071	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		44445603	154980	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL401259	154980	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL502208	214150	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
		16113583	161751	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL413856	161751	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		90665849	109276	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218649	109276	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
		70696688	75879	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048818	75879	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
		44436816	91805	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL241242	91805	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		10984270	98507	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL276137	98507	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		44301387	11264	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1179088	11264	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL59572	11264	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		11692087	62992	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL178610	62992	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
		122178610	121347	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581043	121347	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
		16113695	137027	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
		CHEMBL374643	137027	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
		16113695	137027	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL374643	137027	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		16113695	137027	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL374643	137027	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		16113695	137027	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
		CHEMBL374643	137027	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
		44436888	153056	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL397593	153056	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		11692087	62992	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178610	62992	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
		44409809	75065	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL203578	75065	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44409989	165826	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL424860	165826	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL105462	208468	38	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		90666018	109301	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218891	109301	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		11612155	141009	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL382375	141009	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		118722878	116197	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
		CHEMBL3358451	116197	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
		16114097	79157	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
		CHEMBL2113321	79157	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
		122182189	122008	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593814	122008	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		25260901	113480	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319405	113480	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		122180021	121582	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586027	121582	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
		11179347	77353	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL208477	77353	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		44445593	154787	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL400174	154787	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16203569	141733	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL385803	141733	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		90666034	109317	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218907	109317	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL449590	213962	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
		121879	2234	24	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		5868	2234	24	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		CHEMBL308716	2234	24	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		11568561	169554	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL443560	169554	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
		44338246	98854	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL278909	98854	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL105462	208468	38	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(99)00584-3
		44409767	157242	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL407647	157242	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44445612	97040	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
		CHEMBL266964	97040	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
		44410003	76181	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205794	76181	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16203569	141733	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL385803	141733	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL18872	209058	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(C)(C)N)C(N)=O	10.1021/jm300557t
		46882106	5862	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079340	5862	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
		44436876	147019	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		CHEMBL392663	147019	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		121879	2234	24	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		5868	2234	24	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		CHEMBL308716	2234	24	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		156010733	177080	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4633062	177080	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145962494	162074	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160705	162074	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		145950201	162942	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4174476	162942	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		44409832	76410	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205955	76410	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16204237	84897	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		CHEMBL223638	84897	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		16204343	137191	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
		CHEMBL374918	137191	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
		122178613	121350	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581046	121350	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
		57422749	113439	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319213	113439	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		44410007	76427	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205963	76427	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		118718706	115379	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL3350011	115379	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
		89768546	149017	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
		CHEMBL3942511	149017	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
		16114011	138138	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
		CHEMBL376736	138138	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
		11349789	78773	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL211265	78773	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		16112909	144281	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL390503	144281	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		44378837	13021	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1189851	13021	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL539575	13021	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		44445597	94516	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL251640	94516	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		11176805	77334	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
		CHEMBL208374	77334	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
		156010733	177080	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4633062	177080	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		46882153	5860	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079322	5860	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
		145950201	162942	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4174476	162942	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		46882239	5784	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078700	5784	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
		1221269	122034	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL359530	122034	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44446177	94647	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL252448	94647	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
		16114289	98665	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
		CHEMBL277376	98665	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
		11538533	75001	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
		CHEMBL203280	75001	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
		10415364	126767	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL365294	126767	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL263544	210575	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(N)=O	10.1021/jm0001727
		122180023	121584	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586029	121584	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
		118709507	113483	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319408	113483	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
		90666011	109294	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
		CHEMBL3218884	109294	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
		11538533	75001	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		CHEMBL203280	75001	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		44409998	138536	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL377515	138536	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		90666021	109304	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218894	109304	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		11453509	76178	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL205784	76178	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		44445610	161723	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL413608	161723	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		23648249	79162	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
		CHEMBL2113326	79162	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
		11178309	79901	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL212415	79901	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL3578018	211769	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		CHEMBL3578018	211769	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		44445613	94187	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
		CHEMBL249662	94187	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
		16204229	84317	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		CHEMBL221569	84317	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		44409867	76741	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL206672	76741	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		145962494	162074	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160705	162074	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		44389215	63078	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178838	63078	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		11211892	80216	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		CHEMBL213703	80216	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		122180015	121576	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586021	121576	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		59446138	81621	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163482	81621	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446138	81621	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163482	81621	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		59446127	173036	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4518972	173036	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		60195286	81613	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163474	81613	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		10207327	67071	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		CHEMBL18725	67071	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		16112911	84729	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL222835	84729	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		5311280	81609	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163470	81609	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44389243	64583	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
		CHEMBL181619	64583	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
		23648232	91243	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		CHEMBL240179	91243	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		44445616	161870	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL414930	161870	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		118709471	113460	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319275	113460	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		44390889	64423	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL181313	64423	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		46882270	5817	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078960	5817	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		156016696	177630	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641201	177630	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL3578016	211767	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		CHEMBL2163348	209324	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163348	209324	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		16113800	137812	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL375972	137812	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL3578016	211767	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		156013130	177502	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4639514	177502	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156016696	177630	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641201	177630	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145950877	162995	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4175360	162995	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		44358041	161331	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
		91931457	161331	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
		CHEMBL412565	161331	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
		57422810	177661	4	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
		CHEMBL4641579	177661	4	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
		16113246	94677	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL252643	94677	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		11846624	77916	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		CHEMBL209443	77916	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		46882272	5810	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078900	5810	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		9987037	12032	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1183385	12032	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL294324	12032	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		56942537	125200	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
		CHEMBL3645262	125200	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
		57422761	113440	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319214	113440	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		57422760	113437	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319211	113437	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		57422791	113452	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319226	113452	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
		44445619	154677	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL399650	154677	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113469	137502	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		CHEMBL375408	137502	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		122182045	122000	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593634	122000	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		44446175	94987	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL254741	94987	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		10994861	67271	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		CHEMBL18815	67271	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		10984260	168353	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
		CHEMBL434391	168353	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
		59446135	81615	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
		CHEMBL2163476	81615	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
		59446135	81615	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		CHEMBL2163476	81615	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		59446154	81602	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
		CHEMBL2163453	81602	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
		59446154	81602	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
		CHEMBL2163453	81602	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
		44446178	155123	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL402023	155123	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		753168	123239	40	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL361366	123239	40	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44338253	9287	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		CHEMBL110900	9287	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		44301512	12022	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1183340	12022	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL291333	12022	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		16113799	168713	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL436849	168713	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		11166495	75550	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL204474	75550	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		25262772	113465	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319281	113465	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		44390869	122342	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL359922	122342	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		156013130	177502	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4639514	177502	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		122180014	121575	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586020	121575	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		122178601	121337	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581034	121337	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
		16202767	84996	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL223810	84996	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		46882156	5709	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078115	5709	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		16113474	136633	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		CHEMBL373993	136633	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		59446105	172821	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4514053	172821	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		11556936	81611	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163472	81611	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		60195114	81608	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
		CHEMBL2163468	81608	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
		70690449	75871	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048810	75871	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		70692603	75877	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048816	75877	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		44389192	168646	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
		CHEMBL436275	168646	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
		44394982	66138	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL184093	66138	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL335799	211564	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm0001727
		CHEMBL61663	215839	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
		44445628	161899	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL415135	161899	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		145950877	162995	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4175360	162995	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		11663710	124467	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL363995	124467	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		16113371	79153	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL2113318	79153	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
		16113371	79153	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
		CHEMBL2113318	79153	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
		11713497	123237	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL361349	123237	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
		122182045	122000	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593634	122000	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		11646276	75934	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
		CHEMBL205136	75934	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
		122182046	122001	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593635	122001	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		44436828	92000	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL241664	92000	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL410108	212799	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
		11538533	75001	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL203280	75001	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL500468	214115	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
		11538534	75014	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		CHEMBL203373	75014	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		122182047	122002	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593636	122002	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		70686293	75883	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048822	75883	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		122180016	121577	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586022	121577	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		44389216	123854	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL362595	123854	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
		44389248	122168	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL359714	122168	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		145958774	162266	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4163811	162266	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		44445609	97039	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL266961	97039	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16114532	84696	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL222610	84696	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		23648250	79163	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		CHEMBL2113327	79163	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		44409764	77149	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL207792	77149	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44378979	12844	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1188586	12844	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL536779	12844	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		11197	1066	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
		154699458	1066	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
		CHEMBL4632411	1066	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
		CHEMBL498956	214088	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm8014519
		46882198	5760	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078497	5760	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL3578017	211768	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		CHEMBL3578017	211768	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		145953855	162515	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4167669	162515	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		90666035	109318	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218908	109318	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		328912	62576	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
		CHEMBL178266	62576	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
		178024	1971	33	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
		5867	1971	33	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
		CHEMBL13817	1971	33	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
		57398340	71276	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956993	71276	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57400002	71277	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956994	71277	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57394881	71293	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957010	71293	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57393073	71284	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957001	71284	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		56926461	69036	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923609	69036	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926462	69037	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923610	69037	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		56926680	69050	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923623	69050	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		56926682	69052	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923625	69052	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		11664206	69053	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923626	69053	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		56926893	69063	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
		CHEMBL1923637	69063	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
		11526745	69068	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923642	69068	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134137202	142826	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3893048	142826	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134137257	143137	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3895776	143137	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134133352	143505	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3898794	143505	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
		11527086	144050	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3903118	144050	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		11512561	144369	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3905791	144369	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134133037	144567	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3907497	144567	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134132670	144614	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3907891	144614	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134132152	144932	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3910300	144932	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
		134142839	145386	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3913855	145386	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134142553	145447	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3914259	145447	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134143635	145574	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3915269	145574	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
		134143096	145933	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3918009	145933	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134142204	145937	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3918046	145937	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		11584702	146191	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3920049	146191	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134139279	146447	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3922056	146447	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134138445	147377	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3929593	147377	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134138218	148009	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3934367	148009	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134148686	148171	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3935670	148171	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134149719	148687	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
		CHEMBL3939872	148687	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
		134145791	148786	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3940705	148786	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134143746	150600	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
		CHEMBL3955179	150600	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
		134145221	150632	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3955437	150632	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134155656	151194	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3959816	151194	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134155282	151342	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3961108	151342	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134153496	152285	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3969367	152285	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134153654	152766	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3973513	152766	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134157569	154036	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3984338	154036	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		57345600	71273	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956990	71273	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57345599	71274	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956991	71274	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57398341	71282	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956999	71282	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		178024	1971	33	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
		5867	1971	33	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
		CHEMBL13817	1971	33	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
		57398342	71290	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957007	71290	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57401803	71292	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957009	71292	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57401799	71283	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957000	71283	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57399248	69044	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923617	69044	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		44340008	113388	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
		CHEMBL331801	113388	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
		57399248	69044	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923617	69044	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		24970113	69056	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923629	69056	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		57391293	71280	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956997	71280	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162659411	181225	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4761419	181225	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
		44340268	110521	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
		CHEMBL325062	110521	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
		57401800	71286	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957003	71286	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162657606	181117	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4760409	181117	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		57401801	71288	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957005	71288	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162672839	183022	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4793824	183022	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL500468	214115	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
		56942242	125195	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645257	125195	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
		56925343	69066	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923640	69066	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		57398339	71275	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956992	71275	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162645413	179726	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4744051	179726	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		155540883	172957	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4517399	172957	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		16133832	213331	18	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
		CHEMBL425281	213331	18	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
		162653781	180482	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4753046	180482	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		57401802	71289	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957006	71289	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57401797	71269	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956987	71269	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57398343	71291	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957008	71291	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		56926175	69013	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL1923504	69013	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		56926360	69035	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923608	69035	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926582	69043	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923616	69043	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926681	69051	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923624	69051	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		56926891	69061	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923635	69061	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926892	69062	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923636	69062	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926894	69064	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
		CHEMBL1923638	69064	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
		56925345	69069	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923643	69069	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134130631	142373	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
		CHEMBL3889512	142373	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
		134131442	142396	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3889678	142396	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134131183	142468	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3890296	142468	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134136433	142507	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3890602	142507	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134137008	142543	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3890889	142543	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134137012	142602	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3891381	142602	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134137398	142876	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3893476	142876	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134136665	142899	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
		CHEMBL3893697	142899	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
		134133488	143236	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3896536	143236	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134134248	143351	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3897510	143351	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134134556	143352	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3897527	143352	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134133518	143453	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		CHEMBL3898348	143453	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		134134286	143694	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3900284	143694	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134135296	144011	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3902856	144011	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134132958	144661	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
		CHEMBL3908264	144661	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
		134132137	144813	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3909431	144813	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
		134132893	144863	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3909834	144863	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		24969783	144864	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
		CHEMBL3909838	144864	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
		130334810	145160	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
		CHEMBL3912211	145160	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
		134132394	145184	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3912375	145184	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134142218	145287	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3913052	145287	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134142433	145326	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
		CHEMBL3913335	145326	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
		59778970	145375	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3913763	145375	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134143366	145760	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3916659	145760	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		117812386	145858	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3917385	145858	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134139489	146062	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3919021	146062	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134140270	146373	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3921499	146373	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134140007	146404	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3921750	146404	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134139286	146554	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3922810	146554	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134139113	146653	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
		CHEMBL3923633	146653	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
		134141159	146729	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3924192	146729	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134140968	146790	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
		CHEMBL3924635	146790	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
		134141782	146994	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3926434	146994	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134141886	147118	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3927481	147118	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134138234	147413	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3929852	147413	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
		117812380	147752	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3932408	147752	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134138595	147755	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
		CHEMBL3932434	147755	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
		134138824	148014	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3934402	148014	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134148504	148354	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3937200	148354	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134149092	148453	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		CHEMBL3937924	148453	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		134149306	148474	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3938104	148474	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134149407	148520	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3938452	148520	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134148639	148543	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
		CHEMBL3938683	148543	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
		134146570	148780	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3940653	148780	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134145552	149019	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
		CHEMBL3942528	149019	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
		134145564	149090	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3943086	149090	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		72574018	149104	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3943159	149104	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134146319	149126	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3943294	149126	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134147809	149449	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3946007	149449	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134147441	149489	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		CHEMBL3946348	149489	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		134146888	149763	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3948268	149763	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134147381	149785	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3948472	149785	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134147802	150091	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3950904	150091	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134145064	150150	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3951476	150150	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144205	150274	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3952596	150274	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144429	150286	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3952699	150286	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144211	150331	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3953033	150331	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144606	150335	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3953053	150335	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
		134155024	151012	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3958451	151012	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134155239	151014	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
		CHEMBL3958460	151014	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
		134155132	151092	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3959108	151092	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
		134155178	151379	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
		CHEMBL3961456	151379	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
		134150646	151646	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3963865	151646	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134150029	152115	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3967783	152115	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134150729	152156	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3968175	152156	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134154254	152299	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3969506	152299	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134154486	152442	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
		CHEMBL3970827	152442	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
		134154392	152532	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3971540	152532	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134153247	152720	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
		CHEMBL3973085	152720	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
		134153772	152899	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3974701	152899	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
		52911621	153061	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3975975	153061	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134151758	153104	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3976294	153104	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134152984	153168	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
		CHEMBL3976853	153168	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
		134151899	153319	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3978207	153319	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		134152339	153459	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3979468	153459	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134152133	153523	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3979911	153523	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134157813	153672	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3981238	153672	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134156963	153858	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3982825	153858	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
		57528321	153957	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
		CHEMBL3983626	153957	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
		134156579	154054	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3984464	154054	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134156405	154262	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
		CHEMBL3986375	154262	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
		134156453	154300	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3986628	154300	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56942098	125193	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645255	125193	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		162646324	179736	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4744139	179736	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		162665018	182135	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4782214	182135	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
		58438451	92285	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426689	92285	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		90644553	111735	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
		CHEMBL3287214	111735	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
		56926177	69015	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL1923506	69015	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		56926268	69017	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
		CHEMBL1923510	69017	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
		56926269	69018	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
		CHEMBL1923511	69018	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
		56926356	69019	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
		CHEMBL1923512	69019	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
		56926465	69040	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		CHEMBL1923613	69040	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		56926782	69057	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923631	69057	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926784	69059	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923633	69059	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926785	69060	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923634	69060	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		71452183	83529	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
		CHEMBL2203623	83529	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
		134131439	142395	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
		CHEMBL3889672	142395	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
		134137460	142635	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		CHEMBL3891657	142635	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		134136637	142720	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
		CHEMBL3892319	142720	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
		134136946	142754	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3892517	142754	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134136405	142919	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3893850	142919	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134133771	143341	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
		CHEMBL3897387	143341	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
		134133353	143519	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
		CHEMBL3898864	143519	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
		134134505	143668	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3900035	143668	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134134605	143677	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3900122	143677	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
		134134099	143731	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3900636	143731	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134135897	143994	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3902804	143994	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134134825	144079	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3903351	144079	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
		72989837	144115	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
		CHEMBL3903647	144115	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
		134135712	144138	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
		CHEMBL3903845	144138	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
		134136025	144332	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3905495	144332	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		134134870	144392	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3905987	144392	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134135261	144485	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
		CHEMBL3906788	144485	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
		134134893	144511	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
		CHEMBL3907031	144511	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
		134132666	144565	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3907480	144565	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134132519	144649	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3908156	144649	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
		134132427	144701	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3908583	144701	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134131971	144928	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3910288	144928	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134132265	144971	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
		CHEMBL3910661	144971	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
		134131903	145138	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3912034	145138	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134132099	145210	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3912534	145210	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
		134142223	145343	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
		CHEMBL3913486	145343	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
		134142139	145402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
		CHEMBL3913981	145402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
		76460236	145460	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3914338	145460	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134143044	145473	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3914467	145473	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
		134143657	145736	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3916501	145736	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134143398	145934	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3918022	145934	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134139992	146339	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
		CHEMBL3921227	146339	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
		134140213	146620	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
		CHEMBL3923324	146620	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
		134140762	146665	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
		CHEMBL3923718	146665	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
		134141057	146695	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3923918	146695	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134140844	147225	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
		CHEMBL3928367	147225	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
		68186750	147387	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
		CHEMBL3929656	147387	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
		134138656	147554	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3930811	147554	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134138764	147636	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
		CHEMBL3931402	147636	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
		134138160	147665	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3931716	147665	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134137758	147974	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
		CHEMBL3934093	147974	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
		134137945	147986	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
		CHEMBL3934184	147986	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
		134149048	148076	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
		CHEMBL3934901	148076	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
		134149058	148134	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
		CHEMBL3935422	148134	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
		134149451	148165	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3935626	148165	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134148804	148318	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
		CHEMBL3936957	148318	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
		58012657	148365	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3937314	148365	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		134149772	148479	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3938132	148479	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134149793	148605	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
		CHEMBL3939196	148605	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
		134148754	148699	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
		CHEMBL3939993	148699	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
		134145258	148802	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3940860	148802	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134145652	149023	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3942543	149023	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134145920	149026	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3942554	149026	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134146710	149030	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
		CHEMBL3942610	149030	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
		134145820	149034	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3942642	149034	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134146617	149115	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3943228	149115	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134145420	149313	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
		CHEMBL3944936	149313	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
		134147617	149435	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3945918	149435	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		134147244	149446	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3945984	149446	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134148131	149698	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3947758	149698	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134147387	149817	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3948746	149817	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134147861	149857	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3949023	149857	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
		134147972	149938	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3949704	149938	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
		134147412	149966	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3949926	149966	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134148083	150112	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
		CHEMBL3951110	150112	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
		134144491	150141	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3951362	150141	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134143693	150157	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3951593	150157	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134145200	150452	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3954124	150452	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		134144043	150489	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
		CHEMBL3954394	150489	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
		134144941	150527	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3954620	150527	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144060	150657	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3955632	150657	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134155541	151037	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3958657	151037	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134155247	151050	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
		CHEMBL3958739	151050	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
		117812381	151351	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3961160	151351	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134155292	151402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3961641	151402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134154704	151410	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3961696	151410	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
		134152627	151548	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3963078	151548	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134150950	151605	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
		CHEMBL3963523	151605	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
		57528212	151823	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
		CHEMBL3965338	151823	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
		134150767	151826	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		CHEMBL3965351	151826	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		134150369	151856	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
		CHEMBL3965516	151856	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
		134150388	151925	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3966251	151925	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134150696	152079	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3967506	152079	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134153608	152370	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3970180	152370	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134154369	152394	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3970414	152394	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134153972	152402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3970491	152402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134154079	152403	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3970499	152403	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
		134153529	152448	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3970856	152448	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134154612	152511	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
		CHEMBL3971356	152511	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
		134153232	152579	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
		CHEMBL3971845	152579	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
		134154534	152744	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3973254	152744	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
		134154022	152825	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3973940	152825	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134151581	153208	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3977241	153208	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		57528347	153212	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
		CHEMBL3977265	153212	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
		134152388	153218	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
		CHEMBL3977294	153218	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
		134151706	153354	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3978455	153354	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134151524	153380	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3978661	153380	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134152209	153402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3978864	153402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134152547	153483	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3979606	153483	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		11421086	153566	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
		CHEMBL3980276	153566	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
		134157913	153631	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		CHEMBL3980873	153631	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		134156625	153651	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3981072	153651	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134157438	153748	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3981843	153748	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134157625	153761	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3981960	153761	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		59834193	154152	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
		CHEMBL3985477	154152	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
		134156443	154346	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
		CHEMBL3986906	154346	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
		56926176	69014	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL1923505	69014	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		56926266	69016	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
		CHEMBL1923508	69016	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
		134133634	143634	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3899825	143634	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		57722117	143684	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3900193	143684	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		57722068	143933	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3902231	143933	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
		134135595	143964	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3902597	143964	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134139160	146209	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
		CHEMBL3920156	146209	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
		134140250	146246	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3920479	146246	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		57951693	146277	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
		CHEMBL3920711	146277	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
		134140177	146370	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3921493	146370	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134139639	146639	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
		CHEMBL3923467	146639	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
		134140216	146644	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3923508	146644	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
		134141155	146728	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
		CHEMBL3924187	146728	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
		134137626	147483	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3930400	147483	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134148332	148281	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3936664	148281	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		57528213	148484	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
		CHEMBL3938163	148484	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
		134149424	148636	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3939431	148636	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
		57951672	149594	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		CHEMBL3946954	149594	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		134147008	149936	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3949653	149936	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		134155726	151018	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
		CHEMBL3958492	151018	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
		134155844	151088	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
		CHEMBL3959055	151088	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
		57528307	151127	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
		CHEMBL3959346	151127	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
		134156186	151350	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3961157	151350	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134150525	151564	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
		CHEMBL3963236	151564	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
		134149894	151834	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
		CHEMBL3965402	151834	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
		134150119	152047	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
		CHEMBL3967266	152047	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
		134150914	152080	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
		CHEMBL3967522	152080	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
		57722047	152867	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3974323	152867	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		57951687	152872	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
		CHEMBL3974356	152872	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
		57528291	152916	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
		CHEMBL3974776	152916	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
		134152485	153176	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
		CHEMBL3976941	153176	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
		134151873	153200	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
		CHEMBL3977166	153200	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
		76556607	153555	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
		CHEMBL3980176	153555	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
		134157812	153670	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		CHEMBL3981235	153670	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		134156737	153699	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3981446	153699	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
		134156806	154094	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
		CHEMBL3984892	154094	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
		134157124	154206	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
		CHEMBL3985913	154206	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
		11706547	69046	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923619	69046	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		134138625	148030	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3934561	148030	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		44434011	147864	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL393321	147864	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
		70692601	75875	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048814	75875	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		127046957	139707	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798155	139707	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
		127046472	139694	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798056	139694	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		56926266	69016	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
		CHEMBL1923508	69016	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
		73352329	92265	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426669	92265	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		70692602	75876	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048815	75876	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
		162665974	182235	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4783347	182235	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		44396381	67531	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
		CHEMBL189625	67531	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
		44396377	66943	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
		CHEMBL186647	66943	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
		44396269	67356	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
		CHEMBL188586	67356	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
		56926895	69065	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923639	69065	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		56942244	125197	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645259	125197	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		162648546	179878	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4745666	179878	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
		58438460	111738	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287217	111738	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
		56926356	69019	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923512	69019	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		56926176	69014	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923505	69014	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		71453390	81843	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164500	81843	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		162663952	182152	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4782383	182152	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		118725963	117194	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		CHEMBL3394203	117194	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		44434112	168860	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		CHEMBL438154	168860	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		3174463	66768	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		CHEMBL185876	66768	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		56926464	69039	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
		CHEMBL1923612	69039	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
		118725960	117190	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
		CHEMBL3394199	117190	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
		162657547	180983	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4758721	180983	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		162658148	181148	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4760746	181148	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
		162662164	181410	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4763700	181410	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		127047362	139719	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798204	139719	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		3154000	124270	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
		CHEMBL363467	124270	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
		162651277	180196	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4749525	180196	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		3180629	67353	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		CHEMBL188582	67353	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		44434016	90193	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL238228	90193	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		72190452	92278	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426682	92278	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		118725964	117195	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		CHEMBL3394204	117195	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		70692600	75874	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048813	75874	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		70682036	75878	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048817	75878	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		70686293	75883	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048822	75883	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		58438460	111738	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
		CHEMBL3287217	111738	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
		162660604	181219	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4761319	181219	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		162671996	182831	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4791255	182831	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		25032438	116196	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
		CHEMBL3358450	116196	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
		11692516	69048	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923621	69048	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		67407161	92284	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426688	92284	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		67410074	111737	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287216	111737	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
		56926782	69057	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923631	69057	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		70696687	75873	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048812	75873	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		127046806	139933	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799604	139933	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		127048038	139972	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799862	139972	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		44434076	89777	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
		CHEMBL237717	89777	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
		56926463	69038	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923611	69038	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		11526696	71602	17	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923502	71602	17	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1963249	71602	17	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		72191051	92262	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426666	92262	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		58438460	111738	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287217	111738	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
		56926783	69058	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923632	69058	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		162658631	181083	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4759983	181083	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
		118725958	117189	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
		CHEMBL3394197	117189	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
		162659337	181316	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4762631	181316	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		73355325	92267	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426671	92267	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		70696688	75879	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048818	75879	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
		127048060	139861	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799222	139861	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
		56942388	139943	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799687	139943	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		162677361	183509	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4799766	183509	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		58438475	92273	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
		CHEMBL2426677	92273	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
		44434109	146281	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		CHEMBL392076	146281	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		134139080	147683	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		CHEMBL3931856	147683	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		44434010	88773	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL236311	88773	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		127047655	139614	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3797531	139614	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		44340007	9314	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
		CHEMBL111026	9314	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
		56925344	69067	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923641	69067	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		44434083	90031	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL238155	90031	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
		44434050	145450	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL391428	145450	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
		44396306	67277	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
		CHEMBL188173	67277	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
		145948725	167497	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL4299615	167497	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		57345597	71270	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956988	71270	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		56942243	125196	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645258	125196	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
		162648837	179838	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4745116	179838	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		127048059	139566	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3797225	139566	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		11526745	69068	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923642	69068	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		57400003	71279	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956996	71279	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		155529391	171440	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4463042	171440	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		70690449	75871	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048810	75871	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		118725965	117196	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
		CHEMBL3394205	117196	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
		44434080	89911	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL237933	89911	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		162647450	179871	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4745548	179871	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
		71456910	81901	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164823	81901	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
		3154005	66773	5	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		CHEMBL185887	66773	5	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		70696689	75882	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048821	75882	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		56926681	69051	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923624	69051	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		127047409	139631	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3797639	139631	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		56926785	69060	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923634	69060	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		70688404	75867	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
		CHEMBL2048807	75867	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
		44434009	167453	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL429799	167453	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		53248756	61181	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
		CHEMBL1765654	61181	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
		CHEMBL2170701	209361	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		10253999	123793	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		CHEMBL362303	123793	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		127048061	139736	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798337	139736	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
		162662593	181970	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4780100	181970	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
		44579909	186903	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		CHEMBL489819	186903	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		44434073	89600	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		CHEMBL237507	89600	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		70694649	75884	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2048823	75884	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		162659161	181391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4763471	181391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		162652815	180376	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4751674	180376	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL2170779	209366	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		44434008	146534	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL392268	146534	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		44434110	88512	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		CHEMBL235135	88512	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		44577060	188052	0	None	-69	8	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
		CHEMBL497746	188052	0	None	-69	8	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
		CHEMBL2170780	209367	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		71453404	81903	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164826	81903	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
		70692603	75877	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048816	75877	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		56926360	69035	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923608	69035	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		72190451	92276	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL2426680	92276	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
		44579907	187048	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
		CHEMBL491044	187048	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
		73350846	92266	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426670	92266	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		44576247	214222	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
		CHEMBL506986	214222	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
		44576247	214222	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
		CHEMBL506986	214222	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
		44579880	186835	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
		CHEMBL489401	186835	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
		118725962	117193	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
		CHEMBL3394202	117193	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
		44396384	67408	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
		CHEMBL188839	67408	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
		44434074	154673	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		CHEMBL399625	154673	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		70684155	75885	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2048824	75885	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		72191050	92263	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426667	92263	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		72190449	92272	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426676	92272	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		118725966	117197	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
		CHEMBL3394206	117197	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
		162675268	183358	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4797685	183358	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
		3153999	126831	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		CHEMBL365489	126831	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		71451551	81851	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164508	81851	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
		72190451	92276	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426680	92276	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		72190451	92276	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL2426680	92276	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
		9950632	88706	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
		CHEMBL236038	88706	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
		127046472	139694	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
		CHEMBL3798056	139694	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
		127045859	139699	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
		CHEMBL3798095	139699	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
		127045859	139699	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798095	139699	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		127047523	140063	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3800422	140063	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
		71456897	81850	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164507	81850	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		162653916	180545	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4753794	180545	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		162643920	181780	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4777792	181780	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		155537651	172316	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4475293	172316	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		57391292	71278	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956995	71278	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
		57345598	71287	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957004	71287	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		53373577	92282	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426686	92282	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		57391294	71281	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956998	71281	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		155526063	171036	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4456830	171036	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		162663004	182049	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4781141	182049	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
		155557019	174587	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4556887	174587	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		71453489	209368	15	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
		CHEMBL2170781	209368	15	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
		67405379	92279	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426683	92279	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		25211977	186902	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
		CHEMBL489818	186902	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
		25098836	191458	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		CHEMBL519322	191458	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		127047525	139767	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798559	139767	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		162653309	180473	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4752936	180473	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		44579756	186823	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
		CHEMBL489370	186823	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
		162666964	182510	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4787023	182510	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL2170693	209353	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		44434121	89908	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
		CHEMBL237927	89908	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
		56926584	69047	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923620	69047	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		44434120	89907	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL237926	89907	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
		44434007	88575	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL235446	88575	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		11541143	69045	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923618	69045	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		24969520	69049	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923622	69049	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL2170694	209354	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		56926580	69041	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
		CHEMBL1923614	69041	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
		162653802	180531	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4753592	180531	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		73346226	92264	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426668	92264	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
		162674738	183387	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4797988	183387	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		56926177	69015	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923506	69015	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		56926581	69042	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
		CHEMBL1923615	69042	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
		71458747	81838	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
		CHEMBL2164494	81838	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
		23631116	4112	23	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
		3538	4112	23	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
		CHEMBL243001	4112	23	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
		127046956	139957	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799776	139957	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
		118725961	117191	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
		CHEMBL3394200	117191	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
		162663407	182030	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4780843	182030	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		56926462	69037	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923610	69037	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		70695747	73191	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
		CHEMBL2011816	73191	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
		67406334	111734	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
		CHEMBL3287213	111734	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
		57390496	69055	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
		CHEMBL1923628	69055	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
		71453489	209368	15	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		CHEMBL2170781	209368	15	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		56926269	69018	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
		CHEMBL1923511	69018	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
		56926784	69059	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923633	69059	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		70688404	75867	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
		CHEMBL2048807	75867	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
		70688404	75867	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048807	75867	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
		44434123	145550	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
		CHEMBL391510	145550	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
		56926582	69043	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923616	69043	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		16114404	154897	24	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL400814	154897	24	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
		25190383	81909	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164831	81909	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		11683187	199932	44	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
		CHEMBL594828	199932	44	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
		70684154	75869	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048809	75869	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		44434055	89305	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		CHEMBL236858	89305	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		56942385	125198	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645260	125198	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		56942535	139761	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798525	139761	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		24180592	97013	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
		CHEMBL266647	97013	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
		44434113	88649	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL235793	88649	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		44434051	89415	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
		CHEMBL237058	89415	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
		118725954	117187	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
		CHEMBL3394193	117187	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
		24969603	69054	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
		CHEMBL1923627	69054	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
		57394882	71294	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957011	71294	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		9876514	9140	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
		CHEMBL109980	9140	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
		70682037	75881	20	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
		CHEMBL2048820	75881	20	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
		145948708	167496	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL4299606	167496	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		67410074	111737	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287216	111737	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
		56926465	69040	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
		CHEMBL1923613	69040	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
		44434119	89906	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
		CHEMBL237925	89906	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
		70694648	75872	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048811	75872	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		155561671	175664	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4581511	175664	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		56926894	69064	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923638	69064	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		162672372	183086	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4794448	183086	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
		56925345	69069	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923643	69069	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		56926464	69039	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923612	69039	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
		56942387	139662	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3797857	139662	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL105462	208468	38	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm960054c
		56926680	69050	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923623	69050	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		162649014	179941	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4746362	179941	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
		162666112	182314	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4784240	182314	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
		162676229	183304	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4797064	183304	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		58438475	92273	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426677	92273	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		58438475	92273	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
		CHEMBL2426677	92273	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
		56926461	69036	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923609	69036	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		118725956	117188	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
		CHEMBL3394195	117188	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
		155551597	173949	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4541252	173949	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		57394797	71285	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957002	71285	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162649450	180054	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4747770	180054	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
		58438464	3065	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		9060	3065	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		CHEMBL3287218	3065	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		DB14870	3065	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		58438464	3065	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		9060	3065	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		CHEMBL3287218	3065	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		DB14870	3065	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		67406334	111734	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
		CHEMBL3287213	111734	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
		57401798	71271	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956989	71271	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		58438475	92273	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
		CHEMBL2426677	92273	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
		11541319	69070	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
		CHEMBL1923644	69070	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
		162659375	181351	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4763077	181351	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
		127046807	139940	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799671	139940	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		127047654	139977	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799883	139977	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		121879	2234	24	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
		5868	2234	24	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
		CHEMBL308716	2234	24	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
		162665952	182379	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4785149	182379	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		134139753	146036	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3918783	146036	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		162663868	181988	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4780408	181988	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		56926268	69017	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
		CHEMBL1923510	69017	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
		56926175	69013	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923504	69013	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		23635235	166501	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
		CHEMBL427860	166501	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
		70686292	75880	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048819	75880	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		90644554	111736	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287215	111736	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
		70682037	75881	20	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048820	75881	20	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		11664206	69053	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923626	69053	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		216208	9727	33	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
		CHEMBL113313	9727	33	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
		56926682	69052	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923625	69052	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		67408128	92280	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426684	92280	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		24180646	148182	0	None	-1023	8	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
		CHEMBL393576	148182	0	None	-1023	8	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
		57390496	69055	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
		CHEMBL1923628	69055	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
		CHEMBL501261	214135	23	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
		56926892	69062	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923636	69062	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		44434012	89074	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL236513	89074	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		127046473	139780	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798645	139780	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		56942099	125194	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645256	125194	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		66601728	81841	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164499	81841	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		162657465	181041	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4759418	181041	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
		56926891	69061	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923635	69061	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		44434015	88491	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL235011	88491	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		67407808	92283	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL2426687	92283	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
		56926173	69012	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923501	69012	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		3153998	67521	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		CHEMBL189561	67521	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		56926893	69063	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
		CHEMBL1923637	69063	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
		66788278	125192	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645254	125192	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		127045858	139862	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799225	139862	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
		162677268	183573	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4800459	183573	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		58438487	92281	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426685	92281	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
		67407808	92283	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426687	92283	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		67407808	92283	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL2426687	92283	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
		67406727	117192	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		CHEMBL3394201	117192	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		162656896	180860	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4757313	180860	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
		44579823	184081	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		CHEMBL482420	184081	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		44396320	66817	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
		CHEMBL186045	66817	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
		162674996	183389	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4798018	183389	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		44434111	146283	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		CHEMBL392077	146283	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		9745	2453	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
		9804938	2453	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
		CHEMBL278623	2453	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
		DB13074	2453	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
		9745	2453	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
		9804938	2453	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
		CHEMBL278623	2453	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
		DB13074	2453	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
		1102	1321	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
		1093	1794	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
		1093	1794	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		4345065	1794	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
		4345065	1794	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		1100	1608	45	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
		6918297	1608	45	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
		CHEMBL108335	1608	45	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
		1099	1787	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
		1099	1787	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
		1092	3158	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		134715446	3158	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		2232	3158	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		6918245	3158	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		CHEMBL106593	3158	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		58438464	3065	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		9060	3065	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		CHEMBL3287218	3065	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		DB14870	3065	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		58438464	3065	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		9060	3065	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		CHEMBL3287218	3065	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		DB14870	3065	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		58438464	3065	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		9060	3065	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		CHEMBL3287218	3065	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		DB14870	3065	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		12413	3070	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
		164946906	3070	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
		12413	3070	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
		164946906	3070	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
		23631116	4112	23	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
		3538	4112	23	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
		CHEMBL243001	4112	23	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
		1098	1391	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
		1098	1391	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14763915
		1101	657	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15339248
		10740	1938	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
		146170991	1938	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
		1092	3158	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		134715446	3158	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		2232	3158	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		6918245	3158	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		CHEMBL106593	3158	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		178024	1971	33	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
		5867	1971	33	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
		CHEMBL13817	1971	33	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
		1099	1787	0	None	-	1	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
		1093	1794	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		4345065	1794	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793

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