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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44570962	190636	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480821	190636	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	145950336	169606	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172656	169606	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	156016416	184436	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	184436	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	101274	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251572	101274	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156014430	184002	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	184002	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016416	184436	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	184436	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	101274	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	CHEMBL251572	101274	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	44570963	190659	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481013	190659	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	156014430	184002	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	184002	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444563	161734	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401134	161734	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	156011926	184179	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	184179	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44571002	197877	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL518774	197877	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44449987	102668	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259166	102668	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	25010378	166177	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	CHEMBL410074	166177	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	44449955	166191	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410085	166191	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	156011926	184179	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	184179	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	184585	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	184585	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156015100	184351	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	184351	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	184585	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	184585	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44570960	190767	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481796	190767	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	24894012	183576	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL460680	183576	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	156015100	184351	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	184351	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437979	17099	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	17099	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44437979	17099	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	17099	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44454303	104345	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	104345	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	156020725	184884	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	184884	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44570764	190828	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482220	190828	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	24803512	95782	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364468	95782	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	156020725	184884	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	184884	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	9917957	116495	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	CHEMBL322912	116495	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	44447855	201635	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL539929	201635	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	178024	8752	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	8752	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	8752	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	156013414	184251	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	184251	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	184263	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	184263	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44452749	102990	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL260819	102990	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44570765	198219	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL519301	198219	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007047	95740	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364427	95740	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	178024	8752	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	8752	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	8752	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	25022640	104577	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	104577	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454337	162382	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	162382	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44447839	101766	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254765	101766	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156013414	184251	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	184251	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	184263	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	184263	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44447857	173655	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL428592	173655	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156019724	184770	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	184770	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888474	70238	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL179823	70238	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	11306502	70416	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	70416	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	70416	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	70416	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	70416	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	70416	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888476	129596	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	129596	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	22888476	129596	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	129596	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	44454117	162335	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	162335	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44444559	101211	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251169	101211	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	156011750	184069	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	184069	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156019724	184770	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	184770	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453123	104762	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL272753	104762	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	44570966	190348	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480037	190348	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007062	95742	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364429	95742	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	24803514	95787	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364472	95787	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	44447852	162341	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404354	162341	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156011750	184069	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	184069	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450016	167339	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411259	167339	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	44454367	102036	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	102036	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	22867441	17087	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	17087	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	16114096	85935	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113324	85935	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	22867441	17087	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	17087	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447841	161857	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL401827	161857	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	69195371	95666	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364354	95666	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44450101	166239	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410135	166239	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	44391039	138566	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369329	138566	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44449988	167880	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411697	167880	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	44447843	101795	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254973	101795	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	10280020	69866	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178900	69866	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156021297	184868	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	184868	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444571	100754	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248544	100754	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	10553921	111337	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	111337	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	146053	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	146053	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	156012122	184160	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	184160	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021297	184868	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	184868	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11584048	104805	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	CHEMBL272993	104805	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	24755624	164079	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL407706	164079	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	24755624	164079	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	CHEMBL407706	164079	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	69197353	95720	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364408	95720	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44454060	162111	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	162111	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10553921	111337	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	111337	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	146053	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	146053	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	127047525	146545	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798559	146545	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	156022162	184985	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	184985	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156012122	184160	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	184160	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	20600693	70230	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179785	70230	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44560945	185881	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL471751	185881	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	216208	16499	33	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	16499	33	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	44449891	103249	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL262358	103249	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	216208	16499	33	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	16499	33	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	156021478	184834	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	184834	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437955	17097	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	17097	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	9807597	189796	5	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL47938	189796	5	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	156018364	184692	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	184692	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021478	184834	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	184834	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	184982	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	184982	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156022162	184985	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	184985	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	56926175	75788	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923504	75788	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926356	75794	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923512	75794	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	56926461	75811	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923609	75811	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926462	75812	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923610	75812	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	57399248	75819	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923617	75819	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	11664206	75828	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923626	75828	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926894	75839	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923638	75839	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	11526745	75843	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923642	75843	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11526696	78377	17	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	78377	17	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	78377	17	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	134130631	149151	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	CHEMBL3889512	149151	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	134137202	149604	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3893048	149604	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137257	149915	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3895776	149915	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134133518	150231	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3898348	150231	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134133352	150283	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3898794	150283	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134286	150472	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900284	150472	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134135712	150916	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	CHEMBL3903845	150916	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	11512561	151147	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3905791	151147	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134133037	151345	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3907497	151345	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132893	151641	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3909834	151641	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132152	151710	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3910300	151710	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142218	152065	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3913052	152065	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134142433	152104	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3913335	152104	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	134142839	152164	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913855	152164	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143635	152352	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3915269	152352	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	134143366	152538	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3916659	152538	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134142204	152715	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3918046	152715	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11584702	152969	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3920049	152969	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134140270	153151	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3921499	153151	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134139279	153225	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922056	153225	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134139286	153332	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922810	153332	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134141886	153896	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3927481	153896	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	117812380	154530	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3932408	154530	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138595	154533	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	CHEMBL3932434	154533	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	134138824	154793	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934402	154793	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148504	155133	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3937200	155133	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149306	155253	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3938104	155253	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145791	155565	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3940705	155565	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145564	155869	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3943086	155869	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134147441	156268	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3946348	156268	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134155239	157793	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3958460	157793	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	134155132	157871	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959108	157871	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154079	159182	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970499	159182	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	134153247	159499	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3973085	159499	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	44570763	197038	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517543	197038	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	9890504	96515	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	CHEMBL237699	96515	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	24969109	95650	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364338	95650	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11518200	95665	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364353	95665	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641108	95694	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364382	95694	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197887	95715	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364403	95715	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447856	168593	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL414394	168593	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156018364	184692	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	184692	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	184982	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	184982	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10323604	17081	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	17081	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10323604	17081	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	17081	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447853	101739	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254565	101739	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	25022503	162342	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404355	162342	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44269035	34105	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13675	34105	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44269039	105117	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL275093	105117	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	145956061	169472	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	169472	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44570965	196616	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL516602	196616	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	69194933	95737	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364424	95737	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	69198297	95746	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364432	95746	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447850	101710	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254363	101710	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450015	103093	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261358	103093	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	178024	8752	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	8752	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	8752	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	178024	8752	33	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	5867	8752	33	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	CHEMBL13817	8752	33	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	178024	8752	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	8752	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	8752	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	145956061	169472	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	169472	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44450104	102576	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258761	102576	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	220894	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	220894	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
	22888475	70599	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180246	70599	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL500468	220894	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.040
	162653916	187324	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753794	187324	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL500468	220894	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.02.021
	CHEMBL500468	220894	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.05.100
	178024	8752	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	5867	8752	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	CHEMBL13817	8752	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	156012849	184077	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	184077	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44390996	71078	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181063	71078	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	71390	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	71390	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	71390	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	71390	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44347919	23145	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122939	23145	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	16133832	220110	18	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	CHEMBL425281	220110	18	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	145957574	169080	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	169080	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	9875705	212080	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	212080	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	156012849	184077	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	184077	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013219	184268	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	184268	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11648350	95693	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364381	95693	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007043	95696	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364384	95696	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	69197106	95739	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364426	95739	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	24803348	95744	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364430	95744	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197228	95790	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364475	95790	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	16114291	198073	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL5190973	198073	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	16114292	103709	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	CHEMBL266063	103709	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	9875705	212080	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	212080	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	44436850	98324	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240509	98324	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44447840	101767	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254766	101767	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44447854	101740	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254566	101740	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL105462	215247	38	None	12	2	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm980197u
	44447844	101652	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253965	101652	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450017	103121	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261544	103121	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	10118326	30865	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	30865	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10458218	34260	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13687	34260	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	10745618	119764	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	CHEMBL331093	119764	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	10118326	30865	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	30865	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	156010457	183833	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	183833	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	23649669	160746	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL398372	160746	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	23649669	160746	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	CHEMBL398372	160746	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	23649669	160746	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL398372	160746	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	23649669	160746	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL398372	160746	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44437955	17097	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	17097	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	10626337	108002	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	108002	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156010457	183833	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	183833	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	156012445	184114	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	184114	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015928	184360	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	184360	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452750	103032	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL261030	103032	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44452932	104363	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	CHEMBL270790	104363	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	44570700	190738	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	CHEMBL481620	190738	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	69197169	95711	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364399	95711	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641478	95719	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364407	95719	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	24803350	95755	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364441	95755	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	11547664	95795	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364480	95795	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	44579802	193547	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488965	193547	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44444572	100794	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248745	100794	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145962494	168853	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	168853	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145951150	169555	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	169555	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44434120	96682	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237926	96682	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	9827234	12108	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL106841	12108	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	44411718	17078	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161825	17078	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	17096	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	17096	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	44293557	107865	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL294923	107865	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL540001	107865	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	127046473	146558	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798645	146558	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	156012203	184113	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	184113	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	156016696	184409	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	184409	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11525404	102156	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL256808	102156	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44571004	190825	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482203	190825	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL105462	215247	38	None	12	2	Rat	8.0	pEC50	=	8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(97)10199-8
	24969294	95655	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364343	95655	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	69194607	95670	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364358	95670	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	69197049	95671	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364359	95671	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	69195141	95689	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364377	95689	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	11682686	95702	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364390	95702	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198021	95745	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	CHEMBL2364431	95745	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	11655608	95758	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364444	95758	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194649	95792	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364477	95792	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196750	95794	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364479	95794	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	23730339	154898	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL393531	154898	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	156016696	184409	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	184409	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145993528	174097	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	174097	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	156012203	184113	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	184113	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	145950201	169721	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	169721	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44281466	176161	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	176161	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44452806	103458	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL263916	103458	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44452885	104590	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271948	104590	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	11633712	166114	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410013	166114	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	57390496	75830	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	75830	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	56926782	75832	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923631	75832	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926785	75835	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923634	75835	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926892	75837	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923636	75837	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926893	75838	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	CHEMBL1923637	75838	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	134131183	149246	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890296	149246	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134133488	150014	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3896536	150014	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134870	151170	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3905987	151170	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132958	151439	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	CHEMBL3908264	151439	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	134132265	151749	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	CHEMBL3910661	151749	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	76460236	152238	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3914338	152238	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134141159	153507	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3924192	153507	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149092	155232	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3937924	155232	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134146570	155559	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940653	155559	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145820	155813	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3942642	155813	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155024	157791	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3958451	157791	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155282	158121	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961108	158121	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134152627	158327	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963078	158327	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150696	158858	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967506	158858	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134150029	158894	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967783	158894	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134153608	159149	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970180	159149	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154022	159604	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3973940	159604	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134151899	160098	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3978207	160098	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134156625	160430	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981072	160430	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	16040587	186163	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	CHEMBL473921	186163	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	44576247	221001	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	CHEMBL506986	221001	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	44576247	221001	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL506986	221001	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL3578015	218545	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578018	218548	0	None	-15	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69198097	95676	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364364	95676	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	69198438	95678	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364366	95678	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	69196473	95687	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364375	95687	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197657	95688	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364376	95688	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	69195983	95709	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364397	95709	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196844	95726	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364414	95726	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647817	95730	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	CHEMBL2364418	95730	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	69196864	95748	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364434	95748	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	69198407	95777	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364463	95777	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	44579958	198121	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519171	198121	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	156020713	184867	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	184867	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	134139753	152814	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3918783	152814	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	44449923	103113	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL261497	103113	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	156020713	184867	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	184867	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	44434110	95287	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235135	95287	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578018	218548	0	None	-15	2	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44450102	102546	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL258550	102546	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	16114290	143986	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374992	143986	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11664206	75828	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923626	75828	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	71453489	216147	15	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	216147	15	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	9870965	71088	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181092	71088	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44434051	96190	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237058	96190	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	44434053	153636	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	CHEMBL392522	153636	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	145988557	174039	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	174039	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL2170775	216142	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434083	96806	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL238155	96806	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	44436884	98327	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240522	98327	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	16114098	148389	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL385131	148389	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113246	101452	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252643	101452	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	22888486	71092	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL181108	71092	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	71453489	216147	15	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	CHEMBL2170781	216147	15	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	156018539	184588	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	184588	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145949755	169713	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	169713	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	156013970	184019	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	184019	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156018539	184588	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	184588	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	69197178	95648	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364336	95648	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	69194396	95699	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364387	95699	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	69195258	95731	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364419	95731	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11604627	95747	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364433	95747	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197381	95765	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364451	95765	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	11576185	95772	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364458	95772	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	11633856	95798	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364483	95798	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	59007104	95801	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364486	95801	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2170779	216145	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579824	190889	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482623	190889	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44579883	193616	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489403	193616	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579861	200979	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL528332	200979	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	44579906	199398	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL521612	199398	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	145992125	173529	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	173529	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016682	184545	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	184545	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170776	216143	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	16752689	195147	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL501315	195147	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	44444557	161465	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL399704	161465	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	145957404	168828	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	168828	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	169303	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	169303	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	145950261	169508	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	169508	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156014569	184011	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	184011	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452776	103103	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL261466	103103	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	69196695	95661	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364349	95661	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007058	95669	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	CHEMBL2364357	95669	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	156016682	184545	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	184545	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44579842	191530	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL485091	191530	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	145986461	173992	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	173992	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145950261	169508	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	169508	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	10602593	119619	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330860	119619	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391038	71359	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181627	71359	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170783	216149	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](N)CCCCN)C(c1ccccc1)c1ccccc1)C(N)=O	10.1021/jm300414b
	CHEMBL2170779	216145	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013970	184019	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	184019	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156014569	184011	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	184011	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	56926173	75787	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923501	75787	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	134138625	154809	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3934561	154809	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	155526063	177815	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4456830	177815	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145957404	168828	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	168828	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	169303	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	169303	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	44454060	162111	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	162111	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	57399248	75819	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	75819	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	145949755	169713	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	169713	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44434109	153059	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392076	153059	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	9890375	105046	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	105046	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	105046	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44436876	153797	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL392663	153797	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9890375	105046	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL274599	105046	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL558802	105046	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	9890375	105046	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	105046	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	105046	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44281466	176161	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	176161	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	162672839	189801	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4793824	189801	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	22888428	71124	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181247	71124	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	23730227	154652	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	CHEMBL393330	154652	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	44450133	167172	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL411122	167172	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44579821	191007	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL483455	191007	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	44579879	193774	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490627	193774	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44450071	103360	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263141	103360	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	16113906	144001	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL375102	144001	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	44579752	193739	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490390	193739	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	44436887	97734	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239464	97734	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44434076	96552	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	CHEMBL237717	96552	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	145952740	169280	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	169280	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	23648250	85938	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113327	85938	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16113577	91711	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL223725	91711	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	162657465	187820	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759418	187820	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	44444574	100795	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248746	100795	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145952740	169280	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	169280	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	11532288	103695	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL265950	103695	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	11576186	162004	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	CHEMBL402632	162004	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	44570964	190660	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481014	190660	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44570921	190734	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481601	190734	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	59007073	95649	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364337	95649	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	69197749	95658	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364346	95658	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11682796	95660	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364348	95660	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198460	95672	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	CHEMBL2364360	95672	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	69198360	95680	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364368	95680	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11683967	95692	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364380	95692	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	69195261	95700	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364388	95700	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11516766	95704	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364392	95704	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11525161	95761	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364447	95761	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194533	95791	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364476	95791	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197165	95803	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364488	95803	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44579777	193763	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490601	193763	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44454432	162037	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	162037	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44434112	175639	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL438154	175639	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44579908	193653	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489610	193653	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145954311	169265	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	169265	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44434124	95433	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235817	95433	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	162659161	188170	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763471	188170	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44444556	101177	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	CHEMBL250973	101177	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	145950963	169585	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	169585	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952396	169782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	169782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	156011695	184134	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	184134	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452887	166357	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL410282	166357	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	46882522	12484	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078208	12484	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	69195349	95683	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	CHEMBL2364371	95683	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	69198352	95804	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364489	95804	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	44446188	162170	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403542	162170	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145954311	169265	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	169265	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	46882521	12483	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078207	12483	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	44445620	161457	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399651	161457	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	22862453	105235	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL275795	105235	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	10675061	103318	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL262889	103318	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	10026738	169548	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	169548	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	169548	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	56926464	75814	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	CHEMBL1923612	75814	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	155540883	179736	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	179736	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	10210658	17098	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	17098	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	145952396	169782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	169782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL2170784	216150	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134139080	154461	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3931856	154461	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	156011695	184134	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	184134	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170697	216136	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434080	96686	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44434080	96686	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	96686	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237933	96686	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10210658	17098	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	17098	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10026738	169548	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	169548	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	169548	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	10530983	175164	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL434609	175164	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391003	130099	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL361612	130099	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170780	216146	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145950963	169585	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	169585	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	127047409	146409	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797639	146409	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	10745533	146898	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	146898	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	209299	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	209299	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	16113693	144794	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376471	144794	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	11692516	75823	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923621	75823	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	155557019	181366	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	181366	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	9810101	106025	17	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL281764	106025	17	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10745533	146898	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	146898	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	209299	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	209299	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44579909	193682	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489819	193682	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44436882	152794	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391859	152794	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2170698	216137	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434122	96286	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237302	96286	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	145992142	173550	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	173550	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL3578006	218539	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	145953016	169366	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	169366	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	44454304	104379	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	104379	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	104425	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	104425	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454338	104611	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	104611	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	22867310	36814	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	CHEMBL13891	36814	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	162653802	187310	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753592	187310	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44436886	168734	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL415674	168734	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9987037	18804	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183385	18804	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL294324	18804	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	44391008	71641	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182137	71641	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	22888379	175092	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL434152	175092	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	44444564	101247	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251366	101247	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	145961213	168942	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	168942	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145953016	169366	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	169366	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145949595	169503	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	169503	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	169803	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	169803	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44452929	104319	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL270573	104319	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	46882396	12616	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079187	12616	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570698	190737	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481619	190737	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	24969292	95652	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364340	95652	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	69194665	95685	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364373	95685	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	11524465	95705	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364393	95705	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11576404	95716	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364404	95716	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194865	95735	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364422	95735	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	11712498	95749	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364435	95749	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	69195296	95754	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364440	95754	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11518242	95757	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364443	95757	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	69197366	95762	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364448	95762	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11503413	95779	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	CHEMBL2364465	95779	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	11647900	95785	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364470	95785	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	11669734	95786	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364471	95786	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	44391007	71640	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182136	71640	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	145994050	174124	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	174124	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016392	184425	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	184425	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL3578006	218539	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	25098836	198237	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519322	198237	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957574	169080	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	169080	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	17080	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	17080	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	10626337	108002	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	108002	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156013219	184268	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	184268	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888352	70711	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	70711	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888352	70711	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	70711	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	10649999	23878	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL125498	23878	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156015928	184360	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	184360	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156012445	184114	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	184114	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44411634	17077	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	17077	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44411634	17077	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	17077	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44390986	71443	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181832	71443	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170695	216134	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156011766	184087	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	184087	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44281449	120171	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	120171	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	44281449	120171	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	120171	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	23648249	85937	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113326	85937	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	10166594	71410	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181786	71410	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391010	71648	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL182158	71648	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	23648244	98789	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241775	98789	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	155557019	181366	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	181366	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44444565	101275	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251573	101275	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145957075	169058	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	169058	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	17080	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	17080	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	156013684	184044	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	184044	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156011766	184087	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	184087	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	11539642	104704	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL272540	104704	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	44570702	190615	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480639	190615	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	11683968	95691	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364379	95691	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197883	95714	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364402	95714	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69195597	95727	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	CHEMBL2364415	95727	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	59007081	95741	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364428	95741	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	11648834	95796	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364481	95796	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	44411753	17082	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	17082	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411753	17082	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	17082	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	10415000	174846	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	174846	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	71453489	216147	15	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	216147	15	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013684	184044	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	184044	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10415000	174846	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	174846	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	156019457	184721	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	184721	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449922	102996	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL260849	102996	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44269019	105002	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL274340	105002	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44579840	191528	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL485090	191528	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579907	193827	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491044	193827	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579805	193845	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491221	193845	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434113	95424	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235793	95424	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	127048060	146639	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799222	146639	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	57399248	75819	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923617	75819	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44268965	30834	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13383	30834	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	10675800	120571	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL332414	120571	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391002	130688	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL362798	130688	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44579857	193703	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490009	193703	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44434018	95267	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235012	95267	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44579641	193676	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489794	193676	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579996	193915	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491835	193915	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	44579919	198128	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	CHEMBL519196	198128	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	44454092	104425	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	104425	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44450070	165430	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL409258	165430	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	156016392	184425	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	184425	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145961213	168942	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	168942	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145949595	169503	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	169503	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	169803	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	169803	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44390905	71231	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181337	71231	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391040	71235	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181352	71235	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10579444	121020	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL332987	121020	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	162645413	186505	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744051	186505	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44293091	194965	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	194965	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	16114011	144916	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL376736	144916	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	145981343	173488	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	173488	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44391048	69722	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178502	69722	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44454399	161918	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	161918	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44293091	194965	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	194965	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	155540883	179736	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	179736	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44579801	193940	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL492028	193940	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	168276220	197200	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5177954	197200	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	145958774	169045	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	169045	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145950877	169774	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	169774	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44450135	165482	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL409327	165482	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44454302	166159	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	166159	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	16203237	103726	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	CHEMBL266199	103726	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	56926462	75812	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923610	75812	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	162660604	187998	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761319	187998	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956753	168936	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	168936	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	71453489	216147	15	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	216147	15	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44446190	101331	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL251855	101331	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44446189	162153	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403426	162153	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	10744738	22976	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122420	22976	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL2170699	216138	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44454432	162037	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	162037	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44454397	162303	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL404227	162303	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145949381	169494	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	169494	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	22862431	37258	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13930	37258	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	162653781	187261	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753046	187261	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	156013764	184050	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	184050	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145958317	169092	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	169092	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145949381	169494	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	169494	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950877	169774	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	169774	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	156013764	184050	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	184050	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156020452	184813	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	184813	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	24969201	95656	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364344	95656	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	69197403	95681	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	CHEMBL2364369	95681	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	59007071	95695	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364383	95695	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11547135	95708	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364396	95708	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11567764	95712	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364400	95712	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11511157	95722	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	CHEMBL2364410	95722	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	11547599	95724	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364412	95724	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197133	95734	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	CHEMBL2364421	95734	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	69197849	95759	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364445	95759	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198350	95766	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364452	95766	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	156020452	184813	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	184813	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44579860	195680	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL507551	195680	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145956415	168842	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	168842	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956415	168842	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	168842	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956753	168936	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	168936	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145958774	169045	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	169045	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145955718	169314	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	169314	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952404	169515	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	169515	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	218544	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44436816	98580	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241242	98580	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44391028	71072	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181051	71072	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44390906	138881	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369571	138881	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44434052	96191	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237059	96191	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	44450169	166529	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	CHEMBL410499	166529	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	56926894	75839	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923638	75839	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	44391027	135581	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL366916	135581	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579803	193548	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488966	193548	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145952404	169515	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	169515	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	218544	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	11526696	78377	17	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1923502	78377	17	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1963249	78377	17	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	44450045	166016	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL409894	166016	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	44434012	95849	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL236513	95849	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44454398	104374	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	104374	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	11526745	75843	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923642	75843	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	44391020	70638	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180337	70638	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	162643920	188559	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4777792	188559	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155540883	179736	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	179736	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145955718	169314	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	169314	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	23648236	85927	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	CHEMBL2113317	85927	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	145958317	169092	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	169092	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	162649014	186720	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4746362	186720	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	44434123	152328	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL391510	152328	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	11526696	78377	17	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923502	78377	17	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1963249	78377	17	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	122178179	128041	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	128041	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	145980382	173422	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	173422	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71453489	216147	15	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	216147	15	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134149793	155384	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	CHEMBL3939196	155384	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	145980333	173360	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	173360	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44579823	190860	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482420	190860	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957075	169058	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	169058	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145951150	169555	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	169555	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44449864	165609	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL409462	165609	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	10005618	17095	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	17095	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	84519	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	84519	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	106025	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	106025	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	147988	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	147988	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	215466	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	16114292	103709	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL266063	103709	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16114292	103709	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	103709	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	23730225	160955	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	CHEMBL398570	160955	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	10530781	22350	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122108	22350	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10005618	17095	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	17095	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	84519	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	84519	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	106025	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	106025	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	147988	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	147988	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	215466	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	156011385	184157	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	184157	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449956	103390	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263389	103390	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44447846	101674	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254166	101674	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44444566	161546	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400124	161546	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156011385	184157	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	184157	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156019457	184721	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	184721	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570961	199340	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521246	199340	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	69195095	95738	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364425	95738	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194503	95774	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364460	95774	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	59007103	95800	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	CHEMBL2364485	95800	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	69197358	95806	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364491	95806	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	44450046	102631	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	CHEMBL259016	102631	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	23730341	96517	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL237701	96517	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	71453489	216147	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	216147	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44390914	70412	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180093	70412	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888424	129776	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360877	129776	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	71453489	216147	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	216147	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	162671996	189610	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4791255	189610	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	23730228	96367	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237492	96367	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	71453489	216147	15	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	216147	15	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444568	100753	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248542	100753	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	15481185	84036	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	84036	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	156011736	184202	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	184202	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	25022506	102042	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL256263	102042	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	24803347	161807	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401548	161807	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	46882394	12614	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079185	12614	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	46882395	12615	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079186	12615	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570699	198084	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL519121	198084	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196498	95686	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364374	95686	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	69197028	95725	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364413	95725	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198238	95736	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364423	95736	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11712867	95773	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364459	95773	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	69194471	95788	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364473	95788	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	11698505	95797	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364482	95797	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	9950632	95481	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL236038	95481	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	44579880	193614	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489401	193614	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579841	199333	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL521176	199333	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434010	95548	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL236311	95548	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	9950632	95481	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	9950632	95481	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	95481	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL236038	95481	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44434010	95548	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL236311	95548	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44437966	208872	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	208872	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	209298	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	209298	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437966	208872	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	208872	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	209298	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	209298	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44454368	102037	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL256236	102037	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145987684	174056	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	174056	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44444560	161733	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401133	161733	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	145953855	169294	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	169294	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44570923	190735	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481602	190735	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44570761	196751	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517081	196751	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	122178179	128041	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	128041	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	24969112	95651	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364339	95651	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11540248	95657	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364345	95657	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647560	95659	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364347	95659	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196005	95690	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	CHEMBL2364378	95690	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	69198434	95698	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	CHEMBL2364386	95698	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	69198286	95706	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364394	95706	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11562181	95717	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364405	95717	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196132	95728	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	CHEMBL2364416	95728	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	69197703	95729	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364417	95729	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	69194443	95750	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364436	95750	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	11503069	95753	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364439	95753	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11647941	95760	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364446	95760	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	11576203	95767	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	CHEMBL2364453	95767	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	11683891	95781	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364467	95781	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	69194380	95805	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364490	95805	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	56926783	75833	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923632	75833	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	156021183	184903	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	184903	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156017268	184429	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	184429	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021183	184903	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	184903	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453070	101868	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL255401	101868	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	44453097	161872	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401891	161872	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	44570762	190207	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL479865	190207	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578013	218543	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	156017268	184429	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	184429	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44434114	96193	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237060	96193	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	44450134	168671	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL415095	168671	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44446177	101422	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252448	101422	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL500468	220894	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
	44450105	102577	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL258762	102577	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44447848	101675	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254167	101675	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44580031	199849	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL522446	199849	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL3578013	218543	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44447845	101653	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253966	101653	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44434119	96681	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	CHEMBL237925	96681	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	145953855	169294	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	169294	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44434121	96683	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL237927	96683	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	162646324	186515	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744139	186515	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	10721075	22325	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121960	22325	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	145959787	169064	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	169064	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16114289	105441	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL277376	105441	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	56926892	75837	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923636	75837	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145984632	173170	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	173170	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	155551597	180728	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4541252	180728	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	22862448	103953	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL268231	103953	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	22867465	103994	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	CHEMBL268518	103994	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	44301387	18036	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179088	18036	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL59572	18036	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	56926356	75794	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923512	75794	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	10143731	71102	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181156	71102	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44444558	174556	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL430398	174556	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	145959007	169036	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	169036	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145959787	169064	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	169064	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156021766	184906	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	184906	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452826	102157	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL256809	102157	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452777	102995	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL260831	102995	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	11554351	103314	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL262879	103314	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	11605061	103489	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL264170	103489	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452825	162029	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL402772	162029	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL3578017	218547	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69197033	95682	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364370	95682	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197513	95697	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364385	95697	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196509	95701	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364389	95701	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11669948	95713	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364401	95713	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196071	95771	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364457	95771	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	69194899	95775	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364461	95775	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	44434055	96080	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL236858	96080	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44436889	159836	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397594	159836	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44570922	199342	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521264	199342	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196838	95662	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364350	95662	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	25211977	193681	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489818	193681	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	16113580	144657	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	CHEMBL376258	144657	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	44434111	153061	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392077	153061	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	15481185	84036	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	84036	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	127048059	146344	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797225	146344	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	16113580	144657	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376258	144657	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44450103	102547	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258551	102547	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44391032	71619	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182050	71619	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156011736	184202	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	184202	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450132	102787	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259712	102787	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	145948725	174276	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299615	174276	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	44281450	106421	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	106421	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44281450	106421	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	106421	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44411584	17075	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	17075	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	156015766	184347	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	184347	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44411584	17075	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	17075	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888433	71387	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181735	71387	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579775	193959	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL492230	193959	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	11258291	195883	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL510195	195883	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579882	199845	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL522426	199845	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44450044	167881	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411699	167881	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	56926463	75813	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923611	75813	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145981687	173356	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	173356	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44579640	193675	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489793	193675	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579686	193770	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490614	193770	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	16203238	143887	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	CHEMBL374757	143887	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	44390997	129779	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360891	129779	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL3578017	218547	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	23661656	175823	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL439560	175823	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	44434074	161452	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL399625	161452	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434009	174232	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL429799	174232	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	22867312	30642	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	CHEMBL13366	30642	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	162665952	189158	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4785149	189158	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44434056	151773	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391088	151773	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434007	95350	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235446	95350	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	156021766	184906	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	184906	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44391035	129386	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360247	129386	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	44301512	18794	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183340	18794	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL291333	18794	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	145979268	173443	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	173443	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145959007	169036	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	169036	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44580030	193749	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490422	193749	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	118718706	122157	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3350011	122157	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	44301462	18034	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179075	18034	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL58758	18034	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	16113800	144590	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL375972	144590	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44391015	130333	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL361802	130333	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	162677268	190352	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4800459	190352	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	10507433	23239	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL123430	23239	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	23730458	153350	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	CHEMBL392296	153350	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	44576247	221001	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL506986	221001	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	168285897	198436	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5196194	198436	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	155529391	178219	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4463042	178219	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145956659	168834	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	168834	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	155537651	179095	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4475293	179095	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145981196	173315	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	173315	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	145979819	173252	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	173252	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434016	96968	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL238228	96968	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	16113692	144014	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL375162	144014	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	24970113	75831	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923629	75831	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL2170777	216144	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCC[C@H](NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm300414b
	145956026	169441	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	169441	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	17086	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	17086	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	144967	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	144967	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	146314	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	146314	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	176063	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	176063	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	11526696	78377	17	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	78377	17	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	78377	17	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	10649323	22302	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121803	22302	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10841400	23623	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL124831	23623	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156009875	183902	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	183902	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444562	101246	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251365	101246	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	145956026	169441	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	169441	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	17086	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	17086	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	144967	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	144967	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	146314	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	146314	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	176063	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	176063	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	156009875	183902	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	183902	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015766	184347	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	184347	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44570967	196948	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL517391	196948	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	24969114	95654	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364342	95654	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	59007076	95677	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364365	95677	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	69197196	95679	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364367	95679	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	69197071	95718	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364406	95718	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194482	95733	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364420	95733	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	11719784	95770	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364456	95770	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	59007054	95802	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	CHEMBL2364487	95802	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	16114097	85932	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113321	85932	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	16113710	85936	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113325	85936	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	23730226	154650	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	CHEMBL393329	154650	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	71453489	216147	15	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	CHEMBL2170781	216147	15	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	44411632	17076	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	17076	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888425	69298	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178216	69298	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44411632	17076	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	17076	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL2170782	216148	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579858	193704	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490010	193704	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579778	193798	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490801	193798	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	162657606	187896	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760409	187896	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956659	168834	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	168834	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950987	169619	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	169619	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	69198313	95673	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	CHEMBL2364361	95673	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	69195692	95674	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	CHEMBL2364362	95674	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	69196612	95675	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364363	95675	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	11511158	95723	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364411	95723	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198054	95776	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364462	95776	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	69195074	95789	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364474	95789	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	69195546	95799	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364484	95799	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	44580028	200029	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL523786	200029	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	44434011	154642	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL393321	154642	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	57390496	75830	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	75830	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	145988894	173923	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	173923	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434086	155634	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL394130	155634	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	145950987	169619	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	169619	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	44449924	166724	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	CHEMBL410730	166724	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	56926785	75835	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923634	75835	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434078	96685	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237932	96685	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434008	153312	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL392268	153312	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44411913	17085	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	17085	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44268939	37220	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13926	37220	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44411913	17085	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	17085	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44434015	95266	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL235011	95266	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44411905	17084	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	17084	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10506325	108018	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	108018	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	16113371	85928	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL2113318	85928	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	162676229	190083	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797064	190083	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL3578005	218538	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	44348031	119866	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL331303	119866	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44411905	17084	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	17084	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	17096	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	17096	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	10506325	108018	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	108018	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	44436857	152434	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL391588	152434	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	156021787	184922	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	184922	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	10006735	123791	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	123791	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	10006735	123791	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	123791	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	156021787	184922	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	184922	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	11712108	168087	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL412303	168087	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	44571003	199367	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL521439	199367	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578005	218538	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	69196876	95664	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364352	95664	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11562329	95703	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364391	95703	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	69196868	95707	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364395	95707	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196990	95763	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364449	95763	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	69195880	95780	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364466	95780	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	11518463	95783	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364469	95783	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	69195024	95807	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364492	95807	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44390922	128924	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL359686	128924	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	23631026	174235	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL429817	174235	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL2170779	216145	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44447842	101794	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254972	101794	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44579804	193844	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491220	193844	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145948708	174275	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299606	174275	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	121879	9015	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	5868	9015	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	CHEMBL308716	9015	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	44268996	173242	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL427806	173242	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	122178180	128042	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	128042	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	44579959	191051	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL483865	191051	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44454117	162335	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	162335	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	162677361	190288	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4799766	190288	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170700	216139	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444570	161547	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400125	161547	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156017532	184687	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	184687	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11662746	104589	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271947	104589	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	122178180	128042	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	128042	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578007	218540	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	16750162	95653	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364341	95653	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	11568467	95663	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364351	95663	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197136	95764	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	CHEMBL2364450	95764	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	69195304	95778	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	CHEMBL2364464	95778	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	145949880	169570	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	169570	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	16114099	144002	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375103	144002	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44269018	104123	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL269447	104123	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	145949880	169570	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	169570	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	156015598	184356	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	184356	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	44452827	102201	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL257019	102201	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	46882582	12527	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078490	12527	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	145988647	173851	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	173851	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44454367	102036	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	102036	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	16113691	143497	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	CHEMBL374073	143497	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	16113691	143497	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL374073	143497	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	22867380	36193	1	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13841	36193	1	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	2098	10466	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	36511	10466	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3805	10466	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3835	10466	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	CHEMBL235363	10466	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	155561671	182443	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4581511	182443	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44434073	96375	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL237507	96375	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	145981794	173475	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	173475	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56926173	75787	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	CHEMBL1923501	75787	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	44301389	18047	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179118	18047	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL61292	18047	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	156015598	184356	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	184356	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	156017532	184687	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	184687	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10100708	18806	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183387	18806	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL294408	18806	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44579756	193602	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489370	193602	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145958487	168963	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	168963	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156016840	184410	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	184410	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170779	216145	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	71453489	216147	15	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	216147	15	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	10209618	70273	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179978	70273	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391041	71095	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181123	71095	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10600702	148114	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	148114	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10600702	148114	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	148114	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	9868878	103316	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL262884	103316	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	11306502	70416	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	70416	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888395	70679	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180540	70679	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	156021942	185002	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	185002	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16113248	85939	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113328	85939	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	23730342	96677	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	CHEMBL237916	96677	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	145958487	168963	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	168963	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156010733	183859	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	183859	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013130	184281	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	184281	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016840	184410	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	184410	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156021942	185002	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	185002	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570920	190712	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481408	190712	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44571005	190826	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL482204	190826	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	11539144	95668	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364356	95668	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	69197315	95684	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364372	95684	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11683663	95710	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364398	95710	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	11583902	95751	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364437	95751	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	69198030	95756	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364442	95756	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197149	95768	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364454	95768	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	69196669	95793	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364478	95793	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	10032659	18823	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183505	18823	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL301259	18823	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44450137	103076	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL261234	103076	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	127046472	146472	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798056	146472	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127046472	146472	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798056	146472	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	145988286	173985	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	173985	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL3578007	218540	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	CHEMBL61663	222618	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
	24180592	103788	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	103788	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	162663868	188767	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780408	188767	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	145986080	173231	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	173231	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	168274297	197358	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5180310	197358	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	127047523	146841	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3800422	146841	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	44434118	154957	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL393570	154957	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44446187	101396	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252255	101396	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145959787	169064	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	169064	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	155557019	181366	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	181366	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	56926893	75838	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	CHEMBL1923637	75838	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	44437963	208871	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	208871	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44437963	208871	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	208871	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44579881	193615	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL489402	193615	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	24180646	154961	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	154961	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	24180646	154961	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL393576	154961	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	145959787	169064	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	169064	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	46882520	12628	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	CHEMBL1079311	12628	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	46882458	12750	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1080046	12750	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL3578016	218546	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	59007057	95667	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364355	95667	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11597905	95721	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364409	95721	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198135	95752	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364438	95752	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	11711997	95769	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	CHEMBL2364455	95769	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	44452778	166557	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410527	166557	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	10437444	119658	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330989	119658	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	24969603	75829	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	CHEMBL1923627	75829	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	162649450	186833	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4747770	186833	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	156013130	184281	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	184281	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44450100	167434	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL411330	167434	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	44411720	17079	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	17079	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	17083	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	17083	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411720	17079	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	17079	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	17083	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	17083	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	162656896	187639	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4757313	187639	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	44436883	152931	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	CHEMBL391980	152931	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	156010733	183859	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	183859	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10745674	174733	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	174733	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44579776	200030	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL523795	200030	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	127048061	146514	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798337	146514	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	23730340	96516	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237700	96516	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	56926175	75788	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923504	75788	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	145992835	173613	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	173613	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56925343	75841	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923640	75841	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	145986870	173919	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	173919	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44434054	96079	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL236857	96079	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	44446178	161902	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL402023	161902	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3578016	218546	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	162648837	186617	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745116	186617	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44391024	71059	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180992	71059	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10745674	174733	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	174733	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391021	26225	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL129637	26225	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL2170696	216135	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	23730343	96678	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	CHEMBL237917	96678	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	22888359	70690	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180591	70690	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	16114514	85933	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	CHEMBL2113322	85933	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	44579843	191532	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL485092	191532	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44579643	193550	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488971	193550	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579822	199303	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL520953	199303	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44579755	193722	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490186	193722	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44580032	193613	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489398	193613	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	145991945	173594	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	173594	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	145992253	173707	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	173707	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL2170702	216141	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145993313	173671	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	173671	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16114008	91621	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223532	91621	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL501261	220914	23	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
	9848305	152230	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391429	152230	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	44434050	152228	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL391428	152228	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578015	218545	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL369482	218942	0	None	-	0	Rat	8.0	pED50	=	8	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cn1ccnc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/S0960-894X(01)80239-0
	44269087	105003	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	CHEMBL274341	105003	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	70691550	79975	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011825	79975	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	16114292	103709	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	103709	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL509976	222359	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	25260901	120257	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319405	120257	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	71456897	88625	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164507	88625	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70691551	79976	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011826	79976	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	25261382	120218	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319215	120218	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11431274	84119	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL208424	84119	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11577349	72005	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182655	72005	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	11351838	84425	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	CHEMBL208842	84425	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	11712151	82768	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205470	82768	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	11713497	130015	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL361349	130015	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	44409757	148102	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383454	148102	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	127046807	146718	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	146718	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	3676358	12306	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1076586	12306	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	122182047	128780	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	128780	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	122178603	128117	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	128117	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	11649248	73444	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185399	73444	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	44395020	130810	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL363021	130810	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	44389262	128810	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359506	128810	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	145993628	174170	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4295148	174170	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11211892	86991	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL213703	86991	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	122178611	128126	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	128126	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	11846624	84691	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209443	84691	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11846463	146020	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL378909	146020	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11430392	83499	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	CHEMBL206588	83499	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	57797614	79967	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011817	79967	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44409801	83508	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206638	83508	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11523411	82330	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	CHEMBL204511	82330	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	11537800	82342	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL204564	82342	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	71453392	88622	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164504	88622	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71456910	88676	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164823	88676	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	71460578	88683	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164830	88683	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	122178612	128127	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	128127	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL507636	221212	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	56942387	146440	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	146440	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145991822	173738	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287267	173738	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11676995	72936	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184258	72936	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	127048038	146750	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	146750	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	71458746	88612	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164493	88612	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	145992142	173550	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	173550	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	71460565	88614	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164495	88614	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	11538533	81776	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203280	81776	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	46880462	13039	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081648	13039	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	70693641	79978	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011828	79978	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	44409756	83542	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206820	83542	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46865987	14369	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087908	14369	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880772	12683	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079624	12683	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11538534	81789	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203373	81789	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	145986870	173919	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	173919	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	127046806	146711	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	146711	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178613	128128	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	128128	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	145981196	173315	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	173315	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	46880814	13149	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082190	13149	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178616	128130	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	128130	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	145986461	173992	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	173992	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71451551	88626	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164508	88626	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	46880727	12917	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080939	12917	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122182190	128787	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	128787	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44409840	83117	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205896	83117	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127047362	146497	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	146497	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145989916	173525	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4283454	173525	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	127048038	146750	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	146750	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880673	12877	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080755	12877	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11455251	168093	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL412362	168093	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409611	81462	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203019	81462	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11221946	147624	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL381942	147624	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409839	83033	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205847	83033	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71460576	88680	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164828	88680	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL509976	222359	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11692087	69766	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178610	69766	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	44409758	82749	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205374	82749	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409661	82771	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205484	82771	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880724	13030	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081611	13030	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	71455105	88679	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164827	88679	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	11221946	147624	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	CHEMBL381942	147624	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	44410003	82956	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205794	82956	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880811	12770	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080162	12770	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687379	79973	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011823	79973	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	44394974	73786	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186974	73786	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	218580	6	None	-	1	Rat	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	46880567	13159	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082210	13159	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71460564	88611	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164492	88611	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	145992854	173645	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4285747	173645	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	44394833	133603	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365460	133603	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL509976	222359	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	222359	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	222359	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	127047654	146755	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	146755	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	145993758	174095	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294024	174095	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145993528	174097	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	174097	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL444131	220708	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
	11476589	82763	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205451	82763	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11329138	71234	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL181350	71234	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	70681022	79982	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011833	79982	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL509976	222359	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178611	128126	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	128126	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	46880675	12915	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080927	12915	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11612155	147787	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL382375	147787	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	328912	69350	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178266	69350	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	70685218	79970	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011820	79970	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145981794	173475	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	173475	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11649239	73114	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185057	73114	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL501261	220914	23	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	1744826	69772	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178668	69772	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	11282247	172705	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL425048	172705	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11282247	172705	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL425048	172705	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	1744826	69772	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178668	69772	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409831	82473	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204776	82473	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145979268	173443	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	173443	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44409678	147995	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382853	147995	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11349789	85548	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211265	85548	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11692087	69766	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178610	69766	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11677781	131836	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL364430	131836	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	11538533	81776	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	CHEMBL203280	81776	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	11154823	82804	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205660	82804	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	56942244	131975	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	131975	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44409994	82957	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205796	82957	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	221001	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44395002	72960	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184368	72960	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	11646276	82709	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL205136	82709	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	127046807	146718	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	146718	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113695	143805	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374643	143805	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	145987684	174056	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	174056	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	122178602	128116	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	128116	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	70681020	79979	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011829	79979	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	56942098	131971	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	131971	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	131973	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	131973	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	127046956	146735	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	146735	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	66788278	131970	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	131970	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046956	146735	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	146735	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	57797640	80001	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011892	80001	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880628	12804	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	12804	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	128120	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	128120	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880629	12830	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080556	12830	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	128120	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	128120	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	70681021	79981	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011832	79981	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70691552	79983	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011834	79983	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44576247	221001	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	122178607	128122	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	128122	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	46880631	12907	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080907	12907	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	46880726	12916	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080938	12916	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70689441	80000	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011891	80000	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145988582	174070	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4293608	174070	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	122178610	128125	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	128125	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409666	82662	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204897	82662	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	221001	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL500703	220899	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	44409802	83519	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206687	83519	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178613	128128	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	128128	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	71458747	88613	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164494	88613	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	56942244	131975	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	131975	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11537683	82302	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL204352	82302	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	71449740	88615	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164497	88615	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	122178601	128115	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	128115	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	11337482	83415	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL206399	83415	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	122178614	128129	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	128129	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	44389168	71647	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL182154	71647	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	145991389	173783	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4288108	173783	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145990051	173734	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287218	173734	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44410012	145177	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377305	145177	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71462272	88620	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164502	88620	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	71451563	88685	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164832	88685	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	145988286	173985	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	173985	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	46880813	13148	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082189	13148	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	44409761	82641	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204880	82641	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11846625	84659	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209394	84659	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	122178610	128125	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	128125	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880461	13007	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081483	13007	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	71453391	88621	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164503	88621	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	1221269	128812	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359530	128812	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389151	69279	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178138	69279	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	71451564	88687	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164834	88687	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	71449753	88677	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164825	88677	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44409871	82171	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203948	82171	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880569	12961	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081212	12961	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	70693640	79972	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011822	79972	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL449590	220741	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	44576247	221001	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	145994299	174175	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4295212	174175	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71460577	88681	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164829	88681	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	16113902	144454	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL375859	144454	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	71462274	88624	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL2164506	88624	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL509976	222359	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	70683143	79971	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011821	79971	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880495	13141	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082162	13141	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	11697618	69373	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178289	69373	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145988557	174039	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	174039	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44409771	148031	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383073	148031	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145980333	173360	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	173360	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11329138	71234	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	CHEMBL181350	71234	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	44576247	221001	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11568561	176333	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL443560	176333	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	145991945	173594	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	173594	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	44394982	72912	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184093	72912	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	66788278	131970	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	131970	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942099	131972	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	131972	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942243	131974	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	131974	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	146640	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	146640	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	70681018	79969	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011819	79969	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	70685225	80003	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011894	80003	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11410373	145313	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	CHEMBL377514	145313	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	11339816	82782	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205521	82782	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992253	173707	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	173707	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11503585	71978	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182542	71978	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	44409762	82661	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204884	82661	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180026	128365	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	128365	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	46880846	14384	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088038	14384	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44389248	128946	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359714	128946	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	70695749	79985	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011836	79985	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178614	128129	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	128129	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	70695748	79977	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011827	79977	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	145981687	173356	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	173356	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11508639	83310	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL206091	83310	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409683	83034	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205848	83034	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11626181	131159	2	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363896	131159	2	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	11690097	83447	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL206446	83447	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	44409775	82800	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205605	82800	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	221001	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11655355	81196	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL202642	81196	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	127047654	146755	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	146755	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113799	175492	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL436849	175492	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145986080	173231	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	173231	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56942385	131976	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	131976	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880771	12682	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079623	12682	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11654867	82976	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205833	82976	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	122178600	128114	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	128114	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	46880844	14368	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087907	14368	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11248021	146033	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378989	146033	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122182189	128786	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	128786	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	44409865	147496	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381759	147496	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11751384	148284	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL384524	148284	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409679	82283	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204322	82283	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409868	83517	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206673	83517	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409667	82744	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205294	82744	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	221001	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	56942388	146721	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	146721	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	11166495	82325	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL204474	82325	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	145994050	174124	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	174124	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11538533	81776	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203280	81776	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880770	12681	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079622	12681	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71453390	88618	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164500	88618	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	44409763	148143	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383757	148143	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409989	172605	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL424860	172605	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44410008	148029	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383058	148029	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11178309	86676	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL212415	86676	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11517629	175117	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL434330	175117	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	127047655	146392	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	146392	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	146485	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	146485	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	146640	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	146640	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	56942098	131971	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	131971	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	146485	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	146485	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	46880630	12870	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080735	12870	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70685219	79984	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011835	79984	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	128112	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	128112	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	122178607	128122	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	128122	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	11452801	146076	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL379191	146076	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	46882763	12400	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077617	12400	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44409776	83918	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207754	83918	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145991797	173695	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286597	173695	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	122178616	128130	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	128130	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	11430583	86992	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL213704	86992	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL509976	222359	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11669486	71388	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL181736	71388	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	44409946	146593	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL379887	146593	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127046806	146711	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	146711	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178600	128114	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	128114	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	11605333	83500	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	CHEMBL206589	83500	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	46880845	14383	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088037	14383	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880773	12979	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081301	12979	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178604	128118	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	128118	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	56942387	146440	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	146440	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	221001	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11683469	83481	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL206486	83481	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	44389216	130632	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL362595	130632	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	145979819	173252	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	173252	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880498	12767	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080155	12767	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71462273	88623	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164505	88623	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71453404	88678	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164826	88678	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44389283	69719	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178494	69719	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	11179347	84128	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL208477	84128	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44409764	83924	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207792	83924	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11606121	71350	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	CHEMBL181584	71350	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	11539587	73851	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187271	73851	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	218580	6	None	-	1	Rat	8.3	pIC50	=	8.3	Functional	Inverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	122178608	128123	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	128123	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409821	82812	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205711	82812	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11340044	148113	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL383522	148113	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70683149	79998	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011887	79998	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	71452183	90304	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	90304	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	122178602	128116	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	128116	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	11582836	69687	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178463	69687	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389192	175425	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL436275	175425	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	71455106	88688	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164835	88688	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	44409998	145314	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377515	145314	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145984632	173170	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	173170	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	10415364	133545	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	133545	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	15949382	81623	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203158	81623	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145993313	173671	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	173671	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11605822	131166	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363930	131166	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11154001	86663	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL212354	86663	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	44394930	73106	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185028	73106	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	11699004	72977	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184429	72977	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11618705	173717	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL428698	173717	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	44409785	82578	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204852	82578	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409990	83292	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205995	83292	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145992125	173529	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	173529	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880568	13160	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082211	13160	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687383	79999	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011890	79999	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	128112	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	128112	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL509976	222359	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	57422817	120226	18	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319223	120226	18	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11190594	82760	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205445	82760	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	56942385	131976	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	131976	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	221001	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	16113904	143814	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374655	143814	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	44389215	69852	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178838	69852	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44576247	221001	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409809	81840	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203578	81840	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113468	148578	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL386218	148578	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	11531313	69278	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178137	69278	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389167	130636	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL362612	130636	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880674	12914	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080926	12914	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71455085	88619	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164501	88619	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	46880463	13040	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081649	13040	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	46880812	12793	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080320	12793	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880497	13143	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082164	13143	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	44409770	148146	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383766	148146	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178604	128118	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	128118	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	46880496	13142	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082163	13142	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL502208	220929	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
	145980382	173422	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	173422	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44389186	71389	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL181739	71389	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409864	82274	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204266	82274	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409975	82565	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204835	82565	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409455	82743	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL205286	82743	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	11441554	7008	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	5871	7008	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	CHEMBL212761	7008	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	11340329	86377	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211454	86377	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178605	128119	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	128119	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	127047655	146392	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	146392	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	46880672	12968	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081254	12968	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	66601728	88616	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164499	88616	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70689440	79968	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011818	79968	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	70693644	80002	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011893	80002	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70695747	79966	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	79966	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11225576	172816	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL425594	172816	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11225576	172816	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL425594	172816	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	122178608	128123	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	128123	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	122178609	128124	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	128124	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	56942388	146721	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	146721	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942535	146539	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	146539	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11176805	84109	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	CHEMBL208374	84109	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	71453405	88686	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164833	88686	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	44394913	133951	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365721	133951	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	44409832	83185	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205955	83185	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	25190383	88684	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164831	88684	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	122178615	128082	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	128082	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44410013	83828	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207268	83828	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44389243	71357	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	CHEMBL181619	71357	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	753168	130017	40	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL361366	130017	40	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880566	13158	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082209	13158	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178603	128117	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	128117	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	44409979	147337	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381159	147337	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11256439	82154	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	CHEMBL203843	82154	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	11655578	176812	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL444277	176812	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70681019	79974	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011824	79974	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	122178612	128127	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	128127	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	11617435	82772	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL205486	82772	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	145988647	173851	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	173851	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11663710	131245	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363995	131245	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	56942099	131972	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	131972	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	131973	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	131973	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	11663710	131245	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL363995	131245	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	70695747	79966	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	79966	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70687380	79980	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011831	79980	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178605	128119	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	128119	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	145988894	173923	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	173923	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16203569	148511	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL385803	148511	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145981343	173488	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	173488	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL509976	222359	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Agonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178615	128082	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	128082	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44409810	147678	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382138	147678	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113124	128113	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581032	128113	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	44576247	221001	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	221001	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409536	82284	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL204325	82284	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992835	173613	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	173613	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11327400	82147	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL203782	82147	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11539588	73687	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186540	73687	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	16113796	91456	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL222518	91456	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	11442040	85326	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211211	85326	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178601	128115	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	128115	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	56942243	131974	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	131974	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	46880725	13031	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	CHEMBL1081612	13031	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	122178609	128124	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	128124	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	11454617	148097	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383411	148097	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	46880628	12804	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	12804	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44409684	147663	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382033	147663	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409672	147265	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL380971	147265	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409673	83525	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL206741	83525	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	11453509	82953	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205784	82953	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	127047362	146497	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	146497	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	56942535	146539	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	146539	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145990956	173800	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4288441	173800	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44394947	176002	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL440939	176002	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	44410007	83202	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205963	83202	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11583811	82762	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205450	82762	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11576960	73889	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187427	73889	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	11281346	82793	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205568	82793	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL499371	220874	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
	155540883	179736	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	179736	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155540883	179736	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	179736	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	181366	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	181366	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	181366	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	181366	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57399248	75819	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	75819	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	71452183	90304	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	90304	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	44454117	162335	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	162335	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44454060	162111	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	162111	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	102036	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	102036	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454338	104611	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	104611	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44434080	96686	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	96686	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454302	166159	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	166159	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454092	104425	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	104425	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454432	162037	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	162037	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	9950632	95481	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	95481	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44454399	161918	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	161918	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454432	162037	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	162037	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	25022640	104577	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	104577	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	104425	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	104425	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454303	104345	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	104345	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454304	104379	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	104379	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	56926461	75811	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923609	75811	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	44454398	104374	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	104374	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	44454060	162111	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	162111	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	102036	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	102036	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454337	162382	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	162382	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454117	162335	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	162335	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	1099	8568	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.	Guide to Pharmacology		None	None	None		None	29233536
	121879	9015	24	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	9015	24	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	9015	24	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5869	10852	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	121879	9015	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	5868	9015	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	CHEMBL308716	9015	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	1099	8568	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10628755
	1099	8568	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	121879	9015	24	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	9015	24	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	9015	24	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	1093	8575	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	8575	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1093	8575	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	8575	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	178024	8752	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	178024	8752	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	5867	8752	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	5867	8752	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	CHEMBL13817	8752	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	CHEMBL13817	8752	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	1099	8568	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1099	8568	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	5866	10396	4	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9804743	10396	4	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	CHEMBL360227	10396	4	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9734	9110	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.	Guide to Pharmacology		None	None	None		None	29233536
	11441554	7008	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5871	7008	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	CHEMBL212761	7008	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5872	8905	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	74015851	8905	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	25124566	8655	8	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5870	8655	8	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	CHEMBL3358452	8655	8	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5866	10396	4	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	9804743	10396	4	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	CHEMBL360227	10396	4	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	25124566	8655	8	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	5870	8655	8	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	CHEMBL3358452	8655	8	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		2713	212050	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5353524	212050	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5360566	212050	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		88536661	212050	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		9552079	212050	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1330113	212050	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL790	212050	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		156419	7725	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		3308	7725	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		647	7725	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL1201284	7725	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB01012	7725	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		5920	54049	83	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	651	5	3	4	4.0	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
		7048703	54049	83	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	651	5	3	4	4.0	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL1544	54049	83	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	651	5	3	4	4.0	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
		148192	17192	81	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704	14	5	9	4.2	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1163	17192	81	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704	14	5	9	4.2	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	10.1038/s41467-023-40064-9
		154257	185398	67	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
		CHEMBL46740	185398	67	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
		2600	10551	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	10551	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	10551	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	10551	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	10551	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		47319	33237	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1360	33237	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
		135409453	10545	41	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	10545	41	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	10545	41	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		71496458	122342	87	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL3353410	122342	87	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
		242	7258	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	7258	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	7258	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	7258	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	7258	124	None	-	51	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		39186	92710	54	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	414	6	0	6	3.4	COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1	10.1038/s41467-023-40064-9
		CHEMBL23	92710	54	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	414	6	0	6	3.4	COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1	10.1038/s41467-023-40064-9
		16362	9899	71	None	-	29	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	9899	71	None	-	29	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	9899	71	None	-	29	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	9899	71	None	-	29	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	9899	71	None	-	29	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		3042	8196	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		355	8196	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		868	8196	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		CHEMBL1123	8196	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		DB00804	8196	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		10184665	10763	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		4799	10763	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		7353	10763	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1198857	10763	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		DB09082	10763	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
		3191	109635	97	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL305660	109635	97	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
		3926	214020	40	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL92870	214020	40	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		11626560	207716	94	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
		CHEMBL601719	207716	94	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
		2267	7347	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		271	7347	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		7121	7347	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL639	7347	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB00972	7347	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		135564886	21265	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		135673376	21265	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		137157436	21265	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		145948239	21265	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		71587099	21265	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		CHEMBL1201304	21265	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		2585	7590	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		522	7590	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		551	7590	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		CHEMBL723	7590	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		DB01136	7590	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		1353	8692	93	None	-	85	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	8692	93	None	-	85	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	8692	93	None	-	85	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	8692	93	None	-	85	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	8692	93	None	-	85	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		100	10577	58	None	-	54	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		2637	10577	58	None	-	54	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		5452	10577	58	None	-	54	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL479	10577	58	None	-	54	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB00679	10577	58	None	-	54	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		202	8290	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		60835	8290	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		972	8290	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1175	8290	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		DB00476	8290	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		11976	7707	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		667467	7707	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		CHEMBL908	7707	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		DB01239	7707	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		2218	22055	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
		CHEMBL1213033	22055	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
		41684	37995	105	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
		CHEMBL1401	37995	105	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
		3025	14047	86	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	10	1	4	3.5	CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1	10.1038/s41467-023-40064-9
		CHEMBL1086	14047	86	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	10	1	4	3.5	CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1	10.1038/s41467-023-40064-9
		44112	128068	48	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
		CHEMBL357995	128068	48	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
		68617	212306	62	None	-	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1709	212306	62	None	-	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL809	212306	62	None	-	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		2726	7706	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	7706	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	7706	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	7706	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	7706	68	None	-	72	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		16363	7383	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		312	7383	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		9215	7383	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL297302	7383	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB12867	7383	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2291	9958	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		2561	9958	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		4932	9958	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL631	9958	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		DB01182	9958	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
		24826799	17570	104	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
		CHEMBL1171837	17570	104	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
		2274	9947	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		4917	9947	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		7279	9947	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL728	9947	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00433	9947	58	None	-	31	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		2398	7741	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2801	7741	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		701	7741	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL415	7741	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB01242	7741	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		4046	9261	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		4252	9261	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		CHEMBL416956	9261	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		DB00358	9261	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		3074	24730	26	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL126075	24730	26	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
		4413	104849	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
		CHEMBL273264	104849	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
		25382	15929	37	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL110094	15929	37	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
		2375	165173	106	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	430	5	2	5	2.9	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
		CHEMBL409	165173	106	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	430	5	2	5	2.9	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
		2351	11072	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1008	11072	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1257078	11072	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		448537	167029	89	None	-	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL411	167029	89	None	-	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		3393	214703	24	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	0	3	4.0	CCN(CC)CCN1C(=O)CN=C(c2ccccc2F)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
		CHEMBL968	214703	24	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	0	3	4.0	CCN(CC)CCN1C(=O)CN=C(c2ccccc2F)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
		441243	16608	58	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
		CHEMBL114	16608	58	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
		214	10632	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		2740	10632	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5566	10632	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		66064	10632	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL422	10632	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00831	10632	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		46780481	114308	20	None	-	53	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		9903970	114308	20	None	-	53	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3187365	114308	20	None	-	53	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3544974	114308	20	None	-	53	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		6436173	61890	45	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
		CHEMBL1617	61890	45	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
		8550	21196	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	578	7	1	9	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	10.1038/s41467-023-40064-9
		CHEMBL1200515	21196	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	578	7	1	9	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	10.1038/s41467-023-40064-9
		31101	7516	40	None	-	35	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	7516	40	None	-	35	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	7516	40	None	-	35	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	7516	40	None	-	35	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	7516	40	None	-	35	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		104850	10103	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		4150	10103	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		743	10103	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL111	10103	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		DB06155	10103	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		392622	63086	95	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
		CHEMBL163	63086	95	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
		2995	211184	53	None	-	23	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1696	211184	53	None	-	23	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL72	211184	53	None	-	23	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		3947	213174	53	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL87708	213174	53	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		212	10578	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	10578	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	10578	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	10578	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	10578	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL3039583	217728	0	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
		60065	91144	6	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2218858	91144	6	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		3081361	100709	123	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
		CHEMBL24828	100709	123	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
		107771	127026	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
		CHEMBL35228	127026	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
		3151	8244	97	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		945	8244	97	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		965	8244	97	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL219916	8244	97	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01184	8244	97	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		3949	107390	50	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL29188	107390	50	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
		2435	10362	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		60149	10362	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		98	10362	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		CHEMBL12713	10362	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		DB06144	10362	83	None	-	48	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		25181577	84994	56	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2105695	84994	56	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
		2318	161635	29	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL400599	161635	29	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
		2407	10145	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		59227	10145	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		941	10145	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		CHEMBL1303	10145	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		DB05271	10145	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		3380	29562	34	None	-	1	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	10.1038/s41467-023-40064-9
		CHEMBL13280	29562	34	None	-	1	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	10.1038/s41467-023-40064-9
		2202	9906	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		4850	9906	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		49	9906	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		CHEMBL1371770	9906	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		DB12478	9906	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
		4495	203314	92	None	-	29	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL56367	203314	92	None	-	29	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	10.1038/s41467-023-40064-9
		9801	98360	35	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL24072	98360	35	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		6729	21257	41	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	432	5	0	2	6.5	CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201271	21257	41	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	432	5	0	2	6.5	CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1038/s41467-023-40064-9
		1016	10519	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		2561	10519	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		2733526	10519	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		5384	10519	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL83	10519	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		DB00675	10519	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
		9915743	70316	93	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	556	11	2	8	5.9	CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C	10.1038/s41467-023-40064-9
		CHEMBL180022	70316	93	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	556	11	2	8	5.9	CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C	10.1038/s41467-023-40064-9
		275196	132451	52	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
		CHEMBL364713	132451	52	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
		26987	7736	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	7736	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	7736	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	7736	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	7736	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		11980903	21264	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		22526	21264	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		5281035	21264	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201303	21264	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		25077405	9492	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		3902	9492	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		CHEMBL1201309	9492	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		DB00666	9492	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		102	10899	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	10899	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	10899	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	10899	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	10899	48	None	-	49	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		4034	62596	55	None	-	1	Human	4.4	pAC50	=	4.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	62596	55	None	-	1	Human	4.4	pAC50	=	4.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		5328940	106992	107	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	106992	107	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		10531	8202	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	8202	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	8202	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	8202	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	8202	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		118422671	9533	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		1887	9533	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		71301	9533	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		7246	9533	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		CHEMBL434394	9533	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		DB04861	9533	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
		30323	69259	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		CHEMBL1563	69259	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		CHEMBL178	69259	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		10096344	96369	85	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	10	1.1	CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C	10.1038/s41467-023-40064-9
		CHEMBL237500	96369	85	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	10	1.1	CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C	10.1038/s41467-023-40064-9
		216416	118358	48	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL328190	118358	48	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		319	8106	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		321	8106	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		444031	8106	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		784	8106	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		CHEMBL1346	8106	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		DB00496	8106	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		3149	19386	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1187011	19386	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
		4746	211670	31	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1334033	211670	31	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
		CHEMBL75880	211670	31	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
		2335	18620	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	18620	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	18620	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	18620	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		65709	66655	39	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1729803	66655	39	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
		11643449	96730	3	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	753	6	5	10	2.7	CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1	10.1038/s41467-023-40064-9
		CHEMBL238071	96730	3	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	753	6	5	10	2.7	CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1	10.1038/s41467-023-40064-9
		2448	106099	70	None	-	18	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
		CHEMBL28218	106099	70	None	-	18	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
		4452	9538	19	None	-	18	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		983	9538	19	None	-	18	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL20734	9538	19	None	-	18	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		176	7186	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2157	7186	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2566	7186	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		CHEMBL633	7186	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		DB01118	7186	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		1222	8445	49	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		3396	8445	49	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		85	8445	49	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL46516	8445	49	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		DB04842	8445	49	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		5329102	201505	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	201505	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		72093	41835	9	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL1433361	41835	9	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL2103773	41835	9	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		42890	16197	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
		CHEMBL1117	16197	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
		1164	8411	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		1626	8411	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		3345	8411	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL596	8411	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		DB00813	8411	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		2247	7293	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	7293	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	7293	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	7293	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	7293	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		5482	21192	80	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1200438	21192	80	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		1385580	36049	76	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		4615	36049	76	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL13828	36049	76	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		16722836	25757	99	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	524	10	3	8	4.8	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1	10.1038/s41467-023-40064-9
		CHEMBL1287853	25757	99	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	524	10	3	8	4.8	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1	10.1038/s41467-023-40064-9
		2794	26152	85	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1292	26152	85	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		3883	190314	112	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	369	5	1	4	3.5	Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1	10.1038/s41467-023-40064-9
		CHEMBL480	190314	112	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	369	5	1	4	3.5	Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1	10.1038/s41467-023-40064-9
		178024	8752	33	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
		5867	8752	33	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
		CHEMBL13817	8752	33	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
		22867441	17087	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161835	17087	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		67457995	98608	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
		CHEMBL2413152	98608	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
		22867441	17087	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161835	17087	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		71716660	92777	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		CHEMBL2304221	92777	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		10345516	146053	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
		CHEMBL379074	146053	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
		71716660	92777	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		CHEMBL2304221	92777	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		10345516	146053	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
		CHEMBL379074	146053	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
		9807597	189796	5	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		CHEMBL47938	189796	5	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		10323604	17081	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161828	17081	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10323604	17081	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161828	17081	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		44411920	84653	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		CHEMBL209360	84653	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		162662316	188302	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
		CHEMBL4765101	188302	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
		90666017	116077	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218890	116077	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44411920	84653	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		CHEMBL209360	84653	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
		10625750	174933	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		CHEMBL433087	174933	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		10625750	174933	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		CHEMBL433087	174933	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
		10626337	108002	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
		CHEMBL295984	108002	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
		44411718	17078	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161825	17078	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44293557	107865	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL294923	107865	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL540001	107865	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		16040587	186163	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
		CHEMBL473921	186163	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
		16040587	186163	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
		CHEMBL473921	186163	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
		16752689	195147	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
		CHEMBL501315	195147	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
		9890375	105046	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL274599	105046	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL558802	105046	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		9890375	105046	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL274599	105046	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL558802	105046	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		10026738	169548	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL417182	169548	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL557206	169548	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		10026738	169548	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL417182	169548	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL557206	169548	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		10745533	146898	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL380096	146898	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		10745533	146898	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL380096	146898	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		44411745	17080	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		CHEMBL1161827	17080	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		10626337	108002	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
		CHEMBL295984	108002	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
		44411634	17077	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161824	17077	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		44411634	17077	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161824	17077	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		44411745	17080	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		CHEMBL1161827	17080	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		44411753	17082	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		CHEMBL1161829	17082	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		44411753	17082	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		CHEMBL1161829	17082	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		44293091	194965	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL49884	194965	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		44293091	194965	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		CHEMBL49884	194965	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
		46905972	17181	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
		CHEMBL1162926	17181	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
		15481181	84519	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		CHEMBL209020	84519	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		9810101	106025	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL281764	106025	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		15481188	147988	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
		CHEMBL382844	147988	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
		CHEMBL1793862	215707	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
		216208	16499	33	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
		CHEMBL113313	16499	33	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
		46905972	17181	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
		CHEMBL1162926	17181	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
		15481181	84519	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		CHEMBL209020	84519	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		9810101	106025	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL281764	106025	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		15481188	147988	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
		CHEMBL382844	147988	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
		CHEMBL1793862	215707	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
		15481185	84036	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		CHEMBL207970	84036	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		15481185	84036	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		CHEMBL207970	84036	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
		44411584	17075	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161822	17075	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44411584	17075	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161822	17075	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		22862436	17086	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161834	17086	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10602640	144967	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
		CHEMBL376970	144967	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
		10791616	146314	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL379564	146314	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		10029990	176063	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL441360	176063	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		22862436	17086	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161834	17086	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10602640	144967	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
		CHEMBL376970	144967	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
		10791616	146314	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL379564	146314	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		10029990	176063	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL441360	176063	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		44411632	17076	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161823	17076	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44411632	17076	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161823	17076	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		23529194	108968	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
		CHEMBL302810	108968	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
		16041292	190390	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
		CHEMBL480219	190390	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
		44411913	17085	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161833	17085	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44411913	17085	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		CHEMBL1161833	17085	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
		44411905	17084	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161832	17084	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10506325	108018	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		CHEMBL296104	108018	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		44411905	17084	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		CHEMBL1161832	17084	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
		10506325	108018	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		CHEMBL296104	108018	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
		10600702	148114	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL383526	148114	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		10600702	148114	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL383526	148114	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
		CHEMBL335799	218343	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmc.2013.06.006
		44411720	17079	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		CHEMBL1161826	17079	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		44411902	17083	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		CHEMBL1161831	17083	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		44411720	17079	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		CHEMBL1161826	17079	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
		44411902	17083	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		CHEMBL1161831	17083	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
		44390849	69689	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL178475	69689	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		25227441	120220	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL3319217	120220	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL501253	220912	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCCBr)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
		44582528	200195	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
		91935097	200195	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
		CHEMBL525994	200195	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
		CHEMBL2310891	216274	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		90665845	116049	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218645	116049	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL500468	220894	0	None	-	1	Human	9.9	pIC50	=	9.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.042
		57422686	120224	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319221	120224	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL2310888	216272	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C	10.1021/jm0001727
		11340044	148113	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL383522	148113	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		44336274	115347	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
		CHEMBL320289	115347	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
		122180027	128366	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586033	128366	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		118709502	120249	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319398	120249	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		44390862	70641	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL180349	70641	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		16133832	220110	18	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		CHEMBL425281	220110	18	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		CHEMBL500468	220894	0	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
		90665847	116051	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218647	116051	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		122182190	128787	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		CHEMBL3593815	128787	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		57422687	120225	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319222	120225	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		16114292	103709	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL266063	103709	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
		16114292	103709	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		CHEMBL266063	103709	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		11225576	172816	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL425594	172816	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		122182047	128780	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593636	128780	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		11225576	172816	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL425594	172816	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		25260749	120223	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL3319220	120223	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		57422792	120248	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319397	120248	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		57422692	120222	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319219	120222	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL500468	220894	0	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
		122182043	128776	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593632	128776	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		118709506	120259	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319407	120259	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		178024	8752	33	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
		5867	8752	33	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
		CHEMBL13817	8752	33	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
		11431274	84119	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL208424	84119	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		11410373	145313	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
		CHEMBL377514	145313	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
		44582531	195501	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		91935100	195501	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		CHEMBL504776	195501	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		122182046	128779	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593635	128779	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		25260745	120252	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319400	120252	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
		122182190	128787	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		CHEMBL3593815	128787	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		57422768	120231	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
		CHEMBL3319228	120231	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
		16114096	85935	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
		CHEMBL2113324	85935	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
		178024	8752	33	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
		5867	8752	33	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
		CHEMBL13817	8752	33	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
		57422690	120230	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
		CHEMBL3319227	120230	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
		118709503	120250	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319399	120250	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
		66788278	131970	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		CHEMBL3645254	131970	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		16114292	103709	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
		CHEMBL266063	103709	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
		44436850	98324	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL240509	98324	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		57422793	120247	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
		CHEMBL3319396	120247	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
		178024	8752	33	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
		5867	8752	33	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
		CHEMBL13817	8752	33	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
		57422688	120228	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319225	120228	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		57785733	120227	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319224	120227	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		16113245	128112	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581030	128112	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
		44445600	161567	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL400175	161567	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL437713	220510	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm020424z
		178024	8752	33	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		5867	8752	33	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		CHEMBL13817	8752	33	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		CHEMBL412799	219804	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(N)=O)C(C)C	10.1021/jm0001727
		57422817	120226	18	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319223	120226	18	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		11476589	82763	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205451	82763	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL526723	222476	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
		44436857	152434	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		CHEMBL391588	152434	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		90666039	116099	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218912	116099	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		118709505	120258	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319406	120258	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL2310887	216271	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCC(CCC)C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		122180026	128365	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586032	128365	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		122182043	128776	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593632	128776	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL2310890	216273	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		C/C=C/C=C/C=C/C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		44409536	82284	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL204325	82284	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		44445595	101178	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL250974	101178	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		90665850	116054	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218650	116054	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
		90665851	116055	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218651	116055	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		11134880	106207	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		CHEMBL282891	106207	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		5866	10396	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
		9804743	10396	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
		CHEMBL360227	10396	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
		11712151	82768	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL205470	82768	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		56942098	131971	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		CHEMBL3645255	131971	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		25261382	120218	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319215	120218	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		57422789	120232	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
		CHEMBL3319229	120232	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
		56942244	131975	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
		CHEMBL3645259	131975	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
		90665846	116050	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218646	116050	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		11339816	82782	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205521	82782	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		44409756	83542	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL206820	83542	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		90666012	116072	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218885	116072	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		90666031	116091	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218904	116091	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44390840	130334	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL361804	130334	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		90666017	116077	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218890	116077	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		90666027	116087	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218900	116087	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		44445594	161421	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399447	161421	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		90666013	116073	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218886	116073	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44445599	100959	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL249639	100959	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		44446187	101396	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL252255	101396	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		178024	8752	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		5867	8752	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		CHEMBL13817	8752	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		23648244	98789	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		CHEMBL241775	98789	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		44409776	83918	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL207754	83918	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122178616	128130	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581048	128130	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
		16113471	91496	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		CHEMBL222789	91496	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		156021766	184906	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4648355	184906	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145959787	169064	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164107	169064	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		145953855	169294	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4167669	169294	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		16113585	144013	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL375161	144013	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		145958774	169045	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4163811	169045	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		156016073	184434	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
		CHEMBL4641503	184434	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
		162646061	186310	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
		CHEMBL4741413	186310	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
		70692600	82649	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048813	82649	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2310886	216270	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCNC(=O)CCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		156021766	184906	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4648355	184906	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		44445601	100960	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
		CHEMBL249640	100960	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
		44390901	70853	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL180755	70853	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		145959787	169064	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164107	169064	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		70694648	82647	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048811	82647	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		44445591	161420	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399446	161420	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16113468	148578	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL386218	148578	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		16113468	148578	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL386218	148578	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		46882103	12726	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079872	12726	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		72190450	99050	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426679	99050	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		11441978	137233	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
		CHEMBL368034	137233	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
		CHEMBL2310894	216276	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)c1ccccc1)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm0001727
		122180017	128356	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586023	128356	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		44445592	100958	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL249638	100958	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113577	91711	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		CHEMBL223725	91711	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		16113902	144454	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL375859	144454	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		90666041	116101	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		CHEMBL3218914	116101	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		16113902	144454	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL375859	144454	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		15945877	153717	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL392593	153717	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
		11337482	83415	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
		CHEMBL206399	83415	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
		44409775	82800	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205605	82800	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122182190	128787	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		CHEMBL3593815	128787	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		44445620	161457	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399651	161457	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		11676995	72936	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL184258	72936	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
		16203930	91110	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
		CHEMBL221674	91110	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
		11537683	82302	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
		CHEMBL204352	82302	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
		122180020	128359	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586026	128359	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		44338247	14699	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL109035	14699	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
		44445622	161458	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399653	161458	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		59446139	88376	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163449	88376	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44436812	98539	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL241033	98539	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		11731384	169499	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
		CHEMBL417092	169499	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
		44390888	71190	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL181312	71190	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		60195112	88381	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163466	88381	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2370788	216700	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
		16113904	143814	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL374655	143814	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		90665852	116056	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218652	116056	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		90666032	116092	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218905	116092	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		16113904	143814	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL374655	143814	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL500703	220899	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
		10415364	133545	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL365294	133545	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		53390181	99046	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426675	99046	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		145957075	169058	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164040	169058	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		145956026	169441	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4169979	169441	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		145956061	169472	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4170481	169472	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
		145951150	169555	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL4171914	169555	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
		11328064	167091	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
		CHEMBL411055	167091	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
		44445607	173509	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL428314	173509	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16113581	91912	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL224921	91912	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		90666022	116082	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218895	116082	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		90666028	116088	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218901	116088	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		70682036	82653	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048817	82653	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		16113796	91456	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL222518	91456	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		57422697	120238	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319276	120238	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL499371	220874	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
		59446101	88391	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163477	88391	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446101	88391	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163477	88391	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44389262	128810	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
		CHEMBL359506	128810	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
		16113796	91456	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL222518	91456	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		11576960	73889	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL187427	73889	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		11124146	105929	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL281173	105929	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		122178600	128114	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581033	128114	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
		44409679	82283	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204322	82283	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		9745	9231	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		9804938	9231	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		CHEMBL278623	9231	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		DB13074	9231	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		16113579	91712	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL223726	91712	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL3578015	218545	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		145954311	169265	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4167267	169265	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL3578015	218545	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		11373823	85278	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL211188	85278	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		145954311	169265	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4167267	169265	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		44301389	18047	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1179118	18047	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL61292	18047	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		46882236	12544	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078608	12544	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		16114514	85933	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
		CHEMBL2113322	85933	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
		11523411	82330	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
		CHEMBL204511	82330	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
		57422730	120215	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319212	120215	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		46882763	12400	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1077617	12400	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44576247	221001	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
		CHEMBL506986	221001	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
		145951150	169555	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL4171914	169555	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL433540	220421	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020424z
		1744826	69772	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
		CHEMBL178668	69772	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
		1744826	69772	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL178668	69772	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
		122178603	128117	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581036	128117	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
		16114009	143972	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL374921	143972	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
		23648246	168567	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		CHEMBL414132	168567	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		11655578	176812	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL444277	176812	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		1744826	69772	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178668	69772	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		156021336	184946	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4649089	184946	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		44446190	101331	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL251855	101331	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
		44389167	130636	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL362612	130636	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44338240	115916	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL321403	115916	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		11539587	73851	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL187271	73851	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
		11503585	71978	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL182542	71978	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
		23656300	155545	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
		CHEMBL394054	155545	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
		59446107	88394	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163480	88394	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446107	88394	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163480	88394	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44436807	155090	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		CHEMBL393692	155090	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		46882237	12552	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078677	12552	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44395002	72960	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL184368	72960	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
		44445627	161719	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL401084	161719	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113906	144001	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		CHEMBL375102	144001	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		70692601	82650	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048814	82650	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		145957075	169058	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164040	169058	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		145956026	169441	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4169979	169441	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		145956061	169472	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4170481	169472	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
		46882271	12581	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078899	12581	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		156018364	184692	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645148	184692	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		44445624	161685	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL400879	161685	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16203238	143887	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
		CHEMBL374757	143887	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
		16113694	143971	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL374920	143971	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
		16114181	148718	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL387109	148718	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		44446137	162196	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL403682	162196	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		122180017	128356	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586023	128356	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		44379072	19570	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1188124	19570	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL535353	19570	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		16113905	91472	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL222622	91472	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		11626181	131159	2	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL363896	131159	2	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
		42624369	195642	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		44582535	195642	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		91935102	195642	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		CHEMBL506930	195642	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		16113691	143497	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
		CHEMBL374073	143497	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
		90666023	116083	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218896	116083	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		16113691	143497	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
		CHEMBL374073	143497	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
		57422696	120255	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319403	120255	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		156012849	184077	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4636571	184077	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		44390860	70418	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL180096	70418	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		73347725	99045	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426674	99045	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
		156012849	184077	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4636571	184077	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156015928	184360	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4640615	184360	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156018364	184692	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645148	184692	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145949595	169503	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4171040	169503	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		1100	8389	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
		6918297	8389	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
		CHEMBL108335	8389	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
		11539588	73687	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL186540	73687	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
		122180015	128354	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586021	128354	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		122178615	128082	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3580668	128082	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
		16113798	91108	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		CHEMBL221662	91108	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		16113797	144915	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		CHEMBL376735	144915	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		16113903	175156	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
		CHEMBL434573	175156	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
		44338241	13313	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL108287	13313	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		44410012	145177	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL377305	145177	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16113122	154947	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
		CHEMBL393565	154947	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
		11556937	88397	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163484	88397	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		11556937	88397	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163484	88397	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		9956908	19868	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1190326	19868	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL540604	19868	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		11329138	71234	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
		CHEMBL181350	71234	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
		90665848	116052	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218648	116052	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
		23648245	98790	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		CHEMBL241776	98790	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
		145949595	169503	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4171040	169503	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		11846625	84659	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		CHEMBL209394	84659	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		44409683	83034	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205848	83034	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		46882305	12600	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079091	12600	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		11124146	105929	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL281173	105929	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		56942855	131977	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
		CHEMBL3645261	131977	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
		11016748	105126	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL275141	105126	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		44445602	100961	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
		CHEMBL249659	100961	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
		11256439	82154	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
		CHEMBL203843	82154	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
		44390881	72877	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL183916	72877	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		44338151	116526	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL323026	116526	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		46882238	12555	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078699	12555	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		59446133	181813	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4567432	181813	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		60195284	88385	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163471	88385	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44394930	73106	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL185028	73106	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
		11016748	105126	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL275141	105126	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		59446115	181089	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4550305	181089	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		60195379	88389	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163475	88389	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		46882155	12480	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078114	12480	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		11145720	74114	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
		CHEMBL18853	74114	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
		11846628	84487	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		CHEMBL208930	84487	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		156015928	184360	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4640615	184360	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		16114012	175178	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
		CHEMBL434738	175178	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
		122180018	128357	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586024	128357	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		16113582	143417	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL373995	143417	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		46882807	12536	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078533	12536	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		16114184	157270	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
		CHEMBL395441	157270	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
		44446188	162170	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL403542	162170	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		44436817	173548	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL428383	173548	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		44445618	168677	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL415134	168677	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		44436887	97734	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL239464	97734	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		10907396	105926	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
		CHEMBL281147	105926	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
		11649239	73114	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL185057	73114	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		1100	8389	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
		6918297	8389	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
		CHEMBL108335	8389	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
		16113580	144657	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
		CHEMBL376258	144657	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
		16113580	144657	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL376258	144657	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		44436883	152931	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
		CHEMBL391980	152931	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
		44436889	159836	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL397594	159836	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		11452801	146076	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL379191	146076	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		44445625	161598	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL400381	161598	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		122180019	128358	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586025	128358	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		145957443	168868	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160928	168868	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		10864048	105164	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL275373	105164	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		44389187	70796	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL180722	70796	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44409871	82171	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL203948	82171	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		145959007	169036	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4163623	169036	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		145956659	168834	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160434	168834	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
		145959787	169064	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164107	169064	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		16113248	85939	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		CHEMBL2113328	85939	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		11282247	172705	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL425048	172705	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		11282247	172705	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL425048	172705	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		44409802	83519	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL206687	83519	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		156019457	184721	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645625	184721	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		216208	16499	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
		CHEMBL113313	16499	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
		90666037	116097	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		CHEMBL3218910	116097	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		23648236	85927	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
		CHEMBL2113317	85927	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
		44383343	127120	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
		CHEMBL353007	127120	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
		156014693	183971	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4635089	183971	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		44389151	69279	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
		CHEMBL178138	69279	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
		44409979	147337	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL381159	147337	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44395020	130810	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL363021	130810	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
		16114530	91515	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL222912	91515	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		59446130	88393	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163479	88393	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446130	88393	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163479	88393	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44409761	82641	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204880	82641	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		145956659	168834	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160434	168834	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
		145957443	168868	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160928	168868	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		145959007	169036	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4163623	169036	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		145959787	169064	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164107	169064	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		11328920	150820	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
		CHEMBL390308	150820	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
		122178606	128120	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581039	128120	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
		122178609	128124	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581042	128124	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
		178024	8752	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		5867	8752	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		CHEMBL13817	8752	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
		44409821	82812	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205711	82812	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		46882307	12602	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079108	12602	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
		122182044	128777	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593633	128777	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		5866	10396	4	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
		9804743	10396	4	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
		CHEMBL360227	10396	4	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
		CHEMBL500468	220894	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
		CHEMBL500468	220894	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
		11683469	83481	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
		CHEMBL206486	83481	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
		11454617	148097	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
		CHEMBL383411	148097	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
		90666029	116089	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218902	116089	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44409672	147265	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL380971	147265	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		11154823	82804	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL205660	82804	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		11190594	82760	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205445	82760	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		11583811	82762	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205450	82762	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		25260900	120254	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319402	120254	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
		10918326	105748	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
		CHEMBL279822	105748	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
		44378981	20742	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1196773	20742	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL558181	20742	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		90666033	116093	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218906	116093	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		16113472	175785	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL439251	175785	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		66813470	83607	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
		CHEMBL2069411	83607	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
		122180022	128361	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586028	128361	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		70694649	82659	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2048823	82659	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		10100708	18806	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		CHEMBL1183387	18806	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		CHEMBL294408	18806	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		11577349	72005	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL182655	72005	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
		16114098	148389	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL385131	148389	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		11327400	82147	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL203782	82147	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		44409455	82743	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
		CHEMBL205286	82743	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
		156019457	184721	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645625	184721	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		46882306	12601	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079107	12601	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
		11731384	169499	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
		CHEMBL417092	169499	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
		118709470	120236	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319274	120236	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL507636	221212	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
		156021885	184994	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
		CHEMBL4649741	184994	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
		70688404	82642	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048807	82642	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
		11114279	105025	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
		CHEMBL274460	105025	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
		70688404	82642	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2048807	82642	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
		16113693	144794	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL376471	144794	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		216208	16499	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
		CHEMBL113313	16499	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
		11827047	105996	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
		CHEMBL281578	105996	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
		9745	9231	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		9804938	9231	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		CHEMBL278623	9231	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		DB13074	9231	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
		16113124	128113	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581032	128113	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
		44445605	161760	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL401260	161760	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113578	143970	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
		CHEMBL374919	143970	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
		16113584	144372	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
		CHEMBL375568	144372	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
		44389168	71647	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
		CHEMBL182154	71647	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
		11314908	148590	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		CHEMBL386290	148590	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		11846627	86499	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		CHEMBL211581	86499	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		10929048	75582	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL19220	75582	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		90666020	116080	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218893	116080	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		16114403	153965	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL392805	153965	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
		57422673	120243	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319282	120243	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
		70684154	82644	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048809	82644	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		122180020	128359	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586026	128359	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		16113710	85936	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
		CHEMBL2113325	85936	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
		122178611	128126	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581044	128126	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
		122178614	128129	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581047	128129	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
		16114531	91450	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL222498	91450	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		145974293	169803	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4175823	169803	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		46882197	12514	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078403	12514	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44409980	82955	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205790	82955	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		145952740	169280	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL4167481	169280	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
		44409868	83517	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL206673	83517	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		156017532	184687	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645072	184687	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		11605822	131166	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL363930	131166	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
		162651761	186988	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
		CHEMBL4749698	186988	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
		70686292	82655	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048819	82655	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		10186158	105218	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		CHEMBL275660	105218	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		122178602	128116	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581035	128116	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3586019	218580	6	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
		122180025	128364	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586031	128364	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
		156017532	184687	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4645072	184687	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145952740	169280	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
		CHEMBL4167481	169280	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
		145974293	169803	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4175823	169803	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		44436881	98363	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
		CHEMBL240746	98363	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
		122182189	128786	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593814	128786	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		122180016	128355	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586022	128355	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		46882199	12533	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078498	12533	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44301462	18034	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1179075	18034	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL58758	18034	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		90666042	116102	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		CHEMBL3218915	116102	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
		25262771	120241	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319280	120241	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		42624370	195616	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		44582537	195616	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		91935104	195616	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		CHEMBL506624	195616	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		44445617	161455	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL399649	161455	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		11163070	72342	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
		CHEMBL183123	72342	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
		156012428	184089	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
		CHEMBL4636832	184089	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
		46882766	12444	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1077839	12444	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44436813	154085	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL392902	154085	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		44410013	83828	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL207268	83828	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44235473	88392	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163478	88392	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		44235473	88392	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163478	88392	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44409839	83033	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205847	83033	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16114099	144002	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL375103	144002	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		16113372	85929	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
		CHEMBL2113319	85929	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
		46882273	12590	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078982	12590	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		122182044	128777	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593633	128777	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		121879	9015	24	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		5868	9015	24	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		CHEMBL308716	9015	24	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		CHEMBL2370788	216700	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
		145950261	169508	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4171137	169508	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		44394974	73786	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL186974	73786	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
		44445615	168648	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL414929	168648	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113370	85934	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL2113323	85934	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
		145953016	169366	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4168863	169366	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		156012445	184114	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4637284	184114	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		10186158	105218	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		CHEMBL275660	105218	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		11617435	82772	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
		CHEMBL205486	82772	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
		70696689	82657	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048821	82657	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		70694647	82643	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048808	82643	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		56942242	131973	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
		CHEMBL3645257	131973	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
		122178605	128119	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581038	128119	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
		44445611	161454	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL399648	161454	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		122182189	128786	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593814	128786	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		56942385	131976	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
		CHEMBL3645260	131976	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
		CHEMBL501261	220914	23	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
		56942099	131972	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		CHEMBL3645256	131972	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
		56942243	131974	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
		CHEMBL3645258	131974	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
		122178608	128123	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581041	128123	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
		44409673	83525	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
		CHEMBL206741	83525	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
		CHEMBL105462	215247	38	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		11690097	83447	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		CHEMBL206446	83447	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		57422695	120253	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319401	120253	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
		25124566	8655	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
		5870	8655	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
		CHEMBL3358452	8655	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
		156013219	184268	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4639379	184268	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145957574	169080	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164328	169080	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		46882805	12596	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079046	12596	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
		53390538	99052	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426681	99052	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		178024	8752	33	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
		5867	8752	33	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
		CHEMBL13817	8752	33	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
		44445629	168679	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL415136	168679	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16204239	143062	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		CHEMBL373393	143062	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		11508639	83310	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
		CHEMBL206091	83310	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
		216208	16499	33	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL113313	16499	33	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
		11846630	145713	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL378438	145713	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		156012445	184114	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4637284	184114	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145953016	169366	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4168863	169366	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
		145949755	169713	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4174302	169713	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		16204241	91203	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
		CHEMBL221996	91203	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
		11221946	147624	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
		CHEMBL381942	147624	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
		11221946	147624	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
		CHEMBL381942	147624	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
		46882104	12727	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079873	12727	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		145956415	168842	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160541	168842	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		145950261	169508	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4171137	169508	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		11654867	82976	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205833	82976	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
		10415364	133545	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL365294	133545	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		178024	8752	33	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		5867	8752	33	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		CHEMBL13817	8752	33	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
		16114404	161676	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL400814	161676	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
		90666014	116074	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL3218887	116074	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
		44436885	153207	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
		CHEMBL392191	153207	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
		44436829	159257	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL397109	159257	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		16114404	161676	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		CHEMBL400814	161676	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		122182047	128780	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593636	128780	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		70684155	82660	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2048824	82660	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2163483	216104	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163483	216104	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44409872	81841	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL203581	81841	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44445596	161422	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL399448	161422	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16113692	144014	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
		CHEMBL375162	144014	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
		118709504	120256	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL3319404	120256	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		10907396	105926	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
		CHEMBL281147	105926	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
		11677781	131836	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL364430	131836	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
		44445606	161793	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL401467	161793	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		44379034	19696	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1189120	19696	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL538068	19696	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		44378986	19867	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1190325	19867	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL540603	19867	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		11697618	69373	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178289	69373	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		145956415	168842	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160541	168842	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		44436886	168734	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		CHEMBL415674	168734	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		145949755	169713	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4174302	169713	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
		23648242	85931	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
		CHEMBL2113320	85931	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
		11606121	71350	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
		CHEMBL181584	71350	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
		122180023	128362	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586029	128362	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
		44379301	19832	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1190091	19832	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL540093	19832	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
		44338300	174622	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		CHEMBL430882	174622	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		44338239	174677	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		CHEMBL431245	174677	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		44409762	82661	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204884	82661	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122180018	128357	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586024	128357	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		122182189	128786	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593814	128786	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		10032659	18823	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		CHEMBL1183505	18823	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		CHEMBL301259	18823	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
		60195019	88379	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163464	88379	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		156009875	183902	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4633695	183902	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		11430583	86992	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL213704	86992	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		11517629	175117	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL434330	175117	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
		44409975	82565	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204835	82565	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		53391301	99049	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426678	99049	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		90666019	116079	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218892	116079	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
		11669486	71388	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
		CHEMBL181736	71388	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
		59446141	88395	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163481	88395	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446141	88395	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163481	88395	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44436917	97424	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL239007	97424	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		60165265	122976	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
		CHEMBL3358453	122976	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
		16113002	155092	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
		CHEMBL393693	155092	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
		44409678	147995	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL382853	147995	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122178604	128118	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581037	128118	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
		10929048	75582	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL19220	75582	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		60195018	88378	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163463	88378	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44394913	133951	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL365721	133951	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
		11649248	73444	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL185399	73444	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
		44394833	133603	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL365460	133603	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
		11827047	105996	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
		CHEMBL281578	105996	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
		42624359	200180	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		44582536	200180	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		91935103	200180	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		CHEMBL525751	200180	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
		156009875	183902	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4633695	183902	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156021942	185002	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4649860	185002	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		122180021	128360	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586027	128360	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
		11134880	106207	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		CHEMBL282891	106207	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		11846629	145597	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL378118	145597	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		11114279	105025	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
		CHEMBL274460	105025	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
		145952396	169782	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
		CHEMBL4175534	169782	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
		122178607	128122	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581040	128122	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
		156013219	184268	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4639379	184268	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145957574	169080	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164328	169080	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		11846463	146020	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		CHEMBL378909	146020	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		9890863	138770	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL369533	138770	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		44409864	82274	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL204266	82274	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122180027	128366	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586033	128366	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		11430392	83499	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
		CHEMBL206588	83499	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
		57785737	120219	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319216	120219	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		44390871	71616	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL182035	71616	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		70682037	82656	20	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048820	82656	20	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		156021297	184868	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4647797	184868	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		90666040	116100	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218913	116100	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		90666026	116086	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218899	116086	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		16204021	91482	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
		CHEMBL222710	91482	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
		122180014	128353	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586020	128353	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		90666016	116076	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
		CHEMBL3218889	116076	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
		44389186	71389	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL181739	71389	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44338266	117110	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
		CHEMBL323974	117110	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
		70692602	82651	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048815	82651	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
		11455251	168093	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL412362	168093	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		156021942	185002	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4649860	185002	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		16204037	144011	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL375150	144011	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		11582836	69687	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178463	69687	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44389131	70236	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL179812	70236	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
		122180025	128364	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586031	128364	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
		122178612	128127	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581045	128127	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
		16203237	103726	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
		CHEMBL266199	103726	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
		59446148	181828	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4567800	181828	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		46882152	12627	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079302	12627	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
		11655355	81196	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL202642	81196	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		145952396	169782	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
		CHEMBL4175534	169782	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
		46882764	12403	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1077716	12403	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
		16114290	143986	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL374992	143986	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		90666015	116075	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218888	116075	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
		44436831	158775	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		CHEMBL396681	158775	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		25262608	120240	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
		CHEMBL3319279	120240	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
		10918326	105748	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
		CHEMBL279822	105748	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
		16203918	91562	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		CHEMBL223239	91562	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
		70696687	82648	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048812	82648	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		46882105	13123	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1082044	13123	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44446189	162153	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL403426	162153	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
		44446157	101427	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL252501	101427	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		44446148	162197	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL403683	162197	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		44410008	148029	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL383058	148029	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		59446143	88375	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
		CHEMBL2163448	88375	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
		59446143	88375	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		CHEMBL2163448	88375	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		44338221	14820	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL109094	14820	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
		60195113	88382	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
		CHEMBL2163467	88382	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
		46882804	12595	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079045	12595	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		10864048	105164	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL275373	105164	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		156016110	184477	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4642043	184477	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		156017268	184429	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641472	184429	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		59446118	181479	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4559602	181479	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		60195285	88387	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163473	88387	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44436868	152861	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
		CHEMBL391922	152861	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
		44394947	176002	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL440939	176002	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
		122180022	128361	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586028	128361	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		11751384	148284	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL384524	148284	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		122180026	128365	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586032	128365	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
		122182043	128776	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593632	128776	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		16204226	91574	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL223323	91574	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		118709472	120239	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
		CHEMBL3319277	120239	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
		46882196	12513	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078402	12513	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		44379303	19611	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1188529	19611	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL536706	19611	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL2310893	216275	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
		44445614	176088	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL441567	176088	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		44445598	101151	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL250807	101151	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		145949381	169494	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4170865	169494	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		44436832	158777	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL396682	158777	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		44445626	103841	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL267197	103841	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		90666025	116085	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218898	116085	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		156012122	184160	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4637980	184160	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156012122	184160	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4637980	184160	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156021297	184868	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4647797	184868	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		90666024	116084	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218897	116084	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		57422776	120221	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		CHEMBL3319218	120221	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
		162657463	187819	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
		CHEMBL4759415	187819	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
		44409990	83292	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205995	83292	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122180024	128363	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586030	128363	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		44409758	82749	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205374	82749	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		122182190	128787	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		CHEMBL3593815	128787	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
		44409684	147663	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL382033	147663	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16113003	101522	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
		CHEMBL253126	101522	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
		16113003	101522	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
		CHEMBL253126	101522	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
		122182047	128780	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593636	128780	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		90666030	116090	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218903	116090	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		11605333	83500	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
		CHEMBL206589	83500	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
		122182046	128779	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593635	128779	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		11281346	82793	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL205568	82793	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		145949381	169494	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4170865	169494	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		16204145	143330	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
		CHEMBL373772	143330	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
		90666036	116096	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218909	116096	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		44338235	116439	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL322499	116439	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
		156016392	184425	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641386	184425	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156017268	184429	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641472	184429	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145958317	169092	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164531	169092	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		145949880	169570	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4172217	169570	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		145950963	169585	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4172411	169585	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		156016392	184425	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641386	184425	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		44445608	161794	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL401468	161794	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		59446116	88373	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		CHEMBL2163439	88373	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		23631387	100041	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
		CHEMBL244936	100041	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
		90666038	116098	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
		CHEMBL3218911	116098	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
		44421230	91566	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		CHEMBL223269	91566	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		156018460	184656	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		CHEMBL4644587	184656	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
		145950963	169585	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4172411	169585	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		11618705	173717	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL428698	173717	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
		44436842	153716	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL392592	153716	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
		CHEMBL509976	222359	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
		CHEMBL450217	220742	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrsDisplacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrs	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300414b
		CHEMBL450217	220742	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1074/jbc.m609796200
		10984270	105283	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL276137	105283	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		44436884	98327	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL240522	98327	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL444131	220708	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
		60195020	88380	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163465	88380	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		59446112	179753	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4517723	179753	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL422461	220065	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm0001727
		16114010	143061	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		CHEMBL373392	143061	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		16203349	173069	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL427076	173069	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		11531313	69278	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178137	69278	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44389283	69719	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178494	69719	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		122180019	128358	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586025	128358	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL447282	220728	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm8014519
		145958317	169092	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4164531	169092	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		16114008	91621	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL223532	91621	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		16112910	143155	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL373507	143155	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		16112910	143155	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL373507	143155	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		44436882	152794	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
		CHEMBL391859	152794	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
		145949880	169570	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4172217	169570	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
		122180024	128363	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586030	128363	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
		46882154	12633	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079323	12633	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		59446145	88374	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163444	88374	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446145	88374	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163444	88374	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		11699004	72977	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL184429	72977	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
		11537800	82342	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
		CHEMBL204564	82342	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
		16203236	173041	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
		CHEMBL426905	173041	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
		10207327	73845	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		CHEMBL18725	73845	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		44445603	161759	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL401259	161759	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL502208	220929	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
		16113583	168530	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL413856	168530	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		90665849	116053	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218649	116053	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
		70696688	82654	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048818	82654	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
		44436816	98580	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL241242	98580	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		10984270	105283	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		CHEMBL276137	105283	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
		44301387	18036	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1179088	18036	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL59572	18036	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		11692087	69766	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL178610	69766	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
		122178610	128125	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581043	128125	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
		16113695	143805	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
		CHEMBL374643	143805	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
		16113695	143805	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL374643	143805	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		16113695	143805	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL374643	143805	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		16113695	143805	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
		CHEMBL374643	143805	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
		44436888	159835	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL397593	159835	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		11692087	69766	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178610	69766	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
		44409809	81840	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL203578	81840	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44409989	172605	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL424860	172605	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL105462	215247	38	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		90666018	116078	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		CHEMBL3218891	116078	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
		11612155	147787	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		CHEMBL382375	147787	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
		118722878	122975	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
		CHEMBL3358451	122975	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
		16114097	85932	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
		CHEMBL2113321	85932	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
		122182189	128786	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593814	128786	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		25260901	120257	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319405	120257	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
		122180021	128360	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
		CHEMBL3586027	128360	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
		11179347	84128	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL208477	84128	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		44445593	161566	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		CHEMBL400174	161566	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
		16203569	148511	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL385803	148511	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		90666034	116094	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218907	116094	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL449590	220741	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
		121879	9015	24	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		5868	9015	24	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		CHEMBL308716	9015	24	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		11568561	176333	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL443560	176333	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
		44338246	105630	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL278909	105630	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
		CHEMBL105462	215247	38	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(99)00584-3
		44409767	164021	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL407647	164021	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44445612	103815	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
		CHEMBL266964	103815	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
		44410003	82956	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205794	82956	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16203569	148511	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL385803	148511	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL18872	215837	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(C)(C)N)C(N)=O	10.1021/jm300557t
		46882106	12634	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079340	12634	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
		44436876	153797	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		CHEMBL392663	153797	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
		121879	9015	24	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		5868	9015	24	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		CHEMBL308716	9015	24	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
		156010733	183859	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4633062	183859	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145962494	168853	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160705	168853	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		145950201	169721	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4174476	169721	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		44409832	83185	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205955	83185	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
		16204237	91672	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		CHEMBL223638	91672	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
		16204343	143969	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
		CHEMBL374918	143969	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
		122178613	128128	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581046	128128	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
		57422749	120216	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319213	120216	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		44410007	83202	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL205963	83202	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		118718706	122157	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL3350011	122157	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
		89768546	155796	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
		CHEMBL3942511	155796	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
		16114011	144916	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
		CHEMBL376736	144916	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
		11349789	85548	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL211265	85548	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		16112909	151059	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL390503	151059	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		44378837	19793	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1189851	19793	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL539575	19793	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		44445597	101291	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL251640	101291	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		11176805	84109	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
		CHEMBL208374	84109	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
		156010733	183859	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4633062	183859	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		46882153	12632	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1079322	12632	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
		145950201	169721	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4174476	169721	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		46882239	12556	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078700	12556	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
		1221269	128812	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL359530	128812	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44446177	101422	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL252448	101422	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
		16114289	105441	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
		CHEMBL277376	105441	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
		11538533	81776	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
		CHEMBL203280	81776	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
		10415364	133545	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL365294	133545	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL263544	217354	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(N)=O	10.1021/jm0001727
		122180023	128362	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586029	128362	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
		118709507	120260	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319408	120260	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
		90666011	116071	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
		CHEMBL3218884	116071	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
		11538533	81776	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		CHEMBL203280	81776	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		44409998	145314	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL377515	145314	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		90666021	116081	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218894	116081	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		11453509	82953	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL205784	82953	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		44445610	168502	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL413608	168502	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		23648249	85937	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
		CHEMBL2113326	85937	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
		11178309	86676	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL212415	86676	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
		CHEMBL3578018	218548	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		CHEMBL3578018	218548	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		44445613	100962	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
		CHEMBL249662	100962	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
		16204229	91092	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		CHEMBL221569	91092	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		44409867	83516	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL206672	83516	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		145962494	168853	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		CHEMBL4160705	168853	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
		44389215	69852	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL178838	69852	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		11211892	86991	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		CHEMBL213703	86991	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
		122180015	128354	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586021	128354	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		59446138	88396	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163482	88396	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		59446138	88396	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163482	88396	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		59446127	179815	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4518972	179815	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		60195286	88388	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163474	88388	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		10207327	73845	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		CHEMBL18725	73845	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
		16112911	91504	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		CHEMBL222835	91504	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
		5311280	88384	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163470	88384	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		44389243	71357	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
		CHEMBL181619	71357	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
		23648232	98018	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		CHEMBL240179	98018	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
		44445616	168649	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL414930	168649	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		118709471	120237	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319275	120237	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		44390889	71197	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL181313	71197	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		46882270	12589	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078960	12589	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		156016696	184409	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641201	184409	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL3578016	218546	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		CHEMBL2163348	216103	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL2163348	216103	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		16113800	144590	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL375972	144590	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
		CHEMBL3578016	218546	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		156013130	184281	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4639514	184281	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		156016696	184409	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4641201	184409	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		145950877	169774	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4175360	169774	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		44358041	168110	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
		91931457	168110	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
		CHEMBL412565	168110	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
		57422810	184440	4	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
		CHEMBL4641579	184440	4	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
		16113246	101452	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL252643	101452	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		11846624	84691	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		CHEMBL209443	84691	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
		46882272	12582	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078900	12582	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
		9987037	18804	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1183385	18804	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL294324	18804	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		56942537	131978	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
		CHEMBL3645262	131978	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
		57422761	120217	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319214	120217	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		57422760	120214	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		CHEMBL3319211	120214	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
		57422791	120229	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319226	120229	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
		44445619	161456	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL399650	161456	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16113469	144280	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		CHEMBL375408	144280	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
		122182045	128778	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593634	128778	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		44446175	101762	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL254741	101762	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
		10994861	74045	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		CHEMBL18815	74045	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
		10984260	175132	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
		CHEMBL434391	175132	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
		59446135	88390	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
		CHEMBL2163476	88390	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
		59446135	88390	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		CHEMBL2163476	88390	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
		59446154	88377	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
		CHEMBL2163453	88377	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
		59446154	88377	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
		CHEMBL2163453	88377	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
		44446178	161902	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL402023	161902	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
		753168	130017	40	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL361366	130017	40	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		44338253	16059	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		CHEMBL110900	16059	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
		44301512	18794	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL1183340	18794	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		CHEMBL291333	18794	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
		16113799	175492	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		CHEMBL436849	175492	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
		11166495	82325	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		CHEMBL204474	82325	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
		25262772	120242	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		CHEMBL3319281	120242	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
		44390869	129120	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		CHEMBL359922	129120	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
		156013130	184281	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		CHEMBL4639514	184281	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
		122180014	128353	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586020	128353	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		122178601	128115	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
		CHEMBL3581034	128115	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
		16202767	91771	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		CHEMBL223810	91771	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
		46882156	12481	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078115	12481	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		16113474	143411	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		CHEMBL373993	143411	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
		59446105	179600	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		CHEMBL4514053	179600	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
		11556936	88386	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		CHEMBL2163472	88386	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
		60195114	88383	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
		CHEMBL2163468	88383	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
		70690449	82646	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048810	82646	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		70692603	82652	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048816	82652	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		44389192	175425	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
		CHEMBL436275	175425	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
		44394982	72912	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL184093	72912	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
		CHEMBL335799	218343	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm0001727
		CHEMBL61663	222618	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
		44445628	168678	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL415135	168678	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		145950877	169774	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4175360	169774	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		11663710	131245	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		CHEMBL363995	131245	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
		16113371	85928	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
		CHEMBL2113318	85928	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
		16113371	85928	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
		CHEMBL2113318	85928	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
		11713497	130015	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL361349	130015	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
		122182045	128778	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		CHEMBL3593634	128778	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
		11646276	82709	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
		CHEMBL205136	82709	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
		122182046	128779	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593635	128779	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
		44436828	98775	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL241664	98775	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
		CHEMBL410108	219578	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
		11538533	81776	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL203280	81776	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL500468	220894	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
		11538534	81789	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		CHEMBL203373	81789	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
		122182047	128780	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		CHEMBL3593636	128780	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
		70686293	82658	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048822	82658	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		122180016	128355	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		CHEMBL3586022	128355	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
		44389216	130632	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
		CHEMBL362595	130632	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
		44389248	128946	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		CHEMBL359714	128946	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
		145958774	169045	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		CHEMBL4163811	169045	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
		44445609	103814	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		CHEMBL266961	103814	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
		16114532	91471	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		CHEMBL222610	91471	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
		23648250	85938	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		CHEMBL2113327	85938	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
		44409764	83924	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		CHEMBL207792	83924	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
		44378979	19616	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL1188586	19616	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		CHEMBL536779	19616	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
		11197	7852	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
		154699458	7852	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
		CHEMBL4632411	7852	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
		CHEMBL498956	220867	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm8014519
		46882198	12532	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL1078497	12532	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
		CHEMBL3578017	218547	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		CHEMBL3578017	218547	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
		145953855	169294	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		CHEMBL4167669	169294	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
		90666035	116095	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		CHEMBL3218908	116095	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
		328912	69350	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
		CHEMBL178266	69350	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
		178024	8752	33	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
		5867	8752	33	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
		CHEMBL13817	8752	33	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
		57398340	78051	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956993	78051	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57400002	78052	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956994	78052	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57394881	78068	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957010	78068	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57393073	78059	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957001	78059	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		56926461	75811	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923609	75811	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926462	75812	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923610	75812	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		56926680	75825	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923623	75825	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		56926682	75827	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923625	75827	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		11664206	75828	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923626	75828	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		56926893	75838	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
		CHEMBL1923637	75838	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
		11526745	75843	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923642	75843	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134137202	149604	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3893048	149604	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134137257	149915	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3895776	149915	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134133352	150283	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3898794	150283	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
		11527086	150828	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3903118	150828	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		11512561	151147	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3905791	151147	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134133037	151345	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3907497	151345	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134132670	151392	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3907891	151392	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134132152	151710	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3910300	151710	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
		134142839	152164	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3913855	152164	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134142553	152225	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3914259	152225	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134143635	152352	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3915269	152352	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
		134143096	152711	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3918009	152711	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134142204	152715	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3918046	152715	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		11584702	152969	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3920049	152969	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134139279	153225	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3922056	153225	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134138445	154155	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3929593	154155	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134138218	154788	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3934367	154788	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134148686	154950	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3935670	154950	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134149719	155466	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
		CHEMBL3939872	155466	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
		134145791	155565	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3940705	155565	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134143746	157379	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
		CHEMBL3955179	157379	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
		134145221	157411	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3955437	157411	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134155656	157973	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3959816	157973	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134155282	158121	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3961108	158121	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134153496	159064	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3969367	159064	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134153654	159545	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3973513	159545	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134157569	160815	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3984338	160815	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		57345600	78048	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956990	78048	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57345599	78049	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956991	78049	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57398341	78057	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956999	78057	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		178024	8752	33	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
		5867	8752	33	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
		CHEMBL13817	8752	33	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
		57398342	78065	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957007	78065	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57401803	78067	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957009	78067	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57401799	78058	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957000	78058	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57399248	75819	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923617	75819	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		44340008	120165	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
		CHEMBL331801	120165	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
		57399248	75819	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923617	75819	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		24970113	75831	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923629	75831	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		57391293	78055	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956997	78055	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162659411	188004	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4761419	188004	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
		44340268	117298	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
		CHEMBL325062	117298	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
		57401800	78061	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957003	78061	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162657606	187896	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4760409	187896	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		57401801	78063	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957005	78063	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162672839	189801	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4793824	189801	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL500468	220894	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
		56942242	131973	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645257	131973	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
		56925343	75841	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923640	75841	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		57398339	78050	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956992	78050	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162645413	186505	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4744051	186505	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		155540883	179736	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4517399	179736	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		16133832	220110	18	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
		CHEMBL425281	220110	18	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
		162653781	187261	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4753046	187261	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		57401802	78064	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957006	78064	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57401797	78044	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956987	78044	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		57398343	78066	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957008	78066	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		56926175	75788	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL1923504	75788	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		56926360	75810	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923608	75810	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926582	75818	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923616	75818	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926681	75826	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923624	75826	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		56926891	75836	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923635	75836	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926892	75837	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923636	75837	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926894	75839	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
		CHEMBL1923638	75839	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
		56925345	75844	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL1923643	75844	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134130631	149151	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
		CHEMBL3889512	149151	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
		134131442	149174	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3889678	149174	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134131183	149246	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3890296	149246	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134136433	149285	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3890602	149285	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134137008	149321	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3890889	149321	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134137012	149380	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3891381	149380	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134137398	149654	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3893476	149654	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134136665	149677	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
		CHEMBL3893697	149677	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
		134133488	150014	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3896536	150014	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134134248	150129	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3897510	150129	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134134556	150130	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3897527	150130	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134133518	150231	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		CHEMBL3898348	150231	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		134134286	150472	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3900284	150472	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134135296	150789	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3902856	150789	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134132958	151439	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
		CHEMBL3908264	151439	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
		134132137	151591	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3909431	151591	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
		134132893	151641	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3909834	151641	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		24969783	151642	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
		CHEMBL3909838	151642	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
		130334810	151938	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
		CHEMBL3912211	151938	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
		134132394	151962	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3912375	151962	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134142218	152065	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3913052	152065	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134142433	152104	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
		CHEMBL3913335	152104	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
		59778970	152153	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3913763	152153	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134143366	152538	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3916659	152538	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		117812386	152636	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3917385	152636	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134139489	152840	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3919021	152840	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134140270	153151	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3921499	153151	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134140007	153182	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3921750	153182	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134139286	153332	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3922810	153332	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134139113	153431	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
		CHEMBL3923633	153431	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
		134141159	153507	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3924192	153507	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134140968	153568	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
		CHEMBL3924635	153568	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
		134141782	153772	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3926434	153772	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134141886	153896	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3927481	153896	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134138234	154191	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3929852	154191	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
		117812380	154530	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3932408	154530	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134138595	154533	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
		CHEMBL3932434	154533	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
		134138824	154793	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3934402	154793	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134148504	155133	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3937200	155133	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134149092	155232	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		CHEMBL3937924	155232	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		134149306	155253	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3938104	155253	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134149407	155299	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3938452	155299	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134148639	155322	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
		CHEMBL3938683	155322	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
		134146570	155559	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3940653	155559	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134145552	155798	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
		CHEMBL3942528	155798	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
		134145564	155869	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3943086	155869	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		72574018	155883	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3943159	155883	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134146319	155905	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3943294	155905	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134147809	156228	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3946007	156228	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134147441	156268	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		CHEMBL3946348	156268	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		134146888	156542	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3948268	156542	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134147381	156564	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3948472	156564	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134147802	156870	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3950904	156870	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134145064	156929	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3951476	156929	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144205	157053	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3952596	157053	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144429	157065	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3952699	157065	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144211	157110	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3953033	157110	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144606	157114	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3953053	157114	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
		134155024	157791	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3958451	157791	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134155239	157793	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
		CHEMBL3958460	157793	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
		134155132	157871	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3959108	157871	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
		134155178	158158	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
		CHEMBL3961456	158158	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
		134150646	158425	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3963865	158425	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134150029	158894	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3967783	158894	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134150729	158935	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3968175	158935	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134154254	159078	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3969506	159078	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134154486	159221	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
		CHEMBL3970827	159221	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
		134154392	159311	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3971540	159311	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134153247	159499	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
		CHEMBL3973085	159499	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
		134153772	159678	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3974701	159678	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
		52911621	159840	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3975975	159840	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134151758	159883	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3976294	159883	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134152984	159947	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
		CHEMBL3976853	159947	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
		134151899	160098	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3978207	160098	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		134152339	160238	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3979468	160238	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134152133	160302	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3979911	160302	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134157813	160451	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3981238	160451	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134156963	160637	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3982825	160637	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
		57528321	160736	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
		CHEMBL3983626	160736	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
		134156579	160833	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3984464	160833	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134156405	161041	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
		CHEMBL3986375	161041	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
		134156453	161079	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3986628	161079	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56942098	131971	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645255	131971	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		162646324	186515	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4744139	186515	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		162665018	188914	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4782214	188914	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
		58438451	99060	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426689	99060	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		90644553	118512	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
		CHEMBL3287214	118512	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
		56926177	75790	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL1923506	75790	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		56926268	75792	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
		CHEMBL1923510	75792	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
		56926269	75793	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
		CHEMBL1923511	75793	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
		56926356	75794	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
		CHEMBL1923512	75794	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
		56926465	75815	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		CHEMBL1923613	75815	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		56926782	75832	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923631	75832	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926784	75834	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923633	75834	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		56926785	75835	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL1923634	75835	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		71452183	90304	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
		CHEMBL2203623	90304	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
		134131439	149173	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
		CHEMBL3889672	149173	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
		134137460	149413	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		CHEMBL3891657	149413	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		134136637	149498	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
		CHEMBL3892319	149498	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
		134136946	149532	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3892517	149532	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134136405	149697	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3893850	149697	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134133771	150119	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
		CHEMBL3897387	150119	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
		134133353	150297	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
		CHEMBL3898864	150297	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
		134134505	150446	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3900035	150446	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134134605	150455	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3900122	150455	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
		134134099	150509	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3900636	150509	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134135897	150772	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3902804	150772	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134134825	150857	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3903351	150857	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
		72989837	150893	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
		CHEMBL3903647	150893	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
		134135712	150916	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
		CHEMBL3903845	150916	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
		134136025	151110	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3905495	151110	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		134134870	151170	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3905987	151170	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134135261	151263	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
		CHEMBL3906788	151263	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
		134134893	151289	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
		CHEMBL3907031	151289	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
		134132666	151343	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3907480	151343	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134132519	151427	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3908156	151427	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
		134132427	151479	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3908583	151479	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134131971	151706	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3910288	151706	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134132265	151749	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
		CHEMBL3910661	151749	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
		134131903	151916	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3912034	151916	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134132099	151988	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3912534	151988	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
		134142223	152121	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
		CHEMBL3913486	152121	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
		134142139	152180	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
		CHEMBL3913981	152180	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
		76460236	152238	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3914338	152238	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134143044	152251	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3914467	152251	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
		134143657	152514	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3916501	152514	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134143398	152712	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3918022	152712	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134139992	153117	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
		CHEMBL3921227	153117	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
		134140213	153398	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
		CHEMBL3923324	153398	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
		134140762	153443	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
		CHEMBL3923718	153443	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
		134141057	153473	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3923918	153473	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134140844	154003	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
		CHEMBL3928367	154003	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
		68186750	154165	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
		CHEMBL3929656	154165	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
		134138656	154332	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3930811	154332	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134138764	154414	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
		CHEMBL3931402	154414	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
		134138160	154443	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3931716	154443	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134137758	154752	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
		CHEMBL3934093	154752	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
		134137945	154764	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
		CHEMBL3934184	154764	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
		134149048	154855	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
		CHEMBL3934901	154855	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
		134149058	154913	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
		CHEMBL3935422	154913	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
		134149451	154944	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3935626	154944	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134148804	155097	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
		CHEMBL3936957	155097	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
		58012657	155144	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3937314	155144	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		134149772	155258	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3938132	155258	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134149793	155384	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
		CHEMBL3939196	155384	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
		134148754	155478	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
		CHEMBL3939993	155478	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
		134145258	155581	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3940860	155581	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134145652	155802	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3942543	155802	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134145920	155805	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3942554	155805	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134146710	155809	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
		CHEMBL3942610	155809	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
		134145820	155813	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3942642	155813	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134146617	155894	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3943228	155894	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134145420	156092	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
		CHEMBL3944936	156092	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
		134147617	156214	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3945918	156214	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		134147244	156225	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3945984	156225	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134148131	156477	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3947758	156477	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134147387	156596	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3948746	156596	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134147861	156636	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3949023	156636	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
		134147972	156717	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3949704	156717	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
		134147412	156745	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3949926	156745	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134148083	156891	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
		CHEMBL3951110	156891	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
		134144491	156920	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3951362	156920	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134143693	156936	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3951593	156936	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134145200	157231	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3954124	157231	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		134144043	157268	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
		CHEMBL3954394	157268	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
		134144941	157306	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3954620	157306	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134144060	157436	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3955632	157436	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134155541	157816	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3958657	157816	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134155247	157829	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
		CHEMBL3958739	157829	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
		117812381	158130	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3961160	158130	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134155292	158181	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3961641	158181	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134154704	158189	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3961696	158189	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
		134152627	158327	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3963078	158327	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134150950	158384	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
		CHEMBL3963523	158384	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
		57528212	158602	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
		CHEMBL3965338	158602	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
		134150767	158605	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		CHEMBL3965351	158605	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
		134150369	158635	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
		CHEMBL3965516	158635	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
		134150388	158704	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3966251	158704	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134150696	158858	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3967506	158858	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134153608	159149	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3970180	159149	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134154369	159173	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3970414	159173	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134153972	159181	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3970491	159181	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
		134154079	159182	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3970499	159182	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
		134153529	159227	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3970856	159227	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134154612	159290	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
		CHEMBL3971356	159290	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
		134153232	159358	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
		CHEMBL3971845	159358	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
		134154534	159523	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3973254	159523	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
		134154022	159604	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3973940	159604	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134151581	159987	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3977241	159987	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		57528347	159991	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
		CHEMBL3977265	159991	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
		134152388	159997	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
		CHEMBL3977294	159997	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
		134151706	160133	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		CHEMBL3978455	160133	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
		134151524	160159	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3978661	160159	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134152209	160181	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3978864	160181	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134152547	160262	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3979606	160262	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		11421086	160345	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
		CHEMBL3980276	160345	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
		134157913	160410	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		CHEMBL3980873	160410	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		134156625	160430	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		CHEMBL3981072	160430	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
		134157438	160527	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3981843	160527	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134157625	160540	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3981960	160540	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
		59834193	160931	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
		CHEMBL3985477	160931	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
		134156443	161125	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
		CHEMBL3986906	161125	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
		56926176	75789	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL1923505	75789	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		56926266	75791	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
		CHEMBL1923508	75791	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
		134133634	150412	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3899825	150412	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		57722117	150462	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3900193	150462	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		57722068	150711	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
		CHEMBL3902231	150711	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
		134135595	150742	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3902597	150742	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		134139160	152987	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
		CHEMBL3920156	152987	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
		134140250	153024	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3920479	153024	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
		57951693	153055	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
		CHEMBL3920711	153055	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
		134140177	153148	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3921493	153148	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134139639	153417	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
		CHEMBL3923467	153417	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
		134140216	153422	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3923508	153422	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
		134141155	153506	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
		CHEMBL3924187	153506	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
		134137626	154261	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3930400	154261	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
		134148332	155060	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3936664	155060	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		57528213	155263	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
		CHEMBL3938163	155263	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
		134149424	155415	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3939431	155415	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
		57951672	156373	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		CHEMBL3946954	156373	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		134147008	156715	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		CHEMBL3949653	156715	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
		134155726	157797	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
		CHEMBL3958492	157797	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
		134155844	157867	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
		CHEMBL3959055	157867	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
		57528307	157906	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
		CHEMBL3959346	157906	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
		134156186	158129	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3961157	158129	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
		134150525	158343	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
		CHEMBL3963236	158343	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
		134149894	158613	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
		CHEMBL3965402	158613	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
		134150119	158826	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
		CHEMBL3967266	158826	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
		134150914	158859	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
		CHEMBL3967522	158859	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
		57722047	159646	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3974323	159646	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		57951687	159651	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
		CHEMBL3974356	159651	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
		57528291	159695	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
		CHEMBL3974776	159695	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
		134152485	159955	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
		CHEMBL3976941	159955	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
		134151873	159979	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
		CHEMBL3977166	159979	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
		76556607	160334	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
		CHEMBL3980176	160334	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
		134157812	160449	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		CHEMBL3981235	160449	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
		134156737	160478	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
		CHEMBL3981446	160478	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
		134156806	160873	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
		CHEMBL3984892	160873	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
		134157124	160985	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
		CHEMBL3985913	160985	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
		11706547	75821	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923619	75821	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		134138625	154809	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3934561	154809	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		44434011	154642	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL393321	154642	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
		70692601	82650	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048814	82650	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		127046957	146485	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798155	146485	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
		127046472	146472	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798056	146472	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		56926266	75791	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
		CHEMBL1923508	75791	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
		73352329	99040	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426669	99040	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		70692602	82651	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048815	82651	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
		162665974	189014	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4783347	189014	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		44396381	74305	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
		CHEMBL189625	74305	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
		44396377	73717	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
		CHEMBL186647	73717	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
		44396269	74130	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
		CHEMBL188586	74130	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
		56926895	75840	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923639	75840	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		56942244	131975	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645259	131975	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		162648546	186657	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4745666	186657	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
		58438460	118515	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287217	118515	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
		56926356	75794	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923512	75794	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		56926176	75789	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923505	75789	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		71453390	88618	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164500	88618	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		162663952	188931	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4782383	188931	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		118725963	123972	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		CHEMBL3394203	123972	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		44434112	175639	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		CHEMBL438154	175639	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		3174463	73542	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		CHEMBL185876	73542	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		56926464	75814	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
		CHEMBL1923612	75814	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
		118725960	123968	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
		CHEMBL3394199	123968	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
		162657547	187762	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4758721	187762	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		162658148	187927	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4760746	187927	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
		162662164	188189	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4763700	188189	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		127047362	146497	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798204	146497	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		3154000	131048	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
		CHEMBL363467	131048	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
		162651277	186975	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4749525	186975	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		3180629	74127	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		CHEMBL188582	74127	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		44434016	96968	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL238228	96968	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		72190452	99053	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426682	99053	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		118725964	123973	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		CHEMBL3394204	123973	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		70692600	82649	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048813	82649	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		70682036	82653	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048817	82653	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		70686293	82658	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048822	82658	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		58438460	118515	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
		CHEMBL3287217	118515	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
		162660604	187998	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4761319	187998	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		162671996	189610	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4791255	189610	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		25032438	122974	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
		CHEMBL3358450	122974	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
		11692516	75823	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923621	75823	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		67407161	99059	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426688	99059	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		67410074	118514	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287216	118514	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
		56926782	75832	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923631	75832	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		70696687	82648	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048812	82648	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		127046806	146711	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799604	146711	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		127048038	146750	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799862	146750	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		44434076	96552	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
		CHEMBL237717	96552	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
		56926463	75813	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923611	75813	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		11526696	78377	17	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923502	78377	17	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1963249	78377	17	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		72191051	99037	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426666	99037	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		58438460	118515	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287217	118515	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
		56926783	75833	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923632	75833	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		162658631	187862	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4759983	187862	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
		118725958	123967	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
		CHEMBL3394197	123967	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
		162659337	188095	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4762631	188095	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		73355325	99042	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426671	99042	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		70696688	82654	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048818	82654	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
		127048060	146639	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799222	146639	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
		56942388	146721	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799687	146721	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		162677361	190288	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4799766	190288	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		58438475	99048	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
		CHEMBL2426677	99048	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
		44434109	153059	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		CHEMBL392076	153059	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		134139080	154461	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		CHEMBL3931856	154461	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
		44434010	95548	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL236311	95548	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		127047655	146392	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3797531	146392	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		44340007	16086	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
		CHEMBL111026	16086	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
		56925344	75842	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923641	75842	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		44434083	96806	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL238155	96806	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
		44434050	152228	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL391428	152228	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
		44396306	74051	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
		CHEMBL188173	74051	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
		145948725	174276	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL4299615	174276	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		57345597	78045	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956988	78045	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		56942243	131974	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645258	131974	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
		162648837	186617	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4745116	186617	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		127048059	146344	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3797225	146344	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		11526745	75843	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923642	75843	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		57400003	78054	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956996	78054	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		155529391	178219	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4463042	178219	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		70690449	82646	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048810	82646	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		118725965	123974	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
		CHEMBL3394205	123974	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
		44434080	96686	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL237933	96686	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		162647450	186650	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4745548	186650	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
		71456910	88676	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164823	88676	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
		3154005	73547	5	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		CHEMBL185887	73547	5	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
		70696689	82657	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048821	82657	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		56926681	75826	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923624	75826	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		127047409	146409	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3797639	146409	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		56926785	75835	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923634	75835	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		70688404	82642	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
		CHEMBL2048807	82642	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
		44434009	174232	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL429799	174232	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		53248756	67955	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
		CHEMBL1765654	67955	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
		CHEMBL2170701	216140	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		10253999	130571	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		CHEMBL362303	130571	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		127048061	146514	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798337	146514	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
		162662593	188749	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4780100	188749	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
		44579909	193682	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		CHEMBL489819	193682	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		44434073	96375	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		CHEMBL237507	96375	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		70694649	82659	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2048823	82659	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		162659161	188170	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4763471	188170	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		162652815	187155	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4751674	187155	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL2170779	216145	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		44434008	153312	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL392268	153312	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		44434110	95287	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		CHEMBL235135	95287	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		44577060	194831	0	None	-69	8	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
		CHEMBL497746	194831	0	None	-69	8	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
		CHEMBL2170780	216146	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		71453404	88678	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164826	88678	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
		70692603	82652	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048816	82652	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
		56926360	75810	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923608	75810	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		72190451	99051	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL2426680	99051	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
		44579907	193827	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
		CHEMBL491044	193827	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
		73350846	99041	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426670	99041	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		44576247	221001	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
		CHEMBL506986	221001	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
		44576247	221001	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
		CHEMBL506986	221001	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
		44579880	193614	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
		CHEMBL489401	193614	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
		118725962	123971	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
		CHEMBL3394202	123971	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
		44396384	74182	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
		CHEMBL188839	74182	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
		44434074	161452	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		CHEMBL399625	161452	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
		70684155	82660	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		CHEMBL2048824	82660	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
		72191050	99038	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426667	99038	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		72190449	99047	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426676	99047	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		118725966	123975	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
		CHEMBL3394206	123975	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
		162675268	190137	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4797685	190137	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
		3153999	133609	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		CHEMBL365489	133609	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		71451551	88626	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164508	88626	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
		72190451	99051	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426680	99051	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		72190451	99051	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL2426680	99051	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
		9950632	95481	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
		CHEMBL236038	95481	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
		127046472	146472	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
		CHEMBL3798056	146472	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
		127045859	146477	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
		CHEMBL3798095	146477	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
		127045859	146477	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798095	146477	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		127047523	146841	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3800422	146841	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
		71456897	88625	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164507	88625	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		162653916	187324	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4753794	187324	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
		162643920	188559	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4777792	188559	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		155537651	179095	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4475293	179095	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		57391292	78053	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956995	78053	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
		57345598	78062	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957004	78062	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		53373577	99057	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426686	99057	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		57391294	78056	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956998	78056	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		155526063	177815	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4456830	177815	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		162663004	188828	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4781141	188828	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
		155557019	181366	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4556887	181366	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		71453489	216147	15	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
		CHEMBL2170781	216147	15	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
		67405379	99054	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426683	99054	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		25211977	193681	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
		CHEMBL489818	193681	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
		25098836	198237	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		CHEMBL519322	198237	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		127047525	146545	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798559	146545	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		162653309	187252	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4752936	187252	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		44579756	193602	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
		CHEMBL489370	193602	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
		162666964	189289	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4787023	189289	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL2170693	216132	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		44434121	96683	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
		CHEMBL237927	96683	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
		56926584	75822	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923620	75822	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		44434120	96682	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL237926	96682	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
		44434007	95350	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL235446	95350	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		11541143	75820	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923618	75820	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		24969520	75824	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923622	75824	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL2170694	216133	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		56926580	75816	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
		CHEMBL1923614	75816	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
		162653802	187310	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4753592	187310	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		73346226	99039	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426668	99039	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
		162674738	190166	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4797988	190166	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		56926177	75790	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923506	75790	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		56926581	75817	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
		CHEMBL1923615	75817	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
		71458747	88613	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
		CHEMBL2164494	88613	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
		23631116	10884	23	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
		3538	10884	23	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
		CHEMBL243001	10884	23	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
		127046956	146735	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799776	146735	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
		118725961	123969	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
		CHEMBL3394200	123969	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
		162663407	188809	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4780843	188809	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		56926462	75812	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923610	75812	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		70695747	79966	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
		CHEMBL2011816	79966	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
		67406334	118511	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
		CHEMBL3287213	118511	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
		57390496	75830	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
		CHEMBL1923628	75830	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
		71453489	216147	15	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		CHEMBL2170781	216147	15	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
		56926269	75793	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
		CHEMBL1923511	75793	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
		56926784	75834	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923633	75834	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		70688404	82642	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
		CHEMBL2048807	82642	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
		70688404	82642	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048807	82642	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
		44434123	152328	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
		CHEMBL391510	152328	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
		56926582	75818	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923616	75818	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		16114404	161676	24	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL400814	161676	24	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
		25190383	88684	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164831	88684	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		11683187	206711	44	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
		CHEMBL594828	206711	44	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
		70684154	82644	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048809	82644	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
		44434055	96080	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		CHEMBL236858	96080	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		56942385	131976	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645260	131976	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		56942535	146539	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798525	146539	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		24180592	103788	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
		CHEMBL266647	103788	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
		44434113	95424	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		CHEMBL235793	95424	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
		44434051	96190	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
		CHEMBL237058	96190	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
		118725954	123965	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
		CHEMBL3394193	123965	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
		24969603	75829	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
		CHEMBL1923627	75829	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
		57394882	78069	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957011	78069	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		9876514	15912	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
		CHEMBL109980	15912	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
		70682037	82656	20	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
		CHEMBL2048820	82656	20	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
		145948708	174275	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL4299606	174275	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
		67410074	118514	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287216	118514	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
		56926465	75815	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
		CHEMBL1923613	75815	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
		44434119	96681	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
		CHEMBL237925	96681	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
		70694648	82647	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048811	82647	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
		155561671	182443	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4581511	182443	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		56926894	75839	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		CHEMBL1923638	75839	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
		162672372	189865	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4794448	189865	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
		56925345	75844	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923643	75844	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		56926464	75814	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923612	75814	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
		56942387	146440	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3797857	146440	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL105462	215247	38	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm960054c
		56926680	75825	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923623	75825	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		162649014	186720	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4746362	186720	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
		162666112	189093	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4784240	189093	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
		162676229	190083	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4797064	190083	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
		58438475	99048	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426677	99048	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		58438475	99048	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
		CHEMBL2426677	99048	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
		56926461	75811	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923609	75811	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		118725956	123966	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
		CHEMBL3394195	123966	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
		155551597	180728	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		CHEMBL4541252	180728	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
		57394797	78060	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1957002	78060	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		162649450	186833	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4747770	186833	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
		58438464	9839	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		9060	9839	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		CHEMBL3287218	9839	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		DB14870	9839	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		58438464	9839	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		9060	9839	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		CHEMBL3287218	9839	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		DB14870	9839	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
		67406334	118511	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
		CHEMBL3287213	118511	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
		57401798	78046	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		CHEMBL1956989	78046	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
		58438475	99048	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
		CHEMBL2426677	99048	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
		11541319	75845	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
		CHEMBL1923644	75845	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
		162659375	188130	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4763077	188130	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
		127046807	146718	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799671	146718	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		127047654	146755	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799883	146755	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		121879	9015	24	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
		5868	9015	24	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
		CHEMBL308716	9015	24	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
		162665952	189158	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4785149	189158	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
		134139753	152814	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		CHEMBL3918783	152814	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
		162663868	188767	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4780408	188767	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		56926268	75792	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
		CHEMBL1923510	75792	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
		56926175	75788	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923504	75788	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		23635235	173280	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
		CHEMBL427860	173280	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
		70686292	82655	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048819	82655	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		90644554	118513	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL3287215	118513	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
		70682037	82656	20	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		CHEMBL2048820	82656	20	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
		11664206	75828	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923626	75828	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		216208	16499	33	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
		CHEMBL113313	16499	33	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
		56926682	75827	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		CHEMBL1923625	75827	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
		67408128	99055	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426684	99055	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		24180646	154961	0	None	-1023	8	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
		CHEMBL393576	154961	0	None	-1023	8	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
		57390496	75830	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
		CHEMBL1923628	75830	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
		CHEMBL501261	220914	23	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
		56926892	75837	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923636	75837	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		44434012	95849	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL236513	95849	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		127046473	146558	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3798645	146558	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
		56942099	131972	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645256	131972	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		66601728	88616	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		CHEMBL2164499	88616	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
		162657465	187820	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4759418	187820	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
		56926891	75836	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		CHEMBL1923635	75836	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
		44434015	95266	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		CHEMBL235011	95266	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
		67407808	99058	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL2426687	99058	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
		56926173	75787	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		CHEMBL1923501	75787	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
		3153998	74295	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		CHEMBL189561	74295	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
		56926893	75838	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
		CHEMBL1923637	75838	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
		66788278	131970	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3645254	131970	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
		127045858	146640	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
		CHEMBL3799225	146640	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
		162677268	190352	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4800459	190352	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
		58438487	99056	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426685	99056	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
		67407808	99058	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426687	99058	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		67407808	99058	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
		CHEMBL2426687	99058	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
		67406727	123970	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		CHEMBL3394201	123970	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
		162656896	187639	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4757313	187639	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
		44579823	190860	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		CHEMBL482420	190860	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
		44396320	73591	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
		CHEMBL186045	73591	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
		162674996	190168	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		CHEMBL4798018	190168	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
		44434111	153061	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		CHEMBL392077	153061	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
		9745	9231	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
		9804938	9231	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
		CHEMBL278623	9231	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
		DB13074	9231	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
		9745	9231	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
		9804938	9231	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
		CHEMBL278623	9231	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
		DB13074	9231	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
		1102	8103	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
		1093	8575	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
		1093	8575	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		4345065	8575	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
		4345065	8575	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		1100	8389	45	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
		6918297	8389	45	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
		CHEMBL108335	8389	45	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
		1099	8568	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
		1099	8568	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
		1092	9932	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		134715446	9932	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		2232	9932	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		6918245	9932	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		CHEMBL106593	9932	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
		58438464	9839	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		9060	9839	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		CHEMBL3287218	9839	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		DB14870	9839	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		58438464	9839	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		9060	9839	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		CHEMBL3287218	9839	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		DB14870	9839	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		58438464	9839	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		9060	9839	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		CHEMBL3287218	9839	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		DB14870	9839	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
		12413	9844	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
		164946906	9844	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
		12413	9844	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
		164946906	9844	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
		23631116	10884	23	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
		3538	10884	23	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
		CHEMBL243001	10884	23	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
		1098	8173	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
		1098	8173	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14763915
		1101	7444	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15339248
		10740	8719	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
		146170991	8719	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
		1092	9932	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		134715446	9932	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		2232	9932	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		6918245	9932	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		CHEMBL106593	9932	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		178024	8752	33	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
		5867	8752	33	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
		CHEMBL13817	8752	33	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
		1099	8568	0	None	-	1	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
		1093	8575	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
		4345065	8575	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793

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