Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 10.2 | 10.2 | -54 | 7 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | ||||
| 92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 10.2 | 10.2 | -54 | 7 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | ||||
| CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 10.2 | 10.2 | -54 | 7 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | ||||
| 1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 10.2 | 10.2 | -54 | 7 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | ||||
| 92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 10.2 | 10.2 | -54 | 7 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | ||||
| CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 10.2 | 10.2 | -54 | 7 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | ||||
| CHEMBL413212 | 215515 | None | 0 | Human | Functional | pEC50 | = | 10.2 | 10.2 | -3 | 4 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm00018a005 | ||||
| 1324 | 302 | None | 19 | Rat | Functional | pEC50 | = | 10 | 10.0 | -1 | 8 | Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
ChEMBL | None | None | None | None | 10.1021/jm030452x | ||||
| 16154396 | 302 | None | 19 | Rat | Functional | pEC50 | = | 10 | 10.0 | -1 | 8 | Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
ChEMBL | None | None | None | None | 10.1021/jm030452x | ||||
| 16197727 | 302 | None | 19 | Rat | Functional | pEC50 | = | 10 | 10.0 | -1 | 8 | Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
ChEMBL | None | None | None | None | 10.1021/jm030452x | ||||
| 16197727.0 | 302 | None | 19 | Rat | Functional | pEC50 | = | 10 | 10.0 | -1 | 8 | Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
ChEMBL | None | None | None | None | 10.1021/jm030452x | ||||
| 44285019 | 302 | None | 19 | Rat | Functional | pEC50 | = | 10 | 10.0 | -1 | 8 | Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
ChEMBL | None | None | None | None | 10.1021/jm030452x | ||||
| 57514683 | 302 | None | 19 | Rat | Functional | pEC50 | = | 10 | 10.0 | -1 | 8 | Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
ChEMBL | None | None | None | None | 10.1021/jm030452x | ||||
| 91898441 | 302 | None | 19 | Rat | Functional | pEC50 | = | 10 | 10.0 | -1 | 8 | Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
ChEMBL | None | None | None | None | 10.1021/jm030452x | ||||
| CHEMBL441738 | 302 | None | 19 | Rat | Functional | pEC50 | = | 10 | 10.0 | -1 | 8 | Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
ChEMBL | None | None | None | None | 10.1021/jm030452x | ||||
| DB04931 | 302 | None | 19 | Rat | Functional | pEC50 | = | 10 | 10.0 | -1 | 8 | Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R) |
ChEMBL | None | None | None | None | 10.1021/jm030452x | ||||
| 168284256 | 191055 | None | 0 | Human | Functional | pEC50 | = | 10.0 | 10.0 | -2 | 4 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | 2383 | 48 | 33 | 31 | -4.2 | CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | ||
| CHEMBL5185775 | 191055 | None | 0 | Human | Functional | pEC50 | = | 10.0 | 10.0 | -2 | 4 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | 2383 | 48 | 33 | 31 | -4.2 | CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | ||
| 168281421 | 191066 | None | 0 | Human | Functional | pEC50 | = | 10.0 | 10.0 | 10 | 3 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | 2430 | 43 | 34 | 31 | -3.4 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | ||
| CHEMBL5185945 | 191066 | None | 0 | Human | Functional | pEC50 | = | 10.0 | 10.0 | 10 | 3 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | 2430 | 43 | 34 | 31 | -3.4 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | ||
| 1324 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -15 | 8 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | None | 10.1021/jm00018a005 | ||||
| 16154396 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -15 | 8 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | None | 10.1021/jm00018a005 | ||||
| 16197727 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -15 | 8 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | None | 10.1021/jm00018a005 | ||||
| 16197727.0 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -15 | 8 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | None | 10.1021/jm00018a005 | ||||
| 44285019 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -15 | 8 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | None | 10.1021/jm00018a005 | ||||
| 57514683 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -15 | 8 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | None | 10.1021/jm00018a005 | ||||
| 91898441 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -15 | 8 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | None | 10.1021/jm00018a005 | ||||
| CHEMBL441738 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -15 | 8 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | None | 10.1021/jm00018a005 | ||||
| DB04931 | 302 | None | 19 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -15 | 8 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | None | 10.1021/jm00018a005 | ||||
| 11993702 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | ||||
| 11993702.0 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | ||||
| 5416 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | ||||
| 9272 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | ||||
| CHEMBL3301624 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | ||||
| DB11700 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.2c00793 | ||||
| 11993702 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | ||||
| 11993702.0 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | ||||
| 5416 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | ||||
| 9272 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | ||||
| CHEMBL3301624 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | ||||
| DB11700 | 3593 | None | 20 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 1 | 5 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.1c00095 | ||||
| 168271934 | 190194 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | -1 | 4 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | 2229 | 37 | 32 | 26 | -3.7 | C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O | 10.1021/acs.jmedchem.2c00793 | ||
| CHEMBL5172738 | 190194 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | -1 | 4 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | 2229 | 37 | 32 | 26 | -3.7 | C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O | 10.1021/acs.jmedchem.2c00793 | ||
| 168289404 | 191421 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -4 | 4 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | 2134 | 33 | 32 | 28 | -5.0 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | ||
| CHEMBL5191309 | 191421 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -4 | 4 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | 2134 | 33 | 32 | 28 | -5.0 | CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | ||
| CHEMBL428615 | 215921 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -10 | 5 | Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor |
ChEMBL | None | None | None | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O | 10.1021/jm00018a005 | ||||
| 1323 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -54 | 7 | Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00170 | ||||
| 92432 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -54 | 7 | Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00170 | ||||
| CHEMBL430239 | 2688 | None | 38 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -54 | 7 | Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00170 | ||||
| 168284733 | 191733 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | 1 | 4 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay |
ChEMBL | 2054 | 33 | 32 | 24 | -4.1 | CCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.2c00793 | ||
Showing 1 to 50 of 1,128 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 1971 | 2866 | None | 32 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| 2404 | 2866 | None | 32 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| 4543 | 2866 | None | 32 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| 4543.0 | 2866 | None | 32 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL445 | 2866 | None | 32 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| DB00540 | 2866 | None | 32 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| 216416 | 111644 | None | 40 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 413 | 6 | 1 | 3 | 5.7 | Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL328190 | 111644 | None | 40 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 413 | 6 | 1 | 3 | 5.7 | Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 | 10.1038/s41467-023-40064-9 | ||
| 71496458 | 115628 | None | 61 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 499 | 10 | 2 | 8 | 4.5 | C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL3353410 | 115628 | None | 61 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 499 | 10 | 2 | 8 | 4.5 | C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C | 10.1038/s41467-023-40064-9 | ||
| 135409453 | 3773 | None | 26 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 19 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | ||
| 226 | 3773 | None | 26 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 19 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | ||
| CHEMBL76370 | 3773 | None | 26 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 19 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | ||
| 214 | 3860 | None | 43 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| 2740 | 3860 | None | 43 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| 5566 | 3860 | None | 43 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| 5566.0 | 3860 | None | 43 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| 66064 | 3860 | None | 43 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| CHEMBL422 | 3860 | None | 43 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| DB00831 | 3860 | None | 43 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 29 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| 2435 | 3590 | None | 59 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 48 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1038/s41467-023-40064-9 | ||
| 60149 | 3590 | None | 59 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 48 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1038/s41467-023-40064-9 | ||
| 98 | 3590 | None | 59 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 48 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1038/s41467-023-40064-9 | ||
| CHEMBL12713 | 3590 | None | 59 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 48 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1038/s41467-023-40064-9 | ||
| DB06144 | 3590 | None | 59 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 48 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1038/s41467-023-40064-9 | ||
| 25181577 | 78248 | None | 44 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL2105695 | 78248 | None | 44 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | ||
| 4046 | 2483 | None | 21 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 2 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 378 | 2 | 2 | 3 | 4.4 | OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 | 10.1038/s41467-023-40064-9 | ||
| 4252 | 2483 | None | 21 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 2 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 378 | 2 | 2 | 3 | 4.4 | OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL416956 | 2483 | None | 21 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 2 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 378 | 2 | 2 | 3 | 4.4 | OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 | 10.1038/s41467-023-40064-9 | ||
| DB00358 | 2483 | None | 21 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 2 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 378 | 2 | 2 | 3 | 4.4 | OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 | 10.1038/s41467-023-40064-9 | ||
| 176 | 398 | None | 47 | Human | Binding | pAC50 | = | 4.9 | 4.9 | -6 | 31 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | 10.1038/s41467-023-40064-9 | ||
| 2157 | 398 | None | 47 | Human | Binding | pAC50 | = | 4.9 | 4.9 | -6 | 31 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | 10.1038/s41467-023-40064-9 | ||
| 2157.0 | 398 | None | 47 | Human | Binding | pAC50 | = | 4.9 | 4.9 | -6 | 31 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | 10.1038/s41467-023-40064-9 | ||
| 2566 | 398 | None | 47 | Human | Binding | pAC50 | = | 4.9 | 4.9 | -6 | 31 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL633 | 398 | None | 47 | Human | Binding | pAC50 | = | 4.9 | 4.9 | -6 | 31 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | 10.1038/s41467-023-40064-9 | ||
| DB01118 | 398 | None | 47 | Human | Binding | pAC50 | = | 4.9 | 4.9 | -6 | 31 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | 10.1038/s41467-023-40064-9 | ||
| 2351 | 4301 | None | 35 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 366 | 10 | 0 | 3 | 4.8 | CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1008 | 4301 | None | 35 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 366 | 10 | 0 | 3 | 4.8 | CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1257078 | 4301 | None | 35 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 366 | 10 | 0 | 3 | 4.8 | CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 | 10.1038/s41467-023-40064-9 | ||
| 1046 | 205109 | None | 68 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 123 | 1 | 1 | 3 | -0.4 | NC(=O)c1cnccn1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL614 | 205109 | None | 68 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 123 | 1 | 1 | 3 | -0.4 | NC(=O)c1cnccn1 | 10.1038/s41467-023-40064-9 | ||
| 156419 | 938 | None | 48 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 15 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| 156419.0 | 938 | None | 48 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 15 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| 3308 | 938 | None | 48 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 15 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| 647 | 938 | None | 48 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 15 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1201284 | 938 | None | 48 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 15 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| DB01012 | 938 | None | 48 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 15 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.1038/s41467-023-40064-9 | ||
| 4212 | 201135 | None | 57 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 4 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 444 | 12 | 8 | 10 | -0.1 | O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1417019 | 201135 | None | 57 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 4 | Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 444 | 12 | 8 | 10 | -0.1 | O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21 | 10.1038/s41467-023-40064-9 | ||
Showing 1 to 50 of 2,472 entries