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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	CHEMBL2165920	211792	None	25	Human	Functional	pEC50	=	8.8	8.8	-21	2	Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation countingAgonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm300535s
	CHEMBL5085013	217432	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	4	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		CN1C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCCCNC(=O)C[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@@H]1Cc1ccccc1	10.1021/acs.jmedchem.1c00694
	CHEMBL5085013	217432	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	4	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		CN1C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCCCNC(=O)C[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@@H]1Cc1ccccc1	10.1021/acs.jmedchem.1c00694
	44542330	200428	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 daysAgonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days	ChEMBL	312	3	3	3	3.3	N=C(N)N/N=C/c1ccc(-c2ccccc2C(F)(F)F)s1	10.1021/jm9011998
	CHEMBL573518	200428	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 daysAgonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days	ChEMBL	312	3	3	3	3.3	N=C(N)N/N=C/c1ccc(-c2ccccc2C(F)(F)F)s1	10.1021/jm9011998
	44542328	200573	None	0	Human	Functional	pEC50	=	5.9	5.9	2	2	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assay	ChEMBL	296	3	3	3	2.8	N=C(N)N/N=C/c1ccc(-c2ccccc2C(F)(F)F)o1	10.1021/acs.jmedchem.0c00643
	CHEMBL4785076	200573	None	0	Human	Functional	pEC50	=	5.9	5.9	2	2	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assay	ChEMBL	296	3	3	3	2.8	N=C(N)N/N=C/c1ccc(-c2ccccc2C(F)(F)F)o1	10.1021/acs.jmedchem.0c00643
	CHEMBL574565	200573	None	0	Human	Functional	pEC50	=	5.9	5.9	2	2	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assay	ChEMBL	296	3	3	3	2.8	N=C(N)N/N=C/c1ccc(-c2ccccc2C(F)(F)F)o1	10.1021/acs.jmedchem.0c00643
	123797	2791	None	21	Human	Functional	pEC50	=	6.8	6.8	-5	4	Agonist activity at NPFF1 receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at NPFF1 receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL		None	None	None		None	10.1016/j.bmc.2019.01.003
	1479	2791	None	21	Human	Functional	pEC50	=	6.8	6.8	-5	4	Agonist activity at NPFF1 receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at NPFF1 receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL		None	None	None		None	10.1016/j.bmc.2019.01.003
	CHEMBL429731	2791	None	21	Human	Functional	pEC50	=	6.8	6.8	-5	4	Agonist activity at NPFF1 receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 minsAgonist activity at NPFF1 receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins	ChEMBL		None	None	None		None	10.1016/j.bmc.2019.01.003
	44542326	200354	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 daysAgonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days	ChEMBL	270	4	3	3	2.9	CC(C)c1ccccc1-c1ccc(/C=N/NC(=N)N)o1	10.1021/jm9011998
	CHEMBL572825	200354	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 daysAgonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactosidase levels after 5 days	ChEMBL	270	4	3	3	2.9	CC(C)c1ccccc1-c1ccc(/C=N/NC(=N)N)o1	10.1021/jm9011998
	44542176	200404	None	7	Human	Functional	pEC50	=	4.8	4.8	-1	2	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assay	ChEMBL	318	2	3	2	2.0	N=C(N)N/N=C/c1ccc(Br)c(Br)c1	10.1021/acs.jmedchem.0c00643
	CHEMBL4784123	200404	None	7	Human	Functional	pEC50	=	4.8	4.8	-1	2	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assay	ChEMBL	318	2	3	2	2.0	N=C(N)N/N=C/c1ccc(Br)c(Br)c1	10.1021/acs.jmedchem.0c00643
	CHEMBL573297	200404	None	7	Human	Functional	pEC50	=	4.8	4.8	-1	2	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293T cells harboring EP2 incubated for 15 mins by cAMP assay	ChEMBL	318	2	3	2	2.0	N=C(N)N/N=C/c1ccc(Br)c(Br)c1	10.1021/acs.jmedchem.0c00643
	CHEMBL2165920	211792	None	25	Human	Functional	pEC50	=	7.8	7.8	-21	2	Agonist activity at human NPFF1 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation countingAgonist activity at human NPFF1 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm300535s
	162670510	183084	None	0	Human	Functional	pEC50	=	7.8	7.8	12	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	CHEMBL4793250	183084	None	0	Human	Functional	pEC50	=	7.8	7.8	12	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	162670510	183084	None	0	Human	Functional	pEC50	=	7.8	7.8	12	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	CHEMBL4793250	183084	None	0	Human	Functional	pEC50	=	7.8	7.8	12	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	CHEMBL5091560	217804	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	5	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		CN1C(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCNC(=O)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@@H]1Cc1ccccc1	10.1021/acs.jmedchem.1c00694
	CHEMBL5091560	217804	None	0	Human	Functional	pEC50	=	6.7	6.7	-4	5	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		CN1C(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCNC(=O)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@@H]1Cc1ccccc1	10.1021/acs.jmedchem.1c00694
	162644880	179554	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	CHEMBL4740521	179554	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	162644880	179554	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	CHEMBL4740521	179554	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	118724977	116561	None	0	Human	Functional	pEC50	=	4.7	4.7	-	1	Antagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation after 10 mins by liquid scintillation counting analysis relative to controlAntagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation after 10 mins by liquid scintillation counting analysis relative to control	ChEMBL	394	8	5	4	1.7	N=C(N)NCC(=O)NCC1(Nc2ccccc2)CCN(Cc2ccccc2)CC1	10.1021/jm500989n
	CHEMBL3361416	116561	None	0	Human	Functional	pEC50	=	4.7	4.7	-	1	Antagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation after 10 mins by liquid scintillation counting analysis relative to controlAntagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation after 10 mins by liquid scintillation counting analysis relative to control	ChEMBL	394	8	5	4	1.7	N=C(N)NCC(=O)NCC1(Nc2ccccc2)CCN(Cc2ccccc2)CC1	10.1021/jm500989n
	CHEMBL5090298	217746	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	5	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		CN1C(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NCCCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@@H]1Cc1ccccc1	10.1021/acs.jmedchem.1c00694
	118735685	118951	None	0	Human	Functional	pEC50	=	6.7	6.7	-141	2	Agonist activity at human NPFF1R expressed in CHO cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins by luminescence based assayAgonist activity at human NPFF1R expressed in CHO cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins by luminescence based assay	ChEMBL	1765	61	21	21	3.0	CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1cn([C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)nn1)C(=O)O	10.1021/jm5019675
	CHEMBL3422516	118951	None	0	Human	Functional	pEC50	=	6.7	6.7	-141	2	Agonist activity at human NPFF1R expressed in CHO cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins by luminescence based assayAgonist activity at human NPFF1R expressed in CHO cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins by luminescence based assay	ChEMBL	1765	61	21	21	3.0	CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1cn([C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)nn1)C(=O)O	10.1021/jm5019675
	CHEMBL5090298	217746	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	5	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		CN1C(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NCCCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@@H]1Cc1ccccc1	10.1021/acs.jmedchem.1c00694
	44542178	201217	None	6	Human	Functional	pEC50	=	5.6	5.6	-2	2	Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation countingAgonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	ChEMBL	264	2	3	2	2.2	N=C(N)N/N=C/c1ccc(Cl)c(C(F)(F)F)c1	10.1021/jm300535s
	CHEMBL4794542	201217	None	6	Human	Functional	pEC50	=	5.6	5.6	-2	2	Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation countingAgonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	ChEMBL	264	2	3	2	2.2	N=C(N)N/N=C/c1ccc(Cl)c(C(F)(F)F)c1	10.1021/jm300535s
	CHEMBL583068	201217	None	6	Human	Functional	pEC50	=	5.6	5.6	-2	2	Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation countingAgonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	ChEMBL	264	2	3	2	2.2	N=C(N)N/N=C/c1ccc(Cl)c(C(F)(F)F)c1	10.1021/jm300535s
	162649206	180089	None	0	Human	Functional	pEC50	=	7.6	7.6	7	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	CHEMBL4746919	180089	None	0	Human	Functional	pEC50	=	7.6	7.6	7	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	162649206	180089	None	0	Human	Functional	pEC50	=	7.6	7.6	7	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	CHEMBL4746919	180089	None	0	Human	Functional	pEC50	=	7.6	7.6	7	5	Agonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assayAgonist activity at NPFFR1 (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by competition PKA binding assay	ChEMBL	1118	31	16	15	-3.4	N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c01367
	101882820	116578	None	0	Human	Functional	pEC50	=	5.6	5.6	-4	2	Antagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation after 10 mins by liquid scintillation counting analysis relative to controlAntagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation after 10 mins by liquid scintillation counting analysis relative to control	ChEMBL	443	8	4	3	3.3	N=C(N)NCC(=O)NCC1(Cc2cccc3ccccc23)CCN(Cc2ccccc2)CC1	10.1021/jm500989n
	CHEMBL3361433	116578	None	0	Human	Functional	pEC50	=	5.6	5.6	-4	2	Antagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation after 10 mins by liquid scintillation counting analysis relative to controlAntagonist activity at human NPFF1 receptor expressed in CHO cells assessed as reversal of NPVF-induced inhibition of intracellular cAMP accumulation after 10 mins by liquid scintillation counting analysis relative to control	ChEMBL	443	8	4	3	3.3	N=C(N)NCC(=O)NCC1(Cc2cccc3ccccc23)CCN(Cc2ccccc2)CC1	10.1021/jm500989n
	123797	2791	None	21	Human	Functional	pEC50	=	6.6	6.6	-5	4	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00694
	1479	2791	None	21	Human	Functional	pEC50	=	6.6	6.6	-5	4	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00694
	CHEMBL429731	2791	None	21	Human	Functional	pEC50	=	6.6	6.6	-5	4	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00694
	123797	2791	None	21	Human	Functional	pEC50	=	6.6	6.6	-5	4	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00694
	1479	2791	None	21	Human	Functional	pEC50	=	6.6	6.6	-5	4	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00694
	CHEMBL429731	2791	None	21	Human	Functional	pEC50	=	6.6	6.6	-5	4	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00694
	CHEMBL5086601	217528	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	5	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		CN1C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCCCNC(=O)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@@H]1Cc1ccccc1	10.1021/acs.jmedchem.1c00694
	CHEMBL5086601	217528	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	5	Agonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assayAgonist activity at NPFF1R (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins in presence of 3-isobutyl-1-methylxanthine followed by forskolin and compound addition by competitive PKA binding assay	ChEMBL		None	None	None		CN1C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCCCNC(=O)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@@H]1Cc1ccccc1	10.1021/acs.jmedchem.1c00694

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	155461914	182927	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assayAgonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assay	ChEMBL	1014	25	10	10	2.5	Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCN2CCC(Cc3ccccc3)CC2)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1=O	10.1021/acs.jmedchem.0c00643
	CHEMBL4790994	182927	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assayAgonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assay	ChEMBL	1014	25	10	10	2.5	Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCN2CCC(Cc3ccccc3)CC2)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1=O	10.1021/acs.jmedchem.0c00643
	44542328	200573	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assayAgonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assay	ChEMBL	296	3	3	3	2.8	N=C(N)N/N=C/c1ccc(-c2ccccc2C(F)(F)F)o1	10.1021/acs.jmedchem.0c00643
	CHEMBL4785076	200573	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assayAgonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assay	ChEMBL	296	3	3	3	2.8	N=C(N)N/N=C/c1ccc(-c2ccccc2C(F)(F)F)o1	10.1021/acs.jmedchem.0c00643
	CHEMBL574565	200573	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assayAgonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assay	ChEMBL	296	3	3	3	2.8	N=C(N)N/N=C/c1ccc(-c2ccccc2C(F)(F)F)o1	10.1021/acs.jmedchem.0c00643
	44542178	201217	None	6	Human	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assayAgonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assay	ChEMBL	264	2	3	2	2.2	N=C(N)N/N=C/c1ccc(Cl)c(C(F)(F)F)c1	10.1021/acs.jmedchem.0c00643
	CHEMBL4794542	201217	None	6	Human	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assayAgonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assay	ChEMBL	264	2	3	2	2.2	N=C(N)N/N=C/c1ccc(Cl)c(C(F)(F)F)c1	10.1021/acs.jmedchem.0c00643
	CHEMBL583068	201217	None	6	Human	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assayAgonist activity at NPFFR1 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assay	ChEMBL	264	2	3	2	2.2	N=C(N)N/N=C/c1ccc(Cl)c(C(F)(F)F)c1	10.1021/acs.jmedchem.0c00643
	CHEMBL3360830	214035	None	0	Human	Binding	pEC50	=	7.2	7.2	-6	2	Agonist activity at human NPFF1 receptorAgonist activity at human NPFF1 receptor	ChEMBL		None	None	None		CC(C)C[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](N)Cc1ccc(O)cc1	10.1021/jm500989n
	162676940	183434	None	0	Human	Binding	pEC50	=	7.1	7.1	-	0	Agonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assayAgonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assay	ChEMBL	897	23	13	10	-1.0	Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1=O	10.1021/acs.jmedchem.0c00643
	CHEMBL4797394	183434	None	0	Human	Binding	pEC50	=	7.1	7.1	-	0	Agonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assayAgonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assay	ChEMBL	897	23	13	10	-1.0	Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1=O	10.1021/acs.jmedchem.0c00643
	102270377	182310	None	0	Rat	Binding	pIC50	=	10	10.0	-	1	Displacement of [125I](Tyr)NPF from rat NPFFR1 expressed in rat PC12 cells incubated for 1 hrDisplacement of [125I](Tyr)NPF from rat NPFFR1 expressed in rat PC12 cells incubated for 1 hr	ChEMBL	576	12	7	6	-0.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.0c00643
	CHEMBL4782986	182310	None	0	Rat	Binding	pIC50	=	10	10.0	-	1	Displacement of [125I](Tyr)NPF from rat NPFFR1 expressed in rat PC12 cells incubated for 1 hrDisplacement of [125I](Tyr)NPF from rat NPFFR1 expressed in rat PC12 cells incubated for 1 hr	ChEMBL	576	12	7	6	-0.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.0c00643
	CHEMBL1672379	211289	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsDisplacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs	ChEMBL		None	None	None		None	10.1021/ml1002053
	16735569	142421	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsDisplacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs	ChEMBL	798	21	10	7	1.3	CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml1002053
	CHEMBL388586	142421	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsDisplacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs	ChEMBL	798	21	10	7	1.3	CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml1002053
	1281	2187	None	32	Human	Binding	pIC50	=	8.3	8.3	-	2	Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsDisplacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs	ChEMBL		None	None	None		None	10.1021/ml1002053
	1283	2187	None	32	Human	Binding	pIC50	=	8.3	8.3	-	2	Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsDisplacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs	ChEMBL		None	None	None		None	10.1021/ml1002053
	25240297	2187	None	32	Human	Binding	pIC50	=	8.3	8.3	-	2	Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsDisplacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs	ChEMBL		None	None	None		None	10.1021/ml1002053
	CHEMBL376756	2187	None	32	Human	Binding	pIC50	=	8.3	8.3	-	2	Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsDisplacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs	ChEMBL		None	None	None		None	10.1021/ml1002053
	25138123	179353	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsDisplacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs	ChEMBL	781	21	9	6	2.9	CC(C)C[C@H](/C=C/CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml1002053
	CHEMBL472833	179353	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsDisplacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs	ChEMBL	781	21	9	6	2.9	CC(C)C[C@H](/C=C/CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml1002053
	123797	2791	None	21	Human	Binding	pKd	=	9.0	9.0	-1	4	Binding affinity to human NPFFR1 expressed in green monkey COS-7 cell membranes by [125I]-1DMeNPFF radioligand based saturation binding assayBinding affinity to human NPFFR1 expressed in green monkey COS-7 cell membranes by [125I]-1DMeNPFF radioligand based saturation binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c00643
	1479	2791	None	21	Human	Binding	pKd	=	9.0	9.0	-1	4	Binding affinity to human NPFFR1 expressed in green monkey COS-7 cell membranes by [125I]-1DMeNPFF radioligand based saturation binding assayBinding affinity to human NPFFR1 expressed in green monkey COS-7 cell membranes by [125I]-1DMeNPFF radioligand based saturation binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c00643
	CHEMBL429731	2791	None	21	Human	Binding	pKd	=	9.0	9.0	-1	4	Binding affinity to human NPFFR1 expressed in green monkey COS-7 cell membranes by [125I]-1DMeNPFF radioligand based saturation binding assayBinding affinity to human NPFFR1 expressed in green monkey COS-7 cell membranes by [125I]-1DMeNPFF radioligand based saturation binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c00643
	CHEMBL2165920	211792	None	25	Human	Binding	pKi	=	11	11.0	10	2	Displacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting methodDisplacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting method	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.1c00256
	123797	2791	None	21	Human	Binding	pKi	=	10.2	10.2	-1	4	Displacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting methodDisplacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00256
	1479	2791	None	21	Human	Binding	pKi	=	10.2	10.2	-1	4	Displacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting methodDisplacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00256
	CHEMBL429731	2791	None	21	Human	Binding	pKi	=	10.2	10.2	-1	4	Displacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting methodDisplacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00256
	71463277	84198	None	0	Human	Binding	pKi	=	9.5	9.5	1819	2	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting	ChEMBL	500	12	6	4	1.9	N=C(N)NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmcl.2012.10.049
	CHEMBL2208337	84198	None	0	Human	Binding	pKi	=	9.5	9.5	1819	2	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting	ChEMBL	500	12	6	4	1.9	N=C(N)NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmcl.2012.10.049
	CHEMBL2165920	211792	None	25	Human	Binding	pKi	=	9.2	9.2	10	2	Displacement of [125I]YVP from human NPFFR1 expressed in CHO cells by gamma-counter methodDisplacement of [125I]YVP from human NPFFR1 expressed in CHO cells by gamma-counter method	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c00643
	CHEMBL5093771	217934	None	0	Human	Binding	pKi	=	9.1	9.1	4	2	Displacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting methodDisplacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting method	ChEMBL		None	None	None		N=C(N)NCCC[C@@H](NC(=O)C=C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1Br)C(N)=O	10.1021/acs.jmedchem.1c00256
	71456101	84182	None	0	Human	Binding	pKi	=	9.1	9.1	60	2	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting	ChEMBL	450	12	6	4	0.7	N=C(N)NCCC[C@@H](NC(=O)/C=C/c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmcl.2012.10.049
	CHEMBL2208303	84182	None	0	Human	Binding	pKi	=	9.1	9.1	60	2	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting	ChEMBL	450	12	6	4	0.7	N=C(N)NCCC[C@@H](NC(=O)/C=C/c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmcl.2012.10.049
	71463272	84181	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting	ChEMBL	573	13	6	6	2.6	N=C(N)NCCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc21)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmcl.2012.10.049
	CHEMBL2208301	84181	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting	ChEMBL	573	13	6	6	2.6	N=C(N)NCCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc21)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmcl.2012.10.049
	162673140	183129	None	0	Human	Binding	pKi	=	9	9.0	37	2	Displacement of [3H]-FFRF-NH2 from human NPFFR1 expressed in CHO cell membrane by Topcount scintillation counting methodDisplacement of [3H]-FFRF-NH2 from human NPFFR1 expressed in CHO cell membrane by Topcount scintillation counting method	ChEMBL	241	1	2	3	2.3	NC1=NC=C(c2ccc(Cl)c(Cl)c2)CN1	10.1021/acs.jmedchem.0c00643
	CHEMBL4793841	183129	None	0	Human	Binding	pKi	=	9	9.0	37	2	Displacement of [3H]-FFRF-NH2 from human NPFFR1 expressed in CHO cell membrane by Topcount scintillation counting methodDisplacement of [3H]-FFRF-NH2 from human NPFFR1 expressed in CHO cell membrane by Topcount scintillation counting method	ChEMBL	241	1	2	3	2.3	NC1=NC=C(c2ccc(Cl)c(Cl)c2)CN1	10.1021/acs.jmedchem.0c00643
	CHEMBL2165920	211792	None	25	Human	Binding	pKi	=	8.9	8.9	10	2	Displacement of [125I]YVP from human NPFFR1 expressed in HEK293 cells by radioligand binding assayDisplacement of [125I]YVP from human NPFFR1 expressed in HEK293 cells by radioligand binding assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c00643
	CHEMBL414263	215578	None	4	Rat	Binding	pKi	=	8.8	8.8	-2	4	Displacement of [125I]-1DMeNPFF from rat NPFFR1 expressed in HEK293 cells incubated for 2 hrs by scintillation counting methodDisplacement of [125I]-1DMeNPFF from rat NPFFR1 expressed in HEK293 cells incubated for 2 hrs by scintillation counting method	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.0c00643
	CHEMBL5082175	217279	None	0	Human	Binding	pKi	=	8	8.0	8	2	Displacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting methodDisplacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting method	ChEMBL		None	None	None		N=C(N)NCCC[C@@H](NC(=O)C=C(c1ccccc1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1Br)C(N)=O	10.1021/acs.jmedchem.1c00256
	71457909	84190	None	0	Human	Binding	pKi	=	8	8.0	-2	2	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting	ChEMBL	514	13	6	4	1.8	N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmcl.2012.10.049
	CHEMBL2208319	84190	None	0	Human	Binding	pKi	=	8	8.0	-2	2	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting	ChEMBL	514	13	6	4	1.8	N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmcl.2012.10.049
	44542176	200404	None	7	Human	Binding	pKi	=	7	7.0	1	2	Displacement of 125I-NPFF from human NPFFR1 incubated for 2 hrs by TopCount scintillation counting methodDisplacement of 125I-NPFF from human NPFFR1 incubated for 2 hrs by TopCount scintillation counting method	ChEMBL	318	2	3	2	2.0	N=C(N)N/N=C/c1ccc(Br)c(Br)c1	10.1021/acs.jmedchem.0c00643
	CHEMBL4784123	200404	None	7	Human	Binding	pKi	=	7	7.0	1	2	Displacement of 125I-NPFF from human NPFFR1 incubated for 2 hrs by TopCount scintillation counting methodDisplacement of 125I-NPFF from human NPFFR1 incubated for 2 hrs by TopCount scintillation counting method	ChEMBL	318	2	3	2	2.0	N=C(N)N/N=C/c1ccc(Br)c(Br)c1	10.1021/acs.jmedchem.0c00643
	CHEMBL573297	200404	None	7	Human	Binding	pKi	=	7	7.0	1	2	Displacement of 125I-NPFF from human NPFFR1 incubated for 2 hrs by TopCount scintillation counting methodDisplacement of 125I-NPFF from human NPFFR1 incubated for 2 hrs by TopCount scintillation counting method	ChEMBL	318	2	3	2	2.0	N=C(N)N/N=C/c1ccc(Br)c(Br)c1	10.1021/acs.jmedchem.0c00643
	127041619	137220	None	0	Human	Binding	pKi	=	6	6.0	-12302	2	Displacement of [3H]NPVF from human NPFF1 expressed in CHO cells by radioligand binding assayDisplacement of [3H]NPVF from human NPFF1 expressed in CHO cells by radioligand binding assay	ChEMBL	615	15	7	5	2.2	CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1	10.1021/acs.jmedchem.5b00925
	CHEMBL3746386	137220	None	0	Human	Binding	pKi	=	6	6.0	-12302	2	Displacement of [3H]NPVF from human NPFF1 expressed in CHO cells by radioligand binding assayDisplacement of [3H]NPVF from human NPFF1 expressed in CHO cells by radioligand binding assay	ChEMBL	615	15	7	5	2.2	CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1	10.1021/acs.jmedchem.5b00925
	CHEMBL3747715	137220	None	0	Human	Binding	pKi	=	6	6.0	-12302	2	Displacement of [3H]NPVF from human NPFF1 expressed in CHO cells by radioligand binding assayDisplacement of [3H]NPVF from human NPFF1 expressed in CHO cells by radioligand binding assay	ChEMBL	615	15	7	5	2.2	CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1	10.1021/acs.jmedchem.5b00925

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Ligand source activities (1 row/activity)