Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 90644395 | 112211 | None | 0 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 469 | 6 | 2 | 5 | 5.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | ||
| CHEMBL3290102 | 112211 | None | 0 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 469 | 6 | 2 | 5 | 5.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | ||
| 1574 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity |
ChEMBL | None | None | None | None | 10.1021/jm200006c | ||||
| 1579 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity |
ChEMBL | None | None | None | None | 10.1021/jm200006c | ||||
| 25077406 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity |
ChEMBL | None | None | None | None | 10.1021/jm200006c | ||||
| 3830 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity |
ChEMBL | None | None | None | None | 10.1021/jm200006c | ||||
| CHEMBL407196 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity |
ChEMBL | None | None | None | None | 10.1021/jm200006c | ||||
| 90644399 | 112215 | None | 1 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayPartial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | ||
| CHEMBL3290106 | 112215 | None | 1 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayPartial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | ||
| 119192 | 2481 | None | 38 | Rat | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 6 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | ||
| 1582 | 2481 | None | 38 | Rat | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 6 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | ||
| CHEMBL506981 | 2481 | None | 38 | Rat | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 6 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | ||
| DB06455 | 2481 | None | 38 | Rat | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 6 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | ||
| 118721825 | 116150 | None | 0 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 457 | 8 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | ||
| CHEMBL3356854 | 116150 | None | 0 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 457 | 8 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | ||
| 118721824 | 116149 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 469 | 6 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | ||
| CHEMBL3356853 | 116149 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 469 | 6 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | ||
| 90644392 | 112208 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 513 | 8 | 2 | 6 | 5.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | ||
| CHEMBL3290099 | 112208 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 513 | 8 | 2 | 6 | 5.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | ||
| 90644386 | 112202 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 524 | 6 | 2 | 5 | 5.8 | O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 | 10.1021/jm5003843 | ||
| CHEMBL3290093 | 112202 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 524 | 6 | 2 | 5 | 5.8 | O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 | 10.1021/jm5003843 | ||
| 90644394 | 112210 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 499 | 7 | 2 | 6 | 5.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | ||
| CHEMBL3290101 | 112210 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 499 | 7 | 2 | 6 | 5.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | ||
| 1580 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | -1 | 2 | Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmcl.2014.11.047 | ||
| 5311451 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | -1 | 2 | Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmcl.2014.11.047 | ||
| CHEMBL3040381 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | -1 | 2 | Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayAgonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmcl.2014.11.047 | ||
| 90644398 | 112214 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 467 | 7 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | ||
| CHEMBL3290105 | 112214 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 467 | 7 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | ||
| 1580 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | ||
| 5311451 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | ||
| CHEMBL3040381 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | ||
| 90644390 | 112206 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 520 | 7 | 2 | 7 | 4.9 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | ||
| CHEMBL3290097 | 112206 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 520 | 7 | 2 | 7 | 4.9 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | ||
| 90644388 | 112204 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 548 | 7 | 2 | 7 | 5.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | ||
| CHEMBL3290095 | 112204 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 548 | 7 | 2 | 7 | 5.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | ||
| 90644383 | 112199 | None | 0 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 | 10.1021/jm5003843 | ||
| CHEMBL3290090 | 112199 | None | 0 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 | 10.1021/jm5003843 | ||
| 1581 | 3670 | None | 10 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC | 10.1021/jm5003843 | ||
| 9915499 | 3670 | None | 10 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC | 10.1021/jm5003843 | ||
| CHEMBL461604 | 3670 | None | 10 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC | 10.1021/jm5003843 | ||
| 1580 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | Agonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assay |
ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm500857r | ||
| 5311451 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | Agonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assay |
ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm500857r | ||
| CHEMBL3040381 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | Agonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assay |
ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm500857r | ||
| 90644393 | 112209 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 483 | 7 | 2 | 5 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | ||
| CHEMBL3290100 | 112209 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 483 | 7 | 2 | 5 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | ||
| 90644385 | 112201 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 518 | 7 | 2 | 6 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | ||
| CHEMBL3290092 | 112201 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 518 | 7 | 2 | 6 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | ||
| 90644397 | 112213 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 481 | 8 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | ||
| CHEMBL3290104 | 112213 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 481 | 8 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | ||
| 146159772 | 2311 | None | 22 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 2 | Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | ||
Showing 1 to 50 of 158 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 16127648 | 14370 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | Binding affinity to human NTR2 by gamma countingBinding affinity to human NTR2 by gamma counting |
ChEMBL | 817 | 22 | 9 | 8 | 1.4 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O | 10.1021/jm100092s | ||
| CHEMBL1172376 | 14370 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | Binding affinity to human NTR2 by gamma countingBinding affinity to human NTR2 by gamma counting |
ChEMBL | 817 | 22 | 9 | 8 | 1.4 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O | 10.1021/jm100092s | ||
| CHEMBL1200171 | 14370 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | Binding affinity to human NTR2 by gamma countingBinding affinity to human NTR2 by gamma counting |
ChEMBL | 817 | 22 | 9 | 8 | 1.4 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O | 10.1021/jm100092s | ||
| 44354086 | 116843 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 843 | 23 | 10 | 13 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN1CCN=C1N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL337721 | 116843 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 843 | 23 | 10 | 13 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN1CCN=C1N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL3622802 | 214341 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay |
ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)O | 10.1021/acs.jmedchem.5b00841 | ||||
| CHEMBL336836 | 214047 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | None | None | None | CCNC(=N)NCCC[C@H](N)C(=O)/N=C(/N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC | 10.1021/jm0300633 | ||||
| CHEMBL258221 | 212975 | None | 16 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 2 | Inhibition of human NTR2Inhibition of human NTR2 |
ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | ||||
| 44354244 | 168428 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 831 | 23 | 11 | 11 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCC/N=C(/N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL434227 | 168428 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 831 | 23 | 11 | 11 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCC/N=C(/N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| 44354075 | 116830 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 803 | 24 | 10 | 11 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL337644 | 116830 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 803 | 24 | 10 | 11 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| 44354087 | 22489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 845 | 24 | 12 | 13 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC1NCCN1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL132524 | 22489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 845 | 24 | 12 | 13 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC1NCCN1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| 44354120 | 22352 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 816 | 23 | 11 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL132409 | 22352 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 816 | 23 | 11 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL258221 | 212975 | None | 16 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -2 | 2 | Displacement of 125I-[Tyr3]-NT from human NTS2 receptorDisplacement of 125I-[Tyr3]-NT from human NTS2 receptor |
ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01848 | ||||
| 1574 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | Inhibition of human NTR2Inhibition of human NTR2 |
ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | ||||
| 1579 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | Inhibition of human NTR2Inhibition of human NTR2 |
ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | ||||
| 25077406 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | Inhibition of human NTR2Inhibition of human NTR2 |
ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | ||||
| 3830 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | Inhibition of human NTR2Inhibition of human NTR2 |
ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | ||||
| CHEMBL407196 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | Inhibition of human NTR2Inhibition of human NTR2 |
ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | ||||
| 44354212 | 116765 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 803 | 24 | 10 | 11 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL337260 | 116765 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 803 | 24 | 10 | 11 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| 11657884 | 116263 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 803 | 22 | 10 | 11 | -0.1 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL335846 | 116263 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 803 | 22 | 10 | 11 | -0.1 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL3622804 | 214343 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCCN)C(=O)O | 10.1021/acs.jmedchem.5b00841 | ||||
| 44354245 | 167950 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 788 | 23 | 10 | 11 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL430910 | 167950 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 788 | 23 | 10 | 11 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL342252 | 214132 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -14 | 4 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||||
| 44354085 | 22472 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 817 | 24 | 9 | 11 | 0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL132507 | 22472 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 817 | 24 | 9 | 11 | 0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL3622806 | 214345 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay |
ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.5b00841 | ||||
| CHEMBL3622803 | 214342 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay |
ChEMBL | None | None | None | C[Si](C)(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O | 10.1021/acs.jmedchem.5b00841 | ||||
| CHEMBL3622805 | 214344 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay |
ChEMBL | None | None | None | CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.5b00841 | ||||
| 44354304 | 117119 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 774 | 22 | 10 | 11 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL339139 | 117119 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 774 | 22 | 10 | 11 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| 44354211 | 22791 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 846 | 25 | 10 | 10 | 0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL132794 | 22791 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 846 | 25 | 10 | 10 | 0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| 44354305 | 24022 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 832 | 24 | 10 | 10 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL133798 | 24022 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 832 | 24 | 10 | 10 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| 44354303 | 23466 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 788 | 23 | 10 | 11 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL133340 | 23466 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 788 | 23 | 10 | 11 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| 44354113 | 24104 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 831 | 25 | 9 | 11 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL133850 | 24104 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 831 | 25 | 9 | 11 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL439494 | 216303 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | None | None | None | None | 10.1021/jm0300633 | ||||
| CHEMBL3622801 | 214340 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O | 10.1021/acs.jmedchem.5b00841 | ||||
| CHEMBL3622806 | 214345 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Inhibition of human NTR2Inhibition of human NTR2 |
ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmcl.2022.128983 | ||||
| 44354302 | 23519 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 803 | 23 | 9 | 11 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
| CHEMBL133378 | 23519 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2Evaluated for binding affinity by inhibiting binding of [125I]Tyr(3)-NT to human Neurotensin receptor 2 |
ChEMBL | 803 | 23 | 9 | 11 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | ||
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