Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ligand		 Fold
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GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
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Value		 AssayType

 Assay
Description		 Source

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CHEMBL1627325 208811 0 None -1 8 Human 10.3 pEC50 = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)(C)C)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm900604g
2098 3694 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
36511 3694 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3805 3694 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3835 3694 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL235363 3694 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL384518 212328 12 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
2098 3694 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
36511 3694 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3805 3694 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3835 3694 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
CHEMBL235363 3694 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
2098 3694 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
36511 3694 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3805 3694 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3835 3694 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 3694 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
2098 3694 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 3694 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 3694 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 3694 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3694 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
73356363 89504 0 None 9 2 Guinea pig 8.9 pEC50 = 8.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372949 89504 0 None 9 2 Guinea pig 8.9 pEC50 = 8.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355648 97124 0 None -22 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL267712 97124 0 None -22 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
44355117 21788 0 None -19 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131923 21788 0 None -19 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
44297675 100620 0 None -47 2 Guinea pig 6.9 pEC50 = 6.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL291903 100620 0 None -47 2 Guinea pig 6.9 pEC50 = 6.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10259515 157137 0 None 954 2 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL407511 157137 0 None 954 2 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL263185 210561 5 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
2089 2766 28 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3795 2766 28 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311311 2766 28 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL217406 2766 28 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL415159 213175 5 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44297866 102044 0 None -38 2 Guinea pig 7.8 pEC50 = 7.8 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL301841 102044 0 None -38 2 Guinea pig 7.8 pEC50 = 7.8 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL441061 213879 19 None 2 2 Guinea pig 8.7 pEC50 = 8.7 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
73348740 89506 0 None 51 2 Guinea pig 8.4 pEC50 = 8.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372953 89506 0 None 51 2 Guinea pig 8.4 pEC50 = 8.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355678 23489 0 None 4 2 Guinea pig 6.5 pEC50 = 6.5 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL133362 23489 0 None 4 2 Guinea pig 6.5 pEC50 = 6.5 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10350201 117161 0 None -6 2 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL339391 117161 0 None -6 2 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10327810 116736 0 None -31 2 Guinea pig 4.4 pEC50 = 4.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337465 116736 0 None -31 2 Guinea pig 4.4 pEC50 = 4.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10055612 96425 0 None 31 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262049 96425 0 None 31 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
14860666 105419 0 None -3 2 Guinea pig 7.4 pEC50 = 7.4 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL311917 105419 0 None -3 2 Guinea pig 7.4 pEC50 = 7.4 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
2098 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
15931130 101981 0 None -1000 2 Guinea pig 6.4 pEC50 = 6.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL301477 101981 0 None -1000 2 Guinea pig 6.4 pEC50 = 6.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
5311135 21723 12 None -1148 3 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131872 21723 12 None -1148 3 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
44355179 24348 0 None -33 2 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134091 24348 0 None -33 2 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134481 208729 0 None -1 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm00100a027
2098 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
36511 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3805 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3835 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL235363 3694 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
10395375 116657 0 None -2 2 Guinea pig 5.3 pEC50 = 5.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337037 116657 0 None -2 2 Guinea pig 5.3 pEC50 = 5.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
10462850 24263 0 None -36 2 Guinea pig 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134012 24263 0 None -36 2 Guinea pig 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
15931129 194978 0 None 1 2 Guinea pig 8.2 pEC50 = 8.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL54622 194978 0 None 1 2 Guinea pig 8.2 pEC50 = 8.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL81919 215886 0 None -676 2 Guinea pig 6.2 pEC50 = 6.2 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL335054 211480 0 None -20 3 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
44297852 99007 0 None -7 2 Guinea pig 7.2 pEC50 = 7.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL280020 99007 0 None -7 2 Guinea pig 7.2 pEC50 = 7.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
2090 2767 25 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311312 2767 25 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL437797 2767 25 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
11765601 96424 0 None -9 2 Guinea pig 6.1 pEC50 = 6.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262048 96424 0 None -9 2 Guinea pig 6.1 pEC50 = 6.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
44355368 25641 0 None -1 3 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL135186 25641 0 None -1 3 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10009596 115509 0 None 1 2 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
CHEMBL335248 115509 0 None 1 2 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
73356365 89507 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
CHEMBL2372954 89507 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
108167 2856 8 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
2107 2856 8 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
CHEMBL1178725 2856 8 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
135434109 4282 0 None - 1 Rat 10.1 pIC50 = 10.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL100636 4282 0 None - 1 Rat 10.1 pIC50 = 10.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
9967131 207505 1 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
CHEMBL94461 207505 1 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
10363809 112130 20 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL329007 112130 20 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44328454 168738 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL437075 168738 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10111225 207477 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL94328 207477 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10477054 4493 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102032 4493 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10458573 4365 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL101148 4365 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
135488049 208215 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL98524 208215 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
2102 1189 21 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
5311057 1189 21 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
CHEMBL441225 1189 21 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
10480465 208415 0 None 1 2 Rat 9.7 pIC50 = 9.7 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL99792 208415 0 None 1 2 Rat 9.7 pIC50 = 9.7 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10272852 107893 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319301 107893 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9821217 107730 21 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319118 107730 21 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL3215877 107730 21 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9871754 5409 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5409 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
2098 3694 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
36511 3694 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3805 3694 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3835 3694 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
CHEMBL235363 3694 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
44433394 146658 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL392368 146658 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433394 146658 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL392368 146658 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
9960689 12005 1 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183286 12005 1 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288600 12005 1 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
9871754 5409 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5409 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
9945487 207751 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95852 207751 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10268178 207659 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95315 207659 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
2102 1189 21 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
5311057 1189 21 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL441225 1189 21 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
104943 55386 39 None 4 4 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
CHEMBL16192 55386 39 None 4 4 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
22879211 208143 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL98125 208143 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44433393 167647 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL430170 167647 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433393 167647 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL430170 167647 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
2098 3694 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
36511 3694 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3805 3694 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3835 3694 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
CHEMBL235363 3694 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
132846 2238 23 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(97)10118-4
13432 2238 23 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(97)10118-4
CHEMBL27006 2238 23 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(97)10118-4
9968267 108556 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL320220 108556 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10089212 4506 0 None - 1 Rat 9.0 pIC50 = 9.0 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102157 4506 0 None - 1 Rat 9.0 pIC50 = 9.0 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10047566 165241 3 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
CHEMBL422931 165241 3 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
10650495 107419 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
CHEMBL318085 107419 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
11801327 9356 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL111295 9356 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
9871754 5409 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5409 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
135413536 448 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
230 448 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
3490 448 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
6918365 448 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
CHEMBL1471 448 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
DB00673 448 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
9832207 11999 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 11999 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 11999 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10817013 9256 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
CHEMBL110770 9256 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
44327794 111422 2 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL327357 111422 2 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL2369600 209634 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
44286165 158395 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1794935 158395 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL40900 158395 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5074991 214349 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10039383 85477 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
CHEMBL22680 85477 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
15542673 207564 0 None 1 2 Guinea pig 6.9 pIC50 = 6.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL94834 207564 0 None 1 2 Guinea pig 6.9 pIC50 = 6.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44327909 112358 0 None 37 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL329450 112358 0 None 37 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304126 209480 0 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
9832306 112724 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330367 112724 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330462 112724 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
10123138 108526 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL317524 108526 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL320002 108526 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10190842 107224 0 None 63 2 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL316705 107224 0 None 63 2 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44286051 12006 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183288 12006 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288840 12006 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44285793 100290 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1201933 100290 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289091 100290 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44331794 4199 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL100178 4199 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL2369697 209650 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10769060 6034 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
CHEMBL108040 6034 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
44285794 141801 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38624 141801 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44213067 12011 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183307 12011 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289727 12011 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10626666 109195 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
CHEMBL321554 109195 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
10602943 107418 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
CHEMBL318084 107418 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
10168749 207621 0 None 3 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95127 207621 0 None 3 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10745241 110531 0 None -1 2 Guinea pig 4.7 pIC50 = 4.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL325116 110531 0 None -1 2 Guinea pig 4.7 pIC50 = 4.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL2369696 209649 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10234086 111634 0 None 6 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL328511 111634 0 None 6 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
10258866 16602 6 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL124066 16602 6 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
136035319 163298 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL418800 163298 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10027061 14952 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL120844 14952 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL2304029 209476 0 None - 1 Rat 4.6 pIC50 = 4.6 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10122529 109556 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL322194 109556 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44349304 16978 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL125385 16978 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10212645 13289 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL1191766 13289 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL542908 13289 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542881 112591 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330172 112591 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10233656 207851 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL96442 207851 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10283825 96693 0 None 1 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL264007 96693 0 None 1 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
153996 112668 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330366 112668 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL539021 112668 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10507650 163330 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL419004 163330 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986134 163833 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL4206396 163833 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
9918576 207337 0 None 2 3 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL93556 207337 0 None 2 3 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
44286200 141853 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38652 141853 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10147107 207620 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431850 207620 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95125 207620 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304032 209477 0 None - 1 Rat 4.5 pIC50 = 4.5 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10212223 208140 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431458 208140 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL98079 208140 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
9832207 11999 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 11999 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 11999 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5083565 214871 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10121390 112739 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330499 112739 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10123040 161095 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL411691 161095 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL537027 161095 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542879 112824 0 None 2 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330719 112824 0 None 2 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349364 116831 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL337987 116831 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10578261 9183 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
CHEMBL110301 9183 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
10360490 88739 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL23617 88739 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
44286038 11210 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL1178749 11210 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL39595 11210 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL2304118 209479 0 None - 1 Rat 5.4 pIC50 = 5.4 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O 10.1021/jm00157a009
10190413 207329 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL410270 207329 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL93519 207329 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
10417124 118480 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL341365 118480 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
44349370 117272 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL339488 117272 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
15542871 207855 0 None 1 2 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
CHEMBL96466 207855 0 None 1 2 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
10530375 5629 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
CHEMBL107763 5629 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
10917690 207605 1 None 3 4 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95051 207605 1 None 3 4 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
44328187 208139 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL98076 208139 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
135556923 107400 0 None - 1 Rat 8.2 pIC50 = 8.2 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL317979 107400 0 None - 1 Rat 8.2 pIC50 = 8.2 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
9832306 112724 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330367 112724 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330462 112724 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL2304130 209482 0 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)O 10.1021/jm00157a009
10917690 207605 1 None -999 4 Human 5.3 pIC50 = 5.3 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL95051 207605 1 None -999 4 Human 5.3 pIC50 = 5.3 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
44285795 96500 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL262540 96500 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44349303 117219 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL339444 117219 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL2304129 209481 0 None - 1 Rat 4.3 pIC50 = 4.3 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10620143 99262 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL281828 99262 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10327313 16877 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL124979 16877 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
15831290 146606 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39232 146606 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
10603544 110564 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL325312 110564 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
10190056 111438 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL327497 111438 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
44285857 11198 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1178703 11198 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38030 11198 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10190638 207542 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94726 207542 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283825 96693 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL264007 96693 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283765 108087 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
CHEMBL319535 108087 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
15542874 112169 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL329055 112169 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10769059 108617 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
CHEMBL320581 108617 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
10123138 108526 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL317524 108526 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320002 108526 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542673 207564 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94834 207564 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333379 207575 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL94906 207575 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10305069 207850 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96441 207850 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL2304115 209478 0 None - 1 Rat 6.2 pIC50 = 6.2 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10190056 111438 0 None -1 2 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL327497 111438 0 None -1 2 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
10212725 98169 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL273915 98169 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
15542679 108527 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320003 108527 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9918576 207337 0 None 2 3 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL93556 207337 0 None 2 3 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
10190413 207329 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL410270 207329 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL93519 207329 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
44328188 111526 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL327888 111526 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542879 112824 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330719 112824 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10121390 112739 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330499 112739 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10123040 161095 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL411691 161095 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL537027 161095 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10190770 208015 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330430 208015 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97357 208015 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10212223 208140 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431458 208140 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL98079 208140 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147107 207620 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431850 207620 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95125 207620 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333241 207793 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL96141 207793 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10233656 207851 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96442 207851 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147218 107466 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL318369 107466 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542881 112591 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330172 112591 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328321 167788 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL430471 167788 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10122529 109556 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL322194 109556 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10169609 207645 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95243 207645 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
10234086 111634 0 None 6 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL328511 111634 0 None 6 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
15542880 207506 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94480 207506 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10168749 207621 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95127 207621 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10305888 207555 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94788 207555 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328320 207601 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL95029 207601 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10284042 207986 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97240 207986 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542869 207609 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95076 207609 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9892984 144265 1 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39049 144265 1 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
11801586 5466 0 None 1 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL107502 5466 0 None 1 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986135 163401 0 None -10 3 Human 4.1 pIC50 = 4.1 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL419500 163401 0 None -10 3 Human 4.1 pIC50 = 4.1 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL5078626 214572 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1OC[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
44331786 107817 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL319212 107817 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
44331715 4734 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL103657 4734 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
44331792 107183 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL316486 107183 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
44349375 115058 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL334304 115058 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10063954 98732 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL277918 98732 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10190770 208015 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330430 208015 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL97357 208015 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349369 16899 0 None - 1 Human 4.0 pIC50 = 4.0 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
CHEMBL125093 16899 0 None - 1 Human 4.0 pIC50 = 4.0 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
44407908 140557 0 None - 0 Human 10.0 pKd = 10 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL381155 140557 0 None - 0 Human 10.0 pKd = 10 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
44408039 75502 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
CHEMBL204297 75502 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
44408088 139825 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL379898 139825 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408089 140186 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL380449 140186 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408045 75606 0 None - 0 Human 9.5 pKd = 9.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL204691 75606 0 None - 0 Human 9.5 pKd = 9.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
104943 55386 39 None -4 4 Human 9.5 pKd = 9.5 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55386 39 None -4 4 Human 9.5 pKd = 9.5 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
3086681 2272 17 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2272 17 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2272 17 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44370529 49059 0 None - 0 Guinea pig 9.3 pKd = 9.3 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
CHEMBL156128 49059 0 None - 0 Guinea pig 9.3 pKd = 9.3 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
44408040 74419 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL202627 74419 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407998 75498 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204262 75498 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407971 140754 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL381822 140754 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44370713 51032 0 None - 0 Guinea pig 9.1 pKd = 9.1 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL157858 51032 0 None - 0 Guinea pig 9.1 pKd = 9.1 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
44305816 163019 0 None - 0 Human 9.1 pKd = 9.1 Functional
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL417572 163019 0 None - 0 Human 9.1 pKd = 9.1 Functional
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
44408051 141227 0 None - 0 Human 9.1 pKd = 9.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL382871 141227 0 None - 0 Human 9.1 pKd = 9.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
21041073 138849 0 None - 0 Human 9.0 pKd = 9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL378156 138849 0 None - 0 Human 9.0 pKd = 9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
9829083 120139 0 None - 1 Human 9.0 pKd = 9 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 120139 0 None - 1 Human 9.0 pKd = 9 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2102 1189 21 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
5311057 1189 21 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
CHEMBL441225 1189 21 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
44407906 74708 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL203064 74708 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
9874480 74773 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203113 74773 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44407907 75697 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204764 75697 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408025 75915 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL204979 75915 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44407917 96558 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
CHEMBL262989 96558 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
44407903 140722 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381778 140722 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
44407902 75424 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL204114 75424 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
44408046 140744 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381814 140744 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
104943 55386 39 None -4 4 Human 8.7 pKd = 8.7 Functional
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 55386 39 None -4 4 Human 8.7 pKd = 8.7 Functional
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44407972 140756 0 None - 0 Human 8.7 pKd = 8.7 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381825 140756 0 None - 0 Human 8.7 pKd = 8.7 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44370530 49123 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL156186 49123 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
44307819 102596 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102596 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 169264 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 169264 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307678 198675 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 198675 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307757 203536 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 203536 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 203771 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 203771 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57394644 68365 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916633 68365 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10032981 106752 0 None - 0 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144347 106752 0 None - 0 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10055415 106756 0 None -2 4 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106756 0 None -2 4 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
118718516 115361 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
CHEMBL3349687 115361 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
9939040 5010 7 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 5010 7 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
44307679 203517 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 203517 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307820 203635 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 203635 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391132 68366 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916634 68366 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10395494 106754 0 None - 0 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144349 106754 0 None - 0 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
9832198 106755 0 None 1 4 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106755 0 None 1 4 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384380 59824 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL172794 59824 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44383617 155702 0 None - 0 Guinea pig 5.9 pKd = 5.9 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL405167 155702 0 None - 0 Guinea pig 5.9 pKd = 5.9 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10395612 106747 0 None - 0 Human 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144339 106747 0 None - 0 Human 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
9801487 206998 0 None - 1 Guinea pig 6.9 pKd = 6.9 Functional
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL91418 206998 0 None - 1 Guinea pig 6.9 pKd = 6.9 Functional
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
52937467 62523 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782141 62523 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44307898 201473 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 201473 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10418001 106753 0 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144348 106753 0 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL439284 213831 22 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00063a015
44307758 203556 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 203556 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391133 68367 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68367 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
10350454 106731 0 None 2 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106731 0 None 2 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10439730 106757 0 None -1 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106757 0 None -1 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44383164 165710 0 None - 0 Guinea pig 6.7 pKd = 6.7 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL424567 165710 0 None - 0 Guinea pig 6.7 pKd = 6.7 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL3349620 211446 11 None - 0 Guinea pig 5.7 pKd = 5.7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718517 115362 0 None - 0 Guinea pig 6.6 pKd = 6.6 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349688 115362 0 None - 0 Guinea pig 6.6 pKd = 6.6 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
44407901 140444 0 None - 0 Human 8.5 pKd = 8.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL380928 140444 0 None - 0 Human 8.5 pKd = 8.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
52937271 62521 0 None - 0 Human 8.4 pKd = 8.4 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782139 62521 0 None - 0 Human 8.4 pKd = 8.4 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
132837 2237 55 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
9461 2237 55 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL22870 2237 55 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
52937273 62519 0 None - 0 Human 7.5 pKd = 7.5 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL1782137 62519 0 None - 0 Human 7.5 pKd = 7.5 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
10145229 9173 0 None - 0 Guinea pig 6.5 pKd = 6.5 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9173 0 None - 0 Guinea pig 6.5 pKd = 6.5 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
10349900 106749 0 None -3 4 Human 6.5 pKd = 6.5 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106749 0 None -3 4 Human 6.5 pKd = 6.5 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10350528 106733 0 None 1 4 Human 7.4 pKd = 7.4 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106733 0 None 1 4 Human 7.4 pKd = 7.4 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384379 129647 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL367312 129647 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL170299 208843 0 None - 0 Guinea pig 6.4 pKd = 6.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44408048 140558 0 None - 0 Human 8.3 pKd = 8.3 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381157 140558 0 None - 0 Human 8.3 pKd = 8.3 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
10259370 106748 0 None - 0 Human 7.3 pKd = 7.3 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144340 106748 0 None - 0 Human 7.3 pKd = 7.3 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10506928 120218 0 None - 1 Human 6.3 pKd = 6.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 120218 0 None - 1 Human 6.3 pKd = 6.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44383616 168563 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL435717 168563 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10325464 120134 0 None - 1 Human 5.3 pKd = 5.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 120134 0 None - 1 Human 5.3 pKd = 5.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
44307821 102114 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 102114 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44337201 108612 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 108612 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
107686 3379 41 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
3522 3379 41 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
CHEMBL131171 3379 41 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
52937270 62520 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782138 62520 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44408033 74772 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203111 74772 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44408047 96768 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
CHEMBL264660 96768 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
15887537 109046 0 None - 0 Guinea pig 7.1 pKd = 7.1 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 109046 0 None - 0 Guinea pig 7.1 pKd = 7.1 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
21121353 101473 0 None 16 4 Human 7.1 pKd = 7.1 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101473 0 None 16 4 Human 7.1 pKd = 7.1 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
57392804 67984 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 67984 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 67984 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57403249 71509 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911968 71509 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1962728 71509 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67983 0 None - 0 Human 10.1 pKi = 10.1 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67983 0 None - 0 Human 10.1 pKi = 10.1 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
52933155 67987 0 None - 0 Human 10.0 pKi = 10 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911970 67987 0 None - 0 Human 10.0 pKi = 10 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 67984 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 67984 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 67984 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67983 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67983 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 67984 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 67984 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 67984 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57398076 67986 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911969 67986 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67983 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67983 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67983 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67983 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
2096 3644 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2096 3644 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 3644 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
25078100 3644 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 3645 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
16131028 3645 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 3645 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2097 3645 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 3645 0 None -112 2 Rat 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 3645 0 None -112 2 Rat 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2096 3644 0 None -25 2 Rat 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 3644 0 None -25 2 Rat 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
135413536 448 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
230 448 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
3490 448 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
6918365 448 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1471 448 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB00673 448 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
30699 217704 0 None -1 14 Human 8.3 pIC50 = 8.3 Functional
NoneNone
Drug Central 423 7 2 8 0.5 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O None
10328936 1546 30 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
2086 1546 30 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
2955 1546 30 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
CHEMBL373569 1546 30 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
135413538 1679 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
4470 1679 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
7623 1679 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1199324 1679 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB06717 1679 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
2096 3644 0 None -25 2 Rat 5.7 pIC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
25078100 3644 0 None -25 2 Rat 5.7 pIC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
2088 2177 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
45749 2177 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2101 3697 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
155817436 2793 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2092 2793 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
107686 3379 41 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
3522 3379 41 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
CHEMBL131171 3379 41 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
10328936 1546 30 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2086 1546 30 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2955 1546 30 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
CHEMBL373569 1546 30 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3849 3194 0 None - 1 Rat 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9243521
135413538 1679 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
4470 1679 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
7623 1679 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
CHEMBL1199324 1679 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
DB06717 1679 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
108167 2856 8 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
2107 2856 8 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
CHEMBL1178725 2856 8 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
17268 3117 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2094 3117 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
10349 2251 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
9809077 2251 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
CHEMBL4303434 2251 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
3850 3486 0 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3086681 2272 17 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
3510 2272 17 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
CHEMBL42407 2272 17 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
2110 2969 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
219077 2969 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
3480 2969 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
CHEMBL346178 2969 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
DB04872 2969 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
2100 3696 0 None - 1 Human 6.4 pIC50 None 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2091 2795 0 None -223 2 Human 6.5 pIC50 None 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2099 3695 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2103 1643 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
6437864 1643 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
132629 2236 15 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
2104 2236 15 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
CHEMBL24999 2236 15 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
168489 3116 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2093 3116 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2109 4137 4 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
9852253 4137 4 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
CHEMBL129683 4137 4 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
132837 2237 55 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9461 2237 55 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
CHEMBL22870 2237 55 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
392622 56312 95 None - 4 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 56312 95 None - 4 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
3793 203209 77 None - 1 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 704 11 0 12 5.6 CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O 10.1038/s41467-023-40064-9
45039617 203209 77 None - 1 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 704 11 0 12 5.6 CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O 10.1038/s41467-023-40064-9
CHEMBL64391 203209 77 None - 1 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 704 11 0 12 5.6 CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O 10.1038/s41467-023-40064-9
3883 183535 112 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL480 183535 112 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
43815 186920 64 None - 25 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL1708 186920 64 None - 25 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL490 186920 64 None - 25 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
1890 2759 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
4449 2759 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
7247 2759 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
CHEMBL623 2759 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
DB01149 2759 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
191 403 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
201 403 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170 403 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
CHEMBL1113 403 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
DB00543 403 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
212 3806 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2639 3806 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
941651 3806 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
CHEMBL1201 3806 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
DB01623 3806 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2247 505 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
249 505 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2603 505 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL296419 505 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
DB00637 505 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2585 803 103 None - 21 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 803 103 None - 21 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 803 103 None - 21 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 803 103 None - 21 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 803 103 None - 21 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
11434515 261 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
11519741 261 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
4484 261 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
7449 261 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
CHEMBL1194325 261 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
DB08897 261 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
213 3853 55 None - 44 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
2717 3853 55 None - 44 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
5533 3853 55 None - 44 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL621 3853 55 None - 44 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
DB00656 3853 55 None - 44 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
10034073 17161 29 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1255800 17161 29 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
2600 3779 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
2608 3779 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
5405 3779 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL17157 3779 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
DB00342 3779 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
644241 95186 121 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
CHEMBL255863 95186 121 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
5360696 1406 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
6953 1406 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
842 1406 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
CHEMBL52440 1406 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
DB00514 1406 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
5328940 100216 107 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
CHEMBL288441 100216 107 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
3157 1470 71 None - 10 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
7170 1470 71 None - 10 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
954 1470 71 None - 10 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
CHEMBL707 1470 71 None - 10 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
DB00590 1470 71 None - 10 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
1353 1911 93 None - 83 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 1911 93 None - 83 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 1911 93 None - 83 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 1911 93 None - 83 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 1911 93 None - 83 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
242 470 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
1024 1289 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
162639143 1289 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
5284373 1289 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
760 1289 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL160 1289 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
DB00091 1289 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
2098 3694 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
36511 3694 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3805 3694 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3835 3694 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 3694 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL384518 212328 12 None - 0 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
CHEMBL428532 213455 6 None - 0 Guinea pig 8.8 pEC50 = 8.8 Binding
Compound was evaluated for effective dose against Muscular receptor in guinea pig ileumCompound was evaluated for effective dose against Muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
44337561 96738 0 None - 0 Guinea pig 8.0 pEC50 = 8.0 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL264395 96738 0 None - 0 Guinea pig 8.0 pEC50 = 8.0 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308430 102263 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL303222 102263 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 210127 0 None - 0 Guinea pig 5.9 pEC50 = 5.9 Binding
Compound was evaluated for effective dose against neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
CHEMBL263185 210561 5 None - 0 Human 7.9 pEC50 = 7.9 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
CHEMBL415159 213175 5 None - 0 Human 7.9 pEC50 = 7.9 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44337560 109750 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL323028 109750 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337787 9167 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL110177 9167 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308431 164522 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL421485 164522 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 210127 0 None - 0 Guinea pig 8.7 pEC50 = 8.7 Binding
Compound was evaluated for effective dose against muscular receptor in guinea pig ileumCompound was evaluated for effective dose against muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
132629 2236 15 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
2104 2236 15 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL24999 2236 15 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL422779 213313 0 None - 0 Guinea pig 8.5 pEC50 = 8.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
CHEMBL106184 208470 0 None - 0 Guinea pig 6.5 pEC50 = 6.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN(CCCN)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
108147 3583 36 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
2127 3583 36 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL106124 3583 36 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL428532 213455 6 None - 0 Guinea pig 8.4 pEC50 = 8.4 Binding
Compound was evaluated for effective dose against Neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against Neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
10843656 96822 0 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
CHEMBL265115 96822 0 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
44337775 163407 0 None - 0 Guinea pig 5.4 pEC50 = 5.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL419558 163407 0 None - 0 Guinea pig 5.4 pEC50 = 5.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337797 109014 0 None - 0 Guinea pig 8.3 pEC50 = 8.3 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL321228 109014 0 None - 0 Guinea pig 8.3 pEC50 = 8.3 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308550 102118 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL302349 102118 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
162673403 183049 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4794099 183049 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
44337530 167897 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL431243 167897 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
162651127 180281 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4750714 180281 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
11238415 99254 0 None - 0 Human 11.0 pIC50 = 11 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL281797 99254 0 None - 0 Human 11.0 pIC50 = 11 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
11352855 97116 0 None - 0 Human 11.0 pIC50 = 11.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL26761 97116 0 None - 0 Human 11.0 pIC50 = 11.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9821217 107730 21 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL319118 107730 21 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3215877 107730 21 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
49863731 15330 0 None - 3 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 15330 0 None - 3 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
25129133 188887 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188887 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
25129133 188887 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188887 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
25129133 188887 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 188887 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
46884430 8320 0 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 8320 0 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11852872 68627 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 68627 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
25027805 71022 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951813 71022 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
44178113 61264 0 None - 3 Human 10.7 pIC50 = 10.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 61264 0 None - 3 Human 10.7 pIC50 = 10.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
57391771 71020 0 None - 0 Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 71020 0 None - 0 Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395695 71622 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917866 71622 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963416 71622 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
87318292 126452 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651897 126452 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
67232184 126446 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651891 126446 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
73265457 126451 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651896 126451 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11248796 161649 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL413027 161649 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
122182823 122061 0 None - 0 Mongolian jird 10.5 pIC50 = 10.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596448 122061 0 None - 0 Mongolian jird 10.5 pIC50 = 10.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433804 146795 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 146795 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
73265450 126442 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651887 126442 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
73265453 126447 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651892 126447 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
57402264 70960 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951626 70960 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57403992 70967 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951633 70967 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
73265456 126450 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651895 126450 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
9828716 71633 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917853 71633 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963487 71633 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
127944 120925 3 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL356062 120925 3 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL555572 120925 3 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
46881682 8097 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8097 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46883879 7770 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 7770 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
57398784 70965 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951631 70965 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
57400919 71619 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917856 71619 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963413 71619 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57397000 71021 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951811 71021 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
11621512 70964 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951630 70964 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57397022 70966 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951632 70966 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265454 126448 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651893 126448 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
57400917 71647 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917852 71647 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963577 71647 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
135539114 208302 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
CHEMBL99055 208302 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
135539114 208302 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
CHEMBL99055 208302 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
122182821 122059 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596446 122059 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
122182822 122060 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596447 122060 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433798 145686 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 145686 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433797 146136 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 146136 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 6543 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6543 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135539114 208302 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
CHEMBL99055 208302 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
57398783 70963 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951629 70963 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
57391771 71020 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 71020 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395688 68625 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917851 68625 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57390405 71621 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917865 71621 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963415 71621 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57397483 71620 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917859 71620 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963414 71620 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400921 71608 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917860 71608 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963300 71608 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57395693 71609 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917862 71609 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963301 71609 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456802 97450 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270090 97450 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
16663280 97961 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272649 97961 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
23653789 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
46881727 5594 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 5594 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 8450 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8450 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8912 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8912 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 8912 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8912 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52949827 17342 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 17342 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
25028925 91365 4 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 91365 4 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
16663280 97961 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
16663280 97961 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL272649 97961 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL272649 97961 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
23653789 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
44444666 154384 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL398720 154384 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
127944 120925 3 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL356062 120925 3 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL555572 120925 3 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
46947062 17460 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17460 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57391807 70961 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951627 70961 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
24889113 7948 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7948 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7948 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52943848 17420 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 17420 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
135406581 31927 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1016/j.bmcl.2018.09.016
CHEMBL140745 31927 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1016/j.bmcl.2018.09.016
73265455 126449 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651894 126449 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2098 3694 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 3694 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 3694 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 3694 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 3694 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
135406581 31927 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
CHEMBL140745 31927 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
44433800 146789 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392463 146789 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433803 146794 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392465 146794 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 6543 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6543 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881820 7561 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 7561 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881729 7939 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7939 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 8450 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8450 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444634 94101 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249145 94101 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
24180495 154682 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399668 154682 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444643 154901 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400848 154901 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
135406581 31927 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
CHEMBL140745 31927 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
73265452 126445 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651890 126445 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11852872 68627 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 68627 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402266 70968 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951634 70968 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265451 126444 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651889 126444 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
11409185 99423 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL282853 99423 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
57402690 68624 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917850 68624 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
9917079 61165 39 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 61165 39 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
5752 4005 24 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
6918331 4005 24 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
CHEMBL522302 4005 24 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
DB12436 4005 24 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
71456209 78657 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL2112366 78657 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
46881729 7939 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7939 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 8013 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8013 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750888 8451 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 8451 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752434 9133 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9133 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52941351 17378 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 17378 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57395691 71648 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917858 71648 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963578 71648 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400923 71623 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917867 71623 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963417 71623 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
10407571 167957 10 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL431690 167957 10 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
57397481 71654 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917855 71654 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963613 71654 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
11983278 166100 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
CHEMBL425956 166100 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
11983278 166100 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
CHEMBL425956 166100 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
135449286 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
CHEMBL52330 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
135449286 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
CHEMBL52330 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
135485796 35250 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL143587 35250 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
135449286 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
CHEMBL52330 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
44407331 141213 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382848 141213 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
135413536 448 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
230 448 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
3490 448 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
6918365 448 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
CHEMBL1471 448 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
DB00673 448 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
44433799 88668 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL235882 88668 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
135449286 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
CHEMBL52330 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
24888943 7947 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090438 7947 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 8013 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 8013 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 8013 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8013 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46881682 8097 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8097 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947645 17243 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17243 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 17307 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 17307 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993313 187031 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL490869 187031 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444631 94100 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249144 94100 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
44444637 94501 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251577 94501 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444685 154772 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 154772 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
135547943 34427 26 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
CHEMBL142819 34427 26 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
135449286 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
CHEMBL52330 193189 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
135413536 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
230 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
3490 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
6918365 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
CHEMBL1471 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
DB00673 448 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
42611207 124786 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642163 124786 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
57399171 68626 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917857 68626 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57398782 70955 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951621 70955 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
135413536 448 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
230 448 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
3490 448 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
6918365 448 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
CHEMBL1471 448 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
DB00673 448 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
135539114 208302 3 None - 0 Human 10.0 pIC50 = 10 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
CHEMBL99055 208302 3 None - 0 Human 10.0 pIC50 = 10 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
CHEMBL5290533 194500 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 479 4 1 8 3.4 COc1cccc(-n2nnnc2C(F)(F)F)c1[C@H]1CO[C@@]2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
135419433 31796 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL140626 31796 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
44407427 141180 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
CHEMBL382803 141180 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
44318589 163343 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL419119 163343 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094861 205809 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83250 205809 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094863 107135 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL316141 107135 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
57393955 71597 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917863 71597 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963216 71597 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46830287 7990 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090648 7990 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993314 171039 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 171039 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44444664 94478 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251387 94478 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
73265449 124412 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3639507 124412 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
10051762 82229 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21709 82229 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44407513 74297 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202417 74297 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
10004377 111408 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL327250 111408 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44325058 112452 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329828 112452 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL1651026 208826 24 None - 1 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cellsDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL1651026 208826 24 None - 1 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting methodDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting method
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.11.014
57398785 70969 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951635 70969 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
24889113 7948 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7948 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7948 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884518 7978 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090547 7978 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884467 7991 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 7991 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 8013 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8013 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884519 8093 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
CHEMBL1091342 8093 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
52943994 17832 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 17832 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993955 184305 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL484134 184305 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444681 94373 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250798 94373 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444688 155004 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL401415 155004 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444658 167064 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL428933 167064 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
45271306 195672 0 None 14 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 195672 0 None 14 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
2098 3694 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
36511 3694 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3805 3694 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3835 3694 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
CHEMBL235363 3694 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
2098 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
36511 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3805 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3835 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
CHEMBL235363 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
2098 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44274207 78573 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
CHEMBL21122 78573 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
10053419 82620 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21792 82620 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44412226 168837 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL437878 168837 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44433789 146134 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 146134 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44444646 94021 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248748 94021 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444693 94497 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251557 94497 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444650 154902 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
CHEMBL400849 154902 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
2098 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
36511 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3805 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3835 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
CHEMBL235363 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
2098 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
36511 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3805 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3835 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL235363 3694 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL389652 212430 0 None 2 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44334114 4546 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
CHEMBL102382 4546 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
44295002 155962 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL406136 155962 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44407325 73364 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
CHEMBL201362 73364 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
57390403 71655 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917861 71655 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963614 71655 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46881728 5595 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 5595 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881821 5600 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 5600 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884516 7826 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089533 7826 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
42639650 188195 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL499004 188195 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444684 94284 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL250390 94284 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
44444695 94537 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251768 94537 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44274251 83162 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21831 83162 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10053174 99508 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL283318 99508 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412207 140332 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380680 140332 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
9821217 107730 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL319118 107730 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL3215877 107730 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
9821217 107730 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL319118 107730 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL3215877 107730 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
57403991 70959 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951625 70959 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
44456522 158884 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL409520 158884 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
22885694 141447 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384177 141447 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24888772 8016 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090752 8016 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752434 9133 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9133 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947646 17245 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256588 17245 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52942803 17246 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 17246 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44444669 154415 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL398919 154415 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
10186401 98927 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
CHEMBL279442 98927 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
24889114 7751 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1089081 7751 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46884515 7825 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089532 7825 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884472 7995 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090653 7995 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993312 179353 11 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL473680 179353 11 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444638 155658 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL404855 155658 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
3086681 2272 17 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2272 17 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2272 17 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44333730 107672 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL319046 107672 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
10098209 99089 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL280662 99089 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
57400915 71618 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917844 71618 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963412 71618 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44416078 140138 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL380210 140138 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
16006943 141444 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384171 141444 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884473 7789 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089397 7789 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883823 8432 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 8432 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52948931 17249 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 17249 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
44444660 154646 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399466 154646 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444685 154772 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 154772 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
44444692 155474 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL404001 155474 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44593632 178769 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
CHEMBL468830 178769 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
44177570 61260 0 None 15 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 61260 0 None 15 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10460917 163749 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL420543 163749 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
2102 1189 21 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
5311057 1189 21 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
CHEMBL441225 1189 21 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
73352606 92973 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441368 92973 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
10460917 163749 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163749 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
57402689 68622 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917845 68622 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
23146876 70957 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951623 70957 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
44433802 146791 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392464 146791 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
44433804 146795 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 146795 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
22885615 80180 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213538 80180 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
52947645 17243 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17243 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52947647 17247 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 17247 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44233185 194822 0 None 47 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 194822 0 None 47 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
57397021 70958 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951624 70958 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
46884471 7749 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089062 7749 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 7769 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 7769 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24888942 7946 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090437 7946 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883824 8433 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093597 8433 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44444640 93980 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248545 93980 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444694 154825 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL400393 154825 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9850771 119878 3 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119878 3 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
15253734 165349 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
CHEMBL423623 165349 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
46227362 202584 0 None 12 4 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 202584 0 None 12 4 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44274166 80251 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL21385 80251 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
44412236 78139 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210365 78139 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
22885699 81020 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215373 81020 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885703 141426 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL384112 141426 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44357006 13725 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL1195055 13725 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL553778 13725 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
44356378 25742 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL135263 25742 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10480465 208415 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99792 208415 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9892852 84380 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL22194 84380 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
24785717 122105 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 122105 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
18669097 99402 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL282725 99402 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
57402692 71610 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917869 71610 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963302 71610 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402221 71023 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951814 71023 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
22885697 141672 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385463 141672 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44433394 146658 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL392368 146658 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
2102 1189 21 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
5311057 1189 21 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
CHEMBL441225 1189 21 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
9892852 84380 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL22194 84380 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10553959 187870 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL49638 187870 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
104943 55386 39 None 1862 3 Human 9.7 pIC50 = 9.7 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
CHEMBL16192 55386 39 None 1862 3 Human 9.7 pIC50 = 9.7 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
9796216 102243 15 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
CHEMBL303118 102243 15 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
44294293 188453 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50270 188453 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10098209 99089 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL280662 99089 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
57402265 70962 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951628 70962 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
44433797 146136 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 146136 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
52948868 17248 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256591 17248 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
46883879 7770 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 7770 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44593636 181620 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 181620 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
11814040 78809 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112743 78809 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
9871891 5459 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107482 5459 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
9871891 5459 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
CHEMBL107482 5459 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
11318556 93935 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 93935 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9871414 98997 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
CHEMBL279977 98997 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
44274253 172277 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL447473 172277 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
10099787 103512 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085129 103512 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10480465 208415 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99792 208415 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412245 77957 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL209657 77957 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44444689 94225 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 94225 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
24755076 91583 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
CHEMBL240706 91583 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
44412445 77919 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
CHEMBL209456 77919 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
135405092 139283 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL379137 139283 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
3086681 2272 17 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
3510 2272 17 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
CHEMBL42407 2272 17 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
10257218 24839 3 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL134500 24839 3 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10460917 163749 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163749 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 5409 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5409 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10101238 34842 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143156 34842 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 208826 24 None - 1 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2013.03.016
44407370 74451 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL202775 74451 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
22885698 139345 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL379289 139345 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44444629 94099 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249143 94099 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9871754 5409 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5409 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
5757 3986 12 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
9832383 3986 12 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
CHEMBL522987 3986 12 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
DB11949 3986 12 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
58993578 122106 0 None - 0 Mongolian jird 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596493 122106 0 None - 0 Mongolian jird 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
9891865 80057 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212991 80057 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
22885692 80178 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213515 80178 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44415869 80693 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215147 80693 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885691 81316 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL215889 81316 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
10951720 78807 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112741 78807 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10369373 161960 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL415705 161960 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
24992986 184304 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL484133 184304 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44294659 103514 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085131 103514 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
9869697 64641 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817895 64641 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
10341570 121074 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 121074 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 3694 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
36511 3694 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3805 3694 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3835 3694 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
CHEMBL235363 3694 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
44274153 77880 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL20937 77880 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
135529973 121510 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL358343 121510 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
44407459 141111 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382720 141111 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44456524 97938 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272569 97938 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44416008 80502 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214748 80502 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884470 7994 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090652 7994 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752568 8912 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8912 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
18407037 162259 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL416372 162259 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
18407037 162259 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL416372 162259 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412173 78241 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210630 78241 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44456700 95909 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL259251 95909 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415789 141665 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385414 141665 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10144275 18893 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128369 18893 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
22293490 101310 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL296583 101310 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
24785717 122105 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 122105 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
44356404 23208 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
CHEMBL133140 23208 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
18669091 4685 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL103367 4685 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10008129 61078 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL176500 61078 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9938284 101415 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL297344 101415 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11755227 203076 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63793 203076 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
71450870 78659 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL2112368 78659 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
22885695 139124 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378689 139124 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
46881600 7106 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
CHEMBL1085196 7106 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
44444689 94225 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 94225 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444671 154756 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400060 154756 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
57402688 71606 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917843 71606 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963298 71606 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
52941489 17731 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17731 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10768417 165602 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL424291 165602 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 208826 24 None - 1 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
58993533 122098 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596485 122098 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
19797422 96663 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL263795 96663 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
104943 55386 39 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL16192 55386 39 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
10346229 83022 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21813 83022 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
21955317 103513 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085130 103513 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44412374 77794 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
CHEMBL209240 77794 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
11678857 139307 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL379224 139307 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44456865 97903 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272469 97903 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
14986135 163401 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
CHEMBL419500 163401 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
44334275 5072 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL105420 5072 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
9871754 5409 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5409 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10415870 103510 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085127 103510 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10483816 191198 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL51893 191198 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
10483816 79630 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115007 79630 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
10415870 140609 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL381390 140609 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
53379508 66461 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817891 66461 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852123 66461 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
22885696 138928 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378416 138928 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44444654 94057 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248943 94057 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
15516313 178717 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL468350 178717 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
44593636 181620 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 181620 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
9871754 5409 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL107172 5409 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
10698096 55873 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL162337 55873 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9871754 5409 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5409 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
44334149 4599 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102730 4599 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10393962 103515 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085132 103515 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
22293475 187128 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 187128 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
18782542 111465 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL327606 111465 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
11146618 78808 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
CHEMBL2112742 78808 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
104943 55386 39 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55386 39 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
44346234 14647 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL120523 14647 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
10415534 166206 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL426577 166206 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
2098 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
36511 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3805 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3835 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL235363 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
22885704 81525 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL216018 81525 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24752568 8912 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 8912 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752568 8912 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8912 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444659 94172 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249568 94172 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9855000 20621 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20621 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
18669080 5008 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL105047 5008 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10210026 101360 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296979 101360 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
58993465 122107 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596494 122107 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
22885702 80507 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214761 80507 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884434 7925 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090288 7925 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44346438 114750 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL333882 114750 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
10098987 59981 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 59981 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55386 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
CHEMBL16192 55386 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
104943 55386 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
CHEMBL16192 55386 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
44410317 77150 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL207794 77150 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415921 141747 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385925 141747 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889458 8430 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093594 8430 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46947062 17460 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17460 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17460 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17460 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
9821217 107730 21 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL319118 107730 21 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL3215877 107730 21 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 182442 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 182442 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44577989 189430 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL513351 189430 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
9984665 5342 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL106864 5342 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
104943 55386 39 None - 3 Guinea pig 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55386 39 None - 3 Guinea pig 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
2098 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
36511 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3805 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3835 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
CHEMBL235363 3694 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
44412493 77894 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
CHEMBL209407 77894 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
44415909 79886 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212349 79886 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
49863732 15331 0 None 24 4 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15331 0 None 24 4 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
135430679 46045 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
CHEMBL153310 46045 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
44294660 103516 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085133 103516 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
53379509 66456 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817892 66456 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852099 66456 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
44433789 146134 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 146134 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24750888 8451 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 8451 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135430775 45345 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152685 45345 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44412235 140175 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380388 140175 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44415808 81461 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215975 81461 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
11756257 167783 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43044 167783 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
18669059 98770 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL278149 98770 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412373 139100 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
CHEMBL378663 139100 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
21955285 188994 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50867 188994 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
104943 55386 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55386 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
24785978 122096 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 122096 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
9329 3741 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9894349 3741 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
CHEMBL339486 3741 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9329 3741 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
9894349 3741 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
CHEMBL339486 3741 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
10392469 194855 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL539928 194855 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44177669 61261 0 None 2 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 61261 0 None 2 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10325507 60442 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL175224 60442 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
44444674 94325 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250596 94325 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44408291 140880 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL381984 140880 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408177 140975 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL382331 140975 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408290 141249 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL383048 141249 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
10007758 178981 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL47070 178981 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
104943 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL16192 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
46227363 199665 0 None 28 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 199665 0 None 28 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44412453 161689 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL413279 161689 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
21955222 101783 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL300014 101783 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10392469 194855 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL539928 194855 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
2102 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
5311057 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
CHEMBL441225 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
10098987 59981 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 59981 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
10720240 35096 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143375 35096 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
2102 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
5311057 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL441225 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
104943 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL16192 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
2102 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
5311057 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
CHEMBL441225 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
2102 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
5311057 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
CHEMBL441225 1189 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
105083 25451 3 None - 1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL135022 25451 3 None - 1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
44410278 140864 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381965 140864 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44408176 74323 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL202439 74323 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
104943 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
CHEMBL16192 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
44593634 182789 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL479049 182789 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
10099939 4987 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL104954 4987 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
9830304 107347 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
CHEMBL317632 107347 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
10099939 4987 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL104954 4987 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
CHEMBL16192 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
104943 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
CHEMBL16192 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
10814682 207714 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL95626 207714 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44433798 145686 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 145686 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
46884468 7992 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090650 7992 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
104943 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL16192 55386 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44415896 138914 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378331 138914 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44299271 196048 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL56038 196048 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
42639649 170745 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL445239 170745 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44334107 4405 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL101421 4405 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
44299271 196048 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56038 196048 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10814682 207714 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL95626 207714 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412159 140921 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL382255 140921 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
46884430 8320 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 8320 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
22901329 99079 1 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL28055 99079 1 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
9805809 103087 8 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
CHEMBL307488 103087 8 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
44334127 4634 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102937 4634 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44415554 139049 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378609 139049 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
136094860 206111 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85792 206111 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44433796 90192 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL238220 90192 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
44444677 154983 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL401281 154983 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44312057 204452 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL72234 204452 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
24785978 122096 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 122096 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
10392925 14439 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120081 14439 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10076669 60218 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174016 60218 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
11800025 121280 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL357887 121280 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
18669082 165716 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL424586 165716 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669082 165716 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL424586 165716 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL2115376 209267 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
2102 1189 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
5311057 1189 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL441225 1189 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44410191 140692 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381555 140692 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415947 80303 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214118 80303 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24750734 8013 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 8013 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 8013 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8013 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
2102 1189 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
5311057 1189 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL441225 1189 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
44305288 202879 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62649 202879 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
10392925 14439 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120081 14439 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
18686789 92974 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441369 92974 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
136094778 139261 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
CHEMBL379010 139261 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
10357939 118079 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL340559 118079 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
44294291 101190 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL295685 101190 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408158 140179 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL380408 140179 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
56662745 64643 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64643 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64643 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
10258336 101282 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296397 101282 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44307416 203008 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63240 203008 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
10258336 101282 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL296397 101282 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44456703 158354 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL408960 158354 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
2102 1189 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
5311057 1189 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
CHEMBL441225 1189 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
2098 3694 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
36511 3694 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3805 3694 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3835 3694 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
CHEMBL235363 3694 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
44412225 139709 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL379816 139709 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL5269970 193613 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1252 41 16 16 -2.3 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
44407431 73229 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
CHEMBL201192 73229 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
10076383 101226 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL296013 101226 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
104943 55386 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL16192 55386 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
44408313 74502 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL202884 74502 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
52941550 17804 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258852 17804 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
104943 55386 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL16192 55386 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44433784 90190 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238210 90190 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
44416136 79807 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212025 79807 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
9855000 20621 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20621 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
10347274 128673 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL366818 128673 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55386 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
CHEMBL16192 55386 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
21955298 79629 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115006 79629 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL396426 212496 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44415967 138701 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL377917 138701 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46947062 17460 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17460 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10502796 32314 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL141034 32314 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44578024 178694 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL468163 178694 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
10372941 119508 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
CHEMBL345520 119508 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
10885893 102912 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL306089 102912 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
10553959 187870 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL49638 187870 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44305221 101028 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL294545 101028 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
10553959 187870 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL49638 187870 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44313273 204969 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL76501 204969 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44433793 148384 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393746 148384 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL396426 212496 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
22293505 189529 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL51417 189529 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
25028925 91365 4 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 91365 4 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
44358731 30340 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139167 30340 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10077113 121543 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL35857 121543 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 55386 39 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 55386 39 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
22293475 187128 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 187128 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415444 80222 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213726 80222 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
52949827 17342 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 17342 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 8013 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8013 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL229280 209458 0 None 23 3 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
44333607 4975 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL104883 4975 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10142159 81544 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21607 81544 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
44274180 163191 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL418186 163191 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
44433787 88532 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL235219 88532 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
11800024 208257 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98811 208257 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
136180340 119609 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL346447 119609 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10053205 116585 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL336589 116585 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11800024 208257 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98811 208257 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44408123 140587 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL381362 140587 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
46881682 8097 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8097 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
104943 55386 39 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL16192 55386 39 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10578351 120228 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL352176 120228 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
71449072 78578 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
CHEMBL2112212 78578 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
56668401 66443 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817890 66443 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852009 66443 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415404 80041 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212931 80041 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10721713 120037 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350381 120037 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
18709649 165006 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42259 165006 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44415550 166136 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL426145 166136 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46881820 7561 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 7561 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44433792 148382 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393745 148382 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
22901329 99079 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL28055 99079 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
22901329 99079 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL28055 99079 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44294689 101613 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL298858 101613 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11016806 204957 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL76455 204957 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
9829083 120139 0 None - 1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 120139 0 None - 1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10816374 18895 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128384 18895 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
132846 2238 23 None - 1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00009-I
13432 2238 23 None - 1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00009-I
CHEMBL27006 2238 23 None - 1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00009-I
132846 2238 23 None - 1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/acs.jmedchem.1c00790
13432 2238 23 None - 1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/acs.jmedchem.1c00790
CHEMBL27006 2238 23 None - 1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/acs.jmedchem.1c00790
132846 2238 23 None - 1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm950654w
13432 2238 23 None - 1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm950654w
CHEMBL27006 2238 23 None - 1 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm950654w
135547943 34427 26 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL142819 34427 26 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
44456828 97580 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270751 97580 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44358610 29483 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138463 29483 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10531050 120352 0 None - 0 Guinea pig 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 120352 0 None - 0 Guinea pig 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
18669087 98730 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL277880 98730 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669087 98730 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL277880 98730 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44325035 112153 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329018 112153 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44415400 80093 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213134 80093 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
9938657 60222 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 60222 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
10502796 32314 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL141034 32314 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
11799022 4467 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL101763 4467 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
46881727 5594 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 5594 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
15549737 178816 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL469176 178816 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 182442 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 182442 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44578056 189757 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL515935 189757 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
19797472 118762 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
CHEMBL341863 118762 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
10341570 121074 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 121074 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 3694 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 3694 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 3694 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 3694 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3694 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
58993655 122099 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596486 122099 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
24752434 9133 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9133 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL2370435 209849 0 None 48 2 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptorDisplacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm8007618
15639110 168142 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL433020 168142 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44274544 81526 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21602 81526 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44328469 112240 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL329090 112240 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
24782914 122095 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596482 122095 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884431 8055 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091043 8055 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10578269 35146 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143464 35146 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
4898 2765 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
5742 2765 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
6451149 2765 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
CHEMBL206253 2765 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
DB09048 2765 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
10047566 165241 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL422931 165241 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10047566 165241 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL422931 165241 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415840 79966 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212663 79966 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10049890 80012 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 80012 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10047566 165241 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL422931 165241 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL389652 212430 0 None 2 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11813209 205099 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL77684 205099 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
18669072 83317 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21909 83317 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
10576865 208127 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98022 208127 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44433810 89879 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL237796 89879 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
9959724 164855 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42191 164855 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
10531050 120352 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 120352 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
489662 83027 2 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL21815 83027 2 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
132846 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/s0960-894x(98)00320-5
13432 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/s0960-894x(98)00320-5
CHEMBL27006 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/s0960-894x(98)00320-5
44297605 194687 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL53312 194687 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
132846 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/j.bmc.2013.09.001
13432 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/j.bmc.2013.09.001
CHEMBL27006 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/j.bmc.2013.09.001
9805809 103087 8 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL307488 103087 8 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
44338517 6335 0 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108200 6335 0 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9938657 60222 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 60222 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
132846 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm980376b
13432 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm980376b
CHEMBL27006 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm980376b
44346206 113661 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL332284 113661 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
132846 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80585-0
13432 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80585-0
CHEMBL27006 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80585-0
10047567 207219 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL92701 207219 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
132846 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00220-N
13432 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00220-N
CHEMBL27006 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00220-N
9890435 97444 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL27003 97444 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
2102 1189 21 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
5311057 1189 21 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL441225 1189 21 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
44458328 99515 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL283356 99515 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
132846 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm9700171
13432 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm9700171
CHEMBL27006 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm9700171
11799022 4467 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL101763 4467 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44458328 99515 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL283356 99515 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44346206 113661 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL332284 113661 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
10576865 208127 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98022 208127 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
10648551 208427 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99873 208427 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
132846 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80280-8
13432 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80280-8
CHEMBL27006 2238 23 None - 1 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80280-8
489662 83027 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21815 83027 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
489662 83027 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21815 83027 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10648551 208427 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99873 208427 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
24799545 87421 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333621 87421 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44407321 74407 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202568 74407 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410193 140334 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL380684 140334 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
44297605 194687 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
CHEMBL53312 194687 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
44456580 155286 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL402895 155286 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
24889111 7924 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090287 7924 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 17243 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17243 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 17307 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 17307 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943994 17832 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 17832 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10047566 165241 3 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL422931 165241 3 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
44458328 99515 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL283356 99515 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
46227361 202583 0 None 14 4 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 202583 0 None 14 4 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL389652 212430 0 None -2 4 Rat 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44335318 5105 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105600 5105 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44312285 102957 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306400 102957 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10047566 165241 3 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL422931 165241 3 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
71450941 79519 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113739 79519 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
44305248 202887 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62679 202887 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
9805809 103087 8 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL307488 103087 8 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
2098 3694 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
36511 3694 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3805 3694 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3835 3694 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
CHEMBL235363 3694 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
CHEMBL5284869 194268 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1[nH]nnc1CN1CCO[C@@]2(CC[C@@H](c3ccccc3C(F)(F)F)CO2)[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
10837742 185865 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL48680 185865 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
44318685 206002 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84881 206002 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44408124 75400 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL203961 75400 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
58993471 122097 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596484 122097 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
58993453 122101 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
CHEMBL3596488 122101 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
56662745 64643 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64643 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64643 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415415 78977 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL211304 78977 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884469 7993 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090651 7993 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
46881779 8450 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8450 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306210 102387 0 None - 0 Guinea pig 9.0 pIC50 = 9.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303896 102387 0 None - 0 Guinea pig 9.0 pIC50 = 9.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44335372 4774 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL103979 4774 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
10414428 4853 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
CHEMBL104301 4853 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
44358603 119045 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342662 119045 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9959330 195557 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL554713 195557 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2098 3694 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 3694 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 3694 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 3694 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3694 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
10578969 57226 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL165007 57226 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10626048 118570 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL341599 118570 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
490428 119576 6 None - 0 Guinea pig 8.9 pIC50 = 8.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 119576 6 None - 0 Guinea pig 8.9 pIC50 = 8.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44294535 103511 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL3085128 103511 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
24801458 87424 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333624 87424 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
44407422 141364 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL383743 141364 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410281 75568 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL204573 75568 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
58993670 122102 0 None - 0 Mongolian jird 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
CHEMBL3596489 122102 0 None - 0 Mongolian jird 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
57399170 71653 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917842 71653 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963612 71653 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456650 155494 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL404089 155494 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
52941570 17244 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256587 17244 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943848 17420 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 17420 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10052312 107390 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL317896 107390 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44338545 9335 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111176 9335 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9916428 112846 2 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
CHEMBL330888 112846 2 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
10793838 120086 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350846 120086 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9892852 84380 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL22194 84380 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9890435 97444 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL27003 97444 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
44333692 4557 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102434 4557 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44270505 12366 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1185492 12366 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL417263 12366 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
9890435 97444 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
CHEMBL27003 97444 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
9890435 97444 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL27003 97444 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44318605 205866 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83772 205866 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44456894 160538 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL411242 160538 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
10049890 80012 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 80012 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
22885690 141783 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL386151 141783 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
52942803 17246 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 17246 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
11756839 5198 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL106087 5198 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
9892852 84380 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL22194 84380 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
44358676 30011 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL138890 30011 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9850771 119878 3 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119878 3 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9892852 84380 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL22194 84380 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44368171 45399 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152742 45399 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10460917 163749 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163749 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 5409 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5409 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11568372 206025 5 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL85047 206025 5 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL5285318 194292 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1[nH]nnc1CN1CCO[C@@]2(CC[C@@H](c3ccccc3OC(F)(F)F)CO2)[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
44318672 206090 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85626 206090 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
57390401 71607 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963299 71607 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3216988 71607 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44415986 80384 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214472 80384 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889113 7948 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7948 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7948 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46881728 5595 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 5595 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44335319 107510 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL318606 107510 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44370448 119759 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL347891 119759 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358604 28521 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
CHEMBL137609 28521 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
44358732 31251 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140124 31251 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358428 119009 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342607 119009 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9871754 5409 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5409 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
2098 3694 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
36511 3694 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3805 3694 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3835 3694 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3694 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
2098 3694 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
36511 3694 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3805 3694 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3835 3694 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
CHEMBL235363 3694 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
136180339 121104 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL357303 121104 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10027219 99582 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL283872 99582 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
44274412 76038 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
CHEMBL20572 76038 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
44410283 138302 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL377091 138302 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
22293475 187128 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 187128 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408295 140325 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL380651 140325 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
2098 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
36511 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3805 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3835 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
CHEMBL235363 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
56662745 64643 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64643 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64643 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
2098 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
36511 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3805 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3835 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
CHEMBL235363 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
44456625 168934 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL438759 168934 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415403 138695 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
CHEMBL377881 138695 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
52941489 17731 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17731 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52941506 17767 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258732 17767 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17460 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17460 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
71699792 124785 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3642162 124785 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
19797432 37755 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 37755 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10438671 27348 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL136764 27348 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358707 31457 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL140299 31457 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
9850771 119878 3 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119878 3 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10076881 162916 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
CHEMBL417407 162916 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
10627355 120010 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 120010 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44338518 7722 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108889 7722 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
44338359 163429 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL419742 163429 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
132629 2236 15 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
2104 2236 15 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
CHEMBL24999 2236 15 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
21050485 167965 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL431732 167965 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
24799366 87418 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333618 87418 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
10648288 101900 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL300856 101900 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
24785977 122069 0 None - 0 Mongolian jird 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596456 122069 0 None - 0 Mongolian jird 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01029
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01029
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01029
10414293 37453 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145535 37453 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
44396853 67273 9 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL188166 67273 9 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
21994307 26814 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136305 26814 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358471 30167 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139015 30167 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
132837 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
9461 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
CHEMBL22870 2237 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
10394703 194967 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54540 194967 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
135480369 33711 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
CHEMBL142216 33711 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
44274269 77031 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20717 77031 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
22293476 79628 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115005 79628 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
24889283 8431 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093595 8431 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
52948931 17249 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 17249 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
52941351 17378 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 17378 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44306310 102320 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303548 102320 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306023 102386 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303890 102386 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10100236 28814 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137887 28814 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358470 29928 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138825 29928 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358561 30476 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139286 30476 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
2098 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
36511 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3805 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3835 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3694 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
10075595 60347 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174526 60347 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10554361 30861 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL139719 30861 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
10529338 31417 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL140263 31417 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10840066 116720 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL337358 116720 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
71541574 87411 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333611 87411 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44307181 203718 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL67667 203718 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
58993542 122108 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596495 122108 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884432 7922 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090285 7922 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947647 17247 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 17247 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 6543 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6543 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 8013 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8013 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306218 162574 0 None - 0 Guinea pig 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL416864 162574 0 None - 0 Guinea pig 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44370973 46765 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL153976 46765 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44370354 121216 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
CHEMBL357757 121216 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
10462250 121393 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL358173 121393 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358720 28500 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137580 28500 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358657 30404 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139226 30404 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10816935 118107 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL340732 118107 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
46881821 5600 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 5600 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
71541373 87425 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333625 87425 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800231 87437 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333637 87437 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24785712 122104 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
CHEMBL3596491 122104 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
57393953 71615 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917849 71615 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963369 71615 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
44415443 77935 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL209531 77935 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415485 79910 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212439 79910 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415502 80037 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212919 80037 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884517 8092 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091341 8092 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 7769 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 7769 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 17243 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17243 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17460 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17460 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 6543 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6543 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
19797432 37755 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 37755 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10650469 57439 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165498 57439 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44328374 207987 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL97241 207987 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
11755361 116568 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL336439 116568 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
15639149 112909 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL331059 112909 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10413173 29658 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
CHEMBL138620 29658 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
44346149 15517 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL121742 15517 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44346551 15582 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL122119 15582 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10359664 114002 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
CHEMBL332644 114002 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
54581461 61263 0 None -6 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 61263 0 None -6 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
10254526 100496 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL291025 100496 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44368083 44959 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152339 44959 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10457416 14886 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14886 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10098987 59981 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 59981 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
14986135 163401 0 None - 0 Guinea pig 8.0 pIC50 = 8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL419500 163401 0 None - 0 Guinea pig 8.0 pIC50 = 8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44402934 71072 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
CHEMBL195222 71072 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
44359091 31248 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
CHEMBL140123 31248 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
44346420 14305 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14305 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
44318657 205919 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84090 205919 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL2371978 210172 0 None 30 3 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
104943 55386 39 None 1862 3 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL16192 55386 39 None 1862 3 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
18391045 100396 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL290043 100396 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
44288896 168987 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 168987 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
19098237 37121 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 37121 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44312056 204723 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL74237 204723 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44358585 31266 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
CHEMBL140134 31266 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
18709652 168286 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL434012 168286 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
44306230 100756 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292799 100756 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44319057 205844 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83585 205844 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
19049350 99280 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL281940 99280 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
19049350 99280 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL281940 99280 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
19049350 99280 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL281940 99280 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
44346694 114810 1 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL334072 114810 1 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44289443 169072 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43970 169072 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
44297749 194462 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL52892 194462 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44333579 4382 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL101288 4382 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
44338510 8633 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
CHEMBL109514 8633 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
44338531 9358 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111304 9358 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
44322648 206318 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL87194 206318 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
44322525 206573 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL88810 206573 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
10095174 206663 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89385 206663 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44415470 165844 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL424883 165844 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884433 7923 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090286 7923 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44294395 187195 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
74972677 187195 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL49233 187195 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
15755315 163181 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
CHEMBL418124 163181 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
15755303 200348 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59768 200348 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755300 202977 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL63059 202977 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44337428 7235 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
CHEMBL108575 7235 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
10793341 108840 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
CHEMBL320989 108840 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
44411742 78303 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
CHEMBL210811 78303 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
44344435 13086 0 None - 0 Human 6.0 pIC50 = 6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL119025 13086 0 None - 0 Human 6.0 pIC50 = 6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
2125 3030 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
5311350 3030 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
CHEMBL444832 3030 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
44291515 101138 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
CHEMBL295301 101138 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
44291788 101412 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
CHEMBL297327 101412 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
44346650 114439 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
CHEMBL333308 114439 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
15755305 100985 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294288 100985 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755312 101060 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
CHEMBL294737 101060 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
15755330 202817 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL62349 202817 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755295 203267 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64631 203267 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL1190873 208593 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
CHEMBL541800 208593 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
10840399 9375 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL111384 9375 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
15755333 100577 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
CHEMBL291602 100577 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
15755331 100848 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293445 100848 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755294 203314 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64829 203314 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64601 215855 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
10744888 108667 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
CHEMBL320762 108667 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
44337578 168087 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL432620 168087 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
15485361 97230 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL26860 97230 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
10362340 90270 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23851 90270 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44274545 82511 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21775 82511 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44362598 36824 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145022 36824 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10362340 90270 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
CHEMBL23851 90270 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
44312026 102851 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL305608 102851 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
44289232 169872 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL444043 169872 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10349900 106749 0 None - 3 Rat 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106749 0 None - 3 Rat 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL2369600 209634 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10477952 98988 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL279916 98988 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
19797474 37471 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145552 37471 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44384902 59947 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL173245 59947 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44362586 37751 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
CHEMBL145799 37751 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
44276673 97357 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26951 97357 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
44324705 112357 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329445 112357 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
44359056 119450 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL345069 119450 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
10039383 85477 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
CHEMBL22680 85477 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
44297603 163128 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL417760 163128 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
11683136 105803 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126963 105803 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
44333708 163376 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL419352 163376 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
11489471 94880 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL25398 94880 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10389968 59893 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL173014 59893 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
21753663 196655 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56442 196655 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
71541576 87413 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333613 87413 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800927 87439 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333639 87439 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
44433783 90189 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238209 90189 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
46883823 8432 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 8432 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11705241 88235 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347857 88235 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
24993314 171039 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 171039 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44306115 203489 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL66151 203489 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44324814 207205 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL92621 207205 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
44288901 163282 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL418697 163282 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
11318556 93935 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 93935 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10840688 120201 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351940 120201 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44299464 199765 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL59380 199765 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44306211 102336 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303680 102336 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
46884467 7991 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 7991 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10202046 121061 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL356912 121061 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
10407571 167957 10 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
CHEMBL431690 167957 10 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
44307162 203360 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL65153 203360 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
71583096 88220 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
CHEMBL2347694 88220 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
15755296 102283 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL303337 102283 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755297 102659 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL304472 102659 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10256518 97395 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
CHEMBL269781 97395 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
10363425 164608 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL421591 164608 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288846 168336 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43432 168336 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10317821 36789 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL144996 36789 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44358472 116795 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL337803 116795 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44294321 12050 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
54093758 12050 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL1183502 12050 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL301168 12050 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
15037921 119625 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346626 119625 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
68928842 124798 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642175 124798 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44312218 204140 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL70461 204140 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10506929 56579 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
CHEMBL164175 56579 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
44328416 207941 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL96956 207941 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
10039383 85477 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
CHEMBL22680 85477 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
19797452 121529 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL358529 121529 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44287503 100206 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL288340 100206 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44299829 199076 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL58774 199076 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
44287541 159657 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL41038 159657 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL449091 213960 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
10692651 101089 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL294960 101089 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
19003165 102174 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
CHEMBL302719 102174 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
3198 205513 76 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 205513 76 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 205513 76 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44297683 168190 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL433285 168190 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
9869033 100424 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL290364 100424 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
71541468 87433 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333633 87433 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
24801626 87440 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333640 87440 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
57403990 70954 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951620 70954 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
44335410 5000 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105009 5000 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44288885 100284 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
CHEMBL289026 100284 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
44396809 166367 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
CHEMBL427514 166367 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
44358709 29790 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
CHEMBL138715 29790 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
44358679 29856 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138770 29856 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358680 116604 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL336715 116604 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44358683 119370 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
CHEMBL344434 119370 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
9869033 100424 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL290364 100424 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
9869033 100424 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL290364 100424 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
9910357 11979 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183052 11979 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL277524 11979 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44338638 5724 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107829 5724 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338546 108608 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL320535 108608 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
9917079 61165 39 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 61165 39 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
44346334 15245 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL121094 15245 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
10837362 30750 1 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL139558 30750 1 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
44299969 197196 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56814 197196 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44359117 119333 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
CHEMBL344217 119333 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
44297491 195350 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55180 195350 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
76325557 105799 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126959 105799 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
76325558 105808 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126968 105808 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
490428 119576 6 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 119576 6 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
22293473 79632 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115009 79632 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
24783682 122072 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596459 122072 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
11724403 168545 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
CHEMBL435564 168545 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
9852911 99383 0 None 8 6 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm000316h
CHEMBL282618 99383 0 None 8 6 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm000316h
CHEMBL2372525 210270 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
CHEMBL5268296 193558 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1264 38 15 16 -2.1 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
15118534 106190 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 467 0 1 5 4.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm00080a025
CHEMBL3138259 106190 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 467 0 1 5 4.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm00080a025
11445389 188391 15 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 692 5 2 6 3.7 CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 10.1021/np50111a008
CHEMBL501675 188391 15 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 692 5 2 6 3.7 CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 10.1021/np50111a008
44287211 160535 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.9 CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL41124 160535 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.9 CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
16755229 173927 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
CHEMBL454087 173927 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
10435750 99256 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00035a006
CHEMBL281804 99256 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00035a006
10506124 101260 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL296228 101260 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10435750 99256 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00066a015
CHEMBL281804 99256 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00066a015
44312952 105395 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL311688 105395 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
44322649 163371 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL419312 163371 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322524 206602 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 7 1 2 6.1 Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
CHEMBL88998 206602 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 7 1 2 6.1 Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
44322704 206722 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 426 6 1 3 4.8 O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89847 206722 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 426 6 1 3 4.8 O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346399 161669 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 536 9 3 3 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL413108 161669 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 536 9 3 3 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
44322678 206561 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 414 5 1 3 4.4 O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL88731 206561 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 414 5 1 3 4.4 O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346333 13056 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL1190061 13056 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL540060 13056 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
10530444 120200 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 11 2 4 4.1 CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL351922 120200 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 11 2 4 4.1 CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44212284 59988 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL173420 59988 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
19797443 165611 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL424307 165611 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10439730 106757 0 None 39 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106757 0 None 39 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44346302 113101 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
CHEMBL331392 113101 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
11724403 168545 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL435564 168545 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
44333821 4776 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 457 5 0 3 5.6 CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL103984 4776 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 457 5 0 3 5.6 CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
44297293 170828 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 617 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL445357 170828 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 617 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44368118 119484 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL345315 119484 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
22859115 207231 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL92818 207231 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44334143 4574 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 497 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102569 4574 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 497 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 10.1016/S0960-894X(96)00563-X
22859115 207231 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92818 207231 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
2090 2767 25 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311312 2767 25 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL437797 2767 25 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
24801795 87429 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 490 6 0 5 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333629 87429 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 490 6 0 5 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44318405 105581 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL312202 105581 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
24784192 122084 0 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596471 122084 0 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44297912 194688 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 527 10 1 5 5.0 COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL53314 194688 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 527 10 1 5 5.0 COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44433786 146910 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 4 0 2 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL392567 146910 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 4 0 2 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
46883824 8433 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093597 8433 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52941570 17244 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256587 17244 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52941550 17804 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258852 17804 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10251123 4838 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 6 1 4 5.1 COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104225 4838 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 6 1 4 5.1 COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
44370893 119843 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 606 17 3 5 4.4 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
CHEMBL348594 119843 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 606 17 3 5 4.4 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
9869033 100424 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 100424 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
71449177 79662 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL2115161 79662 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
71456198 78575 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL2112209 78575 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
44299583 101670 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 473 7 1 2 5.9 NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL299275 101670 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 473 7 1 2 5.9 NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
19968650 169365 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 363 5 1 2 4.9 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm980376b
CHEMBL442028 169365 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 363 5 1 2 4.9 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm980376b
44319222 106143 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313546 106143 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44326280 98078 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 297 5 1 2 4.5 Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 10.1016/0960-894X(95)00476-A
CHEMBL273302 98078 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 297 5 1 2 4.5 Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 10.1016/0960-894X(95)00476-A
49799942 10546 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL1169534 10546 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
44294194 176830 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 430 4 2 2 4.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 10.1016/s0960-894x(02)00249-4
CHEMBL46103 176830 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 430 4 2 2 4.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 10.1016/s0960-894x(02)00249-4
24783421 122076 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596463 122076 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
22850669 202986 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL63109 202986 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
22850669 202986 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL63109 202986 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
44289169 101488 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297883 101488 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44358649 28789 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 9 1 3 7.5 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137868 28789 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 9 1 3 7.5 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358611 29110 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 580 8 2 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 10.1021/jm000986n
CHEMBL138130 29110 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 580 8 2 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 10.1021/jm000986n
44358673 31463 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 10 1 5 4.8 COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140303 31463 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 10 1 5 4.8 COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44289169 101488 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL297883 101488 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44297728 100763 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 751 8 1 5 6.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292874 100763 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 751 8 1 5 6.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44294416 183967 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
74972686 183967 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL48173 183967 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL406442 212608 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
44458825 11990 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
54428149 11990 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1183194 11990 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL283990 11990 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
132961 142102 15 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell lineCompound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80178-5
CHEMBL38824 142102 15 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell lineCompound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80178-5
10364942 93354 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00035a006
CHEMBL24549 93354 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00035a006
71456210 78658 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 293 2 1 2 4.1 c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 10.1016/s0960-894x(02)00509-7
CHEMBL2112367 78658 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 293 2 1 2 4.1 c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 10.1016/s0960-894x(02)00509-7
10364942 93354 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00066a015
CHEMBL24549 93354 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00066a015
49863733 15332 0 None 2 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15332 0 None 2 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44326290 207403 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 271 6 1 3 3.2 COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL93909 207403 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 271 6 1 3 3.2 COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44288789 101376 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL297134 101376 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44386105 131930 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL369498 131930 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
10429546 99057 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL280422 99057 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
46227361 202583 0 None -85 4 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 202583 0 None -85 4 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44289257 100350 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL289573 100350 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44289257 100350 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL289573 100350 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
44288789 101376 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL297134 101376 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL2369603 209636 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44306341 203745 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 499 9 2 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 10.1021/jm00039a022
CHEMBL67843 203745 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 499 9 2 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 10.1021/jm00039a022
10389745 100503 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL291074 100503 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
76318227 105804 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 7 1 2 6.7 CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126964 105804 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 7 1 2 6.7 CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
11612528 105815 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 6 0 2 6.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126974 105815 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 6 0 2 6.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
44334112 5040 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105201 5040 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(96)00563-X
44333950 108241 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 10.1016/S0960-894X(96)00563-X
CHEMBL319700 108241 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 10.1016/S0960-894X(96)00563-X
44276728 168042 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL432279 168042 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
44299875 194788 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL53846 194788 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44274167 83450 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21991 83450 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
44276728 168042 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL432279 168042 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
56678621 66445 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817883 66445 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852017 66445 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44306004 13334 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL1192152 13334 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL543338 13334 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44306694 100804 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL293164 100804 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306354 203009 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 513 10 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 10.1021/jm00039a022
CHEMBL63249 203009 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 513 10 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 10.1021/jm00039a022
44312257 102910 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306065 102910 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44358602 27309 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 8 0 3 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136734 27309 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 8 0 3 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358596 29266 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138269 29266 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
22293565 79704 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115449 79704 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
44303850 101069 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294798 101069 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44303793 200121 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 709 13 3 9 3.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59615 200121 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 709 13 3 9 3.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 10.1021/jm00089a011
68932793 124796 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642173 124796 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44337795 108575 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 593 9 1 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL320308 108575 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 593 9 1 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
9978999 5484 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 4 2 3 5.1 Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL107618 5484 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 4 2 3 5.1 Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44324710 112349 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 2 4 5.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329416 112349 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 2 4 5.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 10.1016/S0960-894X(01)80747-2
44358435 28718 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137792 28718 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44381056 57610 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL166816 57610 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
44294376 12052 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
53927094 12052 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183513 12052 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL301946 12052 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
44294476 186208 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against human NK1 receptorCompound was tested for binding affinity against human NK1 receptor
ChEMBL 497 9 3 3 6.5 CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL48731 186208 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against human NK1 receptorCompound was tested for binding affinity against human NK1 receptor
ChEMBL 497 9 3 3 6.5 CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 10.1016/0960-894X(95)00313-I
132961 142102 15 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL38824 142102 15 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL264353 210618 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44346199 14247 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL119947 14247 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2369630 209645 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44358834 30582 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 10.1021/jm00022a010
CHEMBL139375 30582 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 10.1021/jm00022a010
44346199 14247 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1021/jm9700171
CHEMBL119947 14247 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1021/jm9700171
44433782 145467 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 6.0 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
CHEMBL391441 145467 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 6.0 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
9832198 106755 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106755 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
16214865 173272 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
CHEMBL452531 173272 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
44346259 114117 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL332796 114117 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
44346259 114117 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
CHEMBL332796 114117 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
10767359 56502 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 489 11 2 4 3.7 CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL163481 56502 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 489 11 2 4 3.7 CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44368082 44933 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
CHEMBL152316 44933 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
44287609 100361 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL289666 100361 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
44274316 165415 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 579 8 0 6 6.1 COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL423836 165415 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 579 8 0 6 6.1 COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
56666212 64642 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 442 7 1 4 4.9 COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817896 64642 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 442 7 1 4 4.9 COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
52941489 17731 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17731 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL2112243 209230 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
21994365 25459 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL135028 25459 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44358708 29789 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 665 8 0 3 8.6 CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1021/jm000986n
CHEMBL138714 29789 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 665 8 0 3 8.6 CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1021/jm000986n
44345148 10485 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 477 5 1 3 5.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL116535 10485 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 477 5 1 3 5.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44458598 98848 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL278849 98848 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
9954221 15533 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 426 7 1 2 5.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1021/jm9700171
CHEMBL121852 15533 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 426 7 1 2 5.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1021/jm9700171
44359025 29136 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 485 9 3 4 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL138150 29136 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 485 9 3 4 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
44306435 96789 0 None - 0 Guinea pig 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 566 9 2 5 4.2 CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL264821 96789 0 None - 0 Guinea pig 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 566 9 2 5 4.2 CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
44368326 172626 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 413 7 0 3 5.5 COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL449347 172626 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 413 7 0 3 5.5 COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44299750 195669 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55651 195669 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
10483816 191198 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL51893 191198 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
10407571 167957 10 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL431690 167957 10 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
19797480 121546 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL358589 121546 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10409595 4789 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 415 4 1 3 5.0 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104075 4789 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 415 4 1 3 5.0 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44358473 31464 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 10.1021/jm000986n
CHEMBL140304 31464 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 10.1021/jm000986n
44358801 118969 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 7 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 10.1021/jm00022a010
CHEMBL342386 118969 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 7 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 10.1021/jm00022a010
14986146 44586 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152011 44586 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 10.1016/S0960-894X(01)81197-5
44297488 195108 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 558 9 1 6 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54996 195108 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 558 9 1 6 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44297487 195278 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55129 195278 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10073370 59919 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 1 2 5.2 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
CHEMBL173120 59919 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 1 2 5.2 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
10045010 90191 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23822 90191 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44299854 100664 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL292237 100664 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
10041814 98875 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00035a006
CHEMBL279050 98875 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00035a006
10064734 122963 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm0311487
CHEMBL360815 122963 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm0311487
10041814 98875 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00066a015
CHEMBL279050 98875 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00066a015
1016 3747 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3747 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3747 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3747 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3747 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3747 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
44297424 190987 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 551 9 1 5 3.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL51863 190987 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 551 9 1 5 3.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
2247 505 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 505 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 505 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 505 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 505 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
44358981 161672 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 546 10 4 4 5.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL413122 161672 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 546 10 4 4 5.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 10.1021/jm00022a010
44346319 113456 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 597 9 3 6 5.9 O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL331925 113456 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 597 9 3 6 5.9 O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 10.1021/jm9700171
12096357 56201 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
CHEMBL162636 56201 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
44368158 121767 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL358932 121767 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11518191 105813 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 457 7 1 2 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126972 105813 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 457 7 1 2 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
76314660 105818 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 1 2 6.3 CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126977 105818 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 1 2 6.3 CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
11489240 95290 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL25639 95290 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
10407571 167957 10 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL431690 167957 10 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
44321456 206692 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 8 1 3 5.5 CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL89652 206692 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 8 1 3 5.5 CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
104943 55386 39 None 1862 3 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not testedCompound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not tested
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL16192 55386 39 None 1862 3 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not testedCompound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not tested
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
71541469 87434 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 7 0 3 5.6 CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333634 87434 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 7 0 3 5.6 CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44318658 104783 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 387 4 1 5 3.4 COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
CHEMBL310896 104783 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 387 4 1 5 3.4 COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
44415540 141804 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 5 0 2 6.2 CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL386258 141804 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 5 0 2 6.2 CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
71583094 88218 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347692 88218 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
71452663 78542 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2112070 78542 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
11743207 4814 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 5 0 4 4.8 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104165 4814 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 5 0 4 4.8 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10342371 4944 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104737 4944 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44358710 30214 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 8 0 6 4.1 COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139057 30214 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 8 0 6 4.1 COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10531050 120352 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 120352 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
118722856 116190 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 323 6 2 4 2.1 N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358420 116190 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 323 6 2 4 2.1 N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44321408 107022 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL315435 107022 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44321408 107022 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL315435 107022 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
15037920 45729 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL153042 45729 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
10531291 6573 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL108304 6573 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44380707 120572 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL354564 120572 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
136056467 189201 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
49824386 189201 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL51135 189201 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44348660 118046 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 389 0 1 4 4.1 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL340394 118046 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 389 0 1 4 4.1 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
2812 4779 101 None -43 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4779 101 None -43 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44404006 132756 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
CHEMBL370013 132756 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
10439730 106757 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106757 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44297705 190883 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL51849 190883 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
71450949 79549 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL2114103 79549 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10055415 106756 0 None 15 3 Human 6.8 pIC50 = 6.8 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106756 0 None 15 3 Human 6.8 pIC50 = 6.8 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10344874 120150 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL351387 120150 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
44386231 61380 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
CHEMBL176951 61380 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
15639102 114528 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 6.0 c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL333566 114528 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 6.0 c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
11433531 91128 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 618 7 1 3 9.4 CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL23982 91128 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 618 7 1 3 9.4 CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9933653 99008 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 454 7 1 2 6.4 OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL28003 99008 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 454 7 1 2 6.4 OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
44299444 197189 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 346 7 1 2 5.0 Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56811 197189 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 346 7 1 2 5.0 Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
58993503 122088 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 483 7 1 4 6.0 COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596475 122088 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 483 7 1 4 6.0 COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44297858 155765 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 589 11 2 5 5.4 CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL405820 155765 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 589 11 2 5 5.4 CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
24992986 184304 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL484133 184304 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
18654565 167929 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 698 17 0 5 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL431459 167929 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 698 17 0 5 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
10370818 162651 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 571 6 1 3 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL416983 162651 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 571 6 1 3 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44297708 194970 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 587 10 1 5 5.5 CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54578 194970 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 587 10 1 5 5.5 CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10834930 121501 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 365 6 1 3 4.4 FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL358305 121501 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 365 6 1 3 4.4 FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44213477 205744 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 309 2 1 3 3.6 c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL82692 205744 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 309 2 1 3 3.6 c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 10.1016/s0960-894x(02)00506-1
10369316 88224 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 517 5 0 3 7.2 CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347702 88224 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 517 5 0 3 7.2 CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44328401 112667 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 6.0 c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL330362 112667 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 6.0 c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
10835447 24735 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL134415 24735 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
71583093 88229 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 1 7.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347851 88229 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 1 7.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
15755313 102199 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 649 15 4 9 2.5 CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
CHEMBL302844 102199 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 649 15 4 9 2.5 CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
19797425 37417 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C 10.1021/jm00024a007
CHEMBL145500 37417 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C 10.1021/jm00024a007
CHEMBL64037 215852 0 None - 0 Guinea pig 4.8 pIC50 = 4.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
46227360 202582 0 None -151 4 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 202582 0 None -151 4 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44297680 100644 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292156 100644 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL265155 210638 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm00037a009
122182824 122091 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 7 1 3 6.3 CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596478 122091 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 7 1 3 6.3 CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
56681948 66470 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817882 66470 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852159 66470 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44335466 5054 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL105295 5054 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44358783 30669 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 483 8 3 3 5.9 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C 10.1021/jm00022a010
CHEMBL139471 30669 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 483 8 3 3 5.9 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C 10.1021/jm00022a010
11192771 94336 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 607 8 1 3 8.5 CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL25065 94336 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 607 8 1 3 8.5 CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9985523 99161 0 None - 5 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 572 17 2 6 6.2 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 10.1021/jm960281e
CHEMBL281200 99161 0 None - 5 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 572 17 2 6 6.2 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 10.1021/jm960281e
24799546 87422 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 509 10 0 4 6.5 CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333622 87422 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 509 10 0 4 6.5 CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
58993452 122063 0 None - 0 Mongolian jird 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.8 Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596450 122063 0 None - 0 Mongolian jird 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.8 Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
44458786 11153 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1178356 11153 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL23096 11153 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
44349033 16789 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 0 1 4 5.6 CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124532 16789 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 0 1 4 5.6 CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
22869971 165268 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 430 3 1 2 4.9 N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42306 165268 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 430 3 1 2 4.9 N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
9981979 99158 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm00035a006
CHEMBL281194 99158 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm00035a006
44318349 206065 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
CHEMBL85414 206065 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
44277742 100774 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
CHEMBL29293 100774 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
44321457 168194 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL433336 168194 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
11633082 105802 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126962 105802 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10650263 26087 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL135572 26087 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10501444 101877 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300722 101877 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
135890952 206097 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 406 4 2 6 3.4 Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 10.1016/s0960-894x(02)00506-1
CHEMBL85674 206097 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 406 4 2 6 3.4 Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 10.1016/s0960-894x(02)00506-1
11225834 99209 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL281491 99209 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
10364638 14658 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL120546 14658 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
10094248 4786 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 430 4 0 3 5.4 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL104060 4786 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 430 4 0 3 5.4 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
10006814 5242 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
CHEMBL106326 5242 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
44288548 101258 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL296213 101258 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44288790 170354 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 472 4 1 2 5.1 CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL44474 170354 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 472 4 1 2 5.1 CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
21994270 27094 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 501 7 1 3 6.0 Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL136544 27094 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 501 7 1 3 6.0 Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44312953 204558 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL72951 204558 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
44359088 118784 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 455 8 3 3 5.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 10.1021/jm00022a010
CHEMBL342044 118784 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 455 8 3 3 5.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 10.1021/jm00022a010
178025 119153 6 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL342924 119153 6 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
44305927 100612 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 541 8 2 5 3.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 10.1021/jm00039a022
CHEMBL291868 100612 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 541 8 2 5 3.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 10.1021/jm00039a022
44359111 118891 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 470 8 4 4 4.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL342260 118891 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 470 8 4 4 4.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 10.1021/jm00022a010
10364638 14658 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120546 14658 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1021/jm9700171
44346320 113457 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
CHEMBL331926 113457 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
44321442 206253 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL86806 206253 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44334098 5116 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 477 7 1 3 6.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105631 5116 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 477 7 1 3 6.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
44321457 168194 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL433336 168194 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
9892852 84380 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL22194 84380 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44458328 99515 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283356 99515 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
44458983 99605 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 473 6 2 4 4.4 CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
CHEMBL283989 99605 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 473 6 2 4 4.4 CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
44458351 99390 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL282657 99390 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44277478 167407 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C 10.1016/S0960-894X(00)80349-2
CHEMBL429610 167407 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C 10.1016/S0960-894X(00)80349-2
19797429 170451 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 428 7 0 4 5.4 O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL444872 170451 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 428 7 0 4 5.4 O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10745241 110531 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL325116 110531 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL2369606 209639 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44338530 9357 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111303 9357 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44322429 206264 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 480 5 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL86890 206264 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 480 5 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322610 206645 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89245 206645 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346330 14567 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 522 9 4 3 4.5 O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL120441 14567 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 522 9 4 3 4.5 O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 10.1021/jm9700171
18669055 4610 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 5 0 3 6.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102811 4610 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 5 0 3 6.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
136180338 165186 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 502 10 2 5 5.7 CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL422862 165186 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 502 10 2 5 5.7 CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11757401 59946 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 59946 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9892852 84380 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL22194 84380 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44458328 99515 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283356 99515 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL281971 210847 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm9800346
44287803 100210 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288371 100210 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
25176461 87403 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 404 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333604 87403 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 404 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
25176462 87404 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 390 6 1 3 4.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333605 87404 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 390 6 1 3 4.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 10.1016/j.bmcl.2012.11.094
58993541 122109 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 540 8 0 3 8.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596496 122109 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 540 8 0 3 8.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
136043848 77951 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL209627 77951 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884433 7923 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090286 7923 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
57565074 88222 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347696 88222 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2112240 209227 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44358495 116148 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL335788 116148 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10722491 120035 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 615 12 2 5 5.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 10.1021/jm950616c
CHEMBL350366 120035 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 615 12 2 5 5.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 10.1021/jm950616c
104943 55386 39 None 1862 3 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL16192 55386 39 None 1862 3 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL439019 213818 0 None 3 3 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
44294519 103509 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085126 103509 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44407467 73963 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 2 3 5.1 FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
CHEMBL202141 73963 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 2 3 5.1 FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
44415471 139560 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL379707 139560 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46830287 7990 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090648 7990 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46881729 7939 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7939 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8912 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8912 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1651026 208826 24 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of human tachykinin NK1 receptorInhibition of human tachykinin NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2010.07.034
44358727 26837 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL136323 26837 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44359071 165672 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL424480 165672 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 10.1021/jm00022a010
44177670 61262 0 None -1 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 61262 0 None -1 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
44334108 4649 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 504 6 0 2 7.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL103085 4649 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 504 6 0 2 7.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
135767968 45370 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 386 8 2 5 3.9 Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 10.1016/s0960-894x(97)10163-9
CHEMBL152716 45370 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 386 8 2 5 3.9 Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 10.1016/s0960-894x(97)10163-9
10457416 14886 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14886 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
490428 119576 6 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL346154 119576 6 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44299273 194814 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 402 10 2 3 4.1 Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL53901 194814 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 402 10 2 3 4.1 Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
24782911 122089 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596476 122089 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
16663280 97961 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL272649 97961 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
16663280 97961 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL272649 97961 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10744602 56381 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 523 10 2 4 4.1 CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL163133 56381 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 523 10 2 4 4.1 CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44274277 81075 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 551 7 1 4 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21548 81075 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 551 7 1 4 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 10.1016/s0960-894x(01)00182-2
56681950 66465 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817887 66465 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852130 66465 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415484 168938 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL438789 168938 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884472 7995 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090653 7995 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947646 17245 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256588 17245 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948868 17248 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256591 17248 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
21994340 28021 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 623 7 0 3 7.7 CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137255 28021 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 623 7 0 3 7.7 CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
11800372 118266 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 531 3 0 4 6.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL340931 118266 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 531 3 0 4 6.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL2370874 209939 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/S0960-894X(01)80229-8
44359094 33598 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 511 8 3 4 6.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 10.1021/jm00022a010
CHEMBL142121 33598 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 511 8 3 4 6.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 10.1021/jm00022a010
9927183 195605 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1021/jm9700171
CHEMBL55591 195605 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1021/jm9700171
136180337 121519 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 460 8 3 5 4.6 Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
CHEMBL358437 121519 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 460 8 3 5 4.6 Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
10834119 35631 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 351 5 1 2 5.1 Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 10.1021/jm980376b
CHEMBL143974 35631 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 351 5 1 2 5.1 Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 10.1021/jm980376b
CHEMBL405422 212561 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)SC)C(N)=O 10.1021/jm00037a009
44294224 103507 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 526 5 1 2 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085124 103507 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 526 5 1 2 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
9887525 189825 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL51648 189825 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44415392 141422 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 513 7 2 4 6.1 CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384102 141422 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 513 7 2 4 6.1 CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
24889113 7948 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7948 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7948 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44358467 168241 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL433683 168241 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44328394 207700 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.3 COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL95561 207700 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.3 COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44319084 13697 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194867 13697 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553451 13697 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319321 13704 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194933 13704 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553554 13704 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
132837 2237 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
9461 2237 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
CHEMBL22870 2237 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
CHEMBL405209 212549 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
22293565 79627 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115004 79627 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
46881682 8097 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8097 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
11654898 88230 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347852 88230 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
10369341 5754 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 1 3 6.5 Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL107848 5754 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 1 3 6.5 Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
9980171 9236 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 431 5 0 5 4.0 COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL110679 9236 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 431 5 0 5 4.0 COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
10506929 56579 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
CHEMBL164175 56579 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
18407045 82117 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21662 82117 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL263852 210593 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(N)=O 10.1021/jm00037a009
23025481 64640 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 430 7 0 5 4.8 COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817893 64640 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 430 7 0 5 4.8 COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
57400460 70951 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1951616 70951 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
57398780 70952 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951618 70952 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
46881779 8450 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8450 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
11561036 88231 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347853 88231 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
11539564 88232 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347854 88232 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL389651 212429 0 None 6 3 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
10369844 99338 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 534 7 2 3 6.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL282290 99338 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 534 7 2 3 6.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
24800578 87423 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 419 6 1 4 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333623 87423 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 419 6 1 4 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 10.1016/j.bmcl.2012.11.094
44307417 203073 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.7 NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63762 203073 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.7 NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
57397020 70956 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 583 5 1 3 5.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951622 70956 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 583 5 1 3 5.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
44456847 97452 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 566 6 0 2 7.4 C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270114 97452 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 566 6 0 2 7.4 C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415436 79959 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212644 79959 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415530 80131 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 5 2 2 5.5 CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213316 80131 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 5 2 2 5.5 CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415448 141440 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384157 141440 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46881729 7939 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7939 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10414293 37453 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145535 37453 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
71449143 79520 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113740 79520 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
10603019 5244 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL106334 5244 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10369653 96800 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 4 7.2 Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 10.1021/jm980376b
CHEMBL264997 96800 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 4 7.2 Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 10.1021/jm980376b
10624372 203708 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 475 6 0 4 5.6 COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL67612 203708 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 475 6 0 4 5.6 COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44318640 205856 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 399 4 1 4 4.6 COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83716 205856 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 399 4 1 4 4.6 COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44410155 139289 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 569 6 1 4 6.5 O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL379152 139289 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 569 6 1 4 6.5 O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
24782912 122087 0 None - 0 Mongolian jird 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596474 122087 0 None - 0 Mongolian jird 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2015.04.098
44433800 146789 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392463 146789 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
21994327 26929 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136411 26929 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10815815 120061 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 519 11 2 5 3.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL350582 120061 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 519 11 2 5 3.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL387670 212411 0 None 109 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061369n
44333964 5142 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 511 6 0 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL105763 5142 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 511 6 0 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10837611 32241 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 6 0 2 6.7 CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL140982 32241 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 6 0 2 6.7 CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
10669293 33444 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 373 5 1 2 4.6 Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL141994 33444 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 373 5 1 2 4.6 Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44274362 169191 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL440649 169191 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL2372518 210267 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
2102 1189 21 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
5311057 1189 21 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
CHEMBL441225 1189 21 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
44358767 27110 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136559 27110 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358741 31082 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 491 7 0 5 4.7 Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL139967 31082 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 491 7 0 5 4.7 Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL2371977 210171 0 None 17 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11705830 105814 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 489 9 0 3 6.3 COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126973 105814 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 489 9 0 3 6.3 COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10318976 207291 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 5 1 2 5.5 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL93216 207291 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 5 1 2 5.5 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
44326306 112336 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 319 5 1 2 4.0 Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL329325 112336 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 319 5 1 2 4.0 Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44321442 206253 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
CHEMBL86806 206253 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
24800743 87417 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 411 6 1 4 4.1 CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333617 87417 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 411 6 1 4 4.1 CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
44433802 146791 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392464 146791 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
44335376 4545 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL102376 4545 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44370369 48904 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 541 12 1 3 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL155976 48904 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 541 12 1 3 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
44288951 100482 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 515 5 2 2 5.6 CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL290926 100482 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 515 5 2 2 5.6 CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
19797419 165260 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL423019 165260 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44380708 57574 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL166610 57574 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
9329 3741 5 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
9894349 3741 5 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
CHEMBL339486 3741 5 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
44277726 99110 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL280849 99110 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL413827 213088 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44177145 195728 0 None -6 3 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL557188 195728 0 None -6 3 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44410321 141244 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL382988 141244 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
58993596 122065 0 None - 0 Mongolian jird 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 2 5 3.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596452 122065 0 None - 0 Mongolian jird 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 2 5 3.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 10.1016/j.bmcl.2015.04.098
44324706 207266 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 696 16 0 4 7.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93038 207266 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 696 16 0 4 7.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 10.1016/S0960-894X(01)80747-2
44348756 15568 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 429 0 1 4 5.6 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 10.1021/jm00080a025
CHEMBL122020 15568 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 429 0 1 4 5.6 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 10.1021/jm00080a025
10627355 120010 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 120010 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44297520 196083 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 443 6 1 5 1.9 CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL56069 196083 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 443 6 1 5 1.9 CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44294355 11242 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
49824390 11242 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178897 11242 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL48454 11242 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
12225557 121177 1 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
CHEMBL357717 121177 1 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
156500036 186444 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of NK1 (unknown origin)Inhibition of NK1 (unknown origin)
ChEMBL 428 5 3 4 3.9 Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 10.1021/acs.jmedchem.1c00173
CHEMBL4876457 186444 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of NK1 (unknown origin)Inhibition of NK1 (unknown origin)
ChEMBL 428 5 3 4 3.9 Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 10.1021/acs.jmedchem.1c00173
136046099 11154 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
49824391 11154 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178358 11154 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23181 11154 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
10456618 132235 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 454 4 1 2 5.3 O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL369692 132235 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 454 4 1 2 5.3 O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10698161 5195 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106083 5195 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
11363490 94056 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 474 4 1 2 6.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL24894 94056 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 474 4 1 2 6.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44359054 31826 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 555 8 3 3 7.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 10.1021/jm00022a010
CHEMBL140659 31826 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 555 8 3 3 7.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 10.1021/jm00022a010
10556941 99214 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 738 21 2 7 7.7 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm9800346
CHEMBL281530 99214 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 738 21 2 7 7.7 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm9800346
44333561 4670 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 488 6 1 4 5.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103221 4670 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 488 6 1 4 5.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 10.1016/S0960-894X(96)00563-X
21753665 199678 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 8 1 2 5.2 CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL59310 199678 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 8 1 2 5.2 CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10811257 101827 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300303 101827 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
16755279 175093 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 547 4 0 5 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL456875 175093 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 547 4 0 5 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL413827 213088 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44277726 99110 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL280849 99110 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
10350454 106731 0 None 10 3 Human 7.7 pIC50 = 7.7 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106731 0 None 10 3 Human 7.7 pIC50 = 7.7 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44312951 103202 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL308363 103202 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
9831641 79697 5 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2115415 79697 5 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
10071124 98793 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
CHEMBL278351 98793 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
10506376 55857 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 529 10 2 4 4.4 CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162330 55857 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 529 10 2 4 4.4 CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44304144 13436 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL1192961 13436 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL544284 13436 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44288772 155605 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 413 6 1 3 4.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL40455 155605 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 413 6 1 3 4.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44358416 27310 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 10 1 6 6.1 COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
CHEMBL136735 27310 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 10 1 6 6.1 COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
44383969 129046 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 129046 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
10412224 86722 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm00035a006
CHEMBL23184 86722 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm00035a006
44324845 169293 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 634 16 1 4 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL441458 169293 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 634 16 1 4 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 10.1016/S0960-894X(01)80747-2
104943 55386 39 None 1862 3 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55386 39 None 1862 3 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
10071124 98793 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL278351 98793 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
10004190 130087 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367711 130087 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10071124 98793 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL278351 98793 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
44294481 103508 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 5 1 2 6.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085125 103508 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 5 1 2 6.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
24799711 87432 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 412 6 0 4 4.4 COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333632 87432 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 412 6 0 4 4.4 COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
42639650 188195 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL499004 188195 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44358552 119185 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 8 0 5 5.7 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm000986n
CHEMBL343150 119185 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 8 0 5 5.7 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm000986n
44270411 11983 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183074 11983 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL278487 11983 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44359096 29131 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
CHEMBL138146 29131 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
46227363 199665 0 None -28 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 199665 0 None -28 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44212281 130616 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL368159 130616 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
44346420 14305 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1021/jm9700171
CHEMBL119990 14305 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1021/jm9700171
10393324 120809 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 574 5 2 3 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL355643 120809 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 574 5 2 3 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
56675185 66447 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817834 66447 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852026 66447 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
68870199 124794 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642171 124794 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44348605 113097 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 415 0 1 4 5.2 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 10.1021/jm00080a025
CHEMBL331346 113097 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 415 0 1 4 5.2 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 10.1021/jm00080a025
44288892 101505 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 6 1 2 5.3 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297970 101505 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 6 1 2 5.3 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44289168 169081 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL43977 169081 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL2112246 209233 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
71461705 79618 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2114963 79618 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
9914897 179058 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL47146 179058 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
21994362 29727 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 465 9 1 5 4.1 COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm000986n
CHEMBL138666 29727 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 465 9 1 5 4.1 COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm000986n
9914897 179058 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL47146 179058 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44212688 155046 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 375 8 1 3 4.5 COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40164 155046 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 375 8 1 3 4.5 COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
44212684 162979 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 389 8 0 3 4.9 COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
CHEMBL417519 162979 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 389 8 0 3 4.9 COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
44287557 168696 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 383 6 1 1 5.8 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(96)00280-6
CHEMBL436698 168696 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 383 6 1 1 5.8 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(96)00280-6
15037919 119627 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346633 119627 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44307409 102257 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 353 7 2 4 2.5 COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL303181 102257 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 353 7 2 4 2.5 COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
10458783 98616 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 504 5 2 3 6.4 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL277004 98616 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 504 5 2 3 6.4 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44312219 102381 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL303868 102381 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
15639130 113515 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 5.7 c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL332106 113515 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 5.7 c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44346524 113521 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1021/jm9700171
CHEMBL332140 113521 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1021/jm9700171
10484232 195429 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55229 195429 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
22859118 168213 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 445 8 2 5 4.3 FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
CHEMBL433539 168213 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 445 8 2 5 4.3 FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
44346420 14305 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for binding affinity against human Tachykinin receptor 1Compound was evaluated for binding affinity against human Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14305 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for binding affinity against human Tachykinin receptor 1Compound was evaluated for binding affinity against human Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
58993475 122075 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596462 122075 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
46884434 7925 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090288 7925 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306252 102209 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 602 8 2 5 4.6 Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 10.1021/jm00039a022
CHEMBL302892 102209 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 602 8 2 5 4.6 Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 10.1021/jm00039a022
44306226 102242 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 496 9 3 3 4.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL303116 102242 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 496 9 3 3 4.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
10005824 5903 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 491 5 0 3 7.0 Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O 10.1021/jm00016a014
CHEMBL107959 5903 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 491 5 0 3 7.0 Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O 10.1021/jm00016a014
9868622 6197 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 455 5 1 4 5.5 COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL108126 6197 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 455 5 1 4 5.5 COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
9888665 121981 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 121981 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44312256 204580 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL73097 204580 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44312888 96736 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
CHEMBL264384 96736 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
44319340 205913 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL84055 205913 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319250 107007 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315322 107007 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
158365 188723 6 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1021/np50111a008
CHEMBL504788 188723 6 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1021/np50111a008
44346524 113521 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL332140 113521 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
44328407 107307 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 5.7 c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL317289 107307 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 5.7 c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL406812 212621 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
44344209 114549 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL333726 114549 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
44375297 56792 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL164361 56792 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
19003143 203858 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL68670 203858 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(00)80063-3
10448006 203897 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 10.1016/S0960-894X(00)80063-3
CHEMBL68934 203897 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 10.1016/S0960-894X(00)80063-3
44321047 206181 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL86378 206181 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm9700171
44346550 14688 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 10.1021/jm9700171
CHEMBL120589 14688 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 10.1021/jm9700171
44346476 114126 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm9700171
CHEMBL332843 114126 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm9700171
44287210 100368 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL289728 100368 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
54582278 61153 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 5 1 2 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
CHEMBL1765497 61153 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 5 1 2 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
16755278 189986 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 533 4 1 5 6.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL517102 189986 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 533 4 1 5 6.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL302668 210913 0 None - 0 Guinea pig 4.6 pIC50 = 4.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1 10.1021/jm00089a011
44297648 192579 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 600 9 2 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL52139 192579 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 600 9 2 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL5286807 194357 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 381 2 1 3 4.4 Fc1ccc([C@@H]2NCCO[C@@]23C[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1021/acs.jmedchem.1c00790
44318406 169705 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL443799 169705 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 10.1016/s0960-894x(02)00506-1
24782915 122079 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596466 122079 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44433795 88771 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL236304 88771 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
18709628 166808 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42845 166808 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O 10.1016/s0960-894x(01)00250-5
9873546 78037 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 566 8 1 2 7.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 10.1021/jm060439n
CHEMBL209899 78037 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 566 8 1 2 7.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 10.1021/jm060439n
44348667 114328 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 114328 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 114328 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44288926 101483 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 591 6 1 3 6.8 O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL297833 101483 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 591 6 1 3 6.8 O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
104943 55386 39 None - 3 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55386 39 None - 3 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
25129133 188887 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188887 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44303794 100830 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 16 3 9 3.7 CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293355 100830 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 16 3 9 3.7 CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
71699790 124783 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642160 124783 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44381059 57834 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL167066 57834 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2112246 209233 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
CHEMBL2372444 210245 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
10478708 207573 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 445 8 1 1 6.1 O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL94883 207573 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 445 8 1 1 6.1 O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL5273060 193746 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1264 38 15 16 -2.1 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
21994346 30225 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 435 8 1 4 4.0 COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139071 30225 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 435 8 1 4 4.0 COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44312324 204684 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73896 204684 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
15295988 61073 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.7 O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL176471 61073 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.7 O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10477953 98935 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00035a006
CHEMBL279500 98935 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00035a006
19797451 36807 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145008 36807 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44307118 203010 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 4 1 3 4.5 NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63257 203010 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 4 1 3 4.5 NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
24782656 122082 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 440 6 2 3 5.8 Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596469 122082 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 440 6 2 3 5.8 Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44338639 5726 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107831 5726 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338532 7630 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108822 7630 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44322735 105977 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 472 6 1 2 5.7 Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL313070 105977 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 472 6 1 2 5.7 Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
44322728 206669 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89425 206669 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
9801487 206998 0 None 5 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL91418 206998 0 None 5 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
25129133 188887 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188887 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44306034 102727 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 631 10 3 7 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL304897 102727 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 631 10 3 7 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL2369763 209681 9 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
10027061 14952 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120844 14952 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
44346175 12391 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 494 5 1 2 6.3 Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 10.1021/jm9700171
CHEMBL118565 12391 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 494 5 1 2 6.3 Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 10.1021/jm9700171
22293526 79707 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115452 79707 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
68932391 124788 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642165 124788 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
10459262 4882 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 5 1 3 7.2 Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104435 4882 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 5 1 3 7.2 Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44370954 168332 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 558 10 1 6 4.5 COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL434272 168332 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 558 10 1 6 4.5 COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
1122655 123098 24 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 421 6 1 6 4.7 O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 10.1021/jm0311487
CHEMBL361031 123098 24 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 421 6 1 6 4.7 O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 10.1021/jm0311487
21994363 119357 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 488 7 1 3 5.6 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 10.1021/jm000986n
CHEMBL344370 119357 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 488 7 1 3 5.6 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 10.1021/jm000986n
CHEMBL2112245 209232 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
44308931 204338 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL71553 204338 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL2372517 210266 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
44298065 195701 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 553 9 1 5 3.9 CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 10.1016/s0960-894x(98)00319-9
CHEMBL55691 195701 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 553 9 1 5 3.9 CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 10.1016/s0960-894x(98)00319-9
CHEMBL62581 215845 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/jm00089a011
10769264 9216 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.0 CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110508 9216 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.0 CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
25129135 172597 0 None -1584 4 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172597 0 None -1584 4 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
44384678 61371 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
CHEMBL176860 61371 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
19797431 37435 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145514 37435 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44299814 167962 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 415 3 1 2 5.0 O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 10.1016/S0960-894X(01)80534-5
CHEMBL431725 167962 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 415 3 1 2 5.0 O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 10.1016/S0960-894X(01)80534-5
11409185 99423 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL282853 99423 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
11329897 91898 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 522 5 1 2 7.6 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL24136 91898 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 522 5 1 2 7.6 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
10004190 130087 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367711 130087 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44287443 100272 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288942 100272 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
16755255 189131 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 0 5 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL510547 189131 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 0 5 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
11642147 88216 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347690 88216 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
44288927 168778 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 503 6 1 3 6.5 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43744 168778 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 503 6 1 3 6.5 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44359109 31970 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00022a010
CHEMBL140768 31970 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00022a010
44297563 194957 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 615 8 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54435 194957 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 615 8 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44415393 80378 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
CHEMBL214435 80378 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
15755298 198716 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 732 15 4 9 5.0 CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL58245 198716 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 732 15 4 9 5.0 CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
71699789 124782 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642159 124782 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL2112245 209232 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
44294394 11252 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
53838756 11252 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178980 11252 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL52448 11252 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44297753 162679 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 526 10 1 4 6.1 COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL417026 162679 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 526 10 1 4 6.1 COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
10318912 97491 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 402 4 0 1 7.0 FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL27026 97491 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 402 4 0 1 7.0 FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
10249652 129733 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367423 129733 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm00006a011
15295989 59680 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 1 5.3 O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL172238 59680 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 1 5.3 O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44324746 207298 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 14 1 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93251 207298 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 14 1 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 10.1016/S0960-894X(01)80747-2
44334185 4568 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102525 4568 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1016/S0960-894X(96)00563-X
44346664 16553 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 388 4 1 3 4.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL123764 16553 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 388 4 1 3 4.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm9700171
44334185 4568 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1021/jm9700171
CHEMBL102525 4568 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1021/jm9700171
44297466 101906 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL300896 101906 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44333727 109218 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL321710 109218 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 10.1016/S0960-894X(96)00563-X
10627789 100578 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm9800346
CHEMBL29161 100578 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm9800346
24889458 8430 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093594 8430 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
10790827 119911 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 478 10 2 5 2.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O 10.1021/jm950616c
CHEMBL349273 119911 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 478 10 2 5 2.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O 10.1021/jm950616c
44306309 100994 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 622 8 2 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL294342 100994 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 622 8 2 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10840510 165290 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 555 11 2 6 4.0 COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL423254 165290 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 555 11 2 6 4.0 COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
54581251 61151 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 4 1 2 6.7 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765495 61151 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 4 1 2 6.7 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
56681832 66478 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817833 66478 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852229 66478 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
21994308 30444 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.1 COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139256 30444 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.1 COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10506124 101260 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL296228 101260 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44344995 96456 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL262301 96456 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44290659 101533 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL298247 101533 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL264341 210614 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
CHEMBL269584 210799 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm00037a009
44337703 110687 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 603 9 2 6 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N 10.1021/jm970499g
CHEMBL326001 110687 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 603 9 2 6 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N 10.1021/jm970499g
CHEMBL2369630 209645 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44212285 123818 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
CHEMBL362394 123818 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
44276738 97190 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26831 97190 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
10045837 61377 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.6 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 10.1021/jm00006a011
CHEMBL176919 61377 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.6 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 10.1021/jm00006a011
CHEMBL2369605 209638 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm960281e
16755280 176798 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 409 5 1 6 3.9 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL460683 176798 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 409 5 1 6 3.9 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
54584234 61161 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 479 4 1 5 5.1 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL1765503 61161 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 479 4 1 5 5.1 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL2114443 209255 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
CHEMBL5291459 194532 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCO[C@@]23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1021/acs.jmedchem.1c00790
9851741 80193 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 604 7 1 2 8.0 C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 10.1021/jm060439n
CHEMBL213601 80193 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 604 7 1 2 8.0 C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 10.1021/jm060439n
CHEMBL2112242 209229 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10456592 5299 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 453 4 1 3 6.1 Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL106609 5299 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 453 4 1 3 6.1 Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
56657842 63242 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 839 7 6 7 4.2 C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm000316h
CHEMBL1790897 63242 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 839 7 6 7 4.2 C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm000316h
44359260 115485 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 523 8 3 3 6.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL335106 115485 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 523 8 3 3 6.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm00022a010
10407571 167957 10 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL431690 167957 10 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
10047989 92497 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00035a006
CHEMBL24314 92497 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00035a006
56671766 66444 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817828 66444 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852010 66444 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44303835 101766 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)80747-2
CHEMBL299887 101766 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)80747-2
21256636 30227 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.4 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139072 30227 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.4 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10047989 92497 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00066a015
CHEMBL24314 92497 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00066a015
CHEMBL216813 209341 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
44321430 106986 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
CHEMBL315176 106986 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
10811257 101827 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300303 101827 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44277705 101967 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL30139 101967 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44306217 203042 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 3 4 3.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL63471 203042 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 3 4 3.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44334111 109807 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 10.1016/S0960-894X(96)00563-X
CHEMBL323317 109807 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 10.1016/S0960-894X(96)00563-X
CHEMBL2372521 210269 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2ccccc21)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
24801797 87427 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 476 6 0 5 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333627 87427 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 476 6 0 5 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
71541470 87435 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.5 C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333635 87435 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.5 C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
24801101 87442 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 402 5 1 3 4.7 Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 10.1016/j.bmcl.2012.11.094
CHEMBL2333642 87442 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 402 5 1 3 4.7 Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 10.1016/j.bmcl.2012.11.094
CHEMBL306072 210977 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
67233125 126443 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 564 4 1 3 5.8 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651888 126443 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 564 4 1 3 5.8 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
71541575 87412 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 379 6 0 4 4.2 CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333612 87412 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 379 6 0 4 4.2 CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44277705 101967 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL30139 101967 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
10649948 6688 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
CHEMBL108349 6688 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
18654560 112310 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 668 16 0 4 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329168 112310 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 668 16 0 4 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 10.1016/S0960-894X(01)80747-2
44349003 17990 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 443 1 1 4 6.0 CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL126221 17990 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 443 1 1 4 6.0 CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
10350454 106731 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106731 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44458353 99604 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283979 99604 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
10520658 98647 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
CHEMBL277260 98647 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
44337500 107189 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 604 9 2 4 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL316515 107189 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 604 9 2 4 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44458328 99515 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL283356 99515 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44286798 167432 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL42972 167432 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
10075002 4761 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 508 7 1 5 5.8 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103851 4761 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 508 7 1 5 5.8 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 10.1016/S0960-894X(96)00563-X
10027219 99582 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL283872 99582 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
24799364 87420 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 467 9 1 4 6.0 CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333620 87420 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 467 9 1 4 6.0 CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
9910432 133523 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 428 4 2 2 5.6 FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.026
CHEMBL370816 133523 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 428 4 2 2 5.6 FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.026
22724580 140168 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 429 4 1 2 6.1 FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL380351 140168 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 429 4 1 2 6.1 FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL5268460 193565 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1278 40 16 16 -1.8 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)[C@H]1CCc2ccccc21)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
CHEMBL5282996 194179 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1326 40 16 16 -0.7 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C1c2ccccc2-c2ccccc21)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
44358719 29849 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 573 7 1 3 6.5 Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138764 29849 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 573 7 1 3 6.5 Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358742 30964 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 657 7 0 3 8.4 CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139854 30964 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 657 7 0 3 8.4 CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10603097 56492 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 2 6 4.0 CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL163310 56492 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 2 6 4.0 CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
10674548 57443 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 3 5 3.9 CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165510 57443 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 3 5 3.9 CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44305544 203074 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63785 203074 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
10457416 14886 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120781 14886 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
10457416 14886 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14886 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
11225834 99209 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL281491 99209 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10696382 121983 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 489 7 0 4 5.4 COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL359214 121983 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 489 7 0 4 5.4 COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL2115375 209266 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
56668399 66467 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817886 66467 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852139 66467 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
10530699 120138 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 550 11 2 4 5.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351253 120138 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 550 11 2 4 5.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
9831309 135264 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL372587 135264 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
153996 112668 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL330366 112668 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL539021 112668 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
153996 112668 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL330366 112668 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL539021 112668 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44338583 5796 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00563-2
CHEMBL107875 5796 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00563-2
44338346 5871 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107941 5871 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338587 7439 3 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108667 7439 3 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44359083 29399 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 473 8 3 3 5.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL138390 29399 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 473 8 3 3 5.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 10.1021/jm00022a010
57398781 70953 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951619 70953 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
24888943 7947 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090438 7947 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52941489 17731 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17731 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
18709650 165247 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 501 11 3 5 4.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42295 165247 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 501 11 3 5 4.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
9888665 121981 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 121981 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10721128 56286 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 10 2 4 4.4 CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162977 56286 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 10 2 4 4.4 CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
10769745 57495 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 591 10 2 4 5.1 CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165949 57495 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 591 10 2 4 5.1 CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
132837 2237 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
9461 2237 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
CHEMBL22870 2237 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
44297434 194974 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 599 9 1 4 5.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54602 194974 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 599 9 1 4 5.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
132837 2237 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2237 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2237 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
44273822 75504 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 569 7 1 4 7.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20430 75504 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 569 7 1 4 7.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL2372516 210265 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44289862 100351 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 541 13 2 5 4.9 COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL289600 100351 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 541 13 2 5 4.9 COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
21994258 119403 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 577 7 1 3 6.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL344646 119403 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 577 7 1 3 6.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44328423 107371 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.7 COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL317761 107371 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.7 COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL426363 213345 0 None 26 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
104943 55386 39 None 1862 3 Human 8.5 pIC50 = 8.5 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 55386 39 None 1862 3 Human 8.5 pIC50 = 8.5 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
58993517 122093 0 None - 0 Mongolian jird 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 8 1 3 6.6 CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596480 122093 0 None - 0 Mongolian jird 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 8 1 3 6.6 CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44433794 167452 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL429798 167452 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
9927183 195605 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/j.bmcl.2007.10.010
CHEMBL55591 195605 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/j.bmcl.2007.10.010
15214194 5115 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 552 4 0 3 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL105629 5115 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 552 4 0 3 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C 10.1021/jm00016a014
10096063 108424 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 465 4 0 4 5.5 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL319874 108424 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 465 4 0 4 5.5 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
11757401 59946 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 59946 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
2089 2766 28 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3795 2766 28 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311311 2766 28 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL217406 2766 28 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44415513 165768 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL424709 165768 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44306327 13034 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL1189912 13034 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL539762 13034 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
44306196 100735 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 605 9 2 7 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292715 100735 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 605 9 2 7 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306107 102835 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305547 102835 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
18709663 166102 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 12 2 5 4.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42597 166102 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 12 2 5 4.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44370340 119547 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 640 17 3 5 5.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
CHEMBL345866 119547 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 640 17 3 5 5.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
19797460 121012 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL356518 121012 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44305467 102812 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 430 5 1 2 5.8 CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL305375 102812 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 430 5 1 2 5.8 CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
71720664 87438 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 383 5 1 2 5.2 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333638 87438 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 383 5 1 2 5.2 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
24784193 122094 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596481 122094 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44456651 95450 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL257112 95450 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
73348949 90822 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
CHEMBL2392023 90822 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
44335354 4934 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
CHEMBL104708 4934 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
71458131 79684 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2115343 79684 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44276882 96225 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 10.1016/0960-894X(95)00220-N
CHEMBL26086 96225 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 10.1016/0960-894X(95)00220-N
71541687 87415 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333615 87415 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 10.1016/j.bmcl.2012.11.094
57395687 68623 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917846 68623 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
44433790 89444 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL237100 89444 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
11114226 204550 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 537 10 3 4 7.0 CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL72895 204550 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 537 10 3 4 7.0 CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
10075851 60022 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 536 9 3 3 5.4 O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173564 60022 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 536 9 3 3 5.4 O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55386 39 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 55386 39 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
58993461 122092 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596479 122092 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44370449 119897 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 760 20 2 6 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL349113 119897 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 760 20 2 6 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
46884470 7994 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090652 7994 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
19098237 37121 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 37121 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44319086 13712 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194977 13712 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553617 13712 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
25129135 172597 0 None -7 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172597 0 None -7 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
44334113 5266 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 548 7 1 4 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL106440 5266 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 548 7 1 4 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44326281 207188 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.1 CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92524 207188 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.1 CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44459032 90887 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 393 6 1 3 4.4 CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23926 90887 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 393 6 1 3 4.4 CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44318413 205683 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL82220 205683 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 10.1016/s0960-894x(02)00506-1
24783424 122086 0 None - 0 Mongolian jird 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 493 6 1 2 7.2 FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596473 122086 0 None - 0 Mongolian jird 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 493 6 1 2 7.2 FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
10476776 108560 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 0 4 4.5 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL320231 108560 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 0 4 4.5 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288758 101111 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL295122 101111 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
107686 3379 41 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3379 41 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3379 41 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44344231 113516 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL332111 113516 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
44346159 14522 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 10.1021/jm9700171
CHEMBL120190 14522 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 10.1021/jm9700171
44177669 61261 0 None -52 4 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 61261 0 None -52 4 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44319571 107040 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL315532 107040 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44415437 79977 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212697 79977 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
19797420 36860 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145051 36860 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10553958 101369 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL297068 101369 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
9915428 173633 3 None - 0 Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL45340 173633 3 None - 0 Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
44287895 101207 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL295845 101207 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
44304123 200577 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL59913 200577 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
10405990 208124 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 356 5 0 2 4.9 COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL98011 208124 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 356 5 0 2 4.9 COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
9915428 173633 3 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL45340 173633 3 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44287409 159049 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.9 O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40969 159049 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.9 O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44287368 155221 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 4 0 1 6.5 CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40262 155221 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 4 0 1 6.5 CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44287461 162694 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 493 8 0 1 7.3 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL41705 162694 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 493 8 0 1 7.3 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44357469 161755 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL 1329 41 13 19 -1.6 CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 10.1021/jm990197+
CHEMBL413904 161755 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL 1329 41 13 19 -1.6 CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 10.1021/jm990197+
10367419 4404 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1021/jm9700171
CHEMBL101420 4404 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1021/jm9700171
11661655 105801 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126961 105801 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10480944 59892 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 496 6 1 3 6.2 C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL173013 59892 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 496 6 1 3 6.2 C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
2089 2766 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3795 2766 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311311 2766 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL217406 2766 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44274341 81549 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21611 81549 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 10.1016/s0960-894x(01)00182-2
56681830 66462 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817830 66462 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852124 66462 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
10841047 57470 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 13 2 7 3.7 COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165727 57470 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 13 2 7 3.7 COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9918576 207337 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1021/jm058225d
CHEMBL93556 207337 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1021/jm058225d
CHEMBL2370873 209938 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC(=O)N1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSC)C(N)=O 10.1016/S0960-894X(01)80229-8
44322406 165134 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 514 5 1 3 6.2 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL422773 165134 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 514 5 1 3 6.2 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322515 206716 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 476 6 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89818 206716 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 476 6 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
10367419 4404 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL101420 4404 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1016/S0960-894X(96)00563-X
10460069 166338 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 545 6 1 2 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL427295 166338 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 545 6 1 2 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44383815 60301 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 462 7 1 3 5.7 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/S0960-894X(00)80693-9
CHEMBL174365 60301 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 462 7 1 3 5.7 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/S0960-894X(00)80693-9
12736776 11156 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
53641783 11156 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
CHEMBL1178362 11156 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
CHEMBL23360 11156 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
44459024 11161 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
CHEMBL1178380 11161 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
CHEMBL24818 11161 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
16755254 186174 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 515 4 1 5 5.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL487259 186174 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 515 4 1 5 5.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
44386230 61363 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
CHEMBL176811 61363 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
10350528 106733 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106733 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44322511 107100 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 464 5 1 3 5.0 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL315937 107100 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 464 5 1 3 5.0 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346557 113520 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 9 4 3 5.7 O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL332139 113520 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 9 4 3 5.7 O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
15295990 132107 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.9 O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL369580 132107 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.9 O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
54587143 61150 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 468 4 0 2 5.6 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
CHEMBL1765494 61150 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 468 4 0 2 5.6 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
11547090 88234 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347856 88234 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44306398 203548 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 527 11 2 4 3.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 10.1021/jm00039a022
CHEMBL66592 203548 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 527 11 2 4 3.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 10.1021/jm00039a022
10432488 4896 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 424 4 0 3 5.4 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL104513 4896 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 424 4 0 3 5.4 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 10.1021/jm00016a014
10026002 109684 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 435 4 0 4 4.7 CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL322714 109684 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 435 4 0 4 4.7 CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
44358442 29806 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 569 8 0 3 6.3 CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL138727 29806 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 569 8 0 3 6.3 CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
107686 3379 41 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3379 41 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3379 41 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
104943 55386 39 None - 3 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55386 39 None - 3 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
2089 2766 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3795 2766 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
5311311 2766 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL217406 2766 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL263185 210561 5 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm070577s
44270482 11982 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183073 11982 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL278455 11982 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
12736777 11155 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
54433543 11155 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1178360 11155 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
CHEMBL23287 11155 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
44348666 113492 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 1 1 4 5.6 C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL331978 113492 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 1 1 4 5.6 C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44348801 113468 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 489 0 1 4 6.4 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL331934 113468 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 489 0 1 4 6.4 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44337421 108528 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl 10.1021/jm970499g
CHEMBL320029 108528 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl 10.1021/jm970499g
44287388 156007 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40620 156007 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44297492 193692 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 576 10 1 6 3.8 CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
CHEMBL52717 193692 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 576 10 1 6 3.8 CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
131871 119528 6 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL345711 119528 6 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44306416 100582 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 468 9 3 3 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL291634 100582 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 468 9 3 3 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44370769 50017 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 507 12 1 3 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL156933 50017 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 507 12 1 3 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
19797413 36858 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145050 36858 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10552574 119979 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 476 10 2 4 3.7 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O 10.1021/jm950616c
CHEMBL349882 119979 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 476 10 2 4 3.7 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O 10.1021/jm950616c
44359259 25120 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00022a010
CHEMBL134737 25120 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00022a010
44275987 99344 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL282331 99344 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
9892852 84380 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL22194 84380 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44297939 101676 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 510 9 1 3 6.4 Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL299312 101676 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 510 9 1 3 6.4 Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
71699788 124781 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642158 124781 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
44289256 100531 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 449 7 1 3 5.2 O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL291298 100531 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 449 7 1 3 5.2 O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44270549 11139 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1178214 11139 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL15970 11139 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44312145 204716 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL74176 204716 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
10793140 57415 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 10 1 5 5.0 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O 10.1021/jm950616c
CHEMBL165308 57415 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 10 1 5 5.0 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O 10.1021/jm950616c
44297604 101636 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL299016 101636 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44276732 100005 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 565 8 2 3 7.1 O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL286747 100005 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 565 8 2 3 7.1 O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
24801102 87447 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 350 5 1 3 4.2 Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333647 87447 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 350 5 1 3 4.2 Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 10.1016/j.bmcl.2012.11.094
46884468 7992 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090650 7992 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
44289441 101108 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 511 12 2 4 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL295107 101108 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 511 12 2 4 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O 10.1016/s0960-894x(01)00250-5
10453364 5400 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 396 4 0 3 4.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL107145 5400 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 396 4 0 3 4.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
10433381 5584 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 440 6 0 4 5.2 CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107689 5584 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 440 6 0 4 5.2 CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10350528 106733 0 None 251 3 Human 7.5 pIC50 = 7.5 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106733 0 None 251 3 Human 7.5 pIC50 = 7.5 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44305511 202966 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63014 202966 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
9823811 59915 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 426 7 1 3 5.5 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL173110 59915 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 426 7 1 3 5.5 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
44358814 31093 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL139977 31093 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00022a010
44352062 18934 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128586 18934 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
131954513 162078 38 None - 1 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
CHEMBL4160748 162078 38 None - 1 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
21121353 101473 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101473 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
54587142 61149 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 454 4 1 2 5.3 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
CHEMBL1765493 61149 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 454 4 1 2 5.3 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
44321519 206728 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL89897 206728 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
44321519 206728 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL89897 206728 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44307089 203013 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 445 4 0 2 6.0 CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63278 203013 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 445 4 0 2 6.0 CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL2112244 209231 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cn2ccc3ccccc32)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
76318226 105798 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 6 0 3 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126958 105798 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 6 0 3 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
44294338 12049 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
54307293 12049 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183499 12049 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL300854 12049 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
11568372 206025 5 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL85047 206025 5 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44380745 120298 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL352697 120298 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
10245452 101188 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL 320 4 1 2 3.1 O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 10.1016/0960-894X(95)00582-E
CHEMBL295680 101188 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL 320 4 1 2 3.1 O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 10.1016/0960-894X(95)00582-E
9888665 121981 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 121981 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10506928 120218 0 None 39 2 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 120218 0 None 39 2 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44297498 102002 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL301630 102002 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10552836 4187 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL100141 4187 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
58993657 122067 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2015.04.098
CHEMBL3596454 122067 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2015.04.098
16755228 173704 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 526 4 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
CHEMBL453581 173704 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 526 4 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
19797456 34469 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL142855 34469 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44319249 206072 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
CHEMBL85499 206072 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
44304176 202819 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL62357 202819 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15154442 14166 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
53703341 14166 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
CHEMBL1198573 14166 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
CHEMBL23147 14166 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
10071902 109402 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL321979 109402 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL2369630 209645 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44346480 114862 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 317 7 1 2 4.4 N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL334189 114862 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 317 7 1 2 4.4 N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL2369767 209684 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
44299298 196249 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56176 196249 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
15037918 44854 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152239 44854 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
19797436 36837 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 461 6 0 2 6.3 Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145030 36837 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 461 6 0 2 6.3 Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797448 37242 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145360 37242 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44358500 31512 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 9 0 8 4.2 COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC 10.1021/jm000986n
CHEMBL140360 31512 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 9 0 8 4.2 COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC 10.1021/jm000986n
44287861 161739 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL41375 161739 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
19797446 34545 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL142919 34545 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
10793492 111302 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 10 4 3 4.7 O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL326649 111302 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 10 4 3 4.7 O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
44358426 30885 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 595 6 0 3 7.3 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139753 30885 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 595 6 0 3 7.3 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10336036 112346 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 318 4 1 1 3.8 O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 10.1016/S0960-894X(96)00570-7
CHEMBL32940 112346 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 318 4 1 1 3.8 O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 10.1016/S0960-894X(96)00570-7
44359055 32332 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 584 10 4 5 6.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 10.1021/jm00022a010
CHEMBL141050 32332 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 584 10 4 5 6.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 10.1021/jm00022a010
10501444 101877 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300722 101877 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44287555 158800 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40944 158800 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
23294214 169160 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL440465 169160 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
76332769 105807 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 8 0 2 7.5 CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126967 105807 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 8 0 2 7.5 CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
10646925 30983 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 407 5 1 2 4.1 Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL139868 30983 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 407 5 1 2 4.1 Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44287895 101207 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL295845 101207 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
16755230 172975 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
CHEMBL451773 172975 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
24801459 87431 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 389 5 0 4 4.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333631 87431 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 389 5 0 4 4.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
15755301 101070 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294814 101070 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44345010 14480 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL120126 14480 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
10041813 96954 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
CHEMBL26623 96954 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
10041813 96954 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
CHEMBL26623 96954 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
44297822 195024 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 2 5 4.8 CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL54931 195024 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 2 5 4.8 CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44321099 206225 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL86659 206225 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
15755334 96562 0 None - 0 Guinea pig 4.4 pIC50 = 4.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 578 13 6 6 1.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
CHEMBL263013 96562 0 None - 0 Guinea pig 4.4 pIC50 = 4.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 578 13 6 6 1.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
44177670 61262 0 None -190 4 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 61262 0 None -190 4 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
71541471 87436 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.8 CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333636 87436 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.8 CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
71452815 79712 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2115528 79712 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
44328405 106198 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.4 Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL313863 106198 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.4 Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44338646 9155 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 474 7 1 3 6.0 CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL110086 9155 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 474 7 1 3 6.0 CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
10552836 4187 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL100141 4187 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
10576866 111491 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL327736 111491 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44294398 11243 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
54220048 11243 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
CHEMBL1178902 11243 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
CHEMBL48734 11243 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
16755206 186639 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 512 4 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
CHEMBL488045 186639 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 512 4 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
44303938 203148 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 713 16 5 10 3.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64166 203148 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 713 16 5 10 3.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15154438 11160 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
53968534 11160 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178371 11160 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23682 11160 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
44288936 158168 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 6 0 3 6.9 CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL40875 158168 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 6 0 3 6.9 CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
11409185 99423 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL282853 99423 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
44287390 155773 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.3 O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40587 155773 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.3 O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44338557 9348 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111244 9348 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
132837 2237 55 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
9461 2237 55 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
CHEMBL22870 2237 55 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
132837 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2237 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
11757401 59946 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 59946 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
56671913 66468 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817888 66468 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852140 66468 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
46884473 7789 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089397 7789 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10817203 57530 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 589 12 2 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O 10.1021/jm950616c
CHEMBL166240 57530 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 589 12 2 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O 10.1021/jm950616c
44305271 102244 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL303119 102244 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
44319323 13747 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1195230 13747 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL554092 13747 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL394671 212478 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
CHEMBL394671 212478 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44433788 88533 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 1 3 4.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL235220 88533 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 1 3 4.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
44328425 169471 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 6.0 COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL442962 169471 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 6.0 COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44233184 194768 0 None 12 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 194768 0 None 12 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
9871754 5409 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5409 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
104943 55386 39 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL16192 55386 39 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
44410162 77129 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL207698 77129 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44294261 79633 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115010 79633 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
10086982 116192 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 314 6 3 4 2.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358422 116192 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 314 6 3 4 2.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 10.1021/ml5002954
10072926 109686 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 459 4 1 3 6.1 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL322718 109686 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 459 4 1 3 6.1 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C 10.1021/jm00016a014
9871754 5409 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5409 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
134138503 154440 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
CHEMBL3932836 154440 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
CHEMBL3990081 154440 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
49863734 15333 0 None 13 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15333 0 None 13 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44326362 207297 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.5 CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00476-A
CHEMBL93243 207297 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.5 CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00476-A
16755231 188992 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
CHEMBL508659 188992 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
44306219 102729 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL304901 102729 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44358703 116064 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 625 7 0 4 7.3 COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL335624 116064 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 625 7 0 4 7.3 COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
9853506 13089 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1190281 13089 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL540553 13089 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9799676 195819 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55823 195819 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44456748 169180 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL440587 169180 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
10071073 5351 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 0 4 4.8 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL106904 5351 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 0 4 4.8 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
44233410 195594 0 None 38 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL555504 195594 0 None 38 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44433789 146134 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 146134 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
10792813 57516 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 552 11 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL166144 57516 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 552 11 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44319224 107076 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315814 107076 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
10360490 88739 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL23617 88739 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL238168 210391 7 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O 10.1021/jm070577s
10007035 79525 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL2114031 79525 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
10460415 116539 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 1 3 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL336261 116539 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 1 3 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10745307 165406 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 10.1021/jm950616c
CHEMBL423824 165406 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 10.1021/jm950616c
CHEMBL238168 210391 7 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O 10.1021/jm070577s
11547594 105816 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126975 105816 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
136043853 138915 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378340 138915 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
58993634 122100 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 522 6 1 3 6.6 N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596487 122100 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 522 6 1 3 6.6 N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F 10.1016/j.bmcl.2015.04.098
10438407 100654 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 590 11 2 6 4.4 CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL292190 100654 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 590 11 2 6 4.4 CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
57395686 71617 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917841 71617 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963411 71617 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
53249015 61158 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 550 5 0 4 6.1 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765500 61158 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 550 5 0 4 6.1 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
9939040 5010 7 None 2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL105060 5010 7 None 2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44358864 30346 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139176 30346 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44319306 107097 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315923 107097 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44274183 82464 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21760 82464 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 10.1016/s0960-894x(01)00182-2
56661423 66454 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817832 66454 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852069 66454 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
136043849 138700 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 542 9 2 5 6.1 CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 10.1016/j.bmcl.2006.06.035
CHEMBL377916 138700 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 542 9 2 5 6.1 CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 10.1016/j.bmcl.2006.06.035
44306108 102836 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305548 102836 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
22293578 187127 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 591 7 0 1 9.9 Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL49175 187127 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 591 7 0 1 9.9 Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
44415424 141455 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384244 141455 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
11498370 101176 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL295615 101176 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
15295987 131352 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL368804 131352 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL5283681 194224 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCO[C@]23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1021/acs.jmedchem.1c00790
15755316 202893 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 703 16 4 9 3.7 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 10.1021/jm00089a011
CHEMBL62711 202893 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 703 16 4 9 3.7 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 10.1021/jm00089a011
44299298 196249 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL56176 196249 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
16755256 173099 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 1 5 6.2 Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL452027 173099 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 1 5 6.2 Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL2369599 209633 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm960281e
14986135 163401 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL419500 163401 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44287606 100511 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL291146 100511 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10228092 77305 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20826 77305 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 10.1016/s0960-894x(01)00182-2
58993510 122054 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596200 122054 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 10.1016/j.bmcl.2015.04.098
54580277 61160 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 466 4 0 2 6.7 Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
CHEMBL1765502 61160 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 466 4 0 2 6.7 Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
9830535 206816 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90416 206816 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
9830535 206816 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL90416 206816 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
44294324 12362 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
54414362 12362 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1185473 12362 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL416468 12362 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
71583095 88219 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347693 88219 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
71699791 124784 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642161 124784 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44337667 108857 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 568 9 3 5 4.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL321021 108857 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 568 9 3 5 4.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10744740 109663 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 528 9 2 3 4.6 Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL322508 109663 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 528 9 2 3 4.6 Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
15154446 11152 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
53746881 11152 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178355 11152 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23073 11152 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
10318477 167310 40 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
CHEMBL429395 167310 40 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
10318477 167310 40 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
CHEMBL429395 167310 40 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
107686 3379 41 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
3522 3379 41 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL131171 3379 41 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797466 34598 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL142961 34598 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44297701 101691 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL299388 101691 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
11489240 95290 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL25639 95290 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44274520 82583 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nMTested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nM
ChEMBL 479 5 0 5 4.9 COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21788 82583 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nMTested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nM
ChEMBL 479 5 0 5 4.9 COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 10.1016/s0960-894x(01)00183-4
44358861 118637 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL341681 118637 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 10.1021/jm00022a010
15755299 100888 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 626 13 3 8 3.7 CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293726 100888 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 626 13 3 8 3.7 CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10325464 120134 0 None -25 3 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 120134 0 None -25 3 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
44458828 11159 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
CHEMBL1178368 11159 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
CHEMBL23533 11159 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
44281769 109660 7 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cellsInhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00582-E
CHEMBL32248 109660 7 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cellsInhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00582-E
19098237 37121 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 37121 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10428330 170222 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 356 4 1 3 3.5 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 10.1021/jm00006a011
CHEMBL444552 170222 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 356 4 1 3 3.5 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 10.1021/jm00006a011
44297562 195037 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 629 9 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54940 195037 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 629 9 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10576866 111491 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL327736 111491 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
46881600 7106 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
CHEMBL1085196 7106 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
44302017 199331 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Concentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cellsConcentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59060 199331 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Concentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cellsConcentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
71541370 87441 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 432 5 0 3 5.6 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333641 87441 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 432 5 0 3 5.6 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
10404051 86047 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 325 6 1 3 3.1 CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23077 86047 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 325 6 1 3 3.1 CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
10027661 59699 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 10.1021/jm00006a011
CHEMBL172308 59699 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 10.1021/jm00006a011
54585203 61159 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 1 2 6.3 Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
CHEMBL1765501 61159 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 1 2 6.3 Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
10053205 116585 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL336589 116585 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
46884469 7993 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090651 7993 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL2369630 209645 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44344195 163360 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL419232 163360 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL307433 210980 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44328357 111537 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 7.0 FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL327943 111537 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 7.0 FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44287556 100212 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 397 6 0 1 6.2 CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL288382 100212 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 397 6 0 1 6.2 CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
11641636 105817 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126976 105817 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
24801457 87443 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333643 87443 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44415472 139601 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL379744 139601 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44433781 89927 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 6.4 CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
CHEMBL237992 89927 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 6.4 CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
44303900 162904 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 751 15 3 10 3.9 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL417390 162904 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 751 15 3 10 3.9 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 10.1021/jm00089a011
15154449 11980 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
54080603 11980 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1183064 11980 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL278135 11980 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
44297724 101923 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 585 8 1 4 5.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL301008 101923 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 585 8 1 4 5.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44286772 167839 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL43085 167839 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
56668295 66473 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817836 66473 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852171 66473 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
10393390 98277 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL27463 98277 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
10317867 4864 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 384 6 1 4 4.5 COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104345 4864 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 384 6 1 4 4.5 COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44287511 144738 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL39089 144738 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
24785190 122070 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 415 6 1 3 5.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596457 122070 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 415 6 1 3 5.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 10.1016/j.bmcl.2015.04.098
52941506 17767 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258732 17767 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
76314659 105812 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 8 0 2 7.9 CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126971 105812 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 8 0 2 7.9 CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
44287819 101396 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 486 5 0 4 3.6 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL297244 101396 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 486 5 0 4 3.6 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
10386984 5413 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 1 4 4.5 COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107220 5413 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 1 4 4.5 COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10625208 55861 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 500 10 1 5 3.7 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O 10.1021/jm950616c
CHEMBL162332 55861 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 500 10 1 5 3.7 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O 10.1021/jm950616c
76332768 105806 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 6 0 2 6.7 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126966 105806 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 6 0 2 6.7 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
44288896 168987 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 168987 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL2372519 210268 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2cc3ccccc3cc21)C(N)=O 10.1021/jm00037a009
44277452 101082 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL29487 101082 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
44348667 114328 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 114328 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 114328 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44212283 59859 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL172915 59859 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
71541371 87446 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 374 5 0 3 4.0 CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333646 87446 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 374 5 0 3 4.0 CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
10253192 4923 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 449 4 1 3 5.7 CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104654 4923 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 449 4 1 3 5.7 CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44312028 102852 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL305609 102852 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10627355 120010 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 120010 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44328395 107512 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 6.7 FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL318629 107512 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 6.7 FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
19003169 102788 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 269 6 1 2 3.4 Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL305274 102788 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 269 6 1 2 3.4 Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 10.1016/S0960-894X(00)80063-3
44321047 206181 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm00092a009
CHEMBL86378 206181 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm00092a009
44326328 207105 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 295 5 1 2 4.2 N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92032 207105 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 295 5 1 2 4.2 N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44346420 14305 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell lineCompound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14305 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell lineCompound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
107686 3379 41 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
3522 3379 41 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL131171 3379 41 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
18782568 207282 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 321 3 1 3 4.0 COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL93184 207282 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 321 3 1 3 4.0 COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
24784955 122080 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596467 122080 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL311405 211099 16 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44305865 100684 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 582 10 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 10.1021/jm00039a022
CHEMBL292346 100684 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 582 10 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 10.1021/jm00039a022
CHEMBL2092883 209202 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10258592 99207 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL281481 99207 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
44368172 121515 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 444 8 2 4 4.9 FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
CHEMBL358409 121515 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 444 8 2 4 4.9 FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
10097954 132121 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 513 9 2 3 5.0 CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL369601 132121 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 513 9 2 3 5.0 CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
44287609 100361 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL289666 100361 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
24783681 122081 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596468 122081 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44415458 80349 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 7.3 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
CHEMBL214317 80349 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 7.3 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
44415539 138979 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 5 1 2 5.8 CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378537 138979 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 5 1 2 5.8 CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44305864 203497 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 8 3 5 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 10.1021/jm00039a022
CHEMBL66193 203497 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 8 3 5 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 10.1021/jm00039a022
44358519 30758 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 531 9 1 4 6.1 CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL139569 30758 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 531 9 1 4 6.1 CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44338584 8157 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL109183 8157 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
22353151 9131 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL109937 9131 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
44338618 109326 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL321892 109326 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
44346558 15388 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL121459 15388 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
24889114 7751 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1089081 7751 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
11743365 107388 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 429 4 0 4 4.6 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL317870 107388 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 429 4 0 4 4.6 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 10.1021/jm00016a014
44178113 61264 0 None -12 3 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 61264 0 None -12 3 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44274530 98933 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 549 7 0 4 7.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279488 98933 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 549 7 0 4 7.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
24782655 122083 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596470 122083 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44415486 80914 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 499 7 3 4 5.8 Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 10.1016/j.bmcl.2006.06.035
CHEMBL215315 80914 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 499 7 3 4 5.8 Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 10.1016/j.bmcl.2006.06.035
44358469 31144 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 629 11 3 5 5.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 10.1021/jm000986n
CHEMBL140023 31144 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 629 11 3 5 5.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 10.1021/jm000986n
10623791 30905 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 5 0 2 5.8 CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL139784 30905 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 5 0 2 5.8 CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
71541572 87407 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 440 6 0 3 5.4 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333608 87407 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 440 6 0 3 5.4 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
71541573 87408 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333609 87408 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
22293463 101316 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 7 0 2 9.7 CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL296629 101316 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 7 0 2 9.7 CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415412 78726 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL211257 78726 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10553136 165324 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 491 10 2 5 2.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL423464 165324 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 491 10 2 5 2.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O 10.1021/jm950616c
46884516 7826 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089533 7826 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306036 13768 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL1195366 13768 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL554413 13768 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306318 203785 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 508 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL68225 203785 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 508 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44358545 27439 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 1 3 6.1 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136832 27439 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 1 3 6.1 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
9976640 196628 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1021/jm9700171
CHEMBL56427 196628 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1021/jm9700171
9976640 196628 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56427 196628 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44274170 77072 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20736 77072 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 10.1016/s0960-894x(01)00182-2
44274199 98758 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL278088 98758 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 10.1016/s0960-894x(01)00182-2
10392469 194855 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL539928 194855 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44370928 47756 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 619 18 1 4 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL154803 47756 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 619 18 1 4 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
10603392 57453 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 12 2 6 4.7 CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165566 57453 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 12 2 6 4.7 CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44274118 98954 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL279674 98954 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
57397019 71534 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1951617 71534 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1962935 71534 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
46884519 8093 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
CHEMBL1091342 8093 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
24752434 9133 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9133 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10743826 118586 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 495 6 0 3 5.2 CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL341656 118586 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 495 6 0 3 5.2 CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
44415484 168938 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL438789 168938 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44326361 111493 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL327765 111493 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44326361 111493 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL327765 111493 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
9874168 205704 4 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL82386 205704 4 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
23025461 66452 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852063 66452 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL3216952 66452 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
9805809 103087 8 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL307488 103087 8 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
11844212 98649 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 590 7 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 10.1021/jm060439n
CHEMBL277279 98649 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 590 7 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 10.1021/jm060439n
44348667 114328 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 114328 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 114328 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44338652 108610 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
CHEMBL320544 108610 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
44322736 207001 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 448 6 1 2 6.1 Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
CHEMBL91436 207001 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 448 6 1 2 6.1 Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
44233185 194822 0 None -181 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 194822 0 None -181 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL5083565 214871 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]SP from human NK1R expressed in U373 MG cells incubated for 30 mins by radioligand binding assayDisplacement of [125I]SP from human NK1R expressed in U373 MG cells incubated for 30 mins by radioligand binding assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
44458789 141813 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00109a034
CHEMBL386306 141813 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00109a034
44458351 99390 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL282657 99390 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL410808 212843 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
15755314 102198 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 17 4 9 3.4 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 10.1021/jm00089a011
CHEMBL302843 102198 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 17 4 9 3.4 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 10.1021/jm00089a011
44458789 141813 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00085a015
CHEMBL386306 141813 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00085a015
18655106 200469 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)80747-2
CHEMBL59854 200469 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)80747-2
44287443 100272 1 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288942 100272 1 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10697072 55813 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 511 11 3 5 3.8 COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162288 55813 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 511 11 3 5 3.8 COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
22901331 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
22901331 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
54435601 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
59922977 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
CHEMBL1183068 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
CHEMBL278294 11981 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
44318310 205658 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL81986 205658 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 10.1016/s0960-894x(02)00506-1
44333682 4622 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 619 6 1 3 7.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102887 4622 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 619 6 1 3 7.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 10.1016/S0960-894X(96)00563-X
11490127 92084 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 580 5 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL24194 92084 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 580 5 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
12225557 121177 1 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
CHEMBL357717 121177 1 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
24801792 87444 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333644 87444 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 10.1016/j.bmcl.2012.11.094
54582296 61154 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 5 0 2 6.8 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
CHEMBL1765498 61154 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 5 0 2 6.8 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
10473960 86282 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm9700171
CHEMBL23129 86282 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm9700171
44177570 61260 0 None -169 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 61260 0 None -169 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
68932301 124792 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642169 124792 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44288795 168272 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 467 6 3 5 4.7 O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43394 168272 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 467 6 3 5 4.7 O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10917690 207605 1 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1021/jm058225d
CHEMBL95051 207605 1 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1021/jm058225d
44286718 167727 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL43027 167727 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44383969 129046 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 129046 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
44383969 129046 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 129046 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
54585202 61155 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 536 5 1 4 5.8 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765499 61155 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 536 5 1 4 5.8 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
54585205 61164 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 492 4 0 4 6.0 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
CHEMBL1765506 61164 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 492 4 0 4 6.0 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
46884432 7922 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090285 7922 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44297602 195242 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 614 9 1 5 4.9 CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL55098 195242 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 614 9 1 5 4.9 CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL2114442 209254 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
24783683 122078 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596465 122078 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
24889111 7924 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090287 7924 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10370593 6263 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 561 4 1 3 7.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL108164 6263 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 561 4 1 3 7.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44288976 163231 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL418438 163231 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10349900 106749 0 None 39 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106749 0 None 39 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44312887 102937 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
CHEMBL306267 102937 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
24782658 122073 0 None - 0 Mongolian jird 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596460 122073 0 None - 0 Mongolian jird 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 10.1016/j.bmcl.2015.04.098
22851562 166453 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL42778 166453 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44297451 100660 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292211 100660 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
16755232 173588 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 514 4 1 4 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
CHEMBL453314 173588 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 514 4 1 4 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
21308488 101503 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 1 5 5.4 CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(98)00319-9
CHEMBL297957 101503 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 1 5 5.4 CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(98)00319-9
CHEMBL2369601 209635 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm960281e
10043484 89465 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm9700171
CHEMBL23715 89465 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm9700171
44334006 107616 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL318989 107616 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44297513 101605 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 547 9 1 5 4.0 Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
CHEMBL298772 101605 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 547 9 1 5 4.0 Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
10499624 116634 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 337 5 1 2 4.8 CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL336931 116634 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 337 5 1 2 4.8 CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44308930 204327 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL71498 204327 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
44308930 204327 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL71498 204327 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44299916 195802 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 9 1 2 6.0 Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55796 195802 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 9 1 2 6.0 Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
9869033 100424 5 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 100424 5 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
56675290 66449 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
CHEMBL1817884 66449 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
CHEMBL1852032 66449 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
16755257 173386 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 543 4 0 5 6.6 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL452794 173386 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 543 4 0 5 6.6 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
44324532 206843 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 578 14 1 4 5.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90547 206843 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 578 14 1 4 5.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 10.1016/S0960-894X(01)80747-2
15755319 100681 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 669 15 5 7 3.8 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL292320 100681 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 669 15 5 7 3.8 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10410206 79584 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL2114308 79584 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
10410322 99403 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 10.1021/jm00035a006
CHEMBL282728 99403 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 10.1021/jm00035a006
10043484 89465 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00035a006
CHEMBL23715 89465 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00035a006
10043484 89465 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00066a015
CHEMBL23715 89465 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00066a015
44297931 192714 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 511 9 1 4 5.3 Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL52198 192714 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 511 9 1 4 5.3 Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44287191 157681 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40817 157681 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44275987 99344 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL282331 99344 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
19797477 38664 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL146552 38664 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
9984184 204649 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73618 204649 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44383681 166269 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 430 6 1 2 6.1 Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL426939 166269 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 430 6 1 2 6.1 Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
10411026 61356 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 2 5.2 FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL176772 61356 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 2 5.2 FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 10.1021/jm00006a011
44319341 205890 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 572 10 1 7 3.8 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83885 205890 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 572 10 1 7 3.8 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44297493 163149 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
CHEMBL417914 163149 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
10620143 99262 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL281828 99262 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
54582297 61162 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 493 4 0 5 5.4 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL1765504 61162 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 493 4 0 5 5.4 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
71583092 88225 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 5.1 O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 10.1016/j.bmc.2013.02.010
CHEMBL2347703 88225 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 5.1 O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 10.1016/j.bmc.2013.02.010
44324527 106538 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 550 13 2 4 4.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 10.1016/S0960-894X(01)80747-2
CHEMBL314084 106538 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 550 13 2 4 4.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 10.1016/S0960-894X(01)80747-2
10620143 99262 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
CHEMBL281828 99262 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
44274242 99151 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL281149 99151 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
10553958 101369 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL297068 101369 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL5076397 214435 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of tachykinin NK1 receptor (unknown origin)Inhibition of tachykinin NK1 receptor (unknown origin)
ChEMBL None None None O[C@H]1COC[C@H]1N1CC[C@@H](c2cc3nc(Nc4cnn([C@@H]5CC5(F)F)c4Cl)ncc3cc2Cl)[C@H](F)C1 10.1021/acs.jmedchem.1c01968
10553958 101369 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL297068 101369 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44297469 101781 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL300005 101781 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44328545 207652 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.6 Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL95270 207652 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.6 Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL1196922 208596 0 None - 0 Guinea pig 4.2 pIC50 = 4.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
CHEMBL558620 208596 0 None - 0 Guinea pig 4.2 pIC50 = 4.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
10692651 101089 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL294960 101089 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44294261 79708 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115454 79708 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2112241 209228 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None COc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)O)NC2=O)cc1 10.1021/jm960281e
44375315 56507 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163510 56507 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
10530317 5228 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL106239 5228 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
44286754 163144 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL417881 163144 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
104974 3475 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
2111 3475 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
3481 3475 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL308148 3475 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
DB06660 3475 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL2369604 209637 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44324531 206755 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 13 2 4 4.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90035 206755 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 13 2 4 4.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 10.1016/S0960-894X(01)80747-2
44433803 146794 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392465 146794 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
44289934 101259 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 529 12 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL296216 101259 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 529 12 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44358672 119358 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 0 5 4.9 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br 10.1021/jm000986n
CHEMBL344378 119358 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 0 5 4.9 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br 10.1021/jm000986n
21121353 101473 0 None 19 3 Human 8.2 pIC50 = 8.2 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101473 0 None 19 3 Human 8.2 pIC50 = 8.2 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
71452678 78577 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2112211 78577 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
9868530 77332 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 453 6 1 3 5.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL20837 77332 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 453 6 1 3 5.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
24800398 87410 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 6.1 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333610 87410 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 6.1 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
56678486 66469 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817837 66469 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852157 66469 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
9874168 205704 4 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL82386 205704 4 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
44408144 75267 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 498 4 0 2 6.4 CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL203700 75267 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 498 4 0 2 6.4 CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 10.1016/j.bmcl.2005.11.111
44415411 138785 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 475 5 0 3 6.3 COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378076 138785 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 475 5 0 3 6.3 COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
2755911 75439 52 None 1 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 75439 52 None 1 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44274104 80560 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 571 7 1 5 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21489 80560 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 571 7 1 5 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 10.1016/s0960-894x(01)00182-2
18669089 98939 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 6 1 3 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279523 98939 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 6 1 3 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
24799187 87426 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 449 6 0 4 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333626 87426 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 449 6 0 4 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
22293526 79631 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115008 79631 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
24785443 122068 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 425 6 1 2 6.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596455 122068 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 425 6 1 2 6.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2015.04.098
44338586 6885 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL108422 6885 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
71541577 87414 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333614 87414 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2012.11.094
46884518 7978 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090547 7978 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306436 101002 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 2 5 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL294370 101002 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 2 5 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44335360 4865 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL104348 4865 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
44358427 31014 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 643 7 1 3 8.0 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139903 31014 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 643 7 1 3 8.0 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44325096 111532 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 323 3 1 3 4.1 COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL327928 111532 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 323 3 1 3 4.1 COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
58993609 122077 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596464 122077 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
40727876 116193 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 417 7 3 4 3.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358423 116193 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 417 7 3 4 3.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 10.1021/ml5002954
44297642 195450 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55240 195450 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
53379507 66453 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817829 66453 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852067 66453 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
10390130 99241 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 474 6 2 2 5.9 NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL281717 99241 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 474 6 2 2 5.9 NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
11619202 88223 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347697 88223 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
107686 3379 41 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3379 41 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3379 41 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44299943 195562 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 359 8 1 2 5.2 CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL55476 195562 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 359 8 1 2 5.2 CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10602065 35397 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 521 8 0 2 7.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL143775 35397 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 521 8 0 2 7.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
44358670 29972 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 545 7 1 5 4.9 CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
CHEMBL138853 29972 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 545 7 1 5 4.9 CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
44297463 163119 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 611 9 1 5 4.5 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL417731 163119 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 611 9 1 5 4.5 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10327540 163505 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 720 21 2 7 7.5 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm960281e
CHEMBL420221 163505 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 720 21 2 7 7.5 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm960281e
44289219 162303 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 480 6 1 2 5.6 O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL416436 162303 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 480 6 1 2 5.6 O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
118722857 116191 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 376 7 2 5 1.6 CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358421 116191 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 376 7 2 5 1.6 CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44333606 5149 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105800 5149 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 10.1016/S0960-894X(96)00563-X
10342797 90889 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00035a006
CHEMBL23927 90889 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00035a006
24800925 87445 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 360 5 1 3 3.7 Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333645 87445 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 360 5 1 3 3.7 Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL405795 212581 7 None - 0 Guinea pig 6.2 pIC50 = 6.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
10458786 5423 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 504 5 0 3 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107283 5423 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 504 5 0 3 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288934 155091 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 599 6 0 3 7.3 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL40189 155091 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 599 6 0 3 7.3 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10087358 60340 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 320 4 1 3 3.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm00006a011
CHEMBL174465 60340 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 320 4 1 3 3.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm00006a011
21308490 101647 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 522 8 1 3 6.2 O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL299089 101647 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 522 8 1 3 6.2 O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00319-9
44346675 114255 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 320 4 1 3 3.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm9700171
CHEMBL333039 114255 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 320 4 1 3 3.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm9700171
44337704 168134 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL432979 168134 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44297859 101717 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 11 1 5 5.5 CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O 10.1016/s0960-894x(98)00319-9
CHEMBL299528 101717 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 11 1 5 5.5 CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O 10.1016/s0960-894x(98)00319-9
21994329 28921 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137972 28921 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL2112246 209233 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
11724403 168545 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL435564 168545 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
10389807 96610 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL26336 96610 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL411230 212874 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44433785 146909 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 526 6 0 2 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL392566 146909 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 526 6 0 2 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
68870858 124791 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642168 124791 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
18391053 166579 1 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 5 2 3 4.0 NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42800 166579 1 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 5 2 3 4.0 NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
19797458 34225 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL142638 34225 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
19797415 38241 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 475 8 0 3 7.3 c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 10.1021/jm00024a007
CHEMBL146223 38241 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 475 8 0 3 7.3 c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 10.1021/jm00024a007
44287481 162982 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 8 1 1 7.0 O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL417522 162982 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 8 1 1 7.0 O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
10650263 26087 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL135572 26087 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
44345147 111299 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL326613 111299 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44297649 188712 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 649 9 1 6 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL50455 188712 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 649 9 1 6 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10052114 166083 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 512 4 2 3 4.9 CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
CHEMBL425848 166083 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 512 4 2 3 4.9 CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
10837320 35447 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 415 5 1 1 6.4 FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL143813 35447 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 415 5 1 1 6.4 FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL265573 210654 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C\c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44384901 169904 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
CHEMBL444086 169904 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
44384986 129774 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
CHEMBL367528 129774 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
44411637 139280 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
CHEMBL379097 139280 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
44344195 163360 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL419232 163360 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
10055415 106756 0 None - 3 Rat 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106756 0 None - 3 Rat 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL418757 213239 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm9800346
58993550 122066 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596453 122066 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
44384677 131458 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
CHEMBL369174 131458 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
44413144 139219 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 465 8 2 3 4.4 CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2006.04.045
CHEMBL378784 139219 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 465 8 2 3 4.4 CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2006.04.045
54582277 61147 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 438 4 1 2 6.0 Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765491 61147 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 438 4 1 2 6.0 Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
28558057 163049 2 None - 0 Human 5.2 pIC50 = 5.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 423 4 1 1 6.5 O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL41762 163049 2 None - 0 Human 5.2 pIC50 = 5.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 423 4 1 1 6.5 O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
24801627 87416 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333616 87416 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
10695397 189605 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 463 6 1 4 4.7 O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL51477 189605 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 463 6 1 4 4.7 O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
46884517 8092 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091341 8092 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10026200 4848 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.9 CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104277 4848 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.9 CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
44385575 59796 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL172676 59796 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
71583203 88221 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
CHEMBL2347695 88221 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
10473960 86282 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00006a012
CHEMBL23129 86282 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00006a012
10473960 86282 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23129 86282 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44415423 139254 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 432 5 1 2 5.9 O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378984 139254 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 432 5 1 2 5.9 O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
71699787 124780 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642157 124780 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
19797468 37756 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145801 37756 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19003156 67141 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 3 3.6 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm0311487
CHEMBL187554 67141 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 3 3.6 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm0311487
10473960 86282 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00066a015
CHEMBL23129 86282 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00066a015
15639109 164034 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 408 6 1 2 5.6 c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL420876 164034 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 408 6 1 2 5.6 c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44321046 206221 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL86643 206221 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44321046 206221 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL86643 206221 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44321493 206239 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 480 7 1 3 6.4 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1021/jm00092a009
CHEMBL86746 206239 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 480 7 1 3 6.4 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1021/jm00092a009
10451098 11806 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 359 4 2 1 4.5 O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 10.1016/S0960-894X(96)00570-7
CHEMBL118194 11806 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 359 4 2 1 4.5 O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 10.1016/S0960-894X(96)00570-7
44307137 102111 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 489 4 0 4 5.1 COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL302315 102111 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 489 4 0 4 5.1 COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
24783930 122074 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596461 122074 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 10.1016/j.bmcl.2015.04.098
10030004 111345 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL326889 111345 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
15391369 102828 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL305509 102828 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44328389 107237 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 408 6 1 2 5.6 c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL316842 107237 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 408 6 1 2 5.6 c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
4189 206922 96 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 206922 96 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 206922 96 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10405461 60339 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 348 4 1 3 3.9 Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 10.1021/jm00006a011
CHEMBL174464 60339 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 348 4 1 3 3.9 Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 10.1021/jm00006a011
2090 2767 25 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311312 2767 25 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL437797 2767 25 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44384987 61354 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL176769 61354 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44289169 101488 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297883 101488 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
54585204 61163 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 478 4 1 4 5.7 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
CHEMBL1765505 61163 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 478 4 1 4 5.7 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
10031310 4710 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 589 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103510 4710 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 589 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 10.1016/S0960-894X(96)00563-X
10339539 109768 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL323128 109768 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
44276788 96496 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 10.1016/0960-894X(95)00220-N
CHEMBL26251 96496 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 10.1016/0960-894X(95)00220-N
44319329 205970 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 389 4 1 2 5.3 FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL84588 205970 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 389 4 1 2 5.3 FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44306045 100667 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 583 9 2 7 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292256 100667 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 583 9 2 7 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
9871754 5409 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL107172 5409 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
21994328 31208 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140086 31208 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
24784190 122085 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 6 1 4 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596472 122085 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 6 1 4 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 10.1016/j.bmcl.2015.04.098
9855000 20621 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20621 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
44328400 108111 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 442 6 1 2 6.3 Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL319559 108111 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 442 6 1 2 6.3 Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44415435 80141 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.3 NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213359 80141 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.3 NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415469 167430 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL429715 167430 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
11546759 88233 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347855 88233 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
21994352 119281 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 605 8 1 4 5.9 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 10.1021/jm000986n
CHEMBL343797 119281 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 605 8 1 4 5.9 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 10.1021/jm000986n
10626865 57523 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 569 11 2 5 4.8 CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL166178 57523 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 569 11 2 5 4.8 CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44328424 107308 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 454 7 1 4 5.2 COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL317297 107308 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 454 7 1 4 5.2 COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
46227360 202582 0 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 202582 0 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
10839068 118724 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 499 7 0 5 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL341745 118724 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 499 7 0 5 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
24993312 179353 11 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL473680 179353 11 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
10436850 79646 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL2115107 79646 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
11546190 105800 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126960 105800 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
19098236 34033 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 525 6 0 2 8.1 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL142477 34033 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 525 6 0 2 8.1 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44319082 168027 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL432183 168027 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
18669085 83376 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 529 7 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21939 83376 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 529 7 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44306693 102348 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 568 9 2 6 3.1 COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 10.1021/jm00039a022
CHEMBL303750 102348 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 568 9 2 6 3.1 COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 10.1021/jm00039a022
44358476 30363 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
CHEMBL139190 30363 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
44297629 190510 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL51794 190510 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
46884515 7825 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089532 7825 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44456866 157970 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL408484 157970 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
24993955 184305 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL484134 184305 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL276294 210828 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S(C)(=O)=O)C(N)=O 10.1021/jm00037a009
44415447 141552 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384796 141552 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44338640 168089 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL432627 168089 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
44321099 206225 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL86659 206225 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44368159 48194 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 5 4.6 CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL155218 48194 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 5 4.6 CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44346420 14305 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14305 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
44288758 101111 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL295122 101111 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
24785191 122071 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 432 6 1 4 5.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596458 122071 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 432 6 1 4 5.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 10.1016/j.bmcl.2015.04.098
44294423 12039 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
53817703 12039 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183414 12039 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL295686 12039 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
15037919 119627 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346633 119627 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
71541376 87430 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 382 5 0 3 4.4 CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333630 87430 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 382 5 0 3 4.4 CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24785445 122064 0 None - 0 Mongolian jird 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 485 6 1 6 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596451 122064 0 None - 0 Mongolian jird 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 485 6 1 6 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
10668476 99448 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL282996 99448 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
9957036 164158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL42103 164158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10668476 99448 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL282996 99448 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44380709 120394 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL353416 120394 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
44297359 192347 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
CHEMBL52070 192347 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
44345156 114107 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL332759 114107 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
10674743 110218 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL323762 110218 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
100951644 169634 16 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of NK1R (unknown origin)Inhibition of NK1R (unknown origin)
ChEMBL 411 7 2 9 2.3 CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 10.1021/acs.jmedchem.9b00260
CHEMBL4437106 169634 16 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of NK1R (unknown origin)Inhibition of NK1R (unknown origin)
ChEMBL 411 7 2 9 2.3 CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 10.1021/acs.jmedchem.9b00260
24889283 8431 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093595 8431 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
44289218 163709 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 481 5 2 2 6.0 O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42050 163709 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 481 5 2 2 6.0 O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
44233184 194768 0 None -12 4 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 194768 0 None -12 4 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
15037920 45729 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL153042 45729 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44363017 37303 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 409 4 0 5 5.7 CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 10.1021/jm00024a007
CHEMBL145407 37303 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 409 4 0 5 5.7 CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 10.1021/jm00024a007
44358982 30665 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 548 10 4 5 4.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL139464 30665 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 548 10 4 5 4.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 10.1021/jm00022a010
42639649 170745 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL445239 170745 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44370352 51494 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL158255 51494 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44212282 61287 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL176682 61287 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
19960248 170084 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
CHEMBL444339 170084 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
10452352 128525 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 380 6 1 5 3.3 COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 10.1021/jm00006a011
CHEMBL366753 128525 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 380 6 1 5 3.3 COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 10.1021/jm00006a011
76336391 105805 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 7 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126965 105805 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 7 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
71541372 87448 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333648 87448 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
11634999 88217 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347691 88217 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
131871 119528 6 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL345711 119528 6 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44359010 29999 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 512 9 4 4 5.2 CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
CHEMBL138883 29999 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 512 9 4 4 5.2 CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
23294208 97148 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL26790 97148 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44299310 96735 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 351 7 1 2 5.0 NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL264376 96735 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 351 7 1 2 5.0 NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL436706 213686 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(N)=O 10.1016/S0960-894X(01)80229-8
44346497 14543 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 351 7 1 2 5.0 N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL120286 14543 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 351 7 1 2 5.0 N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10407632 101824 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 383 6 0 2 5.5 c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL30029 101824 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 383 6 0 2 5.5 c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
10736544 102755 2 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of neurokinin-1 receptorConcentration required for 50% inhibition of neurokinin-1 receptor
ChEMBL 349 6 2 2 2.9 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL305094 102755 2 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of neurokinin-1 receptorConcentration required for 50% inhibition of neurokinin-1 receptor
ChEMBL 349 6 2 2 2.9 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1016/S0960-894X(97)00353-3
10520658 98647 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL277260 98647 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
10025594 90890 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL23928 90890 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
24799365 87419 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 425 7 1 4 4.9 CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333619 87419 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 425 7 1 4 4.9 CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
9852376 99102 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL280789 99102 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
44385121 61168 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 350 7 2 2 4.0 CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 10.1021/jm00006a012
CHEMBL176557 61168 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 350 7 2 2 4.0 CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 10.1021/jm00006a012
44299753 195642 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 443 7 1 2 5.0 NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL55635 195642 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 443 7 1 2 5.0 NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44287861 161739 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL41375 161739 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL415600 213194 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
56661421 66448 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817831 66448 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852028 66448 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
44312000 204679 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73839 204679 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
14999557 102625 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL304246 102625 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
68870105 124787 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642164 124787 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
16755281 176799 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 439 6 1 7 3.9 COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 10.1016/j.bmc.2008.05.067
CHEMBL460684 176799 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 439 6 1 7 3.9 COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 10.1016/j.bmc.2008.05.067
44297698 194990 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54717 194990 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
68932311 124793 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642170 124793 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44322724 206297 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 474 6 1 3 5.2 Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL87066 206297 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 474 6 1 3 5.2 Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
24800577 87428 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 448 6 1 5 3.7 CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333628 87428 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 448 6 1 5 3.7 CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 10.1016/j.bmcl.2012.11.094
15755302 102319 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 614 16 4 8 2.9 CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL303543 102319 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 614 16 4 8 2.9 CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44458869 11986 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
CHEMBL1183106 11986 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
CHEMBL280339 11986 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
44375286 120110 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL351059 120110 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
9827668 112272 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL329105 112272 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11647974 105811 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 0 2 6.3 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126970 105811 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 0 2 6.3 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
9938657 60222 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 60222 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
9827668 112272 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL329105 112272 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44458598 98848 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
CHEMBL278849 98848 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
107686 3379 41 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
3522 3379 41 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL131171 3379 41 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
44274331 82460 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00183-4
CHEMBL21759 82460 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00183-4
44433799 88668 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL235882 88668 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
44306000 100883 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 494 8 2 3 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL293675 100883 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 494 8 2 3 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44370925 119613 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 654 17 1 4 7.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL346485 119613 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 654 17 1 4 7.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
132837 2237 55 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2237 55 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2237 55 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
58993629 122103 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596490 122103 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2015.04.098
24888772 8016 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090752 8016 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44319307 106547 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL314119 106547 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44415399 80054 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
CHEMBL212978 80054 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
44415449 80265 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213908 80265 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44290030 173538 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 10 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL45316 173538 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 10 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O 10.1016/s0960-894x(01)00250-5
19797439 36886 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
CHEMBL145077 36886 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
10577745 57144 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 514 11 1 5 3.6 COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL164563 57144 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 514 11 1 5 3.6 COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
24782913 122090 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596477 122090 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
57402686 71605 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963297 71605 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3217199 71605 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
10053175 4869 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 546 4 0 3 7.1 Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104370 4869 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 546 4 0 3 7.1 Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44319223 107105 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
CHEMBL315982 107105 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
10202046 121061 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL356912 121061 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
46884471 7749 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089062 7749 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44352062 18934 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128586 18934 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
44319355 105522 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL312173 105522 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
71541473 87406 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333607 87406 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
107686 3379 41 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3379 41 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3379 41 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44319308 106378 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313931 106378 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44274181 78238 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 557 7 1 4 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21062 78238 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 557 7 1 4 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 10.1016/s0960-894x(01)00182-2
44358475 30361 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 613 7 0 5 6.2 CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139189 30361 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 613 7 0 5 6.2 CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10063954 98732 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
CHEMBL277918 98732 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
44297484 196003 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 533 9 1 5 3.7 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL56003 196003 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 533 9 1 5 3.7 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
18986937 168157 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 369 5 1 2 5.5 Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
CHEMBL433107 168157 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 369 5 1 2 5.5 Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
68930433 124789 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642166 124789 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
19797417 37316 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145414 37316 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10099318 57187 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL164912 57187 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
14986135 163401 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL419500 163401 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44337620 109739 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 595 9 2 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL322976 109739 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 595 9 2 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
9979913 108471 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 6 0 4 5.5 COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL319932 108471 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 6 0 4 5.5 COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
104974 3475 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
2111 3475 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
3481 3475 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL308148 3475 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
DB06660 3475 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL334721 211399 1 None - 3 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/S0960-894X(96)00570-7
44358520 30371 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 8 1 3 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139198 30371 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 8 1 3 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44346693 15403 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 421 9 1 2 7.1 Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL121480 15403 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 421 9 1 2 7.1 Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44366601 42426 11 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
Binding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uMBinding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uM
ChEMBL 323 4 0 3 3.5 O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
CHEMBL149905 42426 11 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
Binding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uMBinding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uM
ChEMBL 323 4 0 3 3.5 O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
104943 55386 39 None 1862 3 Human 4.1 pIC50 = 4.1 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 55386 39 None 1862 3 Human 4.1 pIC50 = 4.1 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
44346200 14413 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
CHEMBL120038 14413 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
44299876 163177 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 435 10 1 2 6.8 Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL418114 163177 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 435 10 1 2 6.8 Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
44274392 78091 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21018 78091 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 10.1016/s0960-894x(01)00183-4
22293476 79705 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115450 79705 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
44337569 9220 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 597 9 2 5 5.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL110558 9220 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 597 9 2 5 5.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10520658 98647 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL277260 98647 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL2369630 209645 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
9851211 5199 33 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL106092 5199 33 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44287606 100511 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL291146 100511 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10344874 120150 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL351387 120150 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
10907460 9828 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against tachykinin receptor 1Binding affinity against tachykinin receptor 1
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 9828 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against tachykinin receptor 1Binding affinity against tachykinin receptor 1
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
10548166 35100 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 10.1021/jm980376b
CHEMBL143377 35100 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 10.1021/jm980376b
68928720 124797 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642174 124797 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
10454303 5485 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 3 2 3 5.8 Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL107619 5485 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 3 2 3 5.8 Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
44458353 99604 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283979 99604 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
44307090 100710 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 461 6 1 3 5.5 O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL292496 100710 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 461 6 1 3 5.5 O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
21955298 79706 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115451 79706 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2369607 209640 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10840161 168269 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 4.5 CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL433906 168269 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 4.5 CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9832198 106755 0 None 100 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106755 0 None 100 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44294408 11250 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178974 11250 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL52114 11250 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44294305 12040 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
74972643 12040 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183417 12040 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL295781 12040 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
21994241 29767 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 469 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138695 29767 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 469 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
71458099 79591 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2114398 79591 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44348676 17949 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 441 1 1 4 5.8 C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL126009 17949 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 441 1 1 4 5.8 C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
19797445 119438 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL344970 119438 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
44383265 120520 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 456 8 1 4 5.5 COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 10.1016/S0960-894X(00)80693-9
CHEMBL354542 120520 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 456 8 1 4 5.5 COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 10.1016/S0960-894X(00)80693-9
10408564 5983 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 398 5 1 4 4.1 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL108010 5983 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 398 5 1 4 4.1 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10474902 88685 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 380 6 2 4 3.8 COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23597 88685 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 380 6 2 4 3.8 COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44299830 196677 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 417 3 1 3 4.9 FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL56458 196677 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 417 3 1 3 4.9 FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
44274326 81552 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 457 6 1 3 5.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21612 81552 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 457 6 1 3 5.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00182-2
58993640 122062 0 None - 0 Mongolian jird 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 393 7 1 7 2.8 COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596449 122062 0 None - 0 Mongolian jird 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 393 7 1 7 2.8 COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 10.1016/j.bmcl.2015.04.098
2090 2767 25 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
5311312 2767 25 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL437797 2767 25 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
44297523 100693 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 651 9 1 6 4.2 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292404 100693 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 651 9 1 6 4.2 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44288770 159812 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 557 7 1 3 7.6 FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(96)00287-9
CHEMBL41057 159812 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 557 7 1 3 7.6 FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(96)00287-9
10408912 96409 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 404 4 0 2 6.2 FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL26193 96409 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 404 4 0 2 6.2 FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
44274534 98959 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279726 98959 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
46884431 8055 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091043 8055 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
54581461 61263 0 None -2089 4 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 61263 0 None -2089 4 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
44276792 99131 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL281019 99131 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44297685 101078 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL294843 101078 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44334072 5095 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105560 5095 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 10.1016/S0960-894X(96)00563-X
11295303 95062 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL25521 95062 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
44305557 202813 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL62341 202813 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
44287803 100210 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288371 100210 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
44410194 76883 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL206983 76883 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
16755253 186189 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 528 4 0 4 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
CHEMBL487276 186189 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 528 4 0 4 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
118722858 116194 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 399 7 1 5 4.9 O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358424 116194 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 399 7 1 5 4.9 O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 10.1021/ml5002954
44306757 100953 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 511 9 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 10.1021/jm00039a022
CHEMBL294114 100953 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 511 9 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 10.1021/jm00039a022
44306092 203424 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 11 4 4 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL65703 203424 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 11 4 4 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44324793 207002 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 670 17 2 5 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL91438 207002 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 670 17 2 5 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
44324775 207314 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 684 17 1 5 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93401 207314 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 684 17 1 5 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
44289197 101154 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 601 5 2 4 6.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL295425 101154 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 601 5 2 4 6.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 10.1016/0960-894X(96)00287-9
104943 55386 39 None 1862 3 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL16192 55386 39 None 1862 3 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797460 121012 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL356518 121012 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44305557 202813 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL62341 202813 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
10063954 98732 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL277918 98732 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
71541472 87405 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.5 CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333606 87405 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.5 CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44346536 16305 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1021/jm9700171
CHEMBL122580 16305 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1021/jm9700171
44306106 102807 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305368 102807 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10531588 120355 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 597 13 3 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O 10.1021/jm950616c
CHEMBL353116 120355 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 597 13 3 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O 10.1021/jm950616c
44346536 16305 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL122580 16305 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
19049319 163134 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL417784 163134 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
19049319 163134 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL417784 163134 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
19797439 36886 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
CHEMBL145077 36886 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
19049319 163134 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1021/jm0311487
CHEMBL417784 163134 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1021/jm0311487
56658036 66463 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817885 66463 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852128 66463 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
23653789 3587 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 3587 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 3587 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 3587 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
23653789 3587 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 3587 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 3587 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 3587 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
10698085 19405 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL129354 19405 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
24888942 7946 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090437 7946 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44299463 196544 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 409 7 1 2 5.4 Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56372 196544 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 409 7 1 2 5.4 Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
44290080 194857 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 499 11 2 4 4.5 COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL539937 194857 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 499 11 2 4 4.5 COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
44319356 104371 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL310173 104371 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44415529 140027 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL380017 140027 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
24993313 187031 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL490869 187031 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
10499846 31223 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 341 7 1 4 3.5 COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 10.1021/jm980376b
CHEMBL140101 31223 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 341 7 1 4 3.5 COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 10.1021/jm980376b
130847 200580 18 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59915 200580 18 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
43815 186920 64 None - 25 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL1708 186920 64 None - 25 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL490 186920 64 None - 25 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL2112245 209232 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
54581252 61152 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 4 0 2 7.0 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765496 61152 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 4 0 2 7.0 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
11248796 161649 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL413027 161649 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44289102 168509 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 495 8 1 5 5.3 COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL435367 168509 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 495 8 1 5 5.3 COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
76311027 105809 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 499 6 0 2 7.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126969 105809 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 499 6 0 2 7.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
18986942 203915 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 371 5 1 2 5.1 Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
CHEMBL69051 203915 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 371 5 1 2 5.1 Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
44299898 163129 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 399 10 1 2 6.0 Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL417766 163129 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 399 10 1 2 6.0 Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
19797414 37179 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145308 37179 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
44324681 112465 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 0 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329840 112465 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 0 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 10.1016/S0960-894X(01)80747-2
44281769 109660 7 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(01)80821-0
CHEMBL32248 109660 7 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(01)80821-0
44345938 12003 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
CHEMBL118328 12003 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
10339539 109768 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL323128 109768 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL2092730 209201 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
45271306 195672 0 None -645 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 195672 0 None -645 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
46227362 202584 0 None -301 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 202584 0 None -301 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44274254 80206 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21366 80206 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
11661466 36916 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145103 36916 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL2112246 209233 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44274444 82578 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 597 8 0 4 8.0 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21787 82578 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 597 8 0 4 8.0 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
11801586 5466 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL107502 5466 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL2112245 209232 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
CHEMBL2369766 209683 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
56671764 66442 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817821 66442 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852008 66442 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
56671762 66460 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817820 66460 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852121 66460 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
23025476 66475 13 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
CHEMBL1817817 66475 13 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
CHEMBL1852184 66475 13 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
2090 2767 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
5311312 2767 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
CHEMBL437797 2767 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
44358847 30170 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 515 10 3 5 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC 10.1021/jm00022a010
CHEMBL139017 30170 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 515 10 3 5 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC 10.1021/jm00022a010
54586136 61148 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 0 2 6.4 Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765492 61148 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 0 2 6.4 Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
2090 2767 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
5311312 2767 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
CHEMBL437797 2767 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
44375315 56507 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163510 56507 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44318671 106123 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 327 2 1 3 3.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL313432 106123 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 327 2 1 3 3.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 10.1016/s0960-894x(02)00506-1
15037918 44854 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152239 44854 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
5757 3986 12 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
9832383 3986 12 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
CHEMBL522987 3986 12 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
DB11949 3986 12 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
10907397 43884 0 None - 1 Human 10.1 pKd = 10.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151177 43884 0 None - 1 Human 10.1 pKd = 10.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
44366788 44155 0 None - 1 Human 9.9 pKd = 9.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 493 6 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 10.1021/jm0209331
CHEMBL151585 44155 0 None - 1 Human 9.9 pKd = 9.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 493 6 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 10.1021/jm0209331
22901331 11981 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11981 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11981 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11981 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11981 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
18964186 204304 0 None 3 3 Human 9.5 pKd = 9.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1021/jm0209331
CHEMBL71397 204304 0 None 3 3 Human 9.5 pKd = 9.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1021/jm0209331
2102 1189 21 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 1189 21 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 1189 21 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
21836542 42302 0 None - 1 Human 9.4 pKd = 9.4 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 8 1 4 4.1 O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL149794 42302 0 None - 1 Human 9.4 pKd = 9.4 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 8 1 4 4.1 O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11005795 42186 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O 10.1021/jm0209331
CHEMBL149690 42186 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O 10.1021/jm0209331
21699577 43348 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 536 7 1 3 6.4 O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150709 43348 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 536 7 1 3 6.4 O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10918128 119851 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 0 4 4.5 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL348653 119851 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 0 4 4.5 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10973497 43237 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 533 7 0 4 4.2 O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150619 43237 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 533 7 0 4 4.2 O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
23224631 43917 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 541 7 1 4 5.1 O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151231 43917 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 541 7 1 4 5.1 O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11071954 165338 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 578 8 0 5 3.7 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL423584 165338 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 578 8 0 5 3.7 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
22901331 11981 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11981 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11981 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11981 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11981 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
10864234 43983 0 None - 1 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 517 7 0 4 5.2 O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151317 43983 0 None - 1 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 517 7 0 4 5.2 O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10929285 66709 0 None 1 2 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL185572 66709 0 None 1 2 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
21836537 41364 10 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL148998 41364 10 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366712 43503 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 477 7 0 4 4.0 O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL150842 43503 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 477 7 0 4 4.0 O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11028028 43671 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 549 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150997 43671 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 549 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11060266 44145 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL151570 44145 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
22901331 11981 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11981 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11981 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11981 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11981 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
10984417 43780 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 7 0 4 4.3 CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151088 43780 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 7 0 4 4.3 CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
44366743 43965 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 479 7 1 4 3.8 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL151289 43965 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 479 7 1 4 3.8 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
11813113 43136 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 1 4 4.2 O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150537 43136 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 1 4 4.2 O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11827396 43207 1 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150585 43207 1 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836550 119483 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL345309 119483 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11071343 121517 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.9 O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL358418 121517 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.9 O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
44366283 39540 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL147301 39540 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11103819 119479 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 577 8 0 4 6.2 O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL345288 119479 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 577 8 0 4 6.2 O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836558 121285 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 556 9 1 5 3.4 CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL357946 121285 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 556 9 1 5 3.4 CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11123982 44185 0 None - 1 Human 7.0 pKd = 7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 502 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 10.1021/jm0209331
CHEMBL151621 44185 0 None - 1 Human 7.0 pKd = 7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 502 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 10.1021/jm0209331
44300138 100897 0 None - 1 Human 6.0 pKd = 6.0 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL293804 100897 0 None - 1 Human 6.0 pKd = 6.0 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
21836503 41952 0 None - 1 Human 7.9 pKd = 7.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 464 7 1 4 3.2 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL149469 41952 0 None - 1 Human 7.9 pKd = 7.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 464 7 1 4 3.2 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
44300056 100836 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL293374 100836 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL555235 100836 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
44300032 199094 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 525 8 4 3 6.0 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL58873 199094 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 525 8 4 3 6.0 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
52937467 62523 0 None -9 3 Human 7.8 pKd = 7.8 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782141 62523 0 None -9 3 Human 7.8 pKd = 7.8 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
21836538 39487 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 520 8 1 4 3.9 CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL147241 39487 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 520 8 1 4 3.9 CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
10864203 43698 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 514 7 0 4 4.4 CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151026 43698 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 514 7 0 4 4.4 CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
44300037 191932 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 681 14 7 5 4.6 NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL52004 191932 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 681 14 7 5 4.6 NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
104943 55386 39 None 1862 3 Human 7.8 pKd = 7.8 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55386 39 None 1862 3 Human 7.8 pKd = 7.8 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
71452185 83535 0 None -2 2 Human 7.8 pKd = 7.8 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 83535 0 None -2 2 Human 7.8 pKd = 7.8 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44300106 198279 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 623 11 5 3 6.7 CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL57584 198279 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 623 11 5 3 6.7 CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
11135103 121574 0 None - 1 Human 7.7 pKd = 7.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 519 7 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 10.1021/jm0209331
CHEMBL358600 121574 0 None - 1 Human 7.7 pKd = 7.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 519 7 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 10.1021/jm0209331
11113999 43867 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.0 O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151155 43867 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.0 O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11763019 119690 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 10.1021/jm0209331
CHEMBL347284 119690 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 10.1021/jm0209331
44241710 83531 1 None 3 2 Human 7.5 pKd = 7.5 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83531 1 None 3 2 Human 7.5 pKd = 7.5 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44300497 100759 0 None - 1 Human 6.5 pKd = 6.5 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL292816 100759 0 None - 1 Human 6.5 pKd = 6.5 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
22901331 11981 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11981 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11981 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11981 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11981 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
11071001 42971 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 489 9 1 4 4.1 CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 10.1021/jm0209331
CHEMBL150381 42971 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 489 9 1 4 4.1 CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 10.1021/jm0209331
44366988 44007 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 596 9 1 4 5.5 CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151356 44007 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 596 9 1 4 5.5 CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366559 119531 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 557 9 1 5 2.4 CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL345733 119531 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 557 9 1 5 2.4 CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366577 121111 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL357357 121111 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
52937271 62521 0 None - 1 Human 8.4 pKd = 8.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782139 62521 0 None - 1 Human 8.4 pKd = 8.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
118730933 118157 0 None -389 2 Human 6.4 pKd = 6.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408519 118157 0 None -389 2 Human 6.4 pKd = 6.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
6604943 101740 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL299701 101740 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL555236 101740 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
44300034 198505 0 None - 1 Human 5.4 pKd = 5.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 569 9 5 4 5.7 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 10.1016/S0960-894X(97)00328-4
CHEMBL57778 198505 0 None - 1 Human 5.4 pKd = 5.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 569 9 5 4 5.7 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 10.1016/S0960-894X(97)00328-4
71457524 83533 0 None -5 2 Human 7.4 pKd = 7.4 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 83533 0 None -5 2 Human 7.4 pKd = 7.4 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10864032 43701 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 500 7 1 4 4.0 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151028 43701 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 500 7 1 4 4.0 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836496 120892 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 1 4 3.0 NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL355973 120892 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 1 4 3.0 NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
104943 55386 39 None 1862 3 Human 8.3 pKd = 8.3 Binding
Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55386 39 None 1862 3 Human 8.3 pKd = 8.3 Binding
Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
118730934 118158 0 None -363 2 Human 6.3 pKd = 6.3 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408520 118158 0 None -363 2 Human 6.3 pKd = 6.3 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
44300055 101005 0 None - 1 Human 6.3 pKd = 6.3 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL294452 101005 0 None - 1 Human 6.3 pKd = 6.3 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
11813288 43274 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 10.1021/jm0209331
CHEMBL150644 43274 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 10.1021/jm0209331
44366742 43964 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151288 43964 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11103197 78413 0 None - 1 Human 6.2 pKd = 6.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL2111193 78413 0 None - 1 Human 6.2 pKd = 6.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
132927 4084 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
138398059 4084 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
677 4084 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
CHEMBL294453 4084 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
CHEMBL551291 4084 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
9847362 121689 0 None - 1 Human 8.1 pKd = 8.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 465 7 0 4 3.7 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL358694 121689 0 None - 1 Human 8.1 pKd = 8.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 465 7 0 4 3.7 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
135413536 448 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 448 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 448 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 448 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 448 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 448 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
44300139 199043 0 None - 1 Human 6.1 pKd = 6.1 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL58598 199043 0 None - 1 Human 6.1 pKd = 6.1 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
118730932 118156 0 None -2951 2 Human 6.0 pKd = 6.0 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408518 118156 0 None -2951 2 Human 6.0 pKd = 6.0 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
10288987 18214 0 None - 1 Human 11.0 pKi = 11 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 nan
CHEMBL1270066 18214 0 None - 1 Human 11.0 pKi = 11 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 nan
122187724 123066 0 None 17 4 Human 10.8 pKi = 10.8 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609620 123066 0 None 17 4 Human 10.8 pKi = 10.8 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10216430 79905 0 None 204173 2 Human 10.7 pKi = 10.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212428 79905 0 None 204173 2 Human 10.7 pKi = 10.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
5752 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
6918331 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
CHEMBL522302 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
DB12436 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
5752 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
6918331 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
CHEMBL522302 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
DB12436 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
CHEMBL3609617 211831 0 None 501 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10714695 42036 0 None - 1 Human 10.5 pKi = 10.5 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 4 5.0 COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL149557 42036 0 None - 1 Human 10.5 pKi = 10.5 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 4 5.0 COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9852175 78216 15 None 1 3 Mongolian jird 10.5 pKi = 10.5 Binding
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2105667 78216 15 None 1 3 Mongolian jird 10.5 pKi = 10.5 Binding
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2419537 210438 0 None 32 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44264764 13187 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1191008 13187 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL542044 13187 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
22880695 13586 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1194085 13586 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL545594 13586 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
127944 120925 3 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL356062 120925 3 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL555572 120925 3 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL3608939 211828 0 None 1 3 Rat 10.4 pKi = 10.4 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL261390 210518 0 None 34 3 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
44177770 123002 0 None 31 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608937 123002 0 None 31 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10500669 39076 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 391 6 2 5 4.6 COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL146885 39076 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 391 6 2 5 4.6 COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10809458 119387 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 5 2 3 4.0 COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL344536 119387 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 5 2 3 4.0 COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
127944 120925 3 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL356062 120925 3 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL555572 120925 3 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5752 4005 24 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
6918331 4005 24 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
CHEMBL522302 4005 24 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
DB12436 4005 24 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
44264847 12822 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1188354 12822 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL536103 12822 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
44264766 13555 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1193883 13555 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL545360 13555 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
45271306 195672 0 None 14 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 195672 0 None 14 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
11793012 121047 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL356786 121047 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10499614 121978 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 373 6 2 4 4.3 COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL359188 121978 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 373 6 2 4 4.3 COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9852175 78216 15 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2105667 78216 15 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
22880684 13495 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1193478 13495 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL544891 13495 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
24969015 92977 7 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441373 92977 7 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2419538 210439 0 None 75 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 10.1016/j.bmcl.2013.06.065
44177570 61260 0 None 15 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 61260 0 None 15 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44233185 194822 0 None 47 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 194822 0 None 47 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
135413536 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
230 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
3490 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
6918365 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
CHEMBL1471 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
DB00673 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
10641076 168417 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 342 6 2 4 4.0 COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL434884 168417 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 342 6 2 4 4.0 COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10152974 57868 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 519 4 0 2 6.5 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672044 57868 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 519 4 0 2 6.5 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
15463537 13997 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1197007 13997 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL558990 13997 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
51002938 57871 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 531 4 0 2 6.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672047 57871 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 531 4 0 2 6.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL389652 212430 0 None 2 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL389652 212430 0 None 2 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL2419542 210443 0 None 6 3 Rat 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL2419541 210442 0 None 3 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL2419543 210444 0 None 16 4 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
9871118 146132 0 None - 1 Human 10.0 pKi = 10 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 6 2 5 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3919618 146132 0 None - 1 Human 10.0 pKi = 10 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 6 2 5 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2109 4137 4 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9852253 4137 4 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
CHEMBL129683 4137 4 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
10173872 139273 0 None 6309 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL379072 139273 0 None 6309 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
46227362 202584 0 None 12 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 202584 0 None 12 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
51002993 57877 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 602 4 0 3 6.1 CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL1672053 57877 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 602 4 0 3 6.1 CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL3609616 211830 0 None 1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL2419539 210440 0 None 25 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
2109 4137 4 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
9852253 4137 4 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
CHEMBL129683 4137 4 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
10546738 165608 0 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL424301 165608 0 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
23725089 804 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
4401 804 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
5758 804 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
9917021 804 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
CHEMBL1672054 804 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
DB06634 804 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
72203985 92975 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441371 92975 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL1651026 208826 24 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
9961315 117924 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
CHEMBL340326 117924 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
51003118 57875 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672051 57875 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL3609616 211830 0 None -1 4 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10288987 18214 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270066 18214 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10495476 39911 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 314 5 2 3 3.4 COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL147776 39911 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 314 5 2 3 3.4 COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10643148 121544 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 3.7 COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL358575 121544 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 3.7 COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10784942 121990 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 363 6 2 6 2.9 COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL359255 121990 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 363 6 2 6 2.9 COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
51002996 57881 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 5 1 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672058 57881 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 5 1 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
2102 1189 21 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 1189 21 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 1189 21 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
105083 25451 3 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm00051a001
CHEMBL135022 25451 3 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm00051a001
2102 1189 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
5311057 1189 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
CHEMBL441225 1189 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
2102 1189 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
5311057 1189 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
CHEMBL441225 1189 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
9809876 19400 1 None 398 3 Human 9.8 pKi = 9.8 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL129321 19400 1 None 398 3 Human 9.8 pKi = 9.8 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
51003056 57872 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672048 57872 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
49863732 15331 0 None 24 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15331 0 None 24 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
10217362 18294 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270565 18294 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10547681 121078 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL357029 121078 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
21041073 138849 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL378156 138849 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
51003119 57876 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672052 57876 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
53320128 57879 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 505 4 1 2 6.1 CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
CHEMBL1672056 57879 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 505 4 1 2 6.1 CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
10290124 92976 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441372 92976 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
10289148 147112 0 None - 1 Human 9.7 pKi = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 502 5 2 4 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3927453 147112 0 None - 1 Human 9.7 pKi = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 502 5 2 4 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3609618 211832 0 None 16 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44560810 173275 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL452534 173275 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
9958115 173499 0 None 6309 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL453054 173499 0 None 6309 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560811 188993 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL508661 188993 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
11327981 182278 14 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL478392 182278 14 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL229280 209458 0 None 23 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
51003053 57882 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 563 7 1 3 6.7 COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
CHEMBL1672059 57882 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 563 7 1 3 6.7 COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
44177669 61261 0 None 2 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 61261 0 None 2 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10217361 18293 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270564 18293 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
5757 3986 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
9832383 3986 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
CHEMBL522987 3986 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
DB11949 3986 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
5757 3986 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
9832383 3986 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
CHEMBL522987 3986 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
DB11949 3986 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
10289302 18234 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270175 18234 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
9872808 57869 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672045 57869 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
46227363 199665 0 None 28 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 199665 0 None 28 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
2102 1189 21 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5311057 1189 21 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL441225 1189 21 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5757 3986 12 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
9832383 3986 12 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
CHEMBL522987 3986 12 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
DB11949 3986 12 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
2102 1189 21 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
5311057 1189 21 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL441225 1189 21 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
10598278 13924 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1196442 13924 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL556981 13924 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
52943331 18249 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270271 18249 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
52947014 18306 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270664 18306 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
2102 1189 21 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 1189 21 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 1189 21 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
9852904 117037 0 None 34 3 Human 9.6 pKi = 9.6 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
CHEMBL339051 117037 0 None 34 3 Human 9.6 pKi = 9.6 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
51002992 57874 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.0 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672050 57874 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.0 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
122187724 123066 0 None -17 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609620 123066 0 None -17 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
52940937 18277 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 5 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270465 18277 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 5 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10152358 18233 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 6.0 CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270174 18233 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 6.0 CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL389652 212430 0 None 2 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
CHEMBL389652 212430 0 None -2 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL2419541 210442 0 None -3 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL389652 212430 0 None -2 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
153996 112668 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL330366 112668 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL539021 112668 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
9831546 205175 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78284 205175 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL2397481 210416 5 None - 1 Rat 9.5 pKi = 9.5 Binding
Binding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranesBinding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranes
ChEMBL None None None N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
11712457 18350 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 6.5 C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270970 18350 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 6.5 C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL2397481 210416 5 None - 1 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2018.06.009
10128086 79826 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212112 79826 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10128366 80264 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 507 8 1 2 7.7 C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL213906 80264 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 507 8 1 2 7.7 C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10128322 172972 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL451765 172972 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
10311126 173199 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452270 173199 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
44560775 173273 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452532 173273 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
104943 55386 39 None 1862 3 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55386 39 None 1862 3 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
44241723 83532 0 None 12 2 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203704 83532 0 None 12 2 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10603544 110564 0 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL325312 110564 0 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
51002995 57880 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 5 1 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672057 57880 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 5 1 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
52945787 18276 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 5 6.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270464 18276 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 5 6.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
23725089 804 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
4401 804 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
5758 804 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
9917021 804 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
CHEMBL1672054 804 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
DB06634 804 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
122187205 123003 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608938 123003 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
52942011 18336 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270868 18336 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
52943450 18215 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270067 18215 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
52946917 18321 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270766 18321 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10174642 146548 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 516 5 2 4 5.9 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3922759 146548 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 516 5 2 4 5.9 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2102 1189 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
5311057 1189 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
CHEMBL441225 1189 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
2102 1189 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
5311057 1189 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
CHEMBL441225 1189 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
44408025 75915 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL204979 75915 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
10363623 84879 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 400 7 2 4 4.5 COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL22360 84879 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 400 7 2 4 4.5 COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
15463538 13907 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1196327 13907 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL556562 13907 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
102023780 120747 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10417302 120747 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380072 120747 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355041 120747 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9852630 204853 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75598 204853 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
22960738 75284 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 6 1 3 5.4 CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 10.1016/j.bmcl.2005.10.072
CHEMBL203716 75284 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 6 1 3 5.4 CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 10.1016/j.bmcl.2005.10.072
10164354 166001 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 507 7 2 3 4.3 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL425406 166001 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 507 7 2 3 4.3 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
18403344 140914 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 1 4 7.0 Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL382242 140914 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 1 4 7.0 Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
52942012 18337 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270869 18337 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10173872 139274 0 None 5370 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL379073 139274 0 None 5370 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
10128086 139524 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL379520 139524 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
44560832 176813 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 5.7 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL460890 176813 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 5.7 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560834 189997 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 3 4.5 C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL517121 189997 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 3 4.5 C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
104943 55386 39 None 1862 3 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55386 39 None 1862 3 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
11490769 83536 0 None 6 2 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203708 83536 0 None 6 2 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
9874473 41808 0 None 16 3 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41808 0 None 16 3 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44307758 203556 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 203556 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10311483 144873 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 5 2 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3909899 144873 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 5 2 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL2370435 209849 0 None 48 2 Human 9.4 pKi = 9.4 Binding
Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptorDisplacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm8007618
44140365 187039 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL490926 187039 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10173890 78245 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL210641 78245 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
51003178 57878 6 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL1672055 57878 6 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
9873032 75382 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203867 75382 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL3609615 211829 0 None -2 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
2102 1189 21 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
5311057 1189 21 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
CHEMBL441225 1189 21 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
44380081 58108 0 None 100 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167546 58108 0 None 100 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9810434 104383 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL310273 104383 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44407938 140446 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 446 5 1 2 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL380931 140446 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 446 5 1 2 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
52937467 62523 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782141 62523 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
52937467 62523 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL1782141 62523 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
52937467 62523 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782141 62523 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
135416054 80224 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 8 3 5 5.5 C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL213735 80224 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 8 3 5 5.5 C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10151946 80320 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL214194 80320 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
44560809 173500 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL453055 173500 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560833 176852 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 447 5 2 3 4.6 C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL461299 176852 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 447 5 2 3 4.6 C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44241723 83532 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203704 83532 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10698493 109779 0 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 581 9 3 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL323224 109779 0 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 581 9 3 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
10522676 119161 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL342966 119161 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10761962 119226 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 2.7 COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL343404 119226 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 2.7 COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
24969353 199147 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2009.11.078
CHEMBL589371 199147 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2009.11.078
46224928 199402 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591074 199402 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
46889695 6929 0 None 2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084436 6929 0 None 2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
104974 3475 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
2111 3475 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
3481 3475 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
CHEMBL308148 3475 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
DB06660 3475 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
46227361 202583 0 None 14 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 202583 0 None 14 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
11261795 198702 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL492117 198702 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL581391 198702 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
52943348 18307 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270665 18307 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10462 2016 10 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
9808518 2016 10 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
CHEMBL206488 2016 10 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
122187205 123003 0 None -1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608938 123003 0 None -1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10311496 18261 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 3 5.5 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270370 18261 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 3 5.5 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
44380448 120280 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352588 120280 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315483 96599 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL263243 96599 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
101195489 155620 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9875056 155620 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL404599 155620 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9853636 205450 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL80355 205450 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10296442 75506 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL204306 75506 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
24768355 168895 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL438389 168895 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10296442 75506 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL204306 75506 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560773 172969 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL451763 172969 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
10194796 191855 0 None 6309 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL519914 191855 0 None 6309 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL439019 213818 0 None 3 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
52940879 18328 0 None 489 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 563 6 2 3 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1270786 18328 0 None 489 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 563 6 2 3 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
44307773 102360 0 None 17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 102360 0 None 17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 203536 0 None 1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 203536 0 None 1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
46889696 6930 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084437 6930 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
24768355 168895 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL438389 168895 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
71458106 79599 0 None - 1 Human 9.2 pKi = 9.2 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 348 5 2 3 4.0 COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C 10.1016/0960-894X(95)00552-5
CHEMBL2114439 79599 0 None - 1 Human 9.2 pKi = 9.2 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 348 5 2 3 4.0 COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C 10.1016/0960-894X(95)00552-5
51003117 57873 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672049 57873 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
10311306 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
5027 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
5749 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
CHEMBL3707331 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
DB09291 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
104943 55386 39 None 1862 3 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL16192 55386 39 None 1862 3 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
10128131 18250 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 489 6 3 3 5.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270272 18250 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 489 6 3 3 5.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
44380337 57435 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL165465 57435 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380396 57720 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166921 57720 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380082 58115 0 None 12 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167606 58115 0 None 12 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380091 120721 0 None 2 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354772 120721 0 None 2 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380473 120784 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355429 120784 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9896757 204981 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76580 204981 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44241710 83531 1 None 3 2 Human 9.2 pKi = 9.2 Binding
Binding affinity at human NK1 receptorBinding affinity at human NK1 receptor
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83531 1 None 3 2 Human 9.2 pKi = 9.2 Binding
Binding affinity at human NK1 receptorBinding affinity at human NK1 receptor
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44314480 102939 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL306311 102939 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
10127439 173098 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452022 173098 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
44241710 83531 1 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83531 1 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71452185 83535 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 83535 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10817360 5193 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106078 5193 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10769059 108617 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
CHEMBL320581 108617 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
44307898 201473 0 None -1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 201473 0 None -1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL387670 212411 0 None 109 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061369n
132837 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
132837 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
9461 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
CHEMBL22870 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
132837 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2237 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
10128485 148587 11 None - 1 Human 9.1 pKi = 9.1 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 515 5 3 4 4.7 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3939059 148587 11 None - 1 Human 9.1 pKi = 9.1 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 515 5 3 4 4.7 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11296094 6431 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 7 1 4 6.8 CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1082415 6431 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 7 1 4 6.8 CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
2102 1189 21 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
5311057 1189 21 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
CHEMBL441225 1189 21 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
10621261 36530 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 404 6 2 5 4.3 COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL144793 36530 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 404 6 2 5 4.3 COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9929728 39762 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 379 6 2 5 4.4 COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL147619 39762 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 379 6 2 5 4.4 COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
44408039 75502 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
CHEMBL204297 75502 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
44408047 96768 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
CHEMBL264660 96768 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
46224962 199404 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591076 199404 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
10476340 95009 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 404 6 2 5 4.5 COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL25492 95009 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 404 6 2 5 4.5 COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
44380206 57772 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166961 57772 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380132 96427 0 None 4 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL262053 96427 0 None 4 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380290 100090 0 None 21 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287369 100090 0 None 21 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9961955 172773 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL451235 172773 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9810544 204792 0 None -2 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL74956 204792 0 None -2 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44408107 75294 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 478 6 1 2 5.9 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL203740 75294 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 478 6 1 2 5.9 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL389651 212429 0 None 6 3 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
135413536 448 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 448 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 448 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 448 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 448 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 448 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
10817013 9256 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
CHEMBL110770 9256 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
44307821 102114 0 None 4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 102114 0 None 4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307819 102596 0 None 1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102596 0 None 1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 169264 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 169264 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307820 203635 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 203635 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
11734825 13227 0 None 549 2 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL119126 13227 0 None 549 2 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
122187725 123067 0 None 2 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609621 123067 0 None 2 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
46889690 6951 0 None 9 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084522 6951 0 None 9 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL2371977 210171 0 None 17 3 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
CHEMBL2419540 210441 0 None 4 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
10530375 5629 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
CHEMBL107763 5629 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
44380131 57613 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166828 57613 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380415 120315 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352813 120315 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9831674 104411 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL310334 104411 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
9917970 204953 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76437 204953 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337201 108612 0 None 7 3 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 108612 0 None 7 3 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44299271 196048 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00463-7
CHEMBL56038 196048 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00463-7
10231172 139265 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 519 6 2 3 5.1 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 10.1016/j.bmcl.2005.10.072
CHEMBL379038 139265 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 519 6 2 3 5.1 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 10.1016/j.bmcl.2005.10.072
44560755 173200 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452271 173200 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
52946919 18327 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 476 4 1 2 5.4 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1270785 18327 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 476 4 1 2 5.4 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
46889697 6931 0 None 32 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 8 0 5 7.6 COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1084438 6931 0 None 32 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 8 0 5 7.6 COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
51003055 57870 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672046 57870 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
4898 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
5742 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
6451149 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
CHEMBL206253 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
DB09048 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
54581461 61263 0 None -6 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 61263 0 None -6 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
127032533 138787 0 None 10 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1108 22 9 10 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 10.1021/acsmedchemlett.5b00359
CHEMBL3780776 138787 0 None 10 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1108 22 9 10 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 10.1021/acsmedchemlett.5b00359
71716116 86361 0 None 537 2 Human 9.0 pKi = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 516 7 0 6 5.7 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313630 86361 0 None 537 2 Human 9.0 pKi = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 516 7 0 6 5.7 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
44380062 120764 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355295 120764 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9961936 103089 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307498 103089 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315370 204839 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75479 204839 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831075 205153 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78132 205153 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
5759 594 24 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
6450815 594 24 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
CHEMBL204694 594 24 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
44338517 6335 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108200 6335 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358516 168575 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL435796 168575 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44346206 113661 3 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL332284 113661 3 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
145948847 167480 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299423 167480 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10173890 78229 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL210591 78229 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10151946 80365 0 None 1995 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL214388 80365 0 None 1995 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
46889693 6952 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084523 6952 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44177670 61262 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 61262 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL426363 213345 0 None 26 3 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11801327 9356 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL111295 9356 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44307953 169194 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 169194 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 169194 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9875181 171343 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 171343 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 203575 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 203575 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 203771 0 None 1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 203771 0 None 1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10762277 13481 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1193282 13481 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL544660 13481 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
44281977 109394 0 None 1 2 Human 9.0 pKi = 9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32197 109394 0 None 1 2 Human 9.0 pKi = 9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
52949509 18262 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270371 18262 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
2098 3694 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
36511 3694 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
3805 3694 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
3835 3694 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
CHEMBL235363 3694 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
44315298 103111 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307733 103111 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL2372071 210178 12 None - 1 Human 9.0 pKi = 9.0 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1016/s0960-894x(98)00219-4
9808347 140762 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381832 140762 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
127030411 138792 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1053 22 9 9 5.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 10.1021/acsmedchemlett.5b00359
CHEMBL3780820 138792 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1053 22 9 9 5.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 10.1021/acsmedchemlett.5b00359
52946726 18159 0 None 173 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 607 8 2 4 4.5 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1269638 18159 0 None 173 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 607 8 2 4 4.5 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL2419537 210438 0 None -32 4 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44241710 83531 1 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83531 1 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
104943 55386 39 None 1862 3 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL16192 55386 39 None 1862 3 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
10650495 107419 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
CHEMBL318085 107419 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
10626666 109195 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
CHEMBL321554 109195 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
44307741 203787 0 None 15 2 Guinea pig 9.0 pKi = 9.0 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 203787 0 None 15 2 Guinea pig 9.0 pKi = 9.0 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10303099 7277 0 None 9 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 7 2 4 6.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1086003 7277 0 None 9 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 7 2 4 6.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
52940877 18322 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270767 18322 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
44216236 6507 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 603 9 2 5 6.2 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1082737 6507 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 603 9 2 5 6.2 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44380279 57819 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166975 57819 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380414 58155 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167994 58155 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315421 105728 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312612 105728 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
15508105 204831 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75422 204831 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
127033167 138753 0 None 33 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1067 23 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780408 138753 0 None 33 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1067 23 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
9874206 203771 0 None 1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 203771 0 None 1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874473 41808 0 None 16 3 Human 8.9 pKi = 8.9 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41808 0 None 16 3 Human 8.9 pKi = 8.9 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44407998 75498 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204262 75498 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408046 140744 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381814 140744 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44407971 140754 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL381822 140754 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44358335 26863 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136347 26863 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10437488 29926 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138824 29926 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599018 199403 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591075 199403 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
9826304 187015 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL490755 187015 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
2106 3546 4 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9875034 3546 4 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
CHEMBL77023 3546 4 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
44315390 205042 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL77042 205042 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315576 205245 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78851 205245 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10304406 140340 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 613 5 0 5 6.3 Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380705 140340 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 613 5 0 5 6.3 Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
155551678 175432 0 None -4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
CHEMBL4576324 175432 0 None -4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
10218122 138383 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 6.2 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL377242 138383 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 6.2 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10239346 138743 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.9 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL378027 138743 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.9 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
71452185 83535 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 83535 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71453994 83534 0 None 10 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203706 83534 0 None 10 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44307679 203517 0 None -1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 203517 0 None -1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
46889667 6873 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 617 10 2 5 6.6 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084165 6873 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 617 10 2 5 6.6 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
9872249 76550 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 549 5 0 3 6.7 Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206171 76550 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 549 5 0 3 6.7 Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
127031644 138834 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781336 138834 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
127033173 138844 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781519 138844 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
145948797 167476 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299390 167476 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
24768356 155862 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL406030 155862 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
52943089 18160 0 None 263 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 630 4 0 3 5.4 CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2010.08.138
CHEMBL1269639 18160 0 None 263 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 630 4 0 3 5.4 CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2010.08.138
11490769 83536 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203708 83536 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71457524 83533 0 None -5 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 83533 0 None -5 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71455736 83537 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203709 83537 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44380526 58328 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168272 58328 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315369 103019 0 None 1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306952 103019 0 None 1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44305818 14795 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14795 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14795 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
85169 6915 10 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL108438 6915 10 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
85169 6915 10 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL108438 6915 10 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
10204249 75564 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 450 5 2 2 5.1 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL204554 75564 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 450 5 2 2 5.1 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
85169 6915 10 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL108438 6915 10 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
85169 6915 10 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL108438 6915 10 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
44233410 195594 0 None 38 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL555504 195594 0 None 38 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
2102 1189 21 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
5311057 1189 21 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
CHEMBL441225 1189 21 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
44307678 198675 0 None 1 2 Guinea pig 8.8 pKi = 8.8 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 198675 0 None 1 2 Guinea pig 8.8 pKi = 8.8 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
46889694 6576 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1083052 6576 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
46889698 6932 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084439 6932 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44407902 75424 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL204114 75424 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
44338518 7722 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108889 7722 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
22353151 9131 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL109937 9131 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44358612 31201 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 0 3 5.2 CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL140080 31201 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 0 3 5.2 CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358249 116550 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C 10.1016/s0960-894x(02)00956-3
CHEMBL336305 116550 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C 10.1016/s0960-894x(02)00956-3
44338359 163429 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL419742 163429 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44380338 120476 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354196 120476 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315297 204867 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL75698 204867 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL589979 215801 11 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranesBinding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranes
ChEMBL None None None None 10.1021/jm400209h
2098 3694 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
36511 3694 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3805 3694 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3835 3694 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
CHEMBL235363 3694 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
22960739 75610 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 8 1 3 5.4 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 10.1016/j.bmcl.2005.10.072
CHEMBL204714 75610 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 8 1 3 5.4 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 10.1016/j.bmcl.2005.10.072
44177770 123002 0 None -31 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608937 123002 0 None -31 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL589979 215801 11 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589979 215801 11 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
24768354 97966 0 None 28 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 955 22 8 9 3.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1021/jm070332f
CHEMBL272665 97966 0 None 28 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 955 22 8 9 3.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1021/jm070332f
CHEMBL2419543 210444 0 None -16 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL261390 210518 0 None -34 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
71461646 78909 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2112941 78909 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380289 120255 0 None 14 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352364 120255 0 None 14 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44407939 75358 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 460 6 1 2 5.7 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL203753 75358 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 460 6 1 2 5.7 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
9850565 76194 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL205829 76194 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44408838 141266 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL383125 141266 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
71455736 83537 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203709 83537 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10745532 9231 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 564 9 3 4 4.7 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO 10.1021/jm970499g
CHEMBL110656 9231 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 564 9 3 4 4.7 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO 10.1021/jm970499g
10555763 108042 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 612 9 1 3 6.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL319476 108042 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 612 9 1 3 6.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
9874473 41808 0 None 16 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41808 0 None 16 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
46889668 6575 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 5 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1083051 6575 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 5 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44380080 12242 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL1184507 12242 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352842 12242 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10145229 9173 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9173 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337370 107416 0 None 147 2 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL318081 107416 0 None 147 2 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
101658885 161488 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 899 27 12 12 -3.5 N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2018.06.009
CHEMBL4127872 161488 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 899 27 12 12 -3.5 N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2018.06.009
44233184 194768 0 None 12 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 194768 0 None 12 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44380092 120361 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353162 120361 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315589 204838 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75478 204838 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9831707 205027 0 None -3 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76965 205027 0 None -3 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
127033168 138774 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3780686 138774 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
44315589 204838 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
CHEMBL75478 204838 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
49863734 15333 0 None 13 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15333 0 None 13 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
11793946 38228 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 376 6 2 5 3.7 COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL146210 38228 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 376 6 2 5 3.7 COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
44408045 75606 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL204691 75606 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44358318 30246 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL139088 30246 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
22353158 30883 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 476 8 1 4 4.6 OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139750 30883 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 476 8 1 4 4.6 OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358456 118893 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 523 8 0 4 6.2 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342266 118893 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 523 8 0 4 6.2 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10741553 13496 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1193479 13496 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL544892 13496 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
9892922 100903 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1021/jm1016285
CHEMBL293844 100903 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1021/jm1016285
44215305 119254 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343627 119254 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44407907 75697 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204764 75697 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407917 96558 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
CHEMBL262989 96558 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
44408088 139825 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL379898 139825 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44358568 30695 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139499 30695 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
10302076 30733 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 532 11 1 4 5.9 O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139531 30733 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 532 11 1 4 5.9 O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
9892922 100903 0 None - 1 Human 8.0 pKi = 8 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL293844 100903 0 None - 1 Human 8.0 pKi = 8 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
44281685 100031 0 None -5 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286901 100031 0 None -5 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281538 110313 0 None 1 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32385 110313 0 None 1 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
3082491 199317 20 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 277 7 3 3 0.6 CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL590518 199317 20 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 277 7 3 3 0.6 CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL58178 215779 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL591489 215802 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1 10.1021/jm901352b
44380277 59245 0 None 2 2 Human 7.0 pKi = 7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170325 59245 0 None 2 2 Human 7.0 pKi = 7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
73212439 104607 0 None 10 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104782 104607 0 None 10 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
44338531 9358 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111304 9358 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00956-3
44358346 26786 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl 10.1016/s0960-894x(02)00956-3
CHEMBL136279 26786 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl 10.1016/s0960-894x(02)00956-3
46224962 199404 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591076 199404 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL261608 210519 0 None -3 3 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm070332f
44281332 112910 0 None -100 2 Human 7.0 pKi = 7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33106 112910 0 None -100 2 Human 7.0 pKi = 7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44304397 203286 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 473 2 0 2 5.3 CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL64698 203286 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 473 2 0 2 5.3 CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
44304302 203322 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 385 3 1 2 4.3 CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL64862 203322 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 385 3 1 2 4.3 CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
45379600 199177 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 355 8 3 4 1.1 COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 10.1021/jm901352b
CHEMBL589543 199177 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 355 8 3 4 1.1 COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 10.1021/jm901352b
57391133 68367 0 None 1 2 Human 4.0 pKi = 4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68367 0 None 1 2 Human 4.0 pKi = 4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
11799987 5318 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 514 9 2 3 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 10.1021/jm970499g
CHEMBL106754 5318 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 514 9 2 3 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 10.1021/jm970499g
118731115 118171 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 726 16 7 7 2.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408732 118171 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 726 16 7 7 2.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44380107 120100 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 14 1 6 8.6 CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350952 120100 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 14 1 6 8.6 CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
86274487 160089 0 None -933 3 Human 5.0 pKi = 5.0 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4108583 160089 0 None -933 3 Human 5.0 pKi = 5.0 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
44318455 104677 0 None - 1 Human 7.0 pKi = 7.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 510 4 1 4 4.7 N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL310521 104677 0 None - 1 Human 7.0 pKi = 7.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 510 4 1 4 4.7 N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
44334501 5009 0 None - 1 Human 6.0 pKi = 6.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 567 2 0 4 4.4 CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL105055 5009 0 None - 1 Human 6.0 pKi = 6.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 567 2 0 4 4.4 CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
44337207 7830 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108955 7830 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44177669 61261 0 None -52 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 61261 0 None -52 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
46889691 6927 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084434 6927 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL589082 215798 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
44611293 91073 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.1 Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397493 91073 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.1 Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44337078 107195 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 859 11 0 5 10.5 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL316552 107195 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 859 11 0 5 10.5 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL2372070 210177 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
19610193 107232 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
CHEMBL316740 107232 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
44364001 39904 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147767 39904 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314865 205113 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77752 205113 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281505 116890 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33833 116890 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281334 119394 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34460 119394 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363909 35900 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144223 35900 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44281587 53558 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL160210 53558 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
76317390 104609 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104784 104609 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
44408089 140186 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL380449 140186 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408051 141227 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL382871 141227 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44338546 108608 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL320535 108608 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
71717930 86362 0 None -39 2 Human 6.9 pKi = 6.9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 448 7 0 6 4.3 CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 10.1021/jm301653f
CHEMBL2313631 86362 0 None -39 2 Human 6.9 pKi = 6.9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 448 7 0 6 4.3 CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 10.1021/jm301653f
73350089 89408 0 None 19 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370510 89408 0 None 19 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
73354570 89410 0 None 13 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
CHEMBL2370513 89410 0 None 13 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
44314866 102905 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 718 13 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306039 102905 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 718 13 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314454 105617 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312295 105617 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
90644614 112709 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288158 112709 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304470 112709 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644604 112744 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288153 112744 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305011 112744 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358589 29019 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 386 9 1 6 2.9 COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
CHEMBL138056 29019 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 386 9 1 6 2.9 COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
9853827 85221 0 None -794 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225588 85221 0 None -794 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
9872676 78195 0 None -3162 16 Human 5.9 pKi = 5.9 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
CHEMBL210514 78195 0 None -3162 16 Human 5.9 pKi = 5.9 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
53472113 118858 0 None -630 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
CHEMBL3422009 118858 0 None -630 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
2132 3744 58 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
5311424 3744 58 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
CHEMBL10188 3744 58 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
71533722 118860 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
CHEMBL3422010 118860 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
71549769 118868 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
CHEMBL3422018 118868 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
10813332 7774 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 447 6 2 2 5.0 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
CHEMBL108933 7774 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 447 6 2 2 5.0 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
71533722 118860 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
CHEMBL3422010 118860 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
10745123 10543 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL1169522 10543 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44337200 9253 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 795 9 2 7 7.2 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL110766 9253 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 795 9 2 7 7.2 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44363984 35668 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
CHEMBL144011 35668 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
44215306 37174 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145302 37174 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44215303 118962 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342341 118962 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363952 121011 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356508 121011 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
118730933 118157 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408519 118157 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
118730933 118157 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3408519 118157 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
56665366 65908 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 792 14 2 5 8.5 O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835843 65908 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 792 14 2 5 8.5 O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
44177570 61260 0 None -169 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 61260 0 None -169 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44314873 204790 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL74918 204790 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10395141 204825 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75367 204825 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44282002 125506 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL36462 125506 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
76317390 104609 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104784 104609 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
10651193 7453 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL108676 7453 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
11273015 58265 0 None -21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682624 58265 0 None -21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
132837 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
132837 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
9461 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
CHEMBL22870 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
2110 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
2110 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
219077 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
3480 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
CHEMBL346178 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
DB04872 2969 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
44318665 106150 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 1 4 5.2 CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 10.1016/s0960-894x(02)00488-2
CHEMBL313590 106150 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 1 4 5.2 CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 10.1016/s0960-894x(02)00488-2
132837 2237 55 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
9461 2237 55 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
CHEMBL22870 2237 55 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
132837 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2237 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
44337514 5285 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 406 6 1 4 2.8 CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106555 5285 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 406 6 1 4 2.8 CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
15887536 5428 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 646 8 1 4 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107309 5428 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 646 8 1 4 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
54397413 91066 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.0 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397486 91066 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.0 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
44314453 97084 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL267333 97084 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314732 205094 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77592 205094 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44318694 106026 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 575 4 1 3 6.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL313297 106026 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 575 4 1 3 6.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O 10.1016/s0960-894x(02)00488-2
44408864 76521 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 1 1 7.3 CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206016 76521 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 1 1 7.3 CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44363990 16312 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL122643 16312 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363982 35666 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144010 35666 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363442 37940 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145959 37940 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
24768353 97748 0 None -21 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 941 22 9 9 2.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm070332f
CHEMBL271619 97748 0 None -21 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 941 22 9 9 2.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm070332f
44233185 194822 0 None -181 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 194822 0 None -181 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
10394952 104749 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310703 104749 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314486 105656 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312528 105656 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9987474 204833 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75436 204833 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44177670 61262 0 None -190 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 61262 0 None -190 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
44281345 110480 0 None -10 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32477 110480 0 None -10 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337353 5427 0 None -9 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL107306 5427 0 None -9 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL388265 212415 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm901352b
44318677 205694 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 0 3 4.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82278 205694 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 0 3 4.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O 10.1016/s0960-894x(02)00488-2
44337080 110598 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 945 11 2 7 8.8 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
CHEMBL325547 110598 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 945 11 2 7 8.8 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
44380313 58091 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167409 58091 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380095 120856 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355868 120856 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337174 7883 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
CHEMBL108997 7883 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
9566253 75510 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 414 4 1 5 6.1 Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL204327 75510 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 414 4 1 5 6.1 Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL3609617 211831 0 None -501 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
73212437 104611 0 None 630 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104786 104611 0 None 630 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
90644632 111946 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 698 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288168 111946 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 698 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644628 112734 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3288165 112734 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3304854 112734 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
10141196 26800 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 8 1 4 4.7 O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136291 26800 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 8 1 4 4.7 O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
135530616 29792 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 529 8 2 6 4.6 Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 10.1016/s0960-894x(02)00956-3
CHEMBL138716 29792 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 529 8 2 6 4.6 Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 10.1016/s0960-894x(02)00956-3
10230370 30594 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 534 11 1 5 4.7 O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139382 30594 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 534 11 1 5 4.7 O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358408 30971 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 9 0 5 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL139859 30971 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 9 0 5 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44358597 31460 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL140302 31460 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
9852911 99383 0 None 8 6 Human 6.8 pKi = 6.8 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm0205088
CHEMBL282618 99383 0 None 8 6 Human 6.8 pKi = 6.8 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm0205088
10085946 165340 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 296 7 2 3 3.3 CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL423597 165340 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 296 7 2 3 3.3 CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 10.1016/s0960-894x(01)00020-8
25222441 197141 0 None -30 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567849 197141 0 None -30 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
118730936 118160 0 None -16982 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 684 14 7 7 1.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408522 118160 0 None -16982 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 684 14 7 7 1.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
10552479 109003 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 474 7 2 4 4.8 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL321215 109003 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 474 7 2 4 4.8 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44315267 105505 0 None -63 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312141 105505 0 None -63 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44358421 29752 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 422 6 1 4 4.5 FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138682 29752 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 422 6 1 4 4.5 FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44363962 35930 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144249 35930 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44363949 120942 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356105 120942 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314502 204797 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75018 204797 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10531434 7459 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 9 3 3 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL108683 7459 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 9 3 3 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
51351504 60609 1 None -4 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760206 60609 1 None -4 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
118731119 118175 0 None -162181 2 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 686 17 7 7 1.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 10.1016/j.ejmech.2014.12.033
CHEMBL3408736 118175 0 None -162181 2 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 686 17 7 7 1.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 10.1016/j.ejmech.2014.12.033
44351946 117369 1 None -1778 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL339767 117369 1 None -1778 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
44281784 113493 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33198 113493 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44318865 206140 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 671 7 0 7 3.8 COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC 10.1016/s0960-894x(02)00488-2
CHEMBL86053 206140 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 671 7 0 7 3.8 COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC 10.1016/s0960-894x(02)00488-2
44380094 58744 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168584 58744 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
141952732 120465 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380527 120465 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
CHEMBL354091 120465 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44337467 110215 0 None 17 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL323741 110215 0 None 17 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44363936 20035 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL130354 20035 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
9868422 170279 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 0 1 7.0 Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL444624 170279 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 0 1 7.0 Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10507771 109738 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL322975 109738 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
73353537 91070 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397490 91070 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
10790280 108619 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 463 6 2 2 5.1 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL320583 108619 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 463 6 2 2 5.1 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
10649307 110368 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 507 6 2 2 5.2 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br 10.1021/jm970499g
CHEMBL324177 110368 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 507 6 2 2 5.2 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br 10.1021/jm970499g
10531273 9199 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O 10.1021/jm970499g
CHEMBL110393 9199 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O 10.1021/jm970499g
71549913 118856 0 None -1737 3 Human 4.8 pKi = 4.8 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL3422007 118856 0 None -1737 3 Human 4.8 pKi = 4.8 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
44408725 166068 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 375 4 1 3 6.2 Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL425768 166068 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 375 4 1 3 6.2 Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
7088456 199527 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL592133 199527 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
44363908 35783 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144116 35783 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363756 39837 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147715 39837 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44138558 193038 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL522292 193038 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10189341 10119 0 None 10 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL115633 10119 0 None 10 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
10746177 7023 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 602 8 2 3 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL108481 7023 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 602 8 2 3 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F 10.1021/jm970499g
11100291 177677 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 353 8 3 3 0.9 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL464178 177677 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 353 8 3 3 0.9 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
10649931 7875 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 531 9 3 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL108990 7875 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 531 9 3 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL2371916 210152 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1021/jm00391a046
20906619 60668 7 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760338 60668 7 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
73353047 89406 0 None 1 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370509 89406 0 None 1 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44314547 102875 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL305826 102875 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
25221995 196851 0 None -67 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
CHEMBL565894 196851 0 None -67 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
46228976 199144 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 10.1021/jm901352b
CHEMBL589329 199144 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 10.1021/jm901352b
15487997 91062 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.0 CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397482 91062 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.0 CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44363925 40063 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147924 40063 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314871 105693 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312573 105693 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
90644630 111944 0 None 50 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 725 13 2 6 6.2 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3288166 111944 0 None 50 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 725 13 2 6 6.2 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
90644620 112791 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288161 112791 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305870 112791 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44407901 140444 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL380928 140444 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44358409 119342 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 6 1 3 4.7 NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL344265 119342 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 6 1 3 4.7 NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
46224928 199402 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591074 199402 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
54583959 60669 0 None -3 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760339 60669 0 None -3 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
90644606 112790 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288154 112790 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305869 112790 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44338530 9357 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111303 9357 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
11239751 85171 0 None -1995 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL225297 85171 0 None -1995 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44322610 206645 0 None - 1 Human 6.7 pKi = 6.7 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1021/jm058225d
CHEMBL89245 206645 0 None - 1 Human 6.7 pKi = 6.7 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1021/jm058225d
86274490 159886 0 None -1000 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4106866 159886 0 None -1000 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
44315210 102918 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306124 102918 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44409023 140218 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380510 140218 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44560754 173197 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452269 173197 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
10359664 114002 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm00051a001
CHEMBL332644 114002 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm00051a001
9896563 103780 0 None 5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 103780 0 None 5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
9810288 203691 0 None 8 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 203691 0 None 8 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44281633 99987 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286646 99987 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281649 109020 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32124 109020 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281666 109205 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32163 109205 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281650 113797 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33243 113797 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10394882 113812 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33249 113812 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
52943090 18161 0 None 79 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 666 5 0 4 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1269640 18161 0 None 79 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 666 5 0 4 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
71453994 83534 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203706 83534 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44380413 96596 0 None 21 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL263214 96596 0 None 21 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380249 120344 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353027 120344 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
127034831 136513 0 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity at human NK1R assessed as inhibition constantBinding affinity at human NK1R assessed as inhibition constant
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c01456
CHEMBL3736287 136513 0 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity at human NK1R assessed as inhibition constantBinding affinity at human NK1R assessed as inhibition constant
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c01456
72734611 90984 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL2396664 90984 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
72734611 90984 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL2396664 90984 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
127032846 138791 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780818 138791 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
145948744 167475 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299371 167475 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
72734611 90984 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL2396664 90984 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
72734611 90984 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2396664 90984 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10769060 6034 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
CHEMBL108040 6034 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
11353915 6953 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 601 9 1 4 7.6 CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1084525 6953 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 601 9 1 4 7.6 CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
46889692 6928 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084435 6928 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44315209 204911 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76093 204911 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44178113 61264 0 None -12 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 61264 0 None -12 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10793340 5725 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 10.1021/jm970499g
CHEMBL107830 5725 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 10.1021/jm970499g
10817098 110528 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL325106 110528 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
44380090 120720 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354771 120720 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44315422 103139 0 None 2 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307877 103139 0 None 2 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315591 204974 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76529 204974 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315299 205011 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76823 205011 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9940831 14646 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14646 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14646 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10237920 79842 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 416 5 0 2 6.1 C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212173 79842 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 416 5 0 2 6.1 C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
9927183 195605 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/S0960-894X(01)80386-3
CHEMBL55591 195605 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/S0960-894X(01)80386-3
44315572 102981 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306624 102981 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
145948965 167488 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299476 167488 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
11794060 119198 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL343219 119198 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
86302473 112748 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288169 112748 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305156 112748 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44408040 74419 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL202627 74419 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
9874480 74773 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203113 74773 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44407908 140557 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL381155 140557 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
44358317 116537 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 488 9 0 3 6.4 CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL336251 116537 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 488 9 0 3 6.4 CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358425 165446 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL423913 165446 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
145948839 167479 0 None -6 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299415 167479 0 None -6 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44560774 172970 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL451764 172970 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
73348949 90822 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
CHEMBL2392023 90822 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
10816496 5203 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 550 8 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O 10.1021/jm970499g
CHEMBL106100 5203 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 550 8 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O 10.1021/jm970499g
46889669 7011 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084771 7011 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44315231 105399 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL311712 105399 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44408062 140556 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL381151 140556 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
10600310 86359 0 None 13 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 466 7 0 5 4.9 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313628 86359 0 None 13 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 466 7 0 5 4.9 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
44380248 58163 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168144 58163 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71457524 83533 0 None -5 2 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 83533 0 None -5 2 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL3609619 211833 0 None 34 3 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
145948981 167491 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299483 167491 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
9874473 41808 0 None 16 3 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41808 0 None 16 3 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44380732 58992 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL169002 58992 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363436 35715 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144057 35715 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363979 120983 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356268 120983 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10484667 204555 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL72930 204555 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL2370435 209849 0 None -48 2 Guinea pig 7.7 pKi = 7.7 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm00073a022
44314578 205148 0 None 13 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78091 205148 0 None 13 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL5271987 193704 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 761 12 5 7 6.2 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)NC1(C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CNc2[nH]c3ccccc3c2C1 10.1021/acs.jmedchem.6b01029
13821356 106720 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 995 25 10 16 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O 10.1021/jm00391a046
CHEMBL3144091 106720 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 995 25 10 16 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O 10.1021/jm00391a046
44318578 205692 0 None - 1 Human 5.7 pKi = 5.7 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 521 8 1 3 5.6 CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82274 205692 0 None - 1 Human 5.7 pKi = 5.7 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 521 8 1 3 5.6 CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
2110 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
219077 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
3480 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
CHEMBL346178 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
DB04872 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
2110 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
219077 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
3480 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
CHEMBL346178 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
DB04872 2969 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
44337330 5332 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106816 5332 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
86275688 148307 0 None -794 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
CHEMBL3936869 148307 0 None -794 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
18393120 5260 0 None -10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106404 5260 0 None -10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44408736 140886 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 471 4 0 1 7.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL382043 140886 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 471 4 0 1 7.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl 10.1016/j.bmcl.2005.11.047
44314503 204993 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL76704 204993 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL5083565 214871 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]SP from human NK1R expressed in U373 MG cells assessed as inhibitory constant incubated for 30 mins by radioligand binding assayDisplacement of [125I]SP from human NK1R expressed in U373 MG cells assessed as inhibitory constant incubated for 30 mins by radioligand binding assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10839138 86360 0 None -11 2 Human 6.7 pKi = 6.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 500 7 0 5 5.5 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313629 86360 0 None -11 2 Human 6.7 pKi = 6.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 500 7 0 5 5.5 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1021/jm301653f
51351496 60608 7 None -4 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760205 60608 7 None -4 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
86274732 122995 0 None -691 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 388 4 1 8 1.8 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 nan
CHEMBL3608741 122995 0 None -691 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 388 4 1 8 1.8 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 nan
86274727 160783 0 None -912 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4114280 160783 0 None -912 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
18546500 76707 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 0 1 7.1 FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206490 76707 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 0 1 7.1 FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
46228975 201632 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 10.1021/jm901352b
CHEMBL605906 201632 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 10.1021/jm901352b
44334665 167997 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 583 6 1 5 4.0 O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL432007 167997 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 583 6 1 5 4.0 O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
44337308 5446 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107407 5446 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL2372065 210175 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)N1C2CC3CCC2(CS1(=O)=O)C3(C)C)[C@@H](Cc1ccc(Cc2ccccc2)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
44233184 194768 0 None -12 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 194768 0 None -12 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44314504 102916 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306121 102916 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281357 111733 0 None - 1 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 10 1 4 9.1 CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32872 111733 0 None - 1 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 10 1 4 9.1 CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL3609618 211832 0 None -1148 4 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44334664 4540 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 625 6 0 5 4.3 CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 10.1016/s0960-894x(02)00659-5
CHEMBL102356 4540 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 625 6 0 5 4.3 CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 10.1016/s0960-894x(02)00659-5
86274488 160717 0 None -1584 2 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 372 3 0 7 2.7 CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 nan
CHEMBL4113741 160717 0 None -1584 2 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 372 3 0 7 2.7 CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 nan
44380093 120736 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354892 120736 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10010039 39905 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147769 39905 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44305793 100845 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL293432 100845 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314577 159880 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL41068 159880 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
44314299 205145 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78070 205145 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44318269 205990 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 543 3 1 5 4.2 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL84761 205990 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 543 3 1 5 4.2 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O 10.1016/s0960-894x(02)00488-2
44380474 58783 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168769 58783 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10417108 100100 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287454 100100 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314482 103809 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL309087 103809 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380795 206132 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL85980 206132 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337313 108603 0 None -7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320487 108603 0 None -7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44314482 103809 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL309087 103809 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363963 121277 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL357853 121277 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10417108 100100 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL287454 100100 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 103809 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL309087 103809 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 103809 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL309087 103809 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10417108 100100 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity of compound against Tachykinin receptor 1Tested for binding affinity of compound against Tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287454 100100 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity of compound against Tachykinin receptor 1Tested for binding affinity of compound against Tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44338532 7630 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108822 7630 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
9801487 206998 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1021/jm058225d
CHEMBL91418 206998 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1021/jm058225d
10603383 111347 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl 10.1021/jm970499g
CHEMBL326893 111347 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl 10.1021/jm970499g
73345476 89411 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 9 7 8 1.0 CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370514 89411 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 9 7 8 1.0 CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
45379601 200741 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 317 7 3 4 0.8 NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL600224 200741 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 317 7 3 4 0.8 NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
73212518 104600 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 489 8 3 3 4.2 CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104774 104600 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 489 8 3 3 4.2 CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
73212440 104605 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 558 8 2 4 4.2 CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/j.bmcl.2013.12.033
CHEMBL3104780 104605 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 558 8 2 4 4.2 CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/j.bmcl.2013.12.033
90644624 112761 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288163 112761 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305323 112761 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358385 27463 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 702 13 0 6 8.4 COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
CHEMBL136850 27463 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 702 13 0 6 8.4 COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
73212593 104602 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104776 104602 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
73212592 104606 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104781 104606 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
145948981 167491 0 None -9 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299483 167491 0 None -9 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
73353535 91065 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397485 91065 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44281778 109696 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32279 109696 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10794699 9237 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 684 9 2 3 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110688 9237 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 684 9 2 3 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10530592 10544 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL1169523 10544 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44334591 107421 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 667 4 0 5 4.9 CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00659-5
CHEMBL318093 107421 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 667 4 0 5 4.9 CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00659-5
10627789 100578 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm0205088
CHEMBL29161 100578 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm0205088
52937271 62521 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782139 62521 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
52937271 62521 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782139 62521 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
145948797 167476 0 None -26 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299390 167476 0 None -26 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10603365 9289 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL110913 9289 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL261608 210519 0 None -9 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm070332f
44337023 108674 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 861 11 0 7 8.2 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320770 108674 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 861 11 0 7 8.2 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
44462338 205796 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83156 205796 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
145948847 167480 0 None -28 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299423 167480 0 None -28 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10722607 5205 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 10.1021/jm970499g
CHEMBL106106 5205 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 10.1021/jm970499g
10698708 109790 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br 10.1021/jm970499g
CHEMBL323274 109790 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br 10.1021/jm970499g
10697884 164467 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 548 9 2 3 5.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL421408 164467 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 548 9 2 3 5.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44408625 168722 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.4 CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL436951 168722 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.4 CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44315590 167808 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL430609 167808 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL2371978 210172 0 None 30 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
135413536 448 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 448 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 448 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 448 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 448 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 448 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
9918520 102751 0 None 2 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 102751 0 None 2 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
46889466 7278 1 None 30 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 8 1 4 7.4 COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1086004 7278 1 None 30 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 8 1 4 7.4 COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
104943 55386 39 None 1862 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00020-8
CHEMBL16192 55386 39 None 1862 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00020-8
44408100 140686 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 474 6 1 2 6.1 CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL381524 140686 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 474 6 1 2 6.1 CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
44407972 140756 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381825 140756 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44338583 5796 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00956-3
CHEMBL107875 5796 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00956-3
44358280 26878 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136360 26878 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358334 27039 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136504 27039 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358569 116792 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 533 11 1 5 4.1 NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL337789 116792 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 533 11 1 5 4.1 NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358323 118979 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342443 118979 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44315573 103796 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL308983 103796 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337371 5291 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106572 5291 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
25129135 172597 0 None -7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172597 0 None -7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
9918479 57612 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166827 57612 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
22000062 76558 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206268 76558 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
145948809 167478 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299402 167478 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44611294 91074 0 None - 1 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 329 7 3 3 0.9 NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397494 91074 0 None - 1 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 329 7 3 3 0.9 NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10239000 79781 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 1 3 5.3 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL211888 79781 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 1 3 5.3 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
11467400 6506 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 587 8 1 4 7.2 CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1082735 6506 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 587 8 1 4 7.2 CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
9869764 140542 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381058 140542 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
145948955 167487 0 None 7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299466 167487 0 None 7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44409008 75116 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203605 75116 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10530741 9193 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F 10.1021/jm970499g
CHEMBL110355 9193 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F 10.1021/jm970499g
10115747 141156 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 464 5 1 2 5.5 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL382771 141156 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 464 5 1 2 5.5 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL2419540 210441 0 None -4 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
46227360 202582 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 202582 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44138555 193172 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL523156 193172 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
44408766 96924 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL265986 96924 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10507650 163330 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL419004 163330 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
90644635 112706 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288170 112706 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304460 112706 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44408033 74772 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203111 74772 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44337414 9215 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110507 9215 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
46227362 202584 0 None -301 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 202584 0 None -301 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44314154 205067 0 None 24 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77265 205067 0 None 24 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44334845 108907 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 725 6 0 7 5.2 COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00659-5
CHEMBL321098 108907 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 725 6 0 7 5.2 COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00659-5
3668 1561 42 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
5311081 1561 42 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL333357 1561 42 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589982 1561 42 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
44334666 4627 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 736 4 1 7 4.5 O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 10.1016/s0960-894x(02)00659-5
CHEMBL102917 4627 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 736 4 1 7 4.5 O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 10.1016/s0960-894x(02)00659-5
90663661 106711 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 1140 33 10 15 -0.0 CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O 10.1021/jm00391a046
CHEMBL3143946 106711 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 1140 33 10 15 -0.0 CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O 10.1021/jm00391a046
118730935 118159 0 None -10715 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 699 15 6 7 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408521 118159 0 None -10715 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 699 15 6 7 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
44334708 4633 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 609 2 0 4 5.4 CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL102932 4633 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 609 2 0 4 5.4 CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
118731117 118173 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 740 17 7 7 2.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408734 118173 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 740 17 7 7 2.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
56682292 65910 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 808 15 2 6 7.7 O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835845 65910 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 808 15 2 6 7.7 O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
90644631 111945 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 684 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288167 111945 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 684 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358248 26673 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C 10.1016/s0960-894x(02)00956-3
CHEMBL136187 26673 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C 10.1016/s0960-894x(02)00956-3
20599018 199403 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591075 199403 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
44304398 102686 0 None - 1 Human 7.5 pKi = 7.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 459 2 1 2 5.3 CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL304638 102686 0 None - 1 Human 7.5 pKi = 7.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 459 2 1 2 5.3 CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
16655023 107441 2 None -251 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from human cloned NK1 receptorDisplacement of [3H]substance P from human cloned NK1 receptor
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
CHEMBL318235 107441 2 None -251 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from human cloned NK1 receptorDisplacement of [3H]substance P from human cloned NK1 receptor
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
44408911 140563 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 355 4 1 3 5.8 Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL381179 140563 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 355 4 1 3 5.8 Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
73212517 104601 0 None 31 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 475 7 3 3 3.9 CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104775 104601 0 None 31 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 475 7 3 3 3.9 CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
73212516 104603 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104777 104603 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
90644626 112753 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288164 112753 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305163 112753 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44304340 202870 0 None - 1 Human 6.5 pKi = 6.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 503 3 1 4 4.4 COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL62597 202870 0 None - 1 Human 6.5 pKi = 6.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 503 3 1 4 4.4 COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
44337270 108602 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320486 108602 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337007 110408 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 863 9 2 7 8.5 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL324416 110408 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 863 9 2 7 8.5 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
52937273 62519 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL1782137 62519 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
44281572 110392 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32431 110392 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281776 114252 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33302 114252 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
54581461 61263 0 None -2089 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 61263 0 None -2089 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
86275687 143641 0 None -776 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 nan
CHEMBL3899877 143641 0 None -776 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 nan
10007108 163965 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 527 2 1 3 5.4 Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 10.1016/s0960-894x(02)00488-2
CHEMBL420787 163965 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 527 2 1 3 5.4 Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 10.1016/s0960-894x(02)00488-2
44380475 58784 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 675 11 1 4 9.2 CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168770 58784 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 675 11 1 4 9.2 CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314476 105082 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL311387 105082 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
24768355 168895 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL438389 168895 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
24768355 168895 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL438389 168895 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
44281713 99663 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284396 99663 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281788 99986 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286640 99986 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
73353536 91067 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 10.1021/jm400209h
CHEMBL2397487 91067 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 10.1021/jm400209h
2110 2969 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
219077 2969 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
3480 2969 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL346178 2969 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
DB04872 2969 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
10600014 167870 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 459 7 2 3 4.9 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 10.1021/jm970499g
CHEMBL431070 167870 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 459 7 2 3 4.9 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 10.1021/jm970499g
10007326 106866 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 535 2 1 3 5.6 O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL314499 106866 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 535 2 1 3 5.6 O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O 10.1016/s0960-894x(02)00488-2
44314481 204936 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL76334 204936 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
145948839 167479 0 None -85 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299415 167479 0 None -85 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
145948968 167489 0 None -8 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299479 167489 0 None -8 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
45271306 195672 0 None -645 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 195672 0 None -645 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
118730934 118158 0 None -363 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408520 118158 0 None -363 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
51003494 58322 0 None -44 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682680 58322 0 None -44 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
44337355 5346 0 None -26 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106877 5346 0 None -26 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
118731114 118170 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 862 16 7 7 4.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408731 118170 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 862 16 7 7 4.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44363948 36377 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144668 36377 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363912 118757 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL341843 118757 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10507772 109753 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL323044 109753 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44336987 108949 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 791 11 0 5 9.2 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL321154 108949 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 791 11 0 5 9.2 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
9809308 205724 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 0 4 5.4 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82552 205724 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 0 4 5.4 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
4189 206922 96 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 206922 96 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 206922 96 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
44408628 140363 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 5 1 1 6.7 FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380827 140363 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 5 1 1 6.7 FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44380764 120728 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354822 120728 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363978 40490 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL148282 40490 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
11801041 110454 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 9 1 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL324667 110454 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 9 1 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44334654 108201 0 None - 1 Human 7.4 pKi = 7.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 653 3 0 5 4.8 CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
CHEMBL319653 108201 0 None - 1 Human 7.4 pKi = 7.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 653 3 0 5 4.8 CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
52937270 62520 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782138 62520 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
145948809 167478 0 None -11 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299402 167478 0 None -11 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314945 204996 0 None 9 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL76727 204996 0 None 9 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
44281392 99958 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286433 99958 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44323563 207014 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 322 4 2 3 3.4 COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 10.1016/0960-894X(95)00481-8
CHEMBL91475 207014 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 322 4 2 3 3.4 COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 10.1016/0960-894X(95)00481-8
90644629 111659 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.8 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3286415 111659 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.8 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
10300825 29943 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 0 5 4.8 COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL138839 29943 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 0 5 4.8 COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44304301 203317 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 445 2 1 2 5.8 CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL64839 203317 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 445 2 1 2 5.8 CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL5286117 194332 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 484 3 1 3 5.2 CC(=O)N1Cc2[nH]c3ccccc3c2C[C@H]1C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.6b01029
90644616 112736 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288159 112736 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304856 112736 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644610 112749 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288156 112749 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305158 112749 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
2110 2969 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
219077 2969 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
3480 2969 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
CHEMBL346178 2969 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
DB04872 2969 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
44338557 9348 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111244 9348 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44363926 39069 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146882 39069 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314867 157327 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL407749 157327 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44408755 75038 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203481 75038 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10032693 109762 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32309 109762 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
107686 3379 41 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
3522 3379 41 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
CHEMBL131171 3379 41 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
9939040 5010 7 None 2 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 5010 7 None 2 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL2419544 210445 0 None -14 3 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
10602943 107418 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
CHEMBL318084 107418 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
9824321 75442 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL204206 75442 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
9846661 76575 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206294 76575 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44380457 58116 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167613 58116 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9939307 203486 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL66106 203486 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10531666 9191 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 9 2 4 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110340 9191 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 9 2 4 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL3609615 211829 0 None -24 4 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44318312 104866 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL311027 104866 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
86275451 160093 0 None -5623 3 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL4108623 160093 0 None -5623 3 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
57396389 68368 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 734 14 4 6 6.4 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2011.08.042
CHEMBL1916636 68368 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 734 14 4 6 6.4 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2011.08.042
44407890 75174 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL203655 75174 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
44337208 5239 0 None -38 2 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106300 5239 0 None -38 2 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44282003 100111 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287523 100111 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44334500 4536 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 599 5 1 6 4.1 COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC 10.1016/s0960-894x(02)00659-5
CHEMBL102332 4536 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 599 5 1 6 4.1 COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC 10.1016/s0960-894x(02)00659-5
44281744 113474 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33194 113474 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363877 39150 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146947 39150 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44409004 74439 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 4 0 1 7.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
CHEMBL202720 74439 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 4 0 1 7.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
46227361 202583 0 None -85 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 202583 0 None -85 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44318565 205929 0 None - 1 Human 7.3 pKi = 7.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 528 3 2 3 5.2 Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL84161 205929 0 None - 1 Human 7.3 pKi = 7.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 528 3 2 3 5.2 Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL2372339 210222 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1021/jm00391a046
44318497 206000 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 563 3 0 3 5.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL84873 206000 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 563 3 0 3 5.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O 10.1016/s0960-894x(02)00488-2
145948965 167488 0 None -18 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299476 167488 0 None -18 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314872 96872 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL265499 96872 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337202 7975 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109053 7975 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337079 107196 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 877 11 2 7 7.5 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
CHEMBL316553 107196 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 877 11 2 7 7.5 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
44337024 108676 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 793 11 0 7 6.9 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL320771 108676 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 793 11 0 7 6.9 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
145948744 167475 0 None -47 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299371 167475 0 None -47 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10769914 111150 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 10 3 3 5.5 CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL326429 111150 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 10 3 3 5.5 CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL2112592 209240 0 None -1 2 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44380596 59352 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170727 59352 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44408726 76560 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 419 4 1 3 6.3 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
CHEMBL206274 76560 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 419 4 1 3 6.3 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
10091563 39710 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 386 7 2 3 4.7 COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL147543 39710 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 386 7 2 3 4.7 COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
44314861 167780 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL430416 167780 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
11801965 5220 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 616 9 2 3 6.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106217 5220 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 616 9 2 3 6.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10603279 8022 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 10.1021/jm970499g
CHEMBL109080 8022 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 10.1021/jm970499g
9939307 203486 0 None -3 4 Guinea pig 8.3 pKi = 8.3 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 203486 0 None -3 4 Guinea pig 8.3 pKi = 8.3 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44282001 99808 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285422 99808 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281571 110389 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32430 110389 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281976 110574 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32537 110574 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10321715 26705 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136213 26705 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44338618 109326 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL321892 109326 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
10393853 109712 0 None - 1 Human 8.3 pKi = 8.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 603 3 0 5 3.8 CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
CHEMBL322885 109712 0 None - 1 Human 8.3 pKi = 8.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 603 3 0 5 3.8 CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
2755911 75439 52 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 75439 52 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
2755911 75439 52 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 75439 52 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
2755911 75439 52 None -1 2 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL2042018 75439 52 None -1 2 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/j.bmcl.2018.06.009
15887537 109046 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 109046 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
145948968 167489 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299479 167489 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44364030 36647 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144887 36647 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44282004 121761 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL35891 121761 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
90644608 112707 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288155 112707 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304468 112707 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44338652 108610 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
CHEMBL320544 108610 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
46224897 199112 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 3 1 2 5.1 Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 10.1016/j.bmcl.2009.11.078
CHEMBL589130 199112 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 3 1 2 5.1 Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 10.1016/j.bmcl.2009.11.078
73350555 91068 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 10.1021/jm400209h
CHEMBL2397488 91068 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 10.1021/jm400209h
2098 3694 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
36511 3694 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
3805 3694 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
3835 3694 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
CHEMBL235363 3694 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
44334581 5233 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 629 3 1 5 6.0 O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL106273 5233 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 629 3 1 5 6.0 O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
2090 2767 25 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
5311312 2767 25 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
CHEMBL437797 2767 25 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
445694 120029 81 None - 1 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 164 3 2 2 0.0 NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL350320 120029 81 None - 1 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 164 3 2 2 0.0 NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
11305162 74770 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL203109 74770 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
44334489 107298 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 559 3 0 5 4.5 CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
CHEMBL317209 107298 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 559 3 0 5 4.5 CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
44337354 5457 0 None -58 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
CHEMBL107469 5457 0 None -58 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
44314834 205149 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78092 205149 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281771 99640 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284269 99640 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
7088460 199280 1 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL590275 199280 1 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
70689371 78379 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL 1372 34 14 16 -1.0 CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O 10.1016/s0960-894x(98)00219-4
CHEMBL2110361 78379 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL 1372 34 14 16 -1.0 CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O 10.1016/s0960-894x(98)00219-4
46227360 202582 0 None -151 4 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 202582 0 None -151 4 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
18546495 140713 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.6 CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL381744 140713 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.6 CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
44380680 57587 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 673 11 1 3 10.0 CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166759 57587 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 673 11 1 3 10.0 CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44318593 167994 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 552 4 2 3 5.0 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL431974 167994 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 552 4 2 3 5.0 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O 10.1016/s0960-894x(02)00488-2
44281787 163199 0 None -14 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL418224 163199 0 None -14 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
49863733 15332 0 None 2 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15332 0 None 2 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
118730932 118156 0 None -2951 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408518 118156 0 None -2951 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
44364003 118995 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342572 118995 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10295489 140342 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 418 5 2 2 4.4 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL380716 140342 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 418 5 2 2 4.4 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 10.1016/j.bmcl.2005.10.072
44281957 99816 0 None 27 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285475 99816 0 None 27 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10010096 99890 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285986 99890 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
24768356 155862 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL406030 155862 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
10675169 108659 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 605 9 2 4 4.9 CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL320758 108659 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 605 9 2 4 4.9 CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44408846 140545 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381081 140545 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
14991605 91072 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.2 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397492 91072 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.2 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10229773 75501 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 520 6 1 3 5.5 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 10.1016/j.bmcl.2005.10.072
CHEMBL204296 75501 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 520 6 1 3 5.5 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 10.1016/j.bmcl.2005.10.072
44407906 74708 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL203064 74708 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408048 140558 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381157 140558 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44407903 140722 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381778 140722 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
44338586 6885 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL108422 6885 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44338584 8157 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL109183 8157 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10187704 119424 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 556 11 1 6 5.1 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL344847 119424 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 556 11 1 6 5.1 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599010 199367 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL590833 199367 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
118730933 118157 0 None -389 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3408519 118157 0 None -389 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
10578261 9183 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
CHEMBL110301 9183 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
127033168 138774 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3780686 138774 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
56668794 65909 0 None 17 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 806 15 2 5 8.9 O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835844 65909 0 None 17 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 806 15 2 5 8.9 O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
44177145 195728 0 None -6 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL557188 195728 0 None -6 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
9874473 41808 0 None 16 3 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41808 0 None 16 3 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
71549635 160874 0 None -851 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
CHEMBL4115030 160874 0 None -851 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
145948955 167487 0 None -18 4 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299466 167487 0 None -18 4 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314597 104351 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310019 104351 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
118731113 118169 0 None -43651 2 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 670 14 8 7 1.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408730 118169 0 None -43651 2 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 670 14 8 7 1.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
44314298 205142 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78065 205142 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10001148 51445 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 402 6 2 2 5.3 CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL158212 51445 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 402 6 2 2 5.3 CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL5278537 193984 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 746 11 3 6 6.7 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N1Cc2[nH]c3ccccc3c2C[C@H]1C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.6b01029
90644622 112745 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288162 112745 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305013 112745 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358413 26907 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 7 0 4 5.8 CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136389 26907 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 7 0 4 5.8 CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358551 29334 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 514 8 1 6 4.3 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138335 29334 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 514 8 1 6 4.3 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599010 199367 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL590833 199367 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
2089 2766 28 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3795 2766 28 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
5311311 2766 28 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
CHEMBL217406 2766 28 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
90644612 112720 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288157 112720 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304538 112720 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644618 112763 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288160 112763 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305331 112763 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44304381 102085 0 None - 1 Human 6.2 pKi = 6.2 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 507 3 2 2 6.0 O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 10.1016/S0960-894X(97)00353-3
CHEMBL302163 102085 0 None - 1 Human 6.2 pKi = 6.2 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 507 3 2 2 6.0 O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 10.1016/S0960-894X(97)00353-3
7037588 199281 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL590276 199281 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
44318874 205666 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 581 3 0 3 6.1 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82065 205666 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 581 3 0 3 6.1 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O 10.1016/s0960-894x(02)00488-2
3198 205513 76 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 205513 76 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 205513 76 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
131954513 162078 38 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
CHEMBL4160748 162078 38 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
11683187 199932 44 None -676 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL594828 199932 44 None -676 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
8867347 60603 5 None -6 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760200 60603 5 None -6 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
44408821 75391 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL203928 75391 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
73352066 91071 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397491 91071 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44363435 37188 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145314 37188 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380733 58616 0 None 7 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168437 58616 0 None 7 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363983 18166 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL126970 18166 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44281958 109687 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32273 109687 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337289 108038 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL319474 108038 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
46227363 199665 0 None -28 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 199665 0 None -28 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
10651575 5154 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL105847 5154 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
25129133 188887 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188887 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
25129133 188887 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188887 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44380069 57617 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166842 57617 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
127031644 138834 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781336 138834 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
44337288 8045 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109092 8045 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
52937467 62523 0 None -9 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL1782141 62523 0 None -9 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL2419538 210439 0 None -117 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 10.1016/j.bmcl.2013.06.065
10140125 27280 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 471 7 0 4 5.1 N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136709 27280 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 471 7 0 4 5.1 N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
20811360 30326 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139150 30326 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358247 119007 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 438 6 1 4 4.9 FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342602 119007 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 438 6 1 4 4.9 FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44338640 168089 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL432627 168089 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44337324 6711 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108364 6711 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44314548 102909 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306052 102909 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281516 99882 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285929 99882 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
73352065 91063 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397483 91063 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44550460 197037 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567198 197037 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
25129135 172597 0 None -1584 4 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172597 0 None -1584 4 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
73347011 89409 0 None 1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370511 89409 0 None 1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44409000 168941 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 423 5 0 1 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL438801 168941 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 423 5 0 1 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
118731118 118174 0 None -1202 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 822 17 7 7 3.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2014.12.033
CHEMBL3408735 118174 0 None -1202 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 822 17 7 7 3.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2014.12.033
44318486 105421 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 613 6 1 4 5.3 O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00488-2
CHEMBL311946 105421 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 613 6 1 4 5.3 O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00488-2
118731116 118172 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 876 17 7 7 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408733 118172 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 876 17 7 7 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44281743 99639 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284244 99639 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44334630 109655 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 684 4 0 7 4.8 Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL322453 109655 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 684 4 0 7 4.8 Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL5266880 193499 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 498 4 2 3 5.3 CC(=O)NC1(C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCc2[nH]c3ccccc3c2C1 10.1021/acs.jmedchem.6b01029
10721590 7663 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 10 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL108847 7663 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 10 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10746828 6942 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 650 9 2 3 6.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm970499g
CHEMBL108448 6942 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 650 9 2 3 6.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm970499g
CHEMBL2372068 210176 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC(Cc2ccccc2)[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
73212515 104604 0 None 125 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104778 104604 0 None 125 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
44338510 8633 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
CHEMBL109514 8633 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
57394644 68365 0 None - 1 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916633 68365 0 None - 1 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
44334582 161693 0 None - 1 Human 6.1 pKi = 6.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 597 3 0 5 4.1 COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
CHEMBL413383 161693 0 None - 1 Human 6.1 pKi = 6.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 597 3 0 5 4.1 COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
73212519 104599 0 None 12 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 517 8 2 4 3.6 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104773 104599 0 None 12 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 517 8 2 4 3.6 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
44304323 100584 0 None - 1 Human 6.1 pKi = 6.1 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 544 4 1 4 4.6 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 10.1016/S0960-894X(97)00353-3
CHEMBL291650 100584 0 None - 1 Human 6.1 pKi = 6.1 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 544 4 1 4 4.6 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 10.1016/S0960-894X(97)00353-3
90417914 118865 0 None -2570 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
CHEMBL3422015 118865 0 None -2570 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
9887650 16651 0 None -6309 5 Human 5.1 pKi = 5.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortexThe compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortex
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 16651 0 None -6309 5 Human 5.1 pKi = 5.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortexThe compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortex
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
44380794 120283 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 2 6 8.2 O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352614 120283 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 2 6 8.2 O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10078301 119232 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343447 119232 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44364002 121048 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356796 121048 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
127033173 138844 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781519 138844 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
9872295 12622 1 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL1187084 12622 1 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL489924 12622 1 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
44334499 107300 0 None - 1 Human 8.1 pKi = 8.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 652 4 0 6 3.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 10.1016/s0960-894x(02)00659-5
CHEMBL317238 107300 0 None - 1 Human 8.1 pKi = 8.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 652 4 0 6 3.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 10.1016/s0960-894x(02)00659-5
127032846 138791 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780818 138791 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
85169 6915 10 None -2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL108438 6915 10 None -2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
9846662 75912 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL204958 75912 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
3668 1561 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
5311081 1561 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL333357 1561 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589982 1561 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
3668 1561 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
5311081 1561 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
CHEMBL333357 1561 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
CHEMBL589982 1561 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
10299289 192615 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 3 4.6 Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL521605 192615 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 3 4.6 Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10232846 114116 0 None 11 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL332793 114116 0 None 11 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
10767720 78692 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 500 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 10.1021/jm970499g
CHEMBL2112476 78692 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 500 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 10.1021/jm970499g
73351579 89405 0 None -2 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
CHEMBL2370507 89405 0 None -2 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
10792994 7514 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 560 7 2 3 4.5 O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL108725 7514 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 560 7 2 3 4.5 O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
44380763 120033 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350360 120033 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281476 99931 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 662 10 1 5 8.6 CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286235 99931 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 662 10 1 5 8.6 CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314533 105679 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312539 105679 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314946 205063 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77235 205063 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
1016 3747 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3747 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3747 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3747 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3747 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3747 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2247 505 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 505 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 505 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 505 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 505 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2812 4779 101 None -43 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4779 101 None -43 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44407932 75897 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL204918 75897 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
9940831 14646 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14646 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14646 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10032406 39954 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147824 39954 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314868 155698 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL405129 155698 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314487 102913 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306097 102913 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281672 113524 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33215 113524 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL387816 212412 0 None 23 2 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
44611292 91064 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 2 3 1.1 CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397484 91064 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 2 3 1.1 CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44305818 14795 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14795 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14795 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL2419539 210440 0 None -81 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44337173 6689 0 None -30 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108350 6689 0 None -30 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
122187725 123067 0 None -107 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609621 123067 0 None -107 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44281358 98263 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL274557 98263 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337266 5298 0 None -27 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106608 5298 0 None -27 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44407896 138661 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL377712 138661 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
44408697 75431 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 4 1 3 6.8 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL204165 75431 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 4 1 3 6.8 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl 10.1016/j.bmcl.2005.11.047
73355028 91069 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397489 91069 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2111789 209219 0 None -3 2 Human 4.0 pKi = 4.0 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44408910 141292 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 341 4 1 3 5.5 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL383289 141292 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 341 4 1 3 5.5 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
10409484 189661 1 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]substance P from NK1 receptor in human astrocytoma cellsDisplacement of [3H]substance P from NK1 receptor in human astrocytoma cells
ChEMBL 413 0 2 6 0.9 C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O 10.1021/np50106a005
CHEMBL515179 189661 1 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]substance P from NK1 receptor in human astrocytoma cellsDisplacement of [3H]substance P from NK1 receptor in human astrocytoma cells
ChEMBL 413 0 2 6 0.9 C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O 10.1021/np50106a005
44281753 99817 0 None -9 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285476 99817 0 None -9 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
43815 186920 64 None - 25 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL1708 186920 64 None - 25 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL490 186920 64 None - 25 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
132837 2237 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9461 2237 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
CHEMBL22870 2237 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9329 3741 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
9894349 3741 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
CHEMBL339486 3741 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
23653789 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
9280 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
CHEMBL447955 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
DB12973 3587 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
2098 3694 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
36511 3694 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
3805 3694 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
3835 3694 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
CHEMBL235363 3694 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
9278 3850 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
9916461 3850 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
CHEMBL3544984 3850 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
DB12580 3850 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
2098 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3694 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3694 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3694 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3694 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3694 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
None 216187 0 125I-Bolton Hunter 2 5 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
135413536 448 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
230 448 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
3490 448 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
6918365 448 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1471 448 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB00673 448 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
202 1508 77 UNDEFINED -9 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 1508 77 UNDEFINED -9 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 1508 77 UNDEFINED -9 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 1508 77 UNDEFINED -9 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 1508 77 UNDEFINED -9 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
5656 203066 87 UNDEFINED -7 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 203066 87 UNDEFINED -7 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 203127 52 UNDEFINED -1 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 203127 52 UNDEFINED -1 27 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 217332 0 3H-SP -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
119376 1841 48 3H-SUBSTANCE P -43651 26 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
247 1841 48 3H-SUBSTANCE P -43651 26 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
CHEMBL33884 1841 48 3H-SUBSTANCE P -43651 26 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
3294 2006 111 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 2006 111 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 2006 111 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 2006 111 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 2006 111 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
243 3202 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 3202 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 3202 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 3202 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 3202 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
21830793 91835 10 3H-8-OH-DPAT -66069 45 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
CHEMBL2413154 91835 10 3H-8-OH-DPAT -66069 45 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
133090 98423 20 125I-[MePhe7]-NKB -630 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
CHEMBL275544 98423 20 125I-[MePhe7]-NKB -630 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
44208932 140707 7 UNDEFINED -89125 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 140707 7 UNDEFINED -89125 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
1973 203483 15 125I-[SAR9, Met(O2)11]-SP -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 203483 15 125I-[SAR9, Met(O2)11]-SP -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 203483 15 125I-[SAR9, Met(O2)11]-SP -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
5079497 216074 0 125I-[MePhe7]-NKB -1445 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 841 26 8 10 -0.0 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O None
None 216128 0 3H-Leu,4,5 Substance P -1 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 164 3 1 3 0.8 C1CNC1COC2=CN=CC=C2 None
119380 216129 0 3H-Leu,4,5 Substance P -1 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 166 1 0 3 1.8 CC1=NOC(=C1)C2CCCN2C None
None 216493 0 3H-SUBSTANCE P -10471285 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
None 216075 0 125I-Bolton Hunter -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 216075 0 3H-SUBSTANCE P -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 216075 0 125I-Bolton Hunter -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
2098 3694 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3694 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3694 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3694 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3694 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
None 216075 0 125I-Bolton Hunter -1202 8 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 216187 0 125I-Bolton Hunter -1412 5 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 216188 0 125I-Bolton Hunter -2 6 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
9850582 197242 22 125I-Bolton Hunter -309 6 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 197242 22 125I-Bolton Hunter -309 6 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 216075 0 125I-Bolton Hunter -354 8 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 216188 0 125I-Bolton Hunter -2 6 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
9850582 197242 22 3H-Sar9,Met(O2)11-Substance P -588 6 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 197242 22 3H-Sar9,Met(O2)11-Substance P -588 6 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 216075 0 3H-Sar9,Met(O2)11-Substance P -354 8 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 216187 0 125I-Bolton Hunter -2 5 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 216075 0 125I-Bolton Hunter -354 8 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 216075 0 125I-Bolton Hunter -354 8 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
9850582 197242 22 125I-[MePhe7]-NKB -588 6 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 197242 22 125I-[MePhe7]-NKB -588 6 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
2812 4779 101 None -43 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
CHEMBL104 4779 101 None -43 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
2247 505 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
249 505 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2603 505 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
CHEMBL296419 505 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
DB00637 505 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
1016 3747 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2561 3747 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2733526 3747 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5384 3747 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
CHEMBL83 3747 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
DB00675 3747 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
3198 205513 76 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1201049 205513 76 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL808 205513 76 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
4189 206922 96 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 206922 96 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 206922 96 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
None 216072 0 125I-[MePhe7]-NKB -676 4 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 1210 38 14 16 -1.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N None
9850582 197242 22 125I-Bolton Hunter -588 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 197242 22 125I-Bolton Hunter -588 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 216075 0 125I-Bolton Hunter -354 8 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 216073 0 125I-[MePhe7]-NKB -851 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 216075 0 125I-[MePhe7]-NKB -354 8 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
4898 2765 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
5742 2765 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
6451149 2765 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
CHEMBL206253 2765 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
DB09048 2765 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
71544786 217749 0 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 689 8 2 5 6.4 CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=C(C)C=CC=C1)N1CC[N+](C)(COP(O)(O)=O)CC1 None
10311306 3367 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
5027 3367 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
5749 3367 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
CHEMBL3707331 3367 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
DB09291 3367 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
23725089 804 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
4401 804 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
5758 804 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
9917021 804 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
CHEMBL1672054 804 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
DB06634 804 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
None 216188 0 125I-Bolton Hunter 2 6 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
132846 2238 23 None - 1 Human 9.1 pKi = 9.1 Binding
Determined as antagonism of substande P-induced calcium mobilisation in CHO cells expressing hTACR1Determined as antagonism of substande P-induced calcium mobilisation in CHO cells expressing hTACR1
Guide to Pharmacology 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 8982729
13432 2238 23 None - 1 Human 9.1 pKi = 9.1 Binding
Determined as antagonism of substande P-induced calcium mobilisation in CHO cells expressing hTACR1Determined as antagonism of substande P-induced calcium mobilisation in CHO cells expressing hTACR1
Guide to Pharmacology 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 8982729
CHEMBL27006 2238 23 None - 1 Human 9.1 pKi = 9.1 Binding
Determined as antagonism of substande P-induced calcium mobilisation in CHO cells expressing hTACR1Determined as antagonism of substande P-induced calcium mobilisation in CHO cells expressing hTACR1
Guide to Pharmacology 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 8982729
135413536 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
135413536 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
230 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
230 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
3490 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
3490 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
6918365 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
6918365 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
CHEMBL1471 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
CHEMBL1471 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
DB00673 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
DB00673 448 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
10158788 3728 0 None - 1 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 6 2 4 5.0 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N 18187929
5746 3728 0 None - 1 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 6 2 4 5.0 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N 18187929
5752 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
6918331 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
CHEMBL522302 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
DB12436 4005 24 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
2087 1920 0 None 31 4 Human 10.8 pKi = 10.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
119137 3585 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
119137 3585 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
2095 3585 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2095 3585 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
CHEMBL1885865 3585 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL1885865 3585 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
5759 594 24 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
6450815 594 24 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
CHEMBL204694 594 24 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
4898 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
5742 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
6451149 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
CHEMBL206253 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
DB09048 2765 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
107967 1646 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
2114 1646 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
CHEMBL1416993 1646 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
10311306 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
5027 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
5749 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
CHEMBL3707331 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
DB09291 3367 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
10462 2016 10 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
9808518 2016 10 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
CHEMBL206488 2016 10 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
5754 3266 0 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 660 7 1 4 6.8 O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 12130734
9917716 3266 0 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 660 7 1 4 6.8 O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 12130734
5757 3986 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
5757 3986 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
9832383 3986 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
9832383 3986 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
CHEMBL522987 3986 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
CHEMBL522987 3986 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
DB11949 3986 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
DB11949 3986 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
23725089 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
23725089 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
4401 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
4401 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
5758 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
5758 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
9917021 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
9917021 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
CHEMBL1672054 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
CHEMBL1672054 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
DB06634 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
DB06634 804 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
2102 1189 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
2102 1189 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
5311057 1189 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
5311057 1189 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
CHEMBL441225 1189 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
CHEMBL441225 1189 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
188927 1615 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
5751 1615 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
CHEMBL515966 1615 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
3086681 2272 17 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
3510 2272 17 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
CHEMBL42407 2272 17 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
2090 2767 25 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311312 2767 25 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL437797 2767 25 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2110 2969 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
219077 2969 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
3480 2969 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
CHEMBL346178 2969 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
DB04872 2969 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
104974 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
104974 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2111 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
2111 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
3481 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
3481 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
CHEMBL308148 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
CHEMBL308148 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
DB06660 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
DB06660 3475 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2105 3276 0 None - 1 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12206858
2089 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2089 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
2089 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
2089 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3795 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3795 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
3795 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
3795 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311311 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
5311311 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
5311311 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
5311311 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL217406 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL217406 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
CHEMBL217406 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
CHEMBL217406 2766 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2106 3546 4 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
9875034 3546 4 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
CHEMBL77023 3546 4 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
2098 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2098 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
36511 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
36511 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
3805 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3805 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
3835 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3835 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
CHEMBL235363 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL235363 3694 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501