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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	127034769	136581	None	0	Human	Functional	pEC50	=	11.0	11.0	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	812	23	8	10	-1.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)C(N)=O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3736177	136581	None	0	Human	Functional	pEC50	=	11.0	11.0	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	812	23	8	10	-1.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)C(N)=O)C(N)=O	10.1039/C4MD00514G
	CHEMBL2347491	212002	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	CHEMBL3735159	214639	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(C)=O)C(N)=O	10.1039/C4MD00514G
	CHEMBL583102	218271	None	7	Human	Functional	pEC50	=	10.9	10.9	-2	2	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	127035105	136507	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	784	23	8	9	-0.3	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(N)=O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3735427	136507	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	784	23	8	9	-0.3	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(N)=O)C(N)=O	10.1039/C4MD00514G
	127034749	136437	None	0	Rat	Functional	pEC50	=	10.9	10.9	33	2	Agonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	827	24	8	10	-0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3734811	136437	None	0	Rat	Functional	pEC50	=	10.9	10.9	33	2	Agonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	827	24	8	10	-0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	127034928	136609	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	827	24	8	10	-0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3736361	136609	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	827	24	8	10	-0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL2347513	212024	None	0	Human	Functional	pEC50	=	10.8	10.8	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	CHEMBL3735858	214641	None	0	Human	Functional	pEC50	=	10.8	10.8	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(C)=O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3736299	214644	None	0	Human	Functional	pEC50	=	10.8	10.8	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(C)=O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3734932	214637	None	0	Human	Functional	pEC50	=	10.7	10.7	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(C)=O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3736512	214649	None	0	Human	Functional	pEC50	=	10.7	10.7	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O	10.1039/C4MD00514G
	102531127	136548	None	0	Human	Functional	pEC50	=	10.7	10.7	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	869	28	8	10	0.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3735812	136548	None	0	Human	Functional	pEC50	=	10.7	10.7	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	869	28	8	10	0.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	127034748	136488	None	0	Human	Functional	pEC50	=	10.7	10.7	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	813	23	8	10	-0.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3735306	136488	None	0	Human	Functional	pEC50	=	10.7	10.7	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	813	23	8	10	-0.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	108147	3583	None	32	Rat	Functional	pEC50	=	10.6	10.6	1	4	Agonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		None	10.1039/C4MD00514G
	2127	3583	None	32	Rat	Functional	pEC50	=	10.6	10.6	1	4	Agonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		None	10.1039/C4MD00514G
	CHEMBL106124	3583	None	32	Rat	Functional	pEC50	=	10.6	10.6	1	4	Agonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		None	10.1039/C4MD00514G
	CHEMBL2347510	212021	None	0	Human	Functional	pEC50	=	10.6	10.6	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	CHEMBL3736459	214648	None	0	Human	Functional	pEC50	=	10.6	10.6	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O	10.1039/C4MD00514G
	CHEMBL2347512	212023	None	0	Human	Functional	pEC50	=	10.6	10.6	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	125111645	136582	None	1	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	841	26	8	10	-0.0	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3736185	136582	None	1	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	841	26	8	10	-0.0	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	102531125	136475	None	0	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	855	27	8	10	0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3735210	136475	None	0	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	855	27	8	10	0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3735951	214642	None	0	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O	10.1039/C4MD00514G
	CHEMBL2347496	212007	None	0	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	127035706	136451	None	0	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	880	26	9	10	0.5	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3734892	136451	None	0	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	880	26	9	10	0.5	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL2347492	212003	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	CHEMBL2347498	212009	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	CHEMBL2347508	212019	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1016/j.bmc.2013.01.036
	CHEMBL2347494	212005	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	CHEMBL2347509	212020	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	CHEMBL2347497	212008	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	91809194	136477	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	857	26	9	11	-0.3	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3735225	136477	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	857	26	9	11	-0.3	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL2347493	212004	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	127035106	136454	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	800	23	9	10	-0.3	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)NO)C(N)=O	10.1039/C4MD00514G
	CHEMBL3734921	136454	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	800	23	9	10	-0.3	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)NO)C(N)=O	10.1039/C4MD00514G
	CHEMBL2347495	212006	None	0	Human	Functional	pEC50	=	10.3	10.3	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(N)=O	10.1016/j.bmc.2013.01.036
	102531124	136584	None	0	Human	Functional	pEC50	=	10.3	10.3	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	807	26	8	10	-0.2	CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O	10.1039/C4MD00514G
	CHEMBL3736198	136584	None	0	Human	Functional	pEC50	=	10.3	10.3	-	1	Agonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktideAgonist activity at human NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide	ChEMBL	807	26	8	10	-0.2	CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O	10.1039/C4MD00514G
	CHEMBL2347489	212001	None	0	Human	Functional	pEC50	=	10.3	10.3	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1016/j.bmc.2013.01.036
	CHEMBL2370235	212269	None	0	Human	Functional	pEC50	=	10.2	10.2	-	1	Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mMAgonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O	10.1016/j.bmc.2013.01.036

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	108147	3583	None	32	Rat	Binding	pEC50	=	9.3	9.3	2	3	Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)	ChEMBL		None	None	None		None	10.1021/jm960154i
	2127	3583	None	32	Rat	Binding	pEC50	=	9.3	9.3	2	3	Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)	ChEMBL		None	None	None		None	10.1021/jm960154i
	CHEMBL106124	3583	None	32	Rat	Binding	pEC50	=	9.3	9.3	2	3	Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)	ChEMBL		None	None	None		None	10.1021/jm960154i
	118724968	116554	None	0	Human	Binding	pEC50	=	7	7.0	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	840	26	9	10	0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=N)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm500771w
	CHEMBL3361408	116554	None	0	Human	Binding	pEC50	=	7	7.0	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	840	26	9	10	0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=N)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm500771w
	44337560	109806	None	0	Rat	Binding	pEC50	=	6	6.0	-	0	Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)	ChEMBL	950	19	9	10	0.5	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O	10.1021/jm960154i
	CHEMBL323028	109806	None	0	Rat	Binding	pEC50	=	6	6.0	-	0	Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)	ChEMBL	950	19	9	10	0.5	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O	10.1021/jm960154i
	44337530	168000	None	0	Rat	Binding	pEC50	=	6	6.0	-	0	Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)	ChEMBL	964	19	9	10	0.9	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O	10.1021/jm960154i
	CHEMBL431243	168000	None	0	Rat	Binding	pEC50	=	6	6.0	-	0	Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)	ChEMBL	964	19	9	10	0.9	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O	10.1021/jm960154i
	108147	3583	None	32	Human	Binding	pEC50	=	8.0	8.0	-2	3	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL		None	None	None		None	10.1021/jm500771w
	2127	3583	None	32	Human	Binding	pEC50	=	8.0	8.0	-2	3	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL		None	None	None		None	10.1021/jm500771w
	CHEMBL106124	3583	None	32	Human	Binding	pEC50	=	8.0	8.0	-2	3	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL		None	None	None		None	10.1021/jm500771w
	108147	3583	None	32	Rat	Binding	pEC50	=	7.9	7.9	2	3	Agonist activity at rat NK3RAgonist activity at rat NK3R	ChEMBL		None	None	None		None	10.1021/jm500771w
	2127	3583	None	32	Rat	Binding	pEC50	=	7.9	7.9	2	3	Agonist activity at rat NK3RAgonist activity at rat NK3R	ChEMBL		None	None	None		None	10.1021/jm500771w
	CHEMBL106124	3583	None	32	Rat	Binding	pEC50	=	7.9	7.9	2	3	Agonist activity at rat NK3RAgonist activity at rat NK3R	ChEMBL		None	None	None		None	10.1021/jm500771w
	118724964	116550	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	824	26	7	9	1.7	CSCC[C@H](NC(=O)[C@@H](/C=C/CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)CC(C)C)C(N)=O	10.1021/jm500771w
	CHEMBL3361404	116550	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	824	26	7	9	1.7	CSCC[C@H](NC(=O)[C@@H](/C=C/CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)CC(C)C)C(N)=O	10.1021/jm500771w
	118724964	116550	None	0	Rat	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at rat NK3RAgonist activity at rat NK3R	ChEMBL	824	26	7	9	1.7	CSCC[C@H](NC(=O)[C@@H](/C=C/CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)CC(C)C)C(N)=O	10.1021/jm500771w
	CHEMBL3361404	116550	None	0	Rat	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at rat NK3RAgonist activity at rat NK3R	ChEMBL	824	26	7	9	1.7	CSCC[C@H](NC(=O)[C@@H](/C=C/CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)CC(C)C)C(N)=O	10.1021/jm500771w
	118724966	116552	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	824	26	7	9	1.8	CSCC[C@H](NC(=O)/C(=C/CCNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)CC(C)C)C(N)=O	10.1021/jm500771w
	CHEMBL3361406	116552	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	824	26	7	9	1.8	CSCC[C@H](NC(=O)/C(=C/CCNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)CC(C)C)C(N)=O	10.1021/jm500771w
	CHEMBL106184	210929	None	0	Rat	Binding	pEC50	=	5.7	5.7	-	0	Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN(CCCN)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O	10.1021/jm960154i
	10843656	96875	None	0	Rat	Binding	pEC50	=	5.7	5.7	-	0	Effective concentration to activate Tachykinin receptor 3 in rat portal vein(RPV).Effective concentration to activate Tachykinin receptor 3 in rat portal vein(RPV).	ChEMBL	1009	34	10	11	-0.1	CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O	10.1021/jm960154i
	CHEMBL265115	96875	None	0	Rat	Binding	pEC50	=	5.7	5.7	-	0	Effective concentration to activate Tachykinin receptor 3 in rat portal vein(RPV).Effective concentration to activate Tachykinin receptor 3 in rat portal vein(RPV).	ChEMBL	1009	34	10	11	-0.1	CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O	10.1021/jm960154i
	118724967	116553	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	856	26	9	11	0.2	CSCC[C@H](NC(=O)[C@H](CC(C)C)N/C(CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)=N\O)C(N)=O	10.1021/jm500771w
	CHEMBL3361407	116553	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	856	26	9	11	0.2	CSCC[C@H](NC(=O)[C@H](CC(C)C)N/C(CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)=N\O)C(N)=O	10.1021/jm500771w
	118724965	116551	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	826	27	7	9	1.9	CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)CC(C)C)C(N)=O	10.1021/jm500771w
	CHEMBL3361405	116551	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectAgonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect	ChEMBL	826	27	7	9	1.9	CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O)CC(C)C)C(N)=O	10.1021/jm500771w
	2110	2969	None	33	Human	Binding	pIC50	=	9.7	9.7	-3	6	Compound was tested for binding affinity against human Tachykinin receptor 3 in CHO cellsCompound was tested for binding affinity against human Tachykinin receptor 3 in CHO cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/0960-894X(95)00313-I
	219077	2969	None	33	Human	Binding	pIC50	=	9.7	9.7	-3	6	Compound was tested for binding affinity against human Tachykinin receptor 3 in CHO cellsCompound was tested for binding affinity against human Tachykinin receptor 3 in CHO cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/0960-894X(95)00313-I
	3480	2969	None	33	Human	Binding	pIC50	=	9.7	9.7	-3	6	Compound was tested for binding affinity against human Tachykinin receptor 3 in CHO cellsCompound was tested for binding affinity against human Tachykinin receptor 3 in CHO cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/0960-894X(95)00313-I
	CHEMBL346178	2969	None	33	Human	Binding	pIC50	=	9.7	9.7	-3	6	Compound was tested for binding affinity against human Tachykinin receptor 3 in CHO cellsCompound was tested for binding affinity against human Tachykinin receptor 3 in CHO cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/0960-894X(95)00313-I
	DB04872	2969	None	33	Human	Binding	pIC50	=	9.7	9.7	-3	6	Compound was tested for binding affinity against human Tachykinin receptor 3 in CHO cellsCompound was tested for binding affinity against human Tachykinin receptor 3 in CHO cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/0960-894X(95)00313-I
	127034749	136437	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counterDisplacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counter	ChEMBL	827	24	8	10	-0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3734811	136437	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counterDisplacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counter	ChEMBL	827	24	8	10	-0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	127034928	136609	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counterDisplacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counter	ChEMBL	827	24	8	10	-0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	CHEMBL3736361	136609	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counterDisplacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counter	ChEMBL	827	24	8	10	-0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)C(=O)O)C(N)=O	10.1039/C4MD00514G
	44418982	84596	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsDisplacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cells	ChEMBL	635	7	1	7	5.3	COC(=O)N(NC(=O)c1c(CN2CCN(S(=O)(=O)c3ccccc3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1016/j.bmcl.2006.08.085
	CHEMBL222078	84596	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsDisplacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cells	ChEMBL	635	7	1	7	5.3	COC(=O)N(NC(=O)c1c(CN2CCN(S(=O)(=O)c3ccccc3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1016/j.bmcl.2006.08.085
	9831641	79728	None	5	Guinea pig	Binding	pIC50	=	9.1	9.1	-	0	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 3 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 3 of male guinea pig lung membrane	ChEMBL	672	8	0	7	6.0	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
	CHEMBL2115415	79728	None	5	Guinea pig	Binding	pIC50	=	9.1	9.1	-	0	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 3 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 3 of male guinea pig lung membrane	ChEMBL	672	8	0	7	6.0	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
	2110	2969	None	33	Human	Binding	pIC50	=	9.1	9.1	-3	6	Tachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptorsTachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptors	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/S0960-894X(97)00064-4
	219077	2969	None	33	Human	Binding	pIC50	=	9.1	9.1	-3	6	Tachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptorsTachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptors	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/S0960-894X(97)00064-4
	3480	2969	None	33	Human	Binding	pIC50	=	9.1	9.1	-3	6	Tachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptorsTachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptors	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/S0960-894X(97)00064-4
	CHEMBL346178	2969	None	33	Human	Binding	pIC50	=	9.1	9.1	-3	6	Tachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptorsTachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptors	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/S0960-894X(97)00064-4
	DB04872	2969	None	33	Human	Binding	pIC50	=	9.1	9.1	-3	6	Tachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptorsTachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptors	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/S0960-894X(97)00064-4
	44419687	137035	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsDisplacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cells	ChEMBL	445	6	1	4	6.4	COc1c(-c2ccccc2)nc2ccccc2c1C(=O)NN(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2006.08.086
	CHEMBL374354	137035	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsDisplacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cells	ChEMBL	445	6	1	4	6.4	COc1c(-c2ccccc2)nc2ccccc2c1C(=O)NN(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2006.08.086
	108147	3583	None	32	Human	Binding	pIC50	=	9	9.0	-2	3	Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsCompound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(98)00215-7
	2127	3583	None	32	Human	Binding	pIC50	=	9	9.0	-2	3	Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsCompound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(98)00215-7

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