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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	90469674	171925	None	8	Rat	Functional	pEC50	=	10.7	10.7	3	3	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	945	14	10	11	0.0	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)NCCCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	CHEMBL4468523	171925	None	8	Rat	Functional	pEC50	=	10.7	10.7	3	3	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	945	14	10	11	0.0	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)NCCCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	2181	1331	None	29	Rat	Functional	pEC50	=	10.5	10.5	6	4	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00132
	2182	1331	None	29	Rat	Functional	pEC50	=	10.5	10.5	6	4	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00132
	27991	1331	None	29	Rat	Functional	pEC50	=	10.5	10.5	6	4	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00132
	27991.0	1331	None	29	Rat	Functional	pEC50	=	10.5	10.5	6	4	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00132
	CHEMBL1429	1331	None	29	Rat	Functional	pEC50	=	10.5	10.5	6	4	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00132
	CHEMBL264448	1331	None	29	Rat	Functional	pEC50	=	10.5	10.5	6	4	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00132
	DB00035	1331	None	29	Rat	Functional	pEC50	=	10.5	10.5	6	4	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00132
	44419026	168602	None	15	Human	Functional	pEC50	=	10.3	10.3	478	3	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1039	17	13	14	-2.7	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	CHEMBL435323	168602	None	15	Human	Functional	pEC50	=	10.3	10.3	478	3	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1039	17	13	14	-2.7	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	2168	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	2810	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	644077	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	644077.0	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	CHEMBL373742	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	DB00067	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	118476355	173968	None	3	Rat	Functional	pEC50	=	10.3	10.3	5	3	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1044	17	10	12	0.3	CCN(CC)C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1	10.1021/acs.jmedchem.9b00132
	CHEMBL4539370	173968	None	3	Rat	Functional	pEC50	=	10.3	10.3	5	3	Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1044	17	10	12	0.3	CCN(CC)C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1	10.1021/acs.jmedchem.9b00132
	2168	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	2810	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	644077	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	644077.0	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	CHEMBL373742	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	DB00067	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm200278m
	2168	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Binding to human V2 receptor expressed in LV2 cells by cAMP productionBinding to human V2 receptor expressed in LV2 cells by cAMP production	ChEMBL		None	None	None		None	10.1016/j.bmcl.2005.10.107
	2810	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Binding to human V2 receptor expressed in LV2 cells by cAMP productionBinding to human V2 receptor expressed in LV2 cells by cAMP production	ChEMBL		None	None	None		None	10.1016/j.bmcl.2005.10.107
	644077	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Binding to human V2 receptor expressed in LV2 cells by cAMP productionBinding to human V2 receptor expressed in LV2 cells by cAMP production	ChEMBL		None	None	None		None	10.1016/j.bmcl.2005.10.107
	644077.0	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Binding to human V2 receptor expressed in LV2 cells by cAMP productionBinding to human V2 receptor expressed in LV2 cells by cAMP production	ChEMBL		None	None	None		None	10.1016/j.bmcl.2005.10.107
	CHEMBL373742	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Binding to human V2 receptor expressed in LV2 cells by cAMP productionBinding to human V2 receptor expressed in LV2 cells by cAMP production	ChEMBL		None	None	None		None	10.1016/j.bmcl.2005.10.107
	DB00067	3976	None	29	Human	Functional	pEC50	=	10.3	10.3	-12	6	Binding to human V2 receptor expressed in LV2 cells by cAMP productionBinding to human V2 receptor expressed in LV2 cells by cAMP production	ChEMBL		None	None	None		None	10.1016/j.bmcl.2005.10.107
	90469674	171925	None	8	Human	Functional	pEC50	=	10.2	10.2	-3	3	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	945	14	10	11	0.0	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)NCCCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	CHEMBL4468523	171925	None	8	Human	Functional	pEC50	=	10.2	10.2	-3	3	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	945	14	10	11	0.0	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)NCCCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	155523986	171013	None	0	Human	Functional	pEC50	=	10.1	10.1	724	3	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	957	15	12	13	-1.5	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	CHEMBL4454891	171013	None	0	Human	Functional	pEC50	=	10.1	10.1	724	3	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	957	15	12	13	-1.5	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	90469608	172363	None	0	Human	Functional	pEC50	=	10.1	10.1	812	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	975	15	11	12	-0.6	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	CHEMBL4474518	172363	None	0	Human	Functional	pEC50	=	10.1	10.1	812	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	975	15	11	12	-0.6	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	118476384	170976	None	0	Human	Functional	pEC50	=	10	10.0	1778	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	939	14	11	11	-0.8	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)NCCCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	CHEMBL4454160	170976	None	0	Human	Functional	pEC50	=	10	10.0	1778	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	939	14	11	11	-0.8	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)NCCCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	90469675	171520	None	0	Human	Functional	pEC50	=	10	10.0	1412	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	975	15	11	12	-0.6	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	CHEMBL4462743	171520	None	0	Human	Functional	pEC50	=	10	10.0	1412	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	975	15	11	12	-0.6	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	118476338	173495	None	0	Human	Functional	pEC50	=	10	10.0	2290	3	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	957	15	12	13	-1.5	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	CHEMBL4528032	173495	None	0	Human	Functional	pEC50	=	10	10.0	2290	3	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	957	15	12	13	-1.5	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132
	118476337	173693	None	0	Human	Functional	pEC50	=	10	10.0	1584	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1034	16	11	13	-0.5	CCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CSCN1C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1	10.1021/acs.jmedchem.9b00132
	CHEMBL4533159	173693	None	0	Human	Functional	pEC50	=	10	10.0	1584	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1034	16	11	13	-0.5	CCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CSCN1C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1	10.1021/acs.jmedchem.9b00132
	118476357	175694	None	0	Human	Functional	pEC50	=	10	10.0	2630	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1032	16	12	13	-1.5	CCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1	10.1021/acs.jmedchem.9b00132
	CHEMBL4579754	175694	None	0	Human	Functional	pEC50	=	10	10.0	2630	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1032	16	12	13	-1.5	CCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1	10.1021/acs.jmedchem.9b00132
	118476361	173839	None	0	Human	Functional	pEC50	=	10.0	10.0	363	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1034	16	11	13	-0.5	CCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CSCN1C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1	10.1021/acs.jmedchem.9b00132
	CHEMBL4536454	173839	None	0	Human	Functional	pEC50	=	10.0	10.0	363	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	1034	16	11	13	-0.5	CCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CSCN1C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1	10.1021/acs.jmedchem.9b00132
	118476343	174201	None	0	Human	Functional	pEC50	=	9.9	9.9	1174	2	Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assayAgonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay	ChEMBL	963	14	10	12	-0.1	CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CSC[C@H]2C(=O)NCCCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O	10.1021/acs.jmedchem.9b00132

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	3686	94720	None	64	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	338	12	1	5	3.5	COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL252556	94720	None	64	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	338	12	1	5	3.5	COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O	10.1038/s41467-023-40064-9
	2335	11852	None	18	Human	Binding	pAC50	=	4.9	4.9	-	12	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11852	None	18	Human	Binding	pAC50	=	4.9	4.9	-	12	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11852	None	18	Human	Binding	pAC50	=	4.9	4.9	-	12	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11852	None	18	Human	Binding	pAC50	=	4.9	4.9	-	12	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	41684	31229	None	62	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31229	None	62	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	2600	3779	None	53	Human	Binding	pAC50	=	4.8	4.8	-	13	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3779	None	53	Human	Binding	pAC50	=	4.8	4.8	-	13	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3779	None	53	Human	Binding	pAC50	=	4.8	4.8	-	13	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3779	None	53	Human	Binding	pAC50	=	4.8	4.8	-	13	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3779	None	53	Human	Binding	pAC50	=	4.8	4.8	-	13	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	216416	111644	None	40	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111644	None	40	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	107771	120312	None	42	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL35228	120312	None	42	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	214	3860	None	43	Human	Binding	pAC50	=	4.7	4.7	-	29	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	None	43	Human	Binding	pAC50	=	4.7	4.7	-	29	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	None	43	Human	Binding	pAC50	=	4.7	4.7	-	29	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566.0	3860	None	43	Human	Binding	pAC50	=	4.7	4.7	-	29	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	None	43	Human	Binding	pAC50	=	4.7	4.7	-	29	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	None	43	Human	Binding	pAC50	=	4.7	4.7	-	29	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	None	43	Human	Binding	pAC50	=	4.7	4.7	-	29	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	156419	938	None	48	Human	Binding	pAC50	=	4.7	4.7	-	15	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	156419.0	938	None	48	Human	Binding	pAC50	=	4.7	4.7	-	15	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	3308	938	None	48	Human	Binding	pAC50	=	4.7	4.7	-	15	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	647	938	None	48	Human	Binding	pAC50	=	4.7	4.7	-	15	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL1201284	938	None	48	Human	Binding	pAC50	=	4.7	4.7	-	15	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB01012	938	None	48	Human	Binding	pAC50	=	4.7	4.7	-	15	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	68617	207985	None	33	Human	Binding	pAC50	=	4.7	4.7	-	25	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	207985	None	33	Human	Binding	pAC50	=	4.7	4.7	-	25	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	207985	None	33	Human	Binding	pAC50	=	4.7	4.7	-	25	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	212	3806	None	35	Human	Binding	pAC50	=	4.7	4.7	-	25	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3806	None	35	Human	Binding	pAC50	=	4.7	4.7	-	25	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3806	None	35	Human	Binding	pAC50	=	4.7	4.7	-	25	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651.0	3806	None	35	Human	Binding	pAC50	=	4.7	4.7	-	25	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3806	None	35	Human	Binding	pAC50	=	4.7	4.7	-	25	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3806	None	35	Human	Binding	pAC50	=	4.7	4.7	-	25	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	135409453	3773	None	26	Human	Binding	pAC50	=	4.7	4.7	-	19	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	None	26	Human	Binding	pAC50	=	4.7	4.7	-	19	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	None	26	Human	Binding	pAC50	=	4.7	4.7	-	19	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	5328940	100270	None	65	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100270	None	65	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	9915743	63562	None	59	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	556	11	2	8	5.9	CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C	10.1038/s41467-023-40064-9
	CHEMBL180022	63562	None	59	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	556	11	2	8	5.9	CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C	10.1038/s41467-023-40064-9
	1222	1664	None	37	Human	Binding	pAC50	=	4.6	4.6	-	32	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1664	None	37	Human	Binding	pAC50	=	4.6	4.6	-	32	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396.0	1664	None	37	Human	Binding	pAC50	=	4.6	4.6	-	32	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1664	None	37	Human	Binding	pAC50	=	4.6	4.6	-	32	Binding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9

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Main reference

Ligand source activities (1 row/activity)