Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL4102192 oxyr_human Human No 11.0 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1031 17 11 14 -1.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC2CCCCC2)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353930 oxyr_human Human No 11.0 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1005 20 11 14 -2.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CC2CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353932 oxyr_human Human No 11.0 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1005 19 11 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353939 oxyr_human Human No 11.0 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1019 19 11 14 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353940 oxyr_human Human No 11.0 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1035 23 11 14 -1.1 CCCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL3353946 oxyr_human Human No 11.0 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1055 20 11 14 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353948 oxyr_human Human No 11.0 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1059 20 11 14 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353956 oxyr_human Human No 11.0 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1047 20 11 15 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354579 oxyr_human Human No 11.0 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
991 21 12 14 -3.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3301668 oxyr_human Human Yes 11.0 EC50 = 0.0 nM Funct
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C
CHEMBL395429 oxyr_human Human Yes 11.0 EC50 = 0.0 nM Funct
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
None None None None
CHEMBL4567752 oxyr_human Human No 11.0 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor V43A/C47A double mutant high affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor V43A/C47A double mutant high affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2235 53 24 30 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4520170 oxyr_human Human No 10.9 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor high affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor high affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assay
2151 47 24 30 -5.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3277916 oxyr_human Human No 10.9 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
951 18 12 14 -3.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4093931 oxyr_human Human No 10.9 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
986 17 13 14 -5.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4095930 oxyr_human Human No 10.9 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1005 17 11 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCCCC2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4084223 oxyr_human Human No 10.9 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
977 16 11 14 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)NCC(N)=O)C(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4078856 oxyr_human Human No 10.8 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
991 18 11 14 -2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL3353955 oxyr_human Human No 10.7 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 21 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccncc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354571 oxyr_human Human No 10.7 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1061 21 11 15 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2cccs2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354592 oxyr_human Human No 10.7 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1038 20 11 13 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4096848 oxyr_human Human No 10.7 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
949 15 11 14 -3.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354594 oxyr_human Human No 10.6 EC50 = 0.0 nM Funct
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
1041 20 11 13 -1.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4065273 oxyr_human Human No 10.6 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1019 20 11 14 -1.6 CCCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL4101771 oxyr_human Human No 10.6 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1019 20 11 14 -1.6 CCCCCCC(NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL4474284 oxyr_human Human No 10.6 EC50 = 0.0 nM Funct
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
1074 20 12 15 -2.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4094454 oxyr_human Human No 10.5 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1034 19 14 15 -4.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353942 oxyr_human Human No 10.5 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1009 21 11 15 -3.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4092971 oxyr_human Human No 10.5 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
987 15 14 14 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NNC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4583231 oxyr_human Human No 10.5 EC50 = 0.0 nM Funct
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
1024 21 13 16 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL395429 oxyr_human Human Yes 10.4 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
None None None None
CHEMBL439044 oxyr_human Human Yes 10.4 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
991 17 11 14 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL395429 oxyr_human Human Yes 10.4 EC50 = 0.0 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None None
CHEMBL439044 oxyr_human Human Yes 10.4 EC50 = 0.0 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
991 17 11 14 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354588 oxyr_human Human No 10.4 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1023 20 11 13 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354595 oxyr_human Human No 10.4 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1041 20 11 13 -1.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354597 oxyr_human Human No 10.4 EC50 = 0.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1038 21 11 13 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4080341 oxyr_human Human No 10.4 EC50 = 0.0 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
995 19 12 15 -3.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(C)[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353929 oxyr_human Human No 10.3 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
991 19 11 14 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354589 oxyr_human Human No 10.3 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1023 20 11 13 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354598 oxyr_human Human No 10.3 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1038 21 11 13 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4084795 oxyr_human Human No 10.3 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1025 17 11 14 -2.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4063150 oxyr_human Human No 10.3 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
965 16 12 15 -4.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353931 oxyr_human Human No 10.2 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1007 21 11 14 -1.9 CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL3353935 oxyr_human Human No 10.2 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1017 19 11 14 -3.1 CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](O)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL3353949 oxyr_human Human No 10.2 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1071 21 11 15 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(OC)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3277915 oxyr_human Human No 10.2 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
965 18 12 14 -3.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354572 oxyr_human Human No 10.2 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1035 20 11 15 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CC2CCCO2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354587 oxyr_human Human No 10.2 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
988 22 10 12 -1.5 CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL4101586 oxyr_human Human No 10.1 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
950 15 11 14 -2.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC1=O
CHEMBL3342789 oxyr_human Human No 10.1 EC50 = 0.1 nM Funct
Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
334 4 1 5 2.7 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1
CHEMBL4165132 oxyr_human Human Yes 10.1 EC50 = 0.1 nM Funct
Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
271 3 1 4 1.9 Cn1nccc1NS(=O)(=O)c1ccc(Cl)cc1
CHEMBL3354591 oxyr_human Human No 10.1 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1038 20 11 13 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354594 oxyr_human Human No 10.1 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1041 20 11 13 -1.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4065416 oxyr_human Human No 10.1 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
981 19 13 15 -4.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4458988 oxyr_human Human No 10.1 EC50 = 0.1 nM Funct
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
1056 20 12 14 -2.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354584 oxyr_human Human No 10.1 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
974 21 10 12 -1.9 CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL3354600 oxyr_human Human No 10.1 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1029 20 11 14 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL439044 oxyr_human Human Yes 10.0 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
991 17 11 14 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL373742 oxyr_human Human Yes 10.0 EC50 = 0.1 nM Funct
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
None None None None
CHEMBL3342790 oxyr_human Human No 10.0 EC50 = 0.1 nM Funct
Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
368 4 1 5 3.1 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1
CHEMBL4173036 oxyr_human Human Yes 10.0 EC50 = 0.1 nM Funct
Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 mins followed by OT addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
305 3 1 4 2.2 Cn1nccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1
CHEMBL4066923 oxyr_human Human No 10.0 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
979 18 11 14 -2.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4070577 oxyr_human Human No 10.0 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1025 17 11 14 -2.3 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL3353944 oxyr_human Human No 10.0 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1041 20 11 14 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354570 oxyr_human Human No 10.0 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1031 20 11 15 -1.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccco2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354575 oxyr_human Human No 10.0 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
991 21 11 14 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354585 oxyr_human Human No 10.0 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1004 22 11 13 -1.8 CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL1200739 oxyr_human Human Yes 9.9 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
34 0 0 0 0.1 S
CHEMBL4103942 oxyr_human Human Yes 9.9 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
34 0 0 0 0.1 S
CHEMBL4075102 oxyr_human Human No 9.9 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1005 17 10 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4093088 oxyr_human Human No 9.9 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1041 20 12 14 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4096331 oxyr_human Human No 9.9 EC50 = 0.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
970 17 12 13 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353945 oxyr_human Human No 9.9 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1055 20 11 14 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353953 oxyr_human Human No 9.9 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1055 21 11 14 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353954 oxyr_human Human No 9.9 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1056 21 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccn2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354581 oxyr_human Human No 9.9 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
990 21 11 13 -2.2 CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL3353938 oxyr_human Human No 9.9 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1021 22 11 14 -1.5 CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL3354580 oxyr_human Human No 9.9 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
991 21 12 14 -3.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354582 oxyr_human Human No 9.9 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
990 21 11 13 -2.2 CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL3354601 oxyr_human Human No 9.9 EC50 = 0.1 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1029 20 11 14 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353947 oxyr_human Human No 9.8 EC50 = 0.2 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1055 20 11 14 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(C)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4467042 oxyr_human Human No 9.8 EC50 = 0.2 nM Funct
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
1006 21 13 15 -4.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354576 oxyr_human Human No 9.8 EC50 = 0.2 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
991 21 11 14 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4083700 oxyr_human Human No 9.7 EC50 = 0.2 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
991 17 11 14 -2.5 CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4092407 oxyr_human Human No 9.7 EC50 = 0.2 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
975 17 10 13 -2.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353936 oxyr_human Human No 9.7 EC50 = 0.2 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1032 20 10 14 -2.5 CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](OC)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL3354583 oxyr_human Human No 9.6 EC50 = 0.2 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
974 21 10 12 -1.9 CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL3354596 oxyr_human Human No 9.6 EC50 = 0.2 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1025 20 10 12 -1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4100627 oxyr_human Human No 9.6 EC50 = 0.2 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
934 14 10 13 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC1=O
CHEMBL4073891 oxyr_human Human No 9.6 EC50 = 0.3 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1007 18 12 15 -3.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354586 oxyr_human Human No 9.6 EC50 = 0.3 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1004 22 11 13 -1.8 CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1
CHEMBL4072207 oxyr_human Human No 9.6 EC50 = 0.3 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
985 16 12 13 -4.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4564152 oxyr_human Human No 9.6 EC50 = 0.3 nM Bind
Agonist activity at human oxytocin receptor high affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor high affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
1006 19 12 15 -3.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354579 oxyr_human Human No 9.6 EC50 = 0.3 nM Funct
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
991 21 12 14 -3.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3813771 oxyr_human Human No 9.5 EC50 = 0.3 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1005 17 10 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL395429 oxyr_human Human Yes 9.5 EC50 = 0.3 nM Funct
Agonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
None None None None
CHEMBL3354602 oxyr_human Human No 9.5 EC50 = 0.3 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1013 20 10 13 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4092242 oxyr_human Human No 9.5 EC50 = 0.4 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1023 21 13 15 -3.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353937 oxyr_human Human No 9.4 EC50 = 0.4 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
947 19 11 13 -3.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353943 oxyr_human Human No 9.4 EC50 = 0.4 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1009 21 12 15 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354590 oxyr_human Human No 9.4 EC50 = 0.4 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1007 20 10 12 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4208981 oxyr_human Human No 9.4 EC50 = 0.4 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
822 12 8 12 -1.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2COC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353952 oxyr_human Human No 9.3 EC50 = 0.5 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1042 20 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccncc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3814633 oxyr_human Human No 9.3 EC50 = 0.5 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4204637 oxyr_human Human No 9.3 EC50 = 0.5 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
778 10 8 11 -1.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3814744 oxyr_human Human No 9.3 EC50 = 0.5 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4099102 oxyr_human Human No 9.3 EC50 = 0.5 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1091 21 14 15 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354593 oxyr_human Human No 9.3 EC50 = 0.6 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1022 20 10 12 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3815099 oxyr_human Human No 9.2 EC50 = 0.6 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1019 17 9 14 -1.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4206141 oxyr_human Human No 9.2 EC50 = 0.6 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
860 11 8 14 -0.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2c2nnc(C)o2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4213896 oxyr_human Human No 9.2 EC50 = 0.6 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
792 10 8 11 -0.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@@H]2C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL395429 oxyr_human Human Yes 9.2 EC50 = 0.7 nM Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
None None None None
CHEMBL3301668 oxyr_human Human Yes 9.2 EC50 = 0.7 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C
CHEMBL4564152 oxyr_human Human No 9.1 EC50 = 0.8 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assay
1006 19 12 15 -3.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4212399 oxyr_human Human No 9.1 EC50 = 0.8 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
883 13 9 12 0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2CNc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4094019 oxyr_human Human No 9.1 EC50 = 0.8 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
976 16 10 13 -0.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC1=O
CHEMBL3354599 oxyr_human Human No 9.1 EC50 = 0.8 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1022 21 10 12 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353934 oxyr_human Human No 9.1 EC50 = 0.8 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1033 19 10 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](SC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4216826 oxyr_human Human No 9.1 EC50 = 0.8 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
855 11 8 12 0.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2c2ccccn2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354578 oxyr_human Human No 9.1 EC50 = 0.9 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
975 21 10 13 -3.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3352839 oxyr_human Human No 9.1 EC50 = 0.9 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
975 21 11 13 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4564152 oxyr_human Human No 9.0 EC50 = 0.9 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assay
1006 19 12 15 -3.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3354577 oxyr_human Human No 9.0 EC50 = 1.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
975 21 10 13 -3.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353933 oxyr_human Human No 9.0 EC50 = 1.0 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1017 19 10 14 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](OC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3813894 oxyr_human Human No 9.0 EC50 = 1.0 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4063521 oxyr_human Human No 8.9 EC50 = 1.2 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1019 18 13 14 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC1=O
CHEMBL395429 oxyr_human Human Yes 8.9 EC50 = 1.3 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assay
None None None None
CHEMBL4204502 oxyr_human Human No 8.9 EC50 = 1.3 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
821 11 9 12 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353941 oxyr_human Human No 8.9 EC50 = 1.3 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1033 19 11 14 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353950 oxyr_human Human No 8.9 EC50 = 1.3 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1042 20 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccn2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3353951 oxyr_human Human No 8.9 EC50 = 1.3 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1042 20 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccnc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4086714 oxyr_human Human No 8.9 EC50 = 1.4 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1005 17 11 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4070617 oxyr_human Human No 8.8 EC50 = 1.5 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1050 22 15 15 -3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4061446 oxyr_human Human No 8.8 EC50 = 1.6 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1047 19 11 14 -1.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4083280 oxyr_human Human No 8.8 EC50 = 1.6 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1081 19 11 14 -0.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4203673 oxyr_human Human No 8.7 EC50 = 1.8 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
905 14 8 12 -0.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)CCC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4205163 oxyr_human Human No 8.7 EC50 = 1.8 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
934 15 10 13 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3301668 oxyr_human Human Yes 8.0 EC50 = 10 nM Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assayAgonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assay
None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C
CHEMBL3354574 oxyr_human Human No 8.0 EC50 = 10 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1064 21 11 16 -3.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCN2CCOCC2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4442222 oxyr_human Human No 8.0 EC50 = 10.5 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assay
1336 41 13 18 -0.7 CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N(C)CC(N)=O
CHEMBL3814120 oxyr_human Human No 8.0 EC50 = 10.8 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL395429 oxyr_human Human Yes 8.0 EC50 = 10.8 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assayAgonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
None None None None
CHEMBL1817752 oxyr_human Human No 7.0 EC50 = 104.7 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL1819550 oxyr_human Human No 7.0 EC50 = 104.7 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819550 oxyr_human Human No 7.0 EC50 = 105 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4128839 oxyr_human Human No 7.0 EC50 = 109 nM Funct
Agonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
1081 17 11 14 -0.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccc(cc2)SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1817761 oxyr_human Human No 7.0 EC50 = 109.7 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4541104 oxyr_human Human No 8.0 EC50 = 11 nM Bind
Agonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assay
2179 49 24 30 -4.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4546103 oxyr_human Human No 7.9 EC50 = 11.8 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2123 45 24 30 -6.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1817752 oxyr_human Human No 7.0 EC50 = 110 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL1817761 oxyr_human Human No 7.0 EC50 = 110 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1429 oxyr_human Human Yes 7.0 EC50 = 110 nM Bind
Agonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assayAgonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assay
None None None None
CHEMBL264448 oxyr_human Human Yes 7.0 EC50 = 110 nM Bind
Agonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assayAgonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assay
None None None None
CHEMBL1817709 oxyr_human Human Yes 6.0 EC50 = 1100 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None None
CHEMBL276711 oxyr_human Human Yes 4.9 EC50 = 11468 nM Funct
PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
238 1 2 1 3.1 Cc1cc(C)c(/C=C2\C(=O)Nc3ccccc32)[nH]1
CHEMBL4520170 oxyr_human Human No 6.9 EC50 = 117.2 nM Bind
Agonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2151 47 24 30 -5.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4103260 oxyr_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
964 16 11 14 -2.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819547 oxyr_human Human No 5.9 EC50 = 1200 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cscn2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819547 oxyr_human Human No 5.9 EC50 = 1230.3 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cscn2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL363910 oxyr_human Human Yes 6.9 EC50 = 125 nM Bind
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2
CHEMBL3246917 oxyr_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
970 17 12 13 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCNC(=O)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4541104 oxyr_human Human No 7.9 EC50 = 13 nM Bind
Agonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2179 49 24 30 -4.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4520203 oxyr_human Human No 6.9 EC50 = 135 nM Bind
Agonist activity at human oxytocin receptor C47A mutant low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor C47A mutant low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2207 51 24 30 -3.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4520203 oxyr_human Human No 7.9 EC50 = 14 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assay
2207 51 24 30 -3.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4550811 oxyr_human Human No 7.8 EC50 = 14.4 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
1005 18 11 14 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSCC(N)=O)NC1=O
CHEMBL3814126 oxyr_human Human No 7.8 EC50 = 14.7 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1C
CHEMBL4531053 oxyr_human Human No 6.9 EC50 = 140 nM Bind
Agonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assayAgonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assay
1096 17 11 13 0.6 CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CSC[C@H]2C(=O)N[C@H](CCCNC(=N)N)C(=O)NCc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL1587205 oxyr_human Human Yes 4.8 EC50 = 14784 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
425 5 1 5 4.7 N=c1n(CC(=O)c2ccc(Br)s2)c2ccccc2n1Cc1ccccc1
CHEMBL1625302 oxyr_human Human Yes 4.8 EC50 = 14784 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
425 5 1 5 4.7 N=c1n(CC(=O)c2ccc(Br)s2)c2ccccc2n1Cc1ccccc1
CHEMBL395429 oxyr_human Human Yes 7.8 EC50 = 15 nM Bind
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
None None None None
CHEMBL373742 oxyr_human Human Yes 7.8 EC50 = 15 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None None
CHEMBL373742 oxyr_human Human Yes 7.8 EC50 = 15.1 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None None
CHEMBL4567752 oxyr_human Human No 7.8 EC50 = 15.4 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assay
2235 53 24 30 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1817705 oxyr_human Human No 7.8 EC50 = 15.5 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3813858 oxyr_human Human No 7.8 EC50 = 15.6 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3763342 oxyr_human Human Yes 6.8 EC50 = 150 nM Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assayAgonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL445393 oxyr_human Human No 5.8 EC50 = 1500 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
595 8 2 6 4.4 CO[C@@H]1C[C@@H](C(=O)NCCc2ccccn2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1
CHEMBL1630523 oxyr_human Human No 6.8 EC50 = 154 nM Bind
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
1026 17 12 14 -3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CS[Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1356933 oxyr_human Human Yes 4.8 EC50 = 15541 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
265 4 2 2 3.5 Oc1ccc(Cl)cc1CNCc1ccc(F)cc1
CHEMBL1616435 oxyr_human Human Yes 4.8 EC50 = 15541 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
265 4 2 2 3.5 Oc1ccc(Cl)cc1CNCc1ccc(F)cc1
CHEMBL3342796 oxyr_human Human No 5.8 EC50 = 1570 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
437 4 1 6 3.5 O=S(=O)(Nc1ccnn1-c1ncc(C(F)(F)F)cn1)c1ccc(C(F)(F)F)cc1
CHEMBL3342798 oxyr_human Human No 5.8 EC50 = 1570 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
375 6 1 7 3.0 CCc1ccc(S(=O)(=O)Nc2ccnn2-c2nc(C3CC3)ns2)cc1
CHEMBL1817705 oxyr_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4454891 oxyr_human Human No 6.8 EC50 = 160 nM Bind
Agonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assayAgonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assay
957 15 12 13 -1.5 CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL473106 oxyr_human Human Yes 4.8 EC50 = 16681 nM Funct
PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
346 3 0 5 4.0 CCN1C(=S)SC(=O)C1=C1C=C(C)N(Cc2ccco2)C(C)=C1
CHEMBL4104022 oxyr_human Human No 7.8 EC50 = 17 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
948 15 10 13 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3342794 oxyr_human Human No 7.8 EC50 = 17 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
382 4 1 5 3.4 Cc1ccnc(-n2nccc2NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1
CHEMBL4541104 oxyr_human Human No 7.8 EC50 = 17.3 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assay
2179 49 24 30 -4.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4546597 oxyr_human Human No 6.8 EC50 = 173.4 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
1452 49 15 20 -0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819557 oxyr_human Human No 6.8 EC50 = 173.8 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
1005 18 12 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NC)NC1=O
CHEMBL3814232 oxyr_human Human No 6.8 EC50 = 174.9 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1630524 oxyr_human Human No 7.8 EC50 = 18 nM Bind
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
1074 17 12 13 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se][Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4204210 oxyr_mouse Mouse Yes 7.8 EC50 = 18 nM Funct
Agonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
531 4 2 6 4.2 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N(C)C
CHEMBL4546106 oxyr_human Human No 7.7 EC50 = 18.9 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
1322 41 14 18 -1.0 CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL1819556 oxyr_human Human No 6.8 EC50 = 180 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)C2(CCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4520203 oxyr_human Human No 6.7 EC50 = 182 nM Bind
Agonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2207 51 24 30 -3.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1390471 oxyr_human Human Yes 4.7 EC50 = 18834 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
404 9 2 5 4.0 COc1ccc(CCNCC(O)Cn2c3ccccc3c3ccccc32)cc1OC
CHEMBL3342789 oxyr_human Human No 7.7 EC50 = 19 nM Funct
Agonist activity at human OTR expressed in HEK293 cell membranes induction of IP1 accumulation at 0.1 to 10 uM measured after 1 hr by fluorescence assayAgonist activity at human OTR expressed in HEK293 cell membranes induction of IP1 accumulation at 0.1 to 10 uM measured after 1 hr by fluorescence assay
334 4 1 5 2.7 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1
CHEMBL3342789 oxyr_human Human No 7.7 EC50 = 19 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
334 4 1 5 2.7 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1
CHEMBL3342793 oxyr_human Human Yes 7.7 EC50 = 19 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
352 4 1 5 2.9 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1F
CHEMBL3354573 oxyr_human Human No 7.7 EC50 = 19 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
1048 21 12 15 -2.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCC2CCCN2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4520170 oxyr_human Human No 7.7 EC50 = 19.3 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assay
2151 47 24 30 -5.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4537162 oxyr_human Human No 6.7 EC50 = 192.6 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
1724 62 18 24 -0.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4217353 oxyr_human Human No 6.7 EC50 = 194 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
884 13 8 12 0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2COc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1437791 oxyr_human Human No 4.7 EC50 = 19485 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
282 4 2 3 3.4 Oc1ccc(Cl)cc1CNCc1ccc(Cl)nc1
CHEMBL3211384 oxyr_human Human No 4.7 EC50 = 19485 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
282 4 2 3 3.4 Oc1ccc(Cl)cc1CNCc1ccc(Cl)nc1
CHEMBL395429 oxyr_mouse Mouse Yes 8.7 EC50 = 2 nM Funct
Agonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
None None None None
CHEMBL395429 oxyr_human Human Yes 8.7 EC50 = 2.1 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
None None None None
CHEMBL395429 oxyr_human Human Yes 8.6 EC50 = 2.3 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
None None None None
CHEMBL395429 oxyr_human Human Yes 8.6 EC50 = 2.3 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
None None None None
CHEMBL1817709 oxyr_human Human Yes 8.6 EC50 = 2.4 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None None
CHEMBL3813707 oxyr_human Human No 8.6 EC50 = 2.4 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1019 17 9 14 -1.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4537162 oxyr_human Human No 8.6 EC50 = 2.6 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assay
1724 62 18 24 -0.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1630522 oxyr_human Human No 8.6 EC50 = 2.6 nM Bind
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
1026 17 12 14 -3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se]SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4564152 oxyr_human Human No 8.6 EC50 = 2.8 nM Bind
Agonist activity at human oxytocin receptor C47A mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor C47A mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
1006 19 12 15 -3.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3301668 oxyr_human Human Yes 8.5 EC50 = 3.0 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C
CHEMBL4520203 oxyr_human Human No 7.7 EC50 = 20.1 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2207 51 24 30 -3.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4550879 oxyr_human Human No 7.7 EC50 = 20.7 nM Funct
Agonist activity at human OTR receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human OTR receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
1485 46 11 17 7.5 CCCCCCCCCCCCCCCC(=O)N[C@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(OC(=O)OCCCCCCCCCCCCCC)cc2)NC1=O
CHEMBL4541104 oxyr_human Human No 7.7 EC50 = 21.7 nM Bind
Agonist activity at human oxytocin receptor C47A mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor C47A mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2179 49 24 30 -4.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4546103 oxyr_human Human No 7.7 EC50 = 21.9 nM Bind
Agonist activity at human oxytocin receptor C47A mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor C47A mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2123 45 24 30 -6.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3189462 oxyr_human Human Yes 4.7 EC50 = 21762 nM Funct
PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for vasopressin 1 receptor (V1R) agonists: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
379 6 2 6 2.0 CCN(CC)c1ccc2cc(C(N)=O)/c(=N\NC(=O)c3ccncc3)oc2c1
CHEMBL4074898 oxyr_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1010 16 10 13 -0.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O
CHEMBL373742 oxyr_human Human Yes 7.7 EC50 = 22 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
None None None None
CHEMBL443300 oxyr_human Human No 5.7 EC50 = 2200 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
641 6 1 6 5.2 CO[C@@H]1C[C@@H](C(=O)N2CCC(N3CCCCC3)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1
CHEMBL3814165 oxyr_human Human No 7.6 EC50 = 23.9 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4528032 oxyr_human Human No 6.6 EC50 = 230 nM Bind
Agonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assayAgonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assay
957 15 12 13 -1.5 CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL362382 oxyr_human Human No 5.6 EC50 = 2300 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
627 6 1 6 4.8 CO[C@@H]1C[C@@H](C(=O)N2CCC(N3CCCC3)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1
CHEMBL3763342 oxyr_human Human Yes 7.6 EC50 = 24 nM Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL3342791 oxyr_human Human No 5.6 EC50 = 2460 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
351 4 1 4 3.5 O=S(=O)(Nc1ccnn1-c1ccc(F)cc1)c1ccc(Cl)cc1
CHEMBL4204210 oxyr_human Human Yes 7.6 EC50 = 25 nM Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
531 4 2 6 4.2 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N(C)C
CHEMBL4546103 oxyr_human Human No 7.6 EC50 = 25.6 nM Bind
Agonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2123 45 24 30 -6.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3814617 oxyr_human Human No 7.6 EC50 = 26.0 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)N(C)C(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1817756 oxyr_human Human No 6.6 EC50 = 257.0 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL395429 oxyr_human Human Yes 7.6 EC50 = 26 nM Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assayAgonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assay
None None None None
CHEMBL1817756 oxyr_human Human No 6.6 EC50 = 260 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1559201 oxyr_human Human No 5.6 EC50 = 2671 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
472 1 3 3 6.2 CC1(C)CC[C@@]2(C(=O)O)C(C1)C1=CCC3[C@@]4(C)CC[C@H](O)C(C)(C)C4CC[C@@]3(C)[C@]1(C)C[C@H]2O
CHEMBL1549574 oxyr_human Human Yes 4.6 EC50 = 26738 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
402 5 2 3 5.1 COc1ccc(C2NCCc3c2[nH]c2ccccc32)cc1COc1ccc(F)cc1
CHEMBL1624349 oxyr_human Human Yes 4.6 EC50 = 26738 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
402 5 2 3 5.1 COc1ccc(C2NCCc3c2[nH]c2ccccc32)cc1COc1ccc(F)cc1
CHEMBL1630525 oxyr_human Human No 7.6 EC50 = 27.3 nM Bind
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
1174 17 12 13 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Te][Te]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1495292 oxyr_human Human No 4.6 EC50 = 27366 nM Funct
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))]
304 4 2 4 3.7 COc1ccc(CNc2[nH]cnc3c4ccccc4nc2-3)cc1
CHEMBL4217226 oxyr_human Human No 7.6 EC50 = 28 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
681 9 8 10 -1.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL360648 oxyr_human Human Yes 7.6 EC50 = 28 nM Funct
Agonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assayAgonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay
600 4 2 7 4.3 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1
CHEMBL364994 oxyr_human Human No 5.6 EC50 = 2800 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
587 5 1 6 3.8 CO[C@@H]1C[C@@H](C(=O)N2CCCN(C)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1
CHEMBL3813879 oxyr_human Human No 6.6 EC50 = 283.0 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1C
CHEMBL1819548 oxyr_human Human No 7.5 EC50 = 29 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3763342 oxyr_mouse Mouse Yes 7.5 EC50 = 29 nM Funct
Agonist activity at recombinant mouse OTR expressed in CHO-K1 cells assessed as induction of Ca2+ mobilization after overnight incubation by FLIPR assayAgonist activity at recombinant mouse OTR expressed in CHO-K1 cells assessed as induction of Ca2+ mobilization after overnight incubation by FLIPR assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL4567752 oxyr_human Human No 7.5 EC50 = 29.4 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2235 53 24 30 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819548 oxyr_human Human No 7.5 EC50 = 29.5 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819549 oxyr_human Human No 7.5 EC50 = 29.5 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4127791 oxyr_human Human No 6.5 EC50 = 294 nM Funct
Agonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
1095 17 11 14 -0.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3763342 oxyr_human Human Yes 8.5 EC50 = 3 nM Funct
Agonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assayAgonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL395429 oxyr_human Human Yes 8.5 EC50 = 3 nM Funct
Agonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assayAgonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assay
None None None None
CHEMBL1819541 oxyr_human Human No 8.5 EC50 = 3.3 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819541 oxyr_human Human No 8.5 EC50 = 3.3 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4074033 oxyr_human Human No 8.5 EC50 = 3.4 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1007 20 12 14 -2.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4546597 oxyr_human Human No 8.5 EC50 = 3.4 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assay
1452 49 15 20 -0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4102595 oxyr_human Human No 8.4 EC50 = 3.6 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
941 17 10 13 -2.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4205509 oxyr_human Human No 8.4 EC50 = 3.6 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
918 11 8 13 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCCN(C)CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819549 oxyr_human Human No 7.5 EC50 = 30 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4216174 oxyr_human Human No 6.5 EC50 = 300 nM Funct
Agonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assayAgonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay
515 4 2 6 3.4 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=O)N(C)C
CHEMBL4567752 oxyr_human Human No 6.5 EC50 = 301 nM Bind
Agonist activity at human oxytocin receptor C47A mutant low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor C47A mutant low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2235 53 24 30 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1817707 oxyr_human Human No 7.5 EC50 = 31.6 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL2369425 oxyr_human Human No 7.5 EC50 = 32 nM Bind
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
989 17 12 14 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)CCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1817706 oxyr_human Human No 7.5 EC50 = 32 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL1817707 oxyr_human Human No 7.5 EC50 = 32 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL1817706 oxyr_human Human No 7.5 EC50 = 32.4 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL360648 oxyr_human Human Yes 7.5 EC50 = 33 nM Bind
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
600 4 2 7 4.3 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1
CHEMBL1817704 oxyr_human Human No 7.5 EC50 = 33 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL360648 oxyr_human Human Yes 7.5 EC50 = 33 nM Funct
Agonist activity at human OTR receptor expressed in CHO cells co-expressing NFAT-luciferase incubated for 5 hrs by luciferase reporter gene assayAgonist activity at human OTR receptor expressed in CHO cells co-expressing NFAT-luciferase incubated for 5 hrs by luciferase reporter gene assay
600 4 2 7 4.3 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1
CHEMBL360648 oxyr_human Human Yes 7.5 EC50 = 33 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
600 4 2 7 4.3 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1
CHEMBL1817704 oxyr_human Human No 7.5 EC50 = 33.1 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4564152 oxyr_human Human No 7.5 EC50 = 33.4 nM Bind
Agonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
1006 19 12 15 -3.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4520170 oxyr_human Human No 7.5 EC50 = 33.4 nM Bind
Agonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assay
2151 47 24 30 -5.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4129142 oxyr_human Human No 7.5 EC50 = 34 nM Funct
Agonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
1095 17 11 14 -0.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2cccc(c2)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL435323 oxyr_human Human Yes 6.5 EC50 = 350 nM Bind
Agonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assayAgonist activity at human OTR stably expressed in CHOK1 cells by NFAT-luciferase reporter gene assay
1039 17 13 14 -2.7 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL4520203 oxyr_human Human No 7.4 EC50 = 37.9 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assay
2207 51 24 30 -3.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4564152 oxyr_human Human No 8.4 EC50 = 4 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
1006 19 12 15 -3.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4532537 oxyr_human Human No 8.4 EC50 = 4.1 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
1133 26 12 15 -0.9 CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL3813883 oxyr_human Human No 8.4 EC50 = 4.2 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1019 17 9 14 -1.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4061946 oxyr_human Human No 8.4 EC50 = 4.4 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
949 15 11 14 -3.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL24781 oxyr_human Human Yes 8.3 EC50 = 4.6 nM Bind
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
507 5 0 6 3.8 COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C
CHEMBL3814395 oxyr_human Human No 8.3 EC50 = 4.8 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4460622 oxyr_human Human No 8.3 EC50 = 4.8 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
1020 19 12 15 -4.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CSCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4091483 oxyr_human Human No 7.4 EC50 = 40 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
965 16 12 15 -4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL4520170 oxyr_human Human No 7.4 EC50 = 40.5 nM Bind
Agonist activity at human oxytocin receptor C47A mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor C47A mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2151 47 24 30 -5.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4541104 oxyr_human Human No 7.4 EC50 = 40.6 nM Bind
Agonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2179 49 24 30 -4.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL373742 oxyr_human Human Yes 7.4 EC50 = 41 nM Bind
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayActivity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
None None None None
CHEMBL3301668 oxyr_human Human Yes 7.4 EC50 = 41 nM Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C
CHEMBL3763342 oxyr_human Human Yes 6.4 EC50 = 420 nM Funct
Agonist activity at human OTR expressed in HEK293 cells assessed as induction of IP1 accumulation after 1 hr by HTRF assayAgonist activity at human OTR expressed in HEK293 cells assessed as induction of IP1 accumulation after 1 hr by HTRF assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL3763342 oxyr_human Human Yes 6.4 EC50 = 420 nM Funct
Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assayAgonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL1817708 oxyr_human Human No 7.4 EC50 = 43.7 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNCCC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL362483 oxyr_human Human No 6.4 EC50 = 430 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
603 5 1 6 4.6 CO[C@@H]1C[C@@H](C(=S)N2CCCN(C)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1
CHEMBL1817708 oxyr_human Human No 7.4 EC50 = 44 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNCCC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4456573 oxyr_human Human No 6.3 EC50 = 463.8 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
1738 62 17 24 -0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3342795 oxyr_human Human No 7.3 EC50 = 47 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
400 5 1 6 3.7 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(SC(F)(F)F)cc1
CHEMBL182627 oxyr_human Human No 6.3 EC50 = 470 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
611 8 2 6 5.7 CO[C@@H]1C[C@@H](/C(S)=N/CCc2ccccn2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1
CHEMBL181487 oxyr_human Human No 6.3 EC50 = 480 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
643 6 1 6 5.6 CO[C@@H]1C[C@@H](C(=S)N2CCC(N3CCCC3)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1
CHEMBL395429 oxyr_human Human Yes 8.3 EC50 = 5 nM Funct
Agonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assayAgonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
None None None None
CHEMBL4085152 oxyr_human Human No 8.3 EC50 = 5.1 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
992 17 11 14 -1.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC1=O
CHEMBL4205128 oxyr_human Human No 8.3 EC50 = 5.2 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
882 13 8 11 1.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2CCc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4546106 oxyr_human Human No 8.3 EC50 = 5.3 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assay
1322 41 14 18 -1.0 CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL4463103 oxyr_human Human No 8.3 EC50 = 5.3 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
1362 40 13 18 -0.2 CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL4207691 oxyr_human Human No 8.3 EC50 = 5.4 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
724 10 9 11 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3813722 oxyr_human Human No 8.3 EC50 = 5.5 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4560445 oxyr_human Human No 7.3 EC50 = 52.4 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assay
1466 49 14 20 -0.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3342792 oxyr_human Human No 6.3 EC50 = 520 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
388 4 1 6 3.5 Cc1csc(-n2nccc2NS(=O)(=O)c2ccc(C(F)(F)F)cc2)n1
CHEMBL4204210 oxyr_human Human Yes 7.3 EC50 = 55 nM Funct
Agonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assayAgonist activity at human OTR expressed in HEK cells assessed as increase in intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay
531 4 2 6 4.2 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N(C)C
CHEMBL4442222 oxyr_human Human No 7.3 EC50 = 56.9 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
1336 41 13 18 -0.7 CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N(C)CC(N)=O
CHEMBL4567752 oxyr_human Human No 7.2 EC50 = 59 nM Bind
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assay
2235 53 24 30 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4212247 oxyr_human Human No 8.2 EC50 = 6.8 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
958 12 8 13 -0.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC(N3CCCC3)CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3813729 oxyr_human Human No 8.2 EC50 = 7.0 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3763342 oxyr_human Human Yes 7.2 EC50 = 61 nM Funct
Agonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assayAgonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL3763342 oxyr_human Human Yes 7.2 EC50 = 61.3 nM Funct
Agonist activity at recombinant human OTR expressed in CHO-DUKX-A2 cells assessed as stimulation of intracellular calcium concentration by calcium 3 dye based FLIPR assayAgonist activity at recombinant human OTR expressed in CHO-DUKX-A2 cells assessed as stimulation of intracellular calcium concentration by calcium 3 dye based FLIPR assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL3763342 oxyr_human Human Yes 7.2 EC50 = 61.3 nM Funct
Agonist activity at recombinant human OTR expressed in CHO-K1 cells assessed as induction of Ca2+ mobilization after overnight incubation by FLIPR assayAgonist activity at recombinant human OTR expressed in CHO-K1 cells assessed as induction of Ca2+ mobilization after overnight incubation by FLIPR assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL4204210 oxyr_human Human Yes 7.2 EC50 = 62 nM Funct
Agonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assayAgonist activity at human OTR receptor expressed in HEK293FT cells incubated for 30 mins by beta-arrestin recruitment assay
531 4 2 6 4.2 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N(C)C
CHEMBL3301668 oxyr_mouse Mouse Yes 7.2 EC50 = 62 nM Funct
Agonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C
CHEMBL603708 oxyr_human Human No 7.2 EC50 = 63 nM Bind
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
446 4 1 2 6.6 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1
CHEMBL365862 oxyr_human Human No 6.2 EC50 = 640 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
553 4 1 5 4.7 Cc1cc(C(=O)N2CCCCc3sccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1
CHEMBL4456573 oxyr_human Human No 7.2 EC50 = 65.5 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in absence of 10% FBS by pathhunter assay
1738 62 17 24 -0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4520170 oxyr_human Human No 7.2 EC50 = 67.3 nM Bind
Agonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2151 47 24 30 -5.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3813982 oxyr_human Human No 8.1 EC50 = 8.0 nM Funct
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assayAgonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
1019 17 9 14 -1.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819440 oxyr_human Human Yes 7.2 EC50 = 70.8 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL1819440 oxyr_human Human Yes 7.2 EC50 = 71 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
CHEMBL1429 oxyr_human Human Yes 7.1 EC50 = 72 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
None None None None
CHEMBL264448 oxyr_human Human Yes 7.1 EC50 = 72 nM Bind
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
None None None None
CHEMBL4564152 oxyr_human Human No 7.1 EC50 = 74.8 nM Bind
Agonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
1006 19 12 15 -3.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL3342797 oxyr_human Human No 6.1 EC50 = 753 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
432 5 1 7 2.4 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(S(=O)(=O)C(F)(F)F)cc1
CHEMBL1817759 oxyr_human Human No 6.1 EC50 = 776.3 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL3763342 oxyr_mouse Mouse Yes 7.1 EC50 = 78 nM Funct
Agonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL1817759 oxyr_human Human No 6.1 EC50 = 780 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL395429 oxyr_human Human Yes 8.1 EC50 = 8 nM Funct
Agonist activity at SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assayAgonist activity at SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
None None None None
CHEMBL3342790 oxyr_human Human No 8.1 EC50 = 8 nM Funct
Agonist activity at human OTR expressed in HEK293 cell membranes induction of IP1 accumulation at 0.1 to 10 uM measured after 1 hr by fluorescence assayAgonist activity at human OTR expressed in HEK293 cell membranes induction of IP1 accumulation at 0.1 to 10 uM measured after 1 hr by fluorescence assay
368 4 1 5 3.1 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1
CHEMBL3342790 oxyr_human Human No 8.1 EC50 = 8 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodAgonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR method
368 4 1 5 3.1 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1
CHEMBL373742 oxyr_human Human Yes 8.1 EC50 = 8.3 nM Funct
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assayAgonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
None None None None
CHEMBL185152 oxyr_human Human No 6.1 EC50 = 810 nM Bind
Effective concentration for human Oxytocin receptorEffective concentration for human Oxytocin receptor
573 4 1 5 5.0 CN1CCCN(C(=S)[C@@H]2CCCN2C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)CC1
CHEMBL4560445 oxyr_human Human No 6.1 EC50 = 831.2 nM Bind
Agonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assayAgonist activity at recombinant human Gi/Go-coupled OTR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins in presence of 10% FBS by pathhunter assay
1466 49 14 20 -0.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1817763 oxyr_human Human No 6.1 EC50 = 860 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL4567752 oxyr_human Human No 6.1 EC50 = 867 nM Bind
Agonist activity at human oxytocin receptor V43A/C47A double mutant low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assayAgonist activity at human oxytocin receptor V43A/C47A double mutant low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
2235 53 24 30 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1817763 oxyr_human Human No 6.1 EC50 = 871.0 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL3763342 oxyr_human Human Yes 6.1 EC50 = 880 nM Bind
Agonist activity at C-terminal GFP-tagged OTR (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase reporter gene assayAgonist activity at C-terminal GFP-tagged OTR (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase reporter gene assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL3763342 oxyr_human Human Yes 6.1 EC50 = 881 nM Funct
Agonist activity at human OTR stably expressed in HEK cells by calcium flux assayAgonist activity at human OTR stably expressed in HEK cells by calcium flux assay
581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1
CHEMBL4075079 oxyr_human Human No 7.1 EC50 = 89 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1006 18 11 14 -1.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL395429 oxyr_human Human Yes 8.1 EC50 = 9 nM Bind
Agonist activity at C-terminal GFP-tagged OTR (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase reporter gene assayAgonist activity at C-terminal GFP-tagged OTR (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase reporter gene assay
None None None None
CHEMBL1819543 oxyr_human Human No 8.0 EC50 = 9.1 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1819543 oxyr_human Human No 8.0 EC50 = 9.1 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL4094014 oxyr_human Human No 8.0 EC50 = 9.5 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assay
1063 20 12 15 -2.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL1817758 oxyr_human Human No 6.0 EC50 = 970 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL1817758 oxyr_human Human No 6.0 EC50 = 977.2 nM Funct
Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assayAgonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
CHEMBL3142545 oxyr_human Human No 9.5 IC50 = 0.3 nM Funct
Ability to inhibit OT-induced inositol phosphate accumulation was determined in CHO cells expressing the human OT receptorAbility to inhibit OT-induced inositol phosphate accumulation was determined in CHO cells expressing the human OT receptor
1377 36 13 17 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O
CHEMBL3142790 oxyr_human Human No 9.5 IC50 = 0.3 nM Funct
Ability to inhibit OT-induced inositol phosphate accumulation was determined in CHO cells expressing the human OT receptorAbility to inhibit OT-induced inositol phosphate accumulation was determined in CHO cells expressing the human OT receptor
1377 36 13 17 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O
CHEMBL338711 oxyr_rat Rat No 9.2 IC50 = 0.7 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
687 11 2 8 2.5 Cn1cnc(CC(=O)NC(CCS(C)(=O)=O)C(=O)N[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1
CHEMBL285608 oxyr_human Human No 9.0 IC50 = 1 nM Funct
Inhibitory concentration required for antagonist activity against oxytocin receptorInhibitory concentration required for antagonist activity against oxytocin receptor
573 12 3 7 2.3 CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2cccs2)C(N)=O)C1=O
CHEMBL131477 oxyr_rat Rat No 8.9 IC50 = 1.2 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
673 11 3 7 2.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(CCS(C)(=O)=O)NC(=O)Cc1c[nH]cn1)C2
CHEMBL2112895 oxyr_rat Rat No 8.9 IC50 = 1.3 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
637 11 3 8 1.9 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCNCC2)C3(C)C)CC1
CHEMBL2112893 oxyr_rat Rat No 8.9 IC50 = 1.4 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
686 11 2 9 1.7 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCS(=O)(=O)CC2)C3(C)C)CC1
CHEMBL338921 oxyr_rat Rat No 8.8 IC50 = 1.7 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
652 11 3 7 2.3 Cn1cnc(CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1
CHEMBL4449435 oxyr_human Human No 8.0 IC50 = 10 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
431 6 0 7 4.0 COCc1nnc(N2CCC(c3ccc(F)cc3Cl)CC2)n1-c1ccc(OC)nc1
CHEMBL2112247 oxyr_rat Rat No 8.0 IC50 = 10 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL279281 oxyr_rat Rat No 8.0 IC50 = 10 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
557 7 2 6 2.6 C[C@@H](O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL128726 oxyr_rat Rat No 7.0 IC50 = 100 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
535 6 2 5 3.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1cccnc1)C2
CHEMBL130768 oxyr_rat Rat No 7.0 IC50 = 100 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
471 4 1 3 3.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1CCNC1=O)C2
CHEMBL132391 oxyr_rat Rat No 7.0 IC50 = 100 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
595 8 2 5 4.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)CC1CN3CCC1CC3)C2
CHEMBL340362 oxyr_rat Rat No 7.0 IC50 = 100 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
577 6 2 6 2.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CC(S(C)(=O)=O)CN1)C2
CHEMBL237772 oxyr_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
489 3 1 3 5.0 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CC3C=CC(=O)N3Cc3ccccc32)c(Cl)c1
CHEMBL237987 oxyr_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
426 5 3 3 5.0 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2C(=O)O)c(Cl)c1
CHEMBL238206 oxyr_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
505 7 3 4 5.8 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2Cn2cccc2C(=O)O)c(Cl)c1
CHEMBL392363 oxyr_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
489 3 1 3 5.7 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2C=C3CCC(=O)N3Cc3ccccc32)c(Cl)c1
CHEMBL126709 oxyr_rat Rat No 6.0 IC50 = 1000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
417 3 1 3 3.9 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCCc4ccccc43)CC1)[C@@H](O)C2
CHEMBL131613 oxyr_rat Rat No 6.0 IC50 = 1000 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
520 6 1 3 4.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](NC(=O)Cc1ccccc1)C2
CHEMBL340772 oxyr_rat Rat No 6.0 IC50 = 1000 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
506 5 1 3 4.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1ccccc1)C2
CHEMBL340383 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Compound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissueCompound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissue
351 3 0 2 4.0 O=S(=O)(/C=C/c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL125358 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
325 2 0 2 3.4 O=S(=O)(c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL126796 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
331 2 0 3 3.5 O=S(=O)(c1cccs1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL127119 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
362 1 1 1 4.6 O=C(NC1C2CC3CC(C2)CC1C3)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL129413 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
289 1 0 1 3.9 O=C(c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL337976 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
304 1 1 1 4.3 O=C(Nc1ccccc1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL338605 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
339 2 0 2 3.7 Cc1ccccc1S(=O)(=O)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL340149 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
318 1 1 1 4.6 Cc1ccc(NC(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1
CHEMBL274955 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
430 4 2 4 2.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@](O)(CN)C2
CHEMBL338362 oxyr_rat Rat No 5.0 IC50 = 10000 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
510 6 2 4 3.6 CC1(C)[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1c[nH]cn1)C2
CHEMBL441128 oxyr_human Human No 6.0 IC50 = 1002 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1035 20 11 14 -1.3 CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL415418 oxyr_human Human No 7.0 IC50 = 103 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1053 17 11 14 -1.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL603708 oxyr_human Human No 7.0 IC50 = 109 nM Funct
Antagonist activity at OXR receptor (unknown origin)Antagonist activity at OXR receptor (unknown origin)
446 4 1 2 6.6 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1
CHEMBL339497 oxyr_rat Rat No 8.0 IC50 = 11 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
616 9 2 6 3.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(CCS(C)(=O)=O)c1c[nH]cn1)C2
CHEMBL435019 oxyr_rat Rat No 8.0 IC50 = 11 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
484 4 0 4 3.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CCC1=O)C2
CHEMBL128216 oxyr_rat Rat No 7.0 IC50 = 110 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
512 5 1 5 3.1 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CN1C(=O)CCC1=O)C2
CHEMBL131168 oxyr_rat Rat No 7.0 IC50 = 110 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
501 6 2 4 3.6 CC(C)[C@@H](N)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL131388 oxyr_rat Rat No 7.0 IC50 = 110 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
593 9 3 7 1.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C(N)CCS(C)(=O)=O)C2
CHEMBL334610 oxyr_rat Rat No 7.0 IC50 = 110 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
541 6 3 5 3.1 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C1CCCNC1)C2
CHEMBL336992 oxyr_rat Rat No 7.0 IC50 = 110 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
588 6 2 4 4.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1[nH]cnc1Br)C2
CHEMBL422080 oxyr_rat Rat No 7.0 IC50 = 110 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
563 8 2 5 4.1 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)Cc1ccncc1)C2
CHEMBL126717 oxyr_rat Rat No 6.0 IC50 = 1100 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
415 3 0 3 4.1 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCCc4ccccc43)CC1)C(=O)C2
CHEMBL129268 oxyr_rat Rat No 6.0 IC50 = 1100 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
401 3 0 3 3.7 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C(=O)C2
CHEMBL4758081 oxyr_human Human No 5.9 IC50 = 1160 nM Bind
Antagonist activity at human OXTR expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human OXTR expressed in CHO-K1 cells by PathHunter beta-arrestin assay
610 8 0 7 5.4 COC(=O)[C@H]1[C@@H](OCc2cccc(OC)c2)CC[C@H]2CN3CC[C@@]4(C(=O)N(Cc5cccc(OC)c5)c5ccccc54)[C@@H]3C[C@@H]21
CHEMBL382301 oxyr_rat Rat Yes 7.9 IC50 = 12 nM Funct
Antagonism of OT-induced response at OT receptor in rat uterine stripsAntagonism of OT-induced response at OT receptor in rat uterine strips
None None None None
CHEMBL2112899 oxyr_rat Rat No 7.9 IC50 = 12 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
530 8 3 5 2.2 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCC(N)=O)C2
CHEMBL2112902 oxyr_rat Rat No 7.9 IC50 = 12 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
565 8 2 6 2.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCS(C)(=O)=O)C2
CHEMBL276990 oxyr_rat Rat No 7.9 IC50 = 12 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
499 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](N)C1=O)C2
CHEMBL130742 oxyr_rat Rat No 7.9 IC50 = 12 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
530 8 3 5 2.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCC(N)=O)C2
CHEMBL2112666 oxyr_rat Rat No 7.9 IC50 = 12 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
565 8 2 6 2.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCS(C)(=O)=O)C2
CHEMBL341049 oxyr_rat Rat No 7.9 IC50 = 12 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
565 6 1 5 3.7 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(Cc3c[nH]cn3)C1=O)C2
CHEMBL128398 oxyr_rat Rat No 6.9 IC50 = 120 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
510 6 1 5 3.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cn1ccnc1)C2
CHEMBL131269 oxyr_rat Rat No 6.9 IC50 = 120 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
521 6 1 4 4.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1ccncc1)C2
CHEMBL338636 oxyr_rat Rat No 6.9 IC50 = 120 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
549 7 2 5 4.1 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1ccccn1)C2
CHEMBL339493 oxyr_rat Rat No 5.9 IC50 = 1200 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL338757 oxyr_rat Rat No 5.9 IC50 = 1200 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
403 2 0 2 4.2 O=S(=O)(c1ccc(Br)cc1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL337519 oxyr_rat Rat No 5.9 IC50 = 1200 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
510 6 2 4 3.6 CC1(C)[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](NC(=O)Cc1c[nH]cn1)C2
CHEMBL340320 oxyr_rat Rat No 5.9 IC50 = 1200 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
444 4 1 3 3.6 CC(=O)N[C@@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL336362 oxyr_rat Rat No 4.9 IC50 = 12000 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
578 6 1 3 6.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C[C@]13C[C@H]4C[C@H](C[C@H](C4)C1)C3)C2
CHEMBL4444840 oxyr_human Human No 6.9 IC50 = 121 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
444 6 0 8 2.9 COCc1nnc(N2CC3CN(c4ccc(F)cc4Cl)C3C2)n1-c1ccc(OC)nc1
CHEMBL4442843 oxyr_human Human No 5.9 IC50 = 1227 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
473 7 0 8 4.2 COCc1nnc(N2C3CCC2CC(Oc2ccc(F)cc2Cl)C3)n1-c1ccc(OC)nc1
CHEMBL280202 oxyr_rat Rat No 6.9 IC50 = 124 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
555 7 0 5 4.0 CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL201889 oxyr_rat Rat No 5.9 IC50 = 1259 nM Funct
Antagonism of OT-induced response at OT receptor in rat uterine stripsAntagonism of OT-induced response at OT receptor in rat uterine strips
449 2 1 5 5.5 Cc1ccn(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(C(F)(F)F)c2)n1
CHEMBL338018 oxyr_rat Rat No 7.9 IC50 = 13 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O
CHEMBL277022 oxyr_rat Rat No 7.9 IC50 = 13 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
571 7 1 7 2.4 COC(=O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL128258 oxyr_rat Rat No 7.9 IC50 = 13 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
592 7 2 6 2.1 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CCS(N)(=O)=O)C1=O)C2
CHEMBL341289 oxyr_rat Rat No 7.9 IC50 = 13 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
565 6 2 5 3.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3c[nH]cn3)C1=O)C2
CHEMBL405016 oxyr_rat Rat No 7.9 IC50 = 13 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
609 7 2 8 2.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(CC(=O)Nc3nn[nH]n3)C1=O)C2
CHEMBL280678 oxyr_human Human No 6.9 IC50 = 130 nM Funct
Antagonistic activity against Oxytocin receptorAntagonistic activity against Oxytocin receptor
571 7 2 5 3.7 C[C@@H](O)CN1CCC[C@@H](C(=O)NC2CC3CCC2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1
CHEMBL406351 oxyr_human Human No 6.9 IC50 = 130 nM Bind
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O
CHEMBL397407 oxyr_human Human No 6.9 IC50 = 130 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2Cc3ccccc3C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL131239 oxyr_rat Rat No 6.9 IC50 = 130 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
527 6 2 4 4.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CC1CCCNC1)C2
CHEMBL339151 oxyr_rat Rat No 6.9 IC50 = 130 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
472 5 2 4 3.1 CC(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C
CHEMBL127063 oxyr_rat Rat No 5.9 IC50 = 1300 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
413 3 0 3 4.0 CC1C(=O)[C@]2(CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)CCC1C2(C)C
CHEMBL128124 oxyr_rat Rat No 5.9 IC50 = 1300 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
430 4 2 4 2.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CN)C2
CHEMBL4437214 oxyr_human Human No 6.9 IC50 = 132 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
442 5 0 7 3.7 COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc2c(c1)OCO2
CHEMBL4519861 oxyr_human Human No 5.9 IC50 = 1379 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
473 7 0 8 3.9 COCc1nnc(N2C[C@H]3C[C@@H](Oc4ccc(F)cc4Cl)C[C@H]3C2)n1-c1ccc(OC)nc1
CHEMBL234363 oxyr_human Human No 5.9 IC50 = 1380 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL128712 oxyr_rat Rat No 7.9 IC50 = 14 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
499 4 1 4 3.4 CC1NC(=O)N([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL339132 oxyr_rat Rat No 7.9 IC50 = 14 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
499 4 0 4 3.4 CN1CC(=O)N([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL445816 oxyr_human Human No 7.9 IC50 = 14 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
624 14 3 7 1.1 CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C
CHEMBL2113201 oxyr_human Human No 7.9 IC50 = 14 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
569 11 2 7 3.3 CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1
CHEMBL128328 oxyr_rat Rat No 6.9 IC50 = 140 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
473 6 2 4 3.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCN)C2
CHEMBL421090 oxyr_rat Rat No 6.9 IC50 = 140 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
524 7 1 5 3.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCn1ccnc1)C2
CHEMBL435613 oxyr_rat Rat No 6.9 IC50 = 140 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
512 6 1 7 2.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cn1cnnn1)C2
CHEMBL419422 oxyr_rat Rat No 5.9 IC50 = 1400 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
473 5 2 4 3.7 CC(C(=O)O)[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C
CHEMBL4591825 oxyr_human Human Yes 7.8 IC50 = 15 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
429 6 0 7 3.4 COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1
CHEMBL1790937 oxyr_rat Rat No 7.8 IC50 = 15 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL2370623 oxyr_rat Rat No 7.8 IC50 = 15 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCC=NN2C1=O
CHEMBL338308 oxyr_rat Rat No 7.8 IC50 = 15 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCC=NN2C1=O
CHEMBL2112900 oxyr_rat Rat No 7.8 IC50 = 15 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
636 11 2 7 3.5 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCCCC2)C3(C)C)CC1
CHEMBL278377 oxyr_rat Rat No 7.8 IC50 = 15 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
584 9 1 6 3.2 CN(C)CCCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL341289 oxyr_rat Rat No 7.8 IC50 = 15 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
565 6 2 5 3.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3c[nH]cn3)C1=O)C2
CHEMBL2113189 oxyr_human Human No 7.8 IC50 = 15 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
597 11 2 8 2.7 CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)NC(=O)c3ccccc32)c2ccc(Cl)cc2)cc1
CHEMBL283317 oxyr_rat Rat No 6.8 IC50 = 150 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
555 7 0 5 4.0 CCN(CC)[C@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL128327 oxyr_rat Rat No 6.8 IC50 = 150 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
510 5 2 4 4.0 Cc1[nH]cnc1C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL131235 oxyr_rat Rat No 6.8 IC50 = 150 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
522 6 2 4 4.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)/C=C/c1c[nH]cn1)C2
CHEMBL131564 oxyr_rat Rat No 6.8 IC50 = 150 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
538 6 2 4 4.3 CC(C)(C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C)c1c[nH]cn1
CHEMBL339357 oxyr_rat Rat No 6.8 IC50 = 150 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
500 5 1 4 3.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@](O)(CN1CCCC1=O)C2
CHEMBL435009 oxyr_rat Rat No 6.8 IC50 = 150 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
486 6 2 4 3.5 CC(=O)NCC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C
CHEMBL339452 oxyr_rat Rat No 5.8 IC50 = 1500 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@@H](C)N(C)C1=O
CHEMBL436397 oxyr_rat Rat No 5.8 IC50 = 1500 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCCN2C1=O
CHEMBL338576 oxyr_rat Rat No 7.8 IC50 = 16 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
645 10 2 6 3.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)N(CCc1c[nH]cn1)CCS(C)(=O)=O)C2
CHEMBL341289 oxyr_rat Rat No 7.8 IC50 = 16 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
565 6 2 5 3.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3c[nH]cn3)C1=O)C2
CHEMBL2369135 oxyr_human Human No 6.8 IC50 = 160 nM Bind
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H]([C@H](C)c2c(C)cc(OC)cc2C)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O
CHEMBL338294 oxyr_rat Rat No 6.8 IC50 = 160 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O
CHEMBL423156 oxyr_rat Rat No 6.8 IC50 = 160 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
517 6 2 5 3.0 COC(=O)CNC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL126453 oxyr_rat Rat No 4.8 IC50 = 16000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
370 3 0 4 3.3 O=[N+]([O-])c1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1
CHEMBL283524 oxyr_rat Rat No 7.8 IC50 = 17 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
500 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2
CHEMBL128194 oxyr_rat Rat No 6.8 IC50 = 170 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
515 7 2 5 2.8 CC(C(N)=O)[C@@H](N)C(=O)[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL128680 oxyr_rat Rat No 6.8 IC50 = 170 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
521 6 1 4 4.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1cccnc1)C2
CHEMBL130803 oxyr_rat Rat No 6.8 IC50 = 170 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
542 6 2 6 3.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1csc(N)n1)C2
CHEMBL131581 oxyr_rat Rat No 6.8 IC50 = 170 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
538 7 2 4 4.5 CCC(C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C)c1c[nH]cn1
CHEMBL338177 oxyr_rat Rat No 6.8 IC50 = 170 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
555 6 3 4 4.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)NC1CCCCC1)C2
CHEMBL4126100 oxyr_human Human No 5.8 IC50 = 1724 nM Funct
Antagonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by oxytocin addition measured for 5 mins by Fluo-4-AM dye based FLIPR assayAntagonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by oxytocin addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
1139 19 14 15 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL234377 oxyr_human Human No 6.8 IC50 = 176 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1081 19 10 14 -0.9 CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL127686 oxyr_rat Rat No 7.8 IC50 = 18 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None None
CHEMBL1790938 oxyr_rat Rat No 7.8 IC50 = 18 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL2112894 oxyr_rat Rat No 7.8 IC50 = 18 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
610 12 1 7 2.9 CCN(CC)[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1CC2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C
CHEMBL417458 oxyr_rat Rat No 7.8 IC50 = 18 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
570 8 1 6 2.8 CN(C)CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL338383 oxyr_rat Rat No 7.8 IC50 = 18 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
485 4 1 4 3.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CNC1=O)C2
CHEMBL130887 oxyr_rat Rat No 6.8 IC50 = 180 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
535 6 2 5 3.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1ccccn1)C2
CHEMBL337667 oxyr_rat Rat No 6.8 IC50 = 180 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
535 6 2 5 3.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1ccncc1)C2
CHEMBL338635 oxyr_rat Rat No 6.8 IC50 = 180 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
484 4 0 3 4.5 CC1CCC(=O)N1[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL339096 oxyr_rat Rat No 6.8 IC50 = 180 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
499 4 1 5 2.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(=O)C1=O)C2
CHEMBL434993 oxyr_rat Rat No 6.8 IC50 = 180 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
535 7 1 4 4.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCc1cccnc1)C2
CHEMBL126962 oxyr_rat Rat No 5.8 IC50 = 1800 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
399 3 0 3 3.8 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2
CHEMBL420144 oxyr_rat Rat No 5.8 IC50 = 1800 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
399 3 0 3 3.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2
CHEMBL4585239 oxyr_human Human No 6.7 IC50 = 184 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
485 7 0 8 3.5 COc1ccc(-n2c(CO[C@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1
CHEMBL340388 oxyr_rat Rat No 7.7 IC50 = 19 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
593 8 0 6 4.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CCCn3ccnc3)C1=O)C2
CHEMBL338020 oxyr_rat Rat No 6.7 IC50 = 190 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC(C)C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL340479 oxyr_rat Rat No 6.7 IC50 = 190 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None C=CCN1C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]1Cc1ccccc1
CHEMBL276079 oxyr_rat Rat No 6.7 IC50 = 190 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
507 5 1 4 4.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1ccncc1)C2
CHEMBL130351 oxyr_rat Rat No 5.7 IC50 = 1900 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
419 3 1 3 3.7 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(F)ccc43)CC1)[C@@H](O)C2
CHEMBL341274 oxyr_rat Rat No 5.7 IC50 = 1900 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
419 3 1 3 3.7 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(F)cc43)CC1)[C@@H](O)C2
CHEMBL2370761 oxyr_human Human No 4.7 IC50 = 19000 nM Bind
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H]([C@H](C)c2c(C)cc(OC)cc2C)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O
CHEMBL2112249 oxyr_rat Rat No 8.7 IC50 = 2.2 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL336082 oxyr_rat Rat No 8.7 IC50 = 2.2 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
638 11 4 6 2.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1c[nH]cn1)C2
CHEMBL339929 oxyr_rat Rat No 8.6 IC50 = 2.3 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
652 11 3 7 2.3 Cn1cncc1CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL2112897 oxyr_rat Rat No 8.6 IC50 = 2.4 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
638 11 2 8 2.3 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCOCC2)C3(C)C)CC1
CHEMBL130891 oxyr_rat Rat No 8.6 IC50 = 2.6 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
591 7 1 6 2.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CCS(C)(=O)=O)C1=O)C2
CHEMBL395429 oxyr_human Human Yes 8.6 IC50 = 2.7 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
None None None None
CHEMBL2112901 oxyr_rat Rat No 8.6 IC50 = 2.8 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
614 12 3 9 0.8 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(CO)CO)C3(C)C)CC1
CHEMBL2112651 oxyr_rat Rat No 7.7 IC50 = 20 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL20171 oxyr_rat Rat No 7.7 IC50 = 20 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
557 7 1 6 2.5 CN(CCO)C1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL20319 oxyr_rat Rat No 7.7 IC50 = 20 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
587 8 0 6 3.9 CN(C)CCSC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL20757 oxyr_rat Rat No 7.7 IC50 = 20 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
557 7 2 6 2.6 C[C@H](CO)NC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL283994 oxyr_rat Rat No 7.7 IC50 = 20 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
500 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](O)C1=O)C2
CHEMBL128383 oxyr_rat Rat No 7.7 IC50 = 20 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
541 4 1 5 2.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C3CC(O)CN3C1=O)C2
CHEMBL339118 oxyr_rat Rat No 6.7 IC50 = 200 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL281361 oxyr_rat Rat No 6.7 IC50 = 200 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
589 7 1 5 4.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](NCc3ccccc3)C1=O)C2
CHEMBL341507 oxyr_rat Rat No 6.7 IC50 = 200 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
552 7 3 6 1.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CS(N)(=O)=O)C2
CHEMBL340102 oxyr_rat Rat No 5.7 IC50 = 2000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
417 3 1 3 3.9 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCCc4ccccc43)CC1)[C@H](O)C2
CHEMBL129983 oxyr_rat Rat No 7.7 IC50 = 21 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
538 4 1 5 3.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C3CCC(=N)N3C1=O)C2
CHEMBL128388 oxyr_rat Rat No 6.7 IC50 = 210 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
499 5 1 4 3.3 CNC1CCN([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL326085 oxyr_rat Rat No 4.7 IC50 = 21000 nM Bind
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
428 6 0 7 5.1 COc1cc(C)cc2c1Oc1ccc([C@H](CC(C)C)OC(C)=O)c(OC)c1C(=O)OC2
CHEMBL339450 oxyr_rat Rat No 6.7 IC50 = 220 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]2CCCCN2C1=O
CHEMBL276906 oxyr_rat Rat No 6.7 IC50 = 220 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
548 7 2 4 4.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1ccccc1)C2
CHEMBL340334 oxyr_rat Rat No 6.7 IC50 = 220 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
512 6 2 6 2.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1nnn[nH]1)C2
CHEMBL127118 oxyr_rat Rat No 5.7 IC50 = 2200 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
401 3 1 3 3.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@H](O)C2
CHEMBL339093 oxyr_rat Rat No 5.7 IC50 = 2200 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
375 6 1 3 3.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)NCCC1CCc3ccccc31)C(=O)C2
CHEMBL128497 oxyr_rat Rat No 5.7 IC50 = 2200 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
401 3 1 3 3.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@H](O)C2
CHEMBL341021 oxyr_rat Rat Yes 4.7 IC50 = 22000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
337 2 0 1 5.3 O=C(CC1CCCCCCC1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL4542267 oxyr_human Human No 6.7 IC50 = 223 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
485 7 0 8 3.5 COc1ccc(-n2c(CO[C@@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1
CHEMBL4518063 oxyr_human Human No 7.6 IC50 = 23 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
429 6 0 7 3.4 COCc1nnc(N2CC3CC3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1
CHEMBL435409 oxyr_rat Rat No 7.6 IC50 = 23 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
611 10 3 5 3.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)N(CCC(=O)O)CCc1c[nH]cn1)C2
CHEMBL594828 oxyr_human Human Yes 7.6 IC50 = 23.2 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1
CHEMBL129498 oxyr_rat Rat No 5.6 IC50 = 2300 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
417 3 0 3 3.9 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(F)cc43)CC1)C(=O)C2
CHEMBL338170 oxyr_rat Rat No 5.6 IC50 = 2300 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
417 3 0 3 3.9 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(F)ccc43)CC1)C(=O)C2
CHEMBL4575160 oxyr_human Human No 6.6 IC50 = 235 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
424 5 0 7 3.3 COc1ccc(-n2c(CC#N)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1
CHEMBL20205 oxyr_rat Rat No 6.6 IC50 = 240 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
482 4 0 4 3.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C=CC1=O)C2
CHEMBL340016 oxyr_rat Rat No 6.6 IC50 = 240 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
530 8 1 5 4.0 CCOC(=O)CCC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL341267 oxyr_rat Rat No 5.6 IC50 = 2400 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
399 3 0 3 3.8 CC1(C)C2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2
CHEMBL126765 oxyr_rat Rat No 7.6 IC50 = 25 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCC=NN2C1=O
CHEMBL434193 oxyr_human Human No 7.6 IC50 = 25 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1184 18 9 14 0.9 CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)N3Cc4ccccc4C[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL20002 oxyr_rat Rat No 7.6 IC50 = 25 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
542 5 0 6 3.2 CC(=O)OC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL435815 oxyr_rat Rat No 6.6 IC50 = 250 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
520 6 1 3 4.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1ccccc1)C2
CHEMBL338336 oxyr_rat Rat No 5.6 IC50 = 2500 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
401 3 1 3 3.6 CC1(C)C2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@H](O)C2
CHEMBL338221 oxyr_rat Rat No 4.6 IC50 = 25000 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N2CCCC[C@H]2C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)N1C
CHEMBL4560499 oxyr_human Human No 5.6 IC50 = 2561 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
459 6 0 8 3.0 COCc1nnc(N2CC3COCC3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1
CHEMBL130770 oxyr_rat Rat No 6.6 IC50 = 260 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
507 5 1 4 4.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1cccnc1)C2
CHEMBL4466263 oxyr_human Human No 7.6 IC50 = 27 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
417 6 0 7 3.6 COCc1nnc(N2CCC(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1
CHEMBL335886 oxyr_rat Rat No 7.6 IC50 = 27 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
626 6 2 6 3.7 COC(=O)[N+]12CCC(CC1)C(C(=O)NC[C@@]1(O)C[C@H]3CC[C@]1(CS(=O)(=O)N1CCC4(C=Cc5ccccc54)CC1)C3(C)C)C2
CHEMBL132064 oxyr_rat Rat No 6.6 IC50 = 270 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
514 5 1 4 3.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CCC1C(=O)O)C2
CHEMBL129414 oxyr_rat Rat No 5.6 IC50 = 2700 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)N(C)C(=O)[C@H]2CCCCN2C1=O
CHEMBL4557241 oxyr_human Human No 5.6 IC50 = 2794 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
445 7 0 7 4.0 COCc1nnc(C2CCN(Cc3ccc(F)cc3Cl)CC2)n1-c1ccc(OC)nc1
CHEMBL335944 oxyr_rat Rat No 7.5 IC50 = 29 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
539 5 1 4 3.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CN3CCC1CC3)C2
CHEMBL433662 oxyr_rat Rat No 8.5 IC50 = 3.2 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
556 7 2 5 2.7 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CCC(N)=O)C1=O)C2
CHEMBL377414 oxyr_human Human No 8.4 IC50 = 3.7 nM Funct
Agonist activity at human OTR expressed in CHO cells assessed as inhibition of oxytocin-induced calcium mobilization by FLIPR assayAgonist activity at human OTR expressed in CHO cells assessed as inhibition of oxytocin-induced calcium mobilization by FLIPR assay
483 6 1 3 3.3 CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F
CHEMBL4564411 oxyr_human Human No 7.5 IC50 = 30 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
429 6 0 7 3.4 COCc1nnc(N2C[C@@H]3C[C@]3(c3cccc(F)c3Cl)C2)n1-c1ccc(OC)nc1
CHEMBL132157 oxyr_rat Rat No 7.5 IC50 = 30 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
610 7 3 8 2.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CC(=O)Nc3nn[nH]n3)C1=O)C2
CHEMBL337221 oxyr_rat Rat No 7.5 IC50 = 30 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
542 6 1 5 3.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(CC(=O)O)C1=O)C2
CHEMBL338951 oxyr_rat Rat No 7.5 IC50 = 30 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
621 11 1 6 3.8 CCN(CC)C(CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL339155 oxyr_rat Rat No 7.5 IC50 = 30 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
541 7 2 4 4.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCC1CCCNC1)C2
CHEMBL1254117 oxyr_human Human No 7.5 IC50 = 30 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
492 8 2 6 3.1 CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1
CHEMBL334332 oxyr_rat Rat No 6.5 IC50 = 300 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
554 8 3 7 2.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)Cc1nnn[nH]1)C2
CHEMBL125406 oxyr_rat Rat No 5.5 IC50 = 3000 nM Bind
Compound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissueCompound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissue
375 2 0 2 4.6 O=S(=O)(c1ccc2ccccc2c1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL126371 oxyr_rat Rat No 5.5 IC50 = 3000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
403 3 1 3 3.5 CC1(C)C2CC[C@](CS(=O)(=O)N3CCC4(CCc5ccccc54)CC3)(C2)C1O
CHEMBL126565 oxyr_rat Rat No 5.5 IC50 = 3000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
383 3 0 4 3.2 COC(=O)c1ccccc1S(=O)(=O)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL340589 oxyr_rat Rat No 5.5 IC50 = 3000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
486 5 1 4 3.4 CC(C)C(=O)NC1C(=O)[C@]2(CS(=O)(=O)N3CCC4(CCc5ccccc54)CC3)CCC1C2(C)C
CHEMBL2112656 oxyr_rat Rat No 4.5 IC50 = 30000 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL335170 oxyr_rat Rat No 4.5 IC50 = 30000 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
402 3 1 3 3.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N)C2
CHEMBL31065 oxyr_rat Rat Yes 5.5 IC50 = 3040 nM Bind
Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)
608 6 1 7 4.7 O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1
CHEMBL129234 oxyr_rat Rat No 6.5 IC50 = 310 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
508 7 1 4 3.8 CCCS(=O)(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL20126 oxyr_rat Rat No 7.5 IC50 = 32 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
527 6 1 5 3.2 CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O
CHEMBL128652 oxyr_rat Rat No 7.5 IC50 = 32 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
638 11 4 6 2.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)CCC(N)=O)C2
CHEMBL265073 oxyr_rat Rat No 7.5 IC50 = 32 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
610 9 0 7 3.9 COC(=O)CCN(C(=O)Cc1cn(C)cn1)[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL2113179 oxyr_human Human No 7.5 IC50 = 32 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
526 9 3 6 2.9 O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(CCCO)cc1)N/N=C1\C(=O)Nc2ccccc21
CHEMBL337888 oxyr_rat Rat No 6.5 IC50 = 330 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
532 8 2 6 2.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CC[N+](=O)[O-])C2
CHEMBL129733 oxyr_rat Rat No 6.5 IC50 = 340 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL126999 oxyr_rat Rat No 6.5 IC50 = 340 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
403 3 1 3 3.5 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](O)C2
CHEMBL52813 oxyr_rat Rat No 5.5 IC50 = 3400 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O
CHEMBL269624 oxyr_rat Rat No 5.5 IC50 = 3400 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
427 3 0 3 4.4 CC1(C)C(=O)[C@]2(CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)CCC1C2(C)C
CHEMBL340920 oxyr_rat Rat No 5.5 IC50 = 3400 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
458 4 1 4 2.8 CC(=O)NC1C(=O)[C@]2(CS(=O)(=O)N3CCC4(CCc5ccccc54)CC3)CCC1C2(C)C
CHEMBL130905 oxyr_rat Rat No 7.5 IC50 = 35 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
514 5 2 5 2.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CN)C1=O)C2
CHEMBL335182 oxyr_rat Rat No 7.5 IC50 = 35 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
549 7 2 5 3.7 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1ccncc1)C2
CHEMBL130695 oxyr_rat Rat No 6.5 IC50 = 350 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
473 5 1 5 3.5 COC(=O)C[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C
CHEMBL363910 oxyr_human Human Yes 6.5 IC50 = 353 nM Bind
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2
CHEMBL130476 oxyr_rat Rat No 7.4 IC50 = 36 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
576 6 1 5 4.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3cccnc3)C1=O)C2
CHEMBL2370768 oxyr_human Human No 4.4 IC50 = 36000 nM Bind
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H]([C@@H](C)c2c(C)cc(OC)cc2C)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O
CHEMBL4205046 oxyr_human Human No 7.4 IC50 = 37 nM Funct
Antagonist activity at OXR receptor (unknown origin)Antagonist activity at OXR receptor (unknown origin)
408 2 1 4 4.9 Cc1ccn(C(=O)Nc2ccc(C(=O)N3CCCCc4ccccc43)c(Cl)c2)n1
CHEMBL132210 oxyr_rat Rat No 7.4 IC50 = 37 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
554 5 2 4 3.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)NC1CN3CCC1CC3)C2
CHEMBL125748 oxyr_rat Rat No 5.4 IC50 = 3700 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
413 3 0 3 4.0 CC1CN(S(=O)(=O)C[C@]23CCC(CC2=O)C3(C)C)CCC12C=Cc1ccccc12
CHEMBL382301 oxyr_human Human Yes 6.4 IC50 = 372 nM Funct
Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced IP1 accumulation measured after 1 hr by fluorescence assayAntagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced IP1 accumulation measured after 1 hr by fluorescence assay
None None None None
CHEMBL340639 oxyr_rat Rat No 7.4 IC50 = 38 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
566 8 3 6 1.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CCS(N)(=O)=O)C2
CHEMBL265630 oxyr_human Human No 6.4 IC50 = 380 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1053 17 11 14 -1.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL337212 oxyr_rat Rat No 6.4 IC50 = 390 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
444 4 1 3 3.6 CC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL338324 oxyr_rat Rat No 5.4 IC50 = 3900 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
401 3 1 3 3.6 CC1(C)C2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@H](O)C2
CHEMBL339498 oxyr_rat Rat No 8.4 IC50 = 4.1 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
622 10 3 7 1.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(CCS(C)(=O)=O)NC(=O)CN)C2
CHEMBL338984 oxyr_rat Rat No 8.4 IC50 = 4.2 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
524 5 0 5 3.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CC#N)C1=O)C2
CHEMBL154668 oxyr_human Human No 8.3 IC50 = 4.6 nM Bind
Antagonist activity at human OXTR expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human OXTR expressed in CHO-K1 cells by PathHunter beta-arrestin assay
554 9 2 7 1.5 Cc1ccccc1N1CCN(S(=O)(=O)CC23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1
CHEMBL2112896 oxyr_rat Rat No 8.3 IC50 = 4.9 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
582 10 1 7 2.1 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(C)C)C3(C)C)CC1
CHEMBL128749 oxyr_rat Rat No 8.3 IC50 = 4.9 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
593 9 1 6 3.0 CN(C)C(CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL393020 oxyr_human Human No 7.4 IC50 = 40 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1033 19 10 14 -1.5 CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL429971 oxyr_rat Rat No 7.4 IC50 = 40 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
542 7 2 6 2.2 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCCN)C1=O)C2
CHEMBL2112663 oxyr_rat Rat No 7.4 IC50 = 40 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
581 8 3 7 1.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@](O)(CNC(=O)C(N)CS(C)(=O)=O)C2
CHEMBL341490 oxyr_rat Rat Yes 5.4 IC50 = 4000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
339 2 0 2 3.7 Cc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1
CHEMBL4576147 oxyr_human Human No 6.4 IC50 = 401 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
411 5 0 8 2.5 COCc1nnc(N2CC3(CCc4cc(F)ccc4O3)C2)n1-c1ccc(OC)nc1
CHEMBL2112655 oxyr_rat Rat No 6.4 IC50 = 410 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL336742 oxyr_rat Rat No 6.4 IC50 = 410 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
502 7 2 4 3.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCC(=O)O)C2
CHEMBL3763951 oxyr_human Human No 5.4 IC50 = 4129 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as inhibition of agonist-induced IP1 accumulation preincubated for 30 mins followed by agonist addition measured after 1 hr by HTRF assayAntagonist activity at human OTR expressed in HEK293 cells assessed as inhibition of agonist-induced IP1 accumulation preincubated for 30 mins followed by agonist addition measured after 1 hr by HTRF assay
609 7 2 8 4.7 COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1
CHEMBL3763951 oxyr_human Human No 5.4 IC50 = 4129 nM Funct
Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
609 7 2 8 4.7 COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1
CHEMBL132389 oxyr_rat Rat No 7.4 IC50 = 42 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
543 8 3 5 3.4 CC(C)C[C@H](N)C(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C
CHEMBL338503 oxyr_rat Rat No 7.4 IC50 = 42 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
556 7 1 5 3.7 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(CCC(=O)O)C1=O)C2
CHEMBL127445 oxyr_rat Rat No 7.4 IC50 = 43 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
529 7 3 5 3.0 CC(C)[C@H](N)C(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C
CHEMBL4543809 oxyr_human Human No 6.4 IC50 = 433 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
425 5 0 6 4.1 COc1ccc(-n2c(C3CC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1
CHEMBL4538696 oxyr_human Human No 7.4 IC50 = 44 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
461 8 0 7 3.7 COc1ccc(-n2c(COCCF)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1
CHEMBL280356 oxyr_rat Rat No 7.4 IC50 = 44 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
557 7 2 6 2.3 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCC(=O)O)C1=O)C2
CHEMBL340204 oxyr_rat Rat No 7.4 IC50 = 45 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O
CHEMBL128417 oxyr_rat Rat No 7.4 IC50 = 45 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
538 7 3 5 3.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1c[nH]cn1)C2
CHEMBL2111851 oxyr_rat Rat No 7.4 IC50 = 45 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
565 8 2 6 2.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCS(C)(=O)=O)C2
CHEMBL338499 oxyr_rat Rat No 7.4 IC50 = 45 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
542 8 2 4 4.9 CCC(C)(C)C(=O)NCC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C
CHEMBL341311 oxyr_rat Rat No 7.4 IC50 = 45 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
539 7 3 5 2.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)Cc1c[nH]cn1)C2
CHEMBL337842 oxyr_rat Rat No 6.4 IC50 = 450 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
416 3 1 4 4.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)/C(=N\O)C2
CHEMBL339698 oxyr_rat Rat No 5.4 IC50 = 4500 nM Bind
Compound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissueCompound was evaluated for half-maximal inhibition of binding of [3H]oxytocin to Oxytocin receptor in rat uterine tissue
557 3 0 3 5.0 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CC1)c1ccccc1C(Br)C3Br)C(=O)C2
CHEMBL339124 oxyr_rat Rat No 7.3 IC50 = 46 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
512 7 2 5 3.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CCC#N)C2
CHEMBL340153 oxyr_rat Rat No 6.3 IC50 = 460 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
477 4 1 3 5.1 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(c1ccccc1)C2
CHEMBL340150 oxyr_rat Rat No 6.3 IC50 = 460 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
445 4 2 3 3.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(N)=O)C2
CHEMBL132210 oxyr_rat Rat No 7.3 IC50 = 47 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
554 5 2 4 3.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)NC1CN3CCC1CC3)C2
CHEMBL338318 oxyr_rat Rat No 6.3 IC50 = 470 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
401 3 1 3 3.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@H](O)C2
CHEMBL334953 oxyr_rat Rat No 6.3 IC50 = 470 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
401 3 1 3 3.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@H](O)C2
CHEMBL128163 oxyr_rat Rat No 7.3 IC50 = 48 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
543 6 1 5 2.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CC(=O)O)C1=O)C2
CHEMBL341338 oxyr_rat Rat No 7.3 IC50 = 48 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
524 6 1 5 3.6 Cn1cncc1CC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL339464 oxyr_rat Rat No 6.3 IC50 = 480 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
606 7 2 4 5.7 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)CC13CC4CC(CC(C4)C1)C3)C2
CHEMBL393021 oxyr_human Human No 6.3 IC50 = 485 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1007 20 11 14 -1.9 CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL130993 oxyr_rat Rat No 7.3 IC50 = 49 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
565 7 2 5 3.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)C1=CCC(=O)N=C1)C2
CHEMBL419973 oxyr_rat Rat No 7.3 IC50 = 49 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
567 8 2 5 3.5 CN(C)[C@H](Cc1c[nH]cn1)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL449399 oxyr_rat Rat No 7.3 IC50 = 49 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
567 6 1 7 2.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(Cc3nn[nH]n3)C1=O)C2
CHEMBL2113177 oxyr_human Human No 7.3 IC50 = 49 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
596 10 3 8 2.8 O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(NCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21
CHEMBL284120 oxyr_human Human No 8.3 IC50 = 5 nM Funct
Inhibitory concentration required for antagonist activity against oxytocin receptorInhibitory concentration required for antagonist activity against oxytocin receptor
635 12 3 6 3.6 CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O
CHEMBL339768 oxyr_rat Rat No 8.2 IC50 = 5.9 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
608 7 2 6 3.1 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CC(=O)Nc3ncc[nH]3)C1=O)C2
CHEMBL337853 oxyr_rat Rat No 7.3 IC50 = 50 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
540 6 4 7 2.1 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1n[nH]c(N)n1)C2
CHEMBL338548 oxyr_rat Rat No 7.3 IC50 = 50 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
543 6 2 5 2.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CC(=O)O)C1=O)C2
CHEMBL339433 oxyr_rat Rat No 7.3 IC50 = 50 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
513 5 2 5 2.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CN1C(=O)CNC1=O)C2
CHEMBL340676 oxyr_rat Rat No 7.3 IC50 = 50 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
638 11 4 6 2.3 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CC(CC(N)=O)NC(=O)Cc1c[nH]cn1)C2
CHEMBL115277 oxyr_rat Rat No 5.3 IC50 = 5000 nM Bind
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
456 6 0 8 5.0 COc1c([C@H](CC(C)C)OC(C)=O)ccc2c1C(=O)OCc1cc(C)cc(OC(C)=O)c1O2
CHEMBL341077 oxyr_rat Rat Yes 5.3 IC50 = 5000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
303 2 0 1 3.8 O=C(Cc1ccccc1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL233328 oxyr_human Human No 7.3 IC50 = 51 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1081 19 10 14 -0.9 CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL415417 oxyr_human Human No 4.3 IC50 = 51700 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
None None None CC(C)C[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(C)(C)C)C(=O)NCC(N)=O
CHEMBL49429 oxyr_human Human Yes 6.3 IC50 = 519 nM Bind
Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsDisplacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells
473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C
CHEMBL4541860 oxyr_human Human No 7.3 IC50 = 52 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
435 5 0 6 4.2 COc1ccc(-n2c(C(F)F)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1
CHEMBL20230 oxyr_rat Rat No 7.3 IC50 = 52 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
510 6 2 4 3.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1c[nH]cn1)C2
CHEMBL338522 oxyr_rat Rat Yes 7.3 IC50 = 52 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
510 6 2 4 3.6 O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C
CHEMBL131551 oxyr_rat Rat No 7.3 IC50 = 53 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
549 7 2 5 3.7 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1cccnc1)C2
CHEMBL336857 oxyr_rat Rat No 6.3 IC50 = 530 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
534 7 1 3 5.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCc1ccccc1)C2
CHEMBL4165525 oxyr_human Human No 5.3 IC50 = 5320 nM Funct
Antagonist activity at human OXTR expressed in CHOK1 cells assessed as oxytocin-induced beta-arrestin recruitment pre-incubated for 30 mins before oxytocin stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human OXTR expressed in CHOK1 cells assessed as oxytocin-induced beta-arrestin recruitment pre-incubated for 30 mins before oxytocin stimulation for 90 or 180 mins by chemiluminescence method
889 21 2 10 3.3 CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC
CHEMBL340915 oxyr_rat Rat No 7.3 IC50 = 54 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
549 8 2 5 2.7 C[S+]([O-])CCC(N)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL127056 oxyr_rat Rat No 6.3 IC50 = 540 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCN2C1=O
CHEMBL434825 oxyr_rat Rat No 5.3 IC50 = 5400 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
401 5 0 4 3.5 CCOC(=O)C1(c2ccccc2)CCN(S(=O)(=O)c2ccc(C)cc2)CC1C
CHEMBL363910 oxyr_rat Rat Yes 7.3 IC50 = 55 nM Funct
Antagonist activity at OXR receptor in rat uterusAntagonist activity at OXR receptor in rat uterus
402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2
CHEMBL233080 oxyr_human Human No 7.3 IC50 = 55 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1062 19 10 14 -0.7 CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N3CCCC[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL131650 oxyr_rat Rat No 7.3 IC50 = 55 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
530 8 3 5 2.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCC(N)=O)C2
CHEMBL127016 oxyr_rat Rat No 6.3 IC50 = 560 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
419 3 1 3 3.7 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(F)ccc43)CC1)[C@H](O)C2
CHEMBL339302 oxyr_rat Rat No 6.3 IC50 = 560 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
419 3 1 3 3.7 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(F)cc43)CC1)[C@H](O)C2
CHEMBL338118 oxyr_rat Rat No 7.2 IC50 = 57 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
567 6 2 5 3.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C1CN3CCC1CC3)C2
CHEMBL338490 oxyr_rat Rat No 6.2 IC50 = 570 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
548 8 1 3 5.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCCc1ccccc1)C2
CHEMBL127117 oxyr_rat Rat No 5.2 IC50 = 5700 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
341 2 0 2 3.7 Cc1ccc(S(=O)(=O)N2CCC3(CCc4ccccc43)CC2)cc1
CHEMBL4161021 oxyr_human Human No 5.2 IC50 = 5760 nM Funct
Antagonist activity at human OXTR expressed in CHOK1 cells assessed as oxytocin-induced beta-arrestin recruitment pre-incubated for 30 mins before oxytocin stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human OXTR expressed in CHOK1 cells assessed as oxytocin-induced beta-arrestin recruitment pre-incubated for 30 mins before oxytocin stimulation for 90 or 180 mins by chemiluminescence method
886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC
CHEMBL339366 oxyr_rat Rat No 6.2 IC50 = 580 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
515 7 2 4 4.0 CC(C)C[C@@H](N)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL382301 oxyr_human Human Yes 7.2 IC50 = 59 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
None None None None
CHEMBL2113203 oxyr_human Human No 7.2 IC50 = 59 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
555 10 2 7 2.9 CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1
CHEMBL125847 oxyr_rat Rat No 6.2 IC50 = 590 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
415 3 1 3 3.8 C[C@@H]1C2CC[C@@](CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)([C@H]1O)C2(C)C
CHEMBL2112248 oxyr_rat Rat No 8.2 IC50 = 6 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCC=NN2C1=O
CHEMBL339756 oxyr_rat Rat No 8.2 IC50 = 6 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
630 9 0 7 3.3 Cn1cnc(CC(=O)N(CCS(C)(=O)=O)[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1
CHEMBL128219 oxyr_rat Rat No 8.2 IC50 = 6.3 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
601 11 4 6 1.7 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CCN)C2
CHEMBL339524 oxyr_rat Rat No 8.2 IC50 = 6.7 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
596 7 4 8 2.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CNc3n[nH]c(N)n3)C1=O)C2
CHEMBL129971 oxyr_rat Rat No 7.2 IC50 = 60 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
538 6 1 5 4.1 CC(C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C)c1cn(C)cn1
CHEMBL336195 oxyr_rat Rat No 7.2 IC50 = 60 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
485 4 1 4 3.1 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1CCC(N)C1=O)C2
CHEMBL4217872 oxyr_human Human No 6.2 IC50 = 600 nM Funct
Antagonist activity at human OTR expressed in HEK cells assessed as inhibition of OT-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assayAntagonist activity at human OTR expressed in HEK cells assessed as inhibition of OT-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay
491 5 3 6 3.3 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=S)N(C)C
CHEMBL594828 oxyr_human Human Yes 6.2 IC50 = 600 nM Funct
Antagonist activity at human OTR receptor expressed in HEK293FT cells assessed as inhibition of LIT-001-induced calcium release by Aequorin based assayAntagonist activity at human OTR receptor expressed in HEK293FT cells assessed as inhibition of LIT-001-induced calcium release by Aequorin based assay
419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1
CHEMBL129104 oxyr_rat Rat No 6.2 IC50 = 600 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
415 3 1 3 4.0 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@](C)(O)C2
CHEMBL126195 oxyr_rat Rat Yes 5.2 IC50 = 6000 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
355 3 0 3 3.4 COc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1
CHEMBL128228 oxyr_rat Rat No 7.2 IC50 = 61 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
542 6 2 5 2.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CN1CC[C@H](N)C1=O)C2
CHEMBL132211 oxyr_rat Rat No 7.2 IC50 = 61 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
544 8 2 5 2.3 CN(C)CC(=O)NCC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C
CHEMBL339783 oxyr_rat Rat No 6.2 IC50 = 620 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
512 5 1 4 5.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1cccs1)C2
CHEMBL126824 oxyr_rat Rat No 5.2 IC50 = 6200 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
413 3 0 3 4.1 Cc1cccc2c1C1(C=C2)CCN(S(=O)(=O)C[C@]23CCC(CC2=O)C3(C)C)CC1
CHEMBL129581 oxyr_rat Rat No 5.2 IC50 = 6200 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
413 3 0 3 4.1 Cc1cccc2c1C=CC21CCN(S(=O)(=O)C[C@]23CCC(CC2=O)C3(C)C)CC1
CHEMBL4452863 oxyr_human Human No 6.2 IC50 = 624 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
429 6 0 7 3.4 COCc1nnc(N2C[C@H]3C[C@@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1
CHEMBL594828 oxyr_human Human Yes 7.2 IC50 = 63 nM Funct
Antagonist activity at human OTR receptor expressed in HEK293FT cells assessed as inhibition of LIT-001-induced response incubated for 30 mins by beta-arrestin recruitment assayAntagonist activity at human OTR receptor expressed in HEK293FT cells assessed as inhibition of LIT-001-induced response incubated for 30 mins by beta-arrestin recruitment assay
419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1
CHEMBL338235 oxyr_rat Rat No 6.2 IC50 = 630 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
429 4 1 3 4.3 CC[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C
CHEMBL279022 oxyr_rat Rat No 7.2 IC50 = 64 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
589 7 1 5 4.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2
CHEMBL24781 oxyr_rat Rat Yes 6.2 IC50 = 640 nM Funct
Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)
507 5 0 6 3.8 COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C
CHEMBL129246 oxyr_rat Rat No 5.2 IC50 = 6400 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
359 3 0 3 3.1 O=C1CCCCC1CS(=O)(=O)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL419793 oxyr_rat Rat No 7.2 IC50 = 65 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O
CHEMBL132496 oxyr_rat Rat No 7.2 IC50 = 65 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
524 6 1 5 3.6 Cn1cnc(CC(=O)N[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1
CHEMBL341470 oxyr_rat Rat No 6.2 IC50 = 650 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
414 3 1 4 4.0 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)/C(=N\O)C2
CHEMBL435398 oxyr_rat Rat No 6.2 IC50 = 650 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
512 5 1 3 5.2 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CCCCC1)C2
CHEMBL340465 oxyr_rat Rat No 5.2 IC50 = 6500 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
430 3 0 4 2.7 CN1C(=O)C2(CCN(S(=O)(=O)C[C@]34CCC(CC3=O)C4(C)C)CC2)c2ccccc21
CHEMBL129955 oxyr_rat Rat No 5.2 IC50 = 6500 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
402 3 1 3 3.5 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](N)C2
CHEMBL129089 oxyr_rat Rat No 6.2 IC50 = 660 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL338981 oxyr_rat Rat No 6.2 IC50 = 670 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL325752 oxyr_rat Rat Yes 4.2 IC50 = 67000 nM Bind
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
372 4 2 6 4.3 COc1c([C@@H](O)CC(C)C)ccc2c1C(=O)OCc1cc(C)cc(O)c1O2
CHEMBL4475530 oxyr_human Human No 5.2 IC50 = 6759 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
397 5 0 8 2.2 COCc1nnc(N2CC3(C2)OCc2cc(F)ccc23)n1-c1ccc(OC)nc1
CHEMBL4168948 oxyr_human Human No 5.2 IC50 = 6780 nM Funct
Antagonist activity at human OXTR expressed in CHOK1 cells assessed as oxytocin-induced beta-arrestin recruitment pre-incubated for 30 mins before oxytocin stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human OXTR expressed in CHOK1 cells assessed as oxytocin-induced beta-arrestin recruitment pre-incubated for 30 mins before oxytocin stimulation for 90 or 180 mins by chemiluminescence method
886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC
CHEMBL277400 oxyr_human Human No 7.2 IC50 = 68 nM Funct
Antagonistic activity against Oxytocin receptorAntagonistic activity against Oxytocin receptor
513 5 2 4 3.6 CC1(C)C2CCC1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C(NC(=O)C1CCCNC1)C2
CHEMBL421248 oxyr_rat Rat No 7.2 IC50 = 68 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
539 7 3 4 3.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)NCCc1c[nH]cn1)C2
CHEMBL395290 oxyr_human Human No 8.2 IC50 = 7 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL19658 oxyr_rat Rat No 8.2 IC50 = 7 nM Bind
Inhibition of binding of [3H]oxytocin to rat uterine oxytocin receptorInhibition of binding of [3H]oxytocin to rat uterine oxytocin receptor
499 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2
CHEMBL2113185 oxyr_human Human No 8.2 IC50 = 7 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
597 10 2 8 2.7 O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21
CHEMBL2113208 oxyr_human Human No 8.2 IC50 = 7 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
586 13 2 8 3.1 COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1
CHEMBL436189 oxyr_rat Rat No 8.1 IC50 = 7.6 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
701 12 4 8 1.9 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C(CCS(C)(=O)=O)NC(=O)Cc1c[nH]cn1)C2
CHEMBL341108 oxyr_rat Rat No 5.2 IC50 = 7100 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
343 2 0 2 3.6 O=S(=O)(c1ccc(F)cc1)N1CCC2(C=Cc3ccccc32)CC1
CHEMBL405289 oxyr_rat Rat No 7.1 IC50 = 72 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL435159 oxyr_human Human No 6.1 IC50 = 730 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL284442 oxyr_rat Rat No 6.1 IC50 = 744 nM Bind
Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)
609 6 1 8 4.1 O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cnc2o1
CHEMBL395430 oxyr_human Human No 7.1 IC50 = 75 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
CHEMBL129513 oxyr_rat Rat No 6.1 IC50 = 760 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
363 2 0 2 4.4 CC1(C)C2CC[C@@]1(CC(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2
CHEMBL128978 oxyr_rat Rat No 5.1 IC50 = 7600 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
433 3 0 3 4.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(Cl)ccc43)CC1)C(=O)C2
CHEMBL340588 oxyr_rat Rat No 5.1 IC50 = 7600 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
433 3 0 3 4.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(Cl)cc43)CC1)C(=O)C2
CHEMBL127049 oxyr_rat Rat No 6.1 IC50 = 770 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
440 4 1 4 3.8 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC#N)C2
CHEMBL131499 oxyr_rat Rat No 6.1 IC50 = 770 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
440 4 1 4 3.8 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC#N)C2
CHEMBL4203314 oxyr_human Human No 6.1 IC50 = 775 nM Funct
Antagonist activity at human OTR expressed in HEK cells assessed as inhibition of OT-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assayAntagonist activity at human OTR expressed in HEK cells assessed as inhibition of OT-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay
475 5 3 6 2.5 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=O)N(C)C
CHEMBL339681 oxyr_rat Rat Yes 6.1 IC50 = 780 nM Bind
Half-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissueHalf-maximal inhibition of binding of [3H]oxytocin to OT receptor in rat uterine tissue
459 5 2 4 3.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2
CHEMBL232501 oxyr_human Human No 5.1 IC50 = 7850 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1035 18 11 14 -1.3 CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C(C)(C)C)NC2=O)cc1
CHEMBL337615 oxyr_rat Rat No 7.1 IC50 = 79 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
549 7 2 5 4.1 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1ccncc1)C2
CHEMBL2369136 oxyr_human Human No 8.1 IC50 = 8 nM Bind
Binding affinity towards oxytocin receptorBinding affinity towards oxytocin receptor
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H]([C@@H](C)c2c(C)cc(OC)cc2C)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O
CHEMBL2113211 oxyr_human Human No 8.1 IC50 = 8 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
542 10 2 7 3.0 COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1
CHEMBL2112250 oxyr_rat Rat No 8.1 IC50 = 8.3 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL337889 oxyr_rat Rat No 8.1 IC50 = 8.3 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
637 10 4 6 3.2 CC(C)[C@H](NC(=O)Cc1c[nH]cn1)C(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C
CHEMBL435021 oxyr_rat Rat No 8.1 IC50 = 8.4 nM Bind
Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.
None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CNCCN2C(=O)[C@H]2CCCCN2C1=O
CHEMBL2112903 oxyr_rat Rat No 8.1 IC50 = 8.9 nM Bind
Displacement of [3H]OT from binding to oxytocin receptor of rat uterusDisplacement of [3H]OT from binding to oxytocin receptor of rat uterus
554 9 2 7 1.5 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1
CHEMBL1253853 oxyr_rat Rat Yes 8.1 IC50 = 8.9 nM Bind
Inhibition of rat uterus OT receptorInhibition of rat uterus OT receptor
554 9 2 7 1.5 O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C
CHEMBL438849 oxyr_human Human No 7.1 IC50 = 80 nM Bind
Displacement of [3H]OT from human OT receptor expressed in HEK cellsDisplacement of [3H]OT from human OT receptor expressed in HEK cells
1110 19 10 14 -0.1 CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1
CHEMBL132165 oxyr_rat Rat No 7.1 IC50 = 80 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
517 8 3 5 2.7 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CCCO)C2
CHEMBL341339 oxyr_rat Rat No 6.1 IC50 = 800 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
459 5 2 4 3.4 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2
CHEMBL128423 oxyr_rat Rat No 7.1 IC50 = 81 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
549 7 2 5 3.7 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1ccccn1)C2
CHEMBL4580413 oxyr_human Human No 6.1 IC50 = 826 nM Funct
Antagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assayAntagonist activity at human OTR expressed in HEK293 cells assessed as decrease in calcium flux measured after 10 mins in presence of vasopressin by Fluo-4 dye based microplate reader based assay
499 7 0 8 3.9 COc1ccc(-n2c(COC3CCOCC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1
CHEMBL128879 oxyr_rat Rat No 6.1 IC50 = 830 nM Bind
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissueInhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
510 6 2 4 3.6 CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](NC(=O)Cc1c[nH]cn1)C2
CHEMBL2113200 oxyr_human Human No 6.1 IC50 = 840 nM Funct
Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cellsInhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells
570 11 2 8 2.7 CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1
CHEMBL116226 oxyr_rat Rat No 5.1 IC50 = 8400 nM Bind
Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissueCompound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue
414 5 1 7 4.8 COc1c([C@H](CC(C)C)OC(C)=O)ccc2c1C(=O)OCc1cc(C)cc(O)c1O2
CHEMBL4591943 oxyr_human Human No 6.1