Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
155531953 171746 0 None -2 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 171746 0 None -2 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155563693 175394 0 None 36 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 175394 0 None 36 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
11332190 909 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
156598973 909 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 909 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 909 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
11332190 909 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
156598973 909 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 909 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 909 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 215163 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155538662 172417 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 172417 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5088494 215163 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082551 214809 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.0c01804
168275711 190217 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 635 11 2 9 6.0 Cc1ccc(-c2nc(=O)s[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(C4CC4)s3)cc2)c1 10.1016/j.bmc.2021.116587
CHEMBL5174724 190217 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 635 11 2 9 6.0 Cc1ccc(-c2nc(=O)s[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(C4CC4)s3)cc2)c1 10.1016/j.bmc.2021.116587
168293038 192123 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 613 10 2 9 5.3 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(=O)(=O)C1CC1 10.1016/j.bmc.2021.116587
CHEMBL5203480 192123 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 613 10 2 9 5.3 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(=O)(=O)C1CC1 10.1016/j.bmc.2021.116587
CHEMBL5077507 214501 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5077507 214501 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5082551 214809 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.0c01804
168291719 191958 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 587 9 2 9 4.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(C)(=O)=O 10.1016/j.bmc.2021.116587
CHEMBL5200919 191958 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 587 9 2 9 4.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(C)(=O)=O 10.1016/j.bmc.2021.116587
168269858 189975 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 642 13 2 8 6.2 CCONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5170854 189975 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 642 13 2 8 6.2 CCONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
168292803 192063 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202580 192063 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
168292522 192042 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 639 11 2 9 5.9 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202223 192042 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 639 11 2 9 5.9 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519637 170422 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448308 170422 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155530073 171492 0 None 10 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4463797 171492 0 None 10 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519352 170441 3 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 170441 3 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5085505 214970 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5085505 214970 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5080998 214714 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCc1ccccc1 10.1021/acs.jmedchem.0c01804
CHEMBL5080998 214714 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCc1ccccc1 10.1021/acs.jmedchem.0c01804
CHEMBL5092307 215358 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
168286108 191388 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 510 8 2 7 5.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)O 10.1016/j.bmc.2021.116587
CHEMBL5192437 191388 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 510 8 2 7 5.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)O 10.1016/j.bmc.2021.116587
168284015 191251 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5190234 191251 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5092307 215358 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155537257 172267 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4474605 172267 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
155548932 173822 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4538515 173822 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
168280867 190763 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 601 10 2 9 5.2 CCS(=O)(=O)NC(=O)c1nc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)sc1C 10.1016/j.bmc.2021.116587
CHEMBL5183095 190763 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 601 10 2 9 5.2 CCS(=O)(=O)NC(=O)c1nc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)sc1C 10.1016/j.bmc.2021.116587
155544237 173367 0 None 3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 173367 0 None 3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
11936 988 5 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
162679547 988 5 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
CHEMBL5180985 988 5 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
168282236 190963 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 628 12 2 8 5.8 CONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5185986 190963 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 628 12 2 8 5.8 CONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
155535518 172068 0 None 4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472121 172068 0 None 4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5092307 215358 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155535988 172109 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472664 172109 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5082981 214835 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082981 214835 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155518713 170280 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4446260 170280 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL5089041 215193 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(N)=O 10.1021/acs.jmedchem.0c01804
CHEMBL5089041 215193 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(N)=O 10.1021/acs.jmedchem.0c01804
CHEMBL5092307 215358 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 215163 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 215163 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155538284 172399 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4476545 172399 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155569501 176192 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
CHEMBL4593522 176192 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
11332190 909 12 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
156598973 909 12 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 909 12 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 909 12 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
11332190 909 12 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
156598973 909 12 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 909 12 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 909 12 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
155554828 174620 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 174620 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5082981 214835 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082981 214835 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
162649940 179995 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746987 179995 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
162656586 180897 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 530 8 2 7 6.2 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4757632 180897 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 530 8 2 7 6.2 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
162674241 183216 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 518 9 1 8 6.4 CCCCN(c1nc2c(-c3nccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796012 183216 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 518 9 1 8 6.4 CCCCN(c1nc2c(-c3nccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162671889 182857 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(F)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791599 182857 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(F)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168284015 191251 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5190234 191251 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155548932 173822 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4538515 173822 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
162654876 180589 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 8 2 7 5.5 C[C@H](c1ccc(-c2ccccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4754349 180589 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 8 2 7 5.5 C[C@H](c1ccc(-c2ccccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
155531953 171746 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4467290 171746 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162655374 180810 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2c(C(=O)NC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4756747 180810 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2c(C(=O)NC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162677428 183496 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4799609 183496 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155531953 171746 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 171746 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168292803 192063 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202580 192063 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519637 170422 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448308 170422 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519969 170364 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 492 8 1 6 6.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 10.1016/j.bmc.2019.115091
CHEMBL4447627 170364 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 492 8 1 6 6.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 10.1016/j.bmc.2019.115091
162649290 180161 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 509 9 1 7 5.7 CCCCN(c1nc2c(C(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4748968 180161 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 509 9 1 7 5.7 CCCCN(c1nc2c(C(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162663355 181910 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 517 9 1 7 7.0 CCCCN(c1nc2c(-c3cccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4779379 181910 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 517 9 1 7 7.0 CCCCN(c1nc2c(-c3cccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162654668 179927 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(-c3nnn[nH]3)cccc2C(F)(F)F)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746196 179927 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(-c3nnn[nH]3)cccc2C(F)(F)F)cc1 10.1016/j.bmc.2020.115622
162654348 180606 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C(F)(F)F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4754530 180606 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C(F)(F)F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162648650 179894 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 531 10 2 8 5.4 CCCCN(c1nc2c(NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4745883 179894 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 531 10 2 8 5.4 CCCCN(c1nc2c(NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162660049 181360 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 559 10 2 9 4.7 CCCCN(c1nc2c(C(=O)NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4763169 181360 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 559 10 2 9 4.7 CCCCN(c1nc2c(C(=O)NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168282945 190758 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1681 55 6 25 8.6 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCn2nnc3c2-c2ccccc2N(C(=O)CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]4NC(=O)N[C@@H]42)Cc2ccccc2-3)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5183004 190758 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1681 55 6 25 8.6 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCn2nnc3c2-c2ccccc2N(C(=O)CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]4NC(=O)N[C@@H]42)Cc2ccccc2-3)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519352 170441 3 None 1 2 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 170441 3 None 1 2 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155531953 171746 0 None 2 3 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 171746 0 None 2 3 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162659559 181291 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(F)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4762253 181291 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(F)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162671930 182904 3 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 9 2 7 5.7 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4792296 182904 3 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 9 2 7 5.7 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162673878 182988 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 514 8 2 7 5.7 C[C@H](c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4793378 182988 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 514 8 2 7 5.7 C[C@H](c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
162673026 183068 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 516 9 2 7 6.0 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4794289 183068 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 516 9 2 7 6.0 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
162657219 180870 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(C)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4757393 180870 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(C)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155538662 172417 0 None -2 2 Mouse 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 172417 0 None -2 2 Mouse 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162654669 179928 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(C)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746197 179928 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(C)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162649970 180059 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2c(NC(C)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4747813 180059 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2c(NC(C)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155569501 176192 0 None -1 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
CHEMBL4593522 176192 0 None -1 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
162653266 180402 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 2 7 5.5 CCCCN(c1nc2c(CO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4752027 180402 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 2 7 5.5 CCCCN(c1nc2c(CO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155543662 173208 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 10 1 8 5.2 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4522836 173208 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 10 1 8 5.2 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
155530073 171492 0 None 10 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4463797 171492 0 None 10 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155537257 172267 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4474605 172267 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
155567133 175879 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 10.1016/j.bmc.2019.115091
CHEMBL4586253 175879 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 10.1016/j.bmc.2019.115091
162671660 182882 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 539 11 2 8 5.1 CCCCN(c1nc2c(C(=O)N(C)CCO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791896 182882 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 539 11 2 8 5.1 CCCCN(c1nc2c(C(=O)N(C)CCO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162661813 181456 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 453 8 2 7 5.6 CCCCN(c1nc2c(N)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4764426 181456 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 453 8 2 7 5.6 CCCCN(c1nc2c(N)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155526368 171145 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 459 7 1 7 5.3 c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)nc1 10.1016/j.bmc.2019.115091
CHEMBL4458521 171145 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 459 7 1 7 5.3 c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)nc1 10.1016/j.bmc.2019.115091
162662697 181990 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 10 1 7 6.2 CCCCN(c1nc2c(COC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4780439 181990 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 10 1 7 6.2 CCCCN(c1nc2c(COC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162641724 182257 5 None - 1 Human 8.5 pIC50 = 8.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
CHEMBL4783675 182257 5 None - 1 Human 8.5 pIC50 = 8.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
162652190 180345 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccncc3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4751327 180345 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccncc3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162670503 182966 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(OC)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4793031 182966 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(OC)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155554828 174620 0 None -1 2 Mouse 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 174620 0 None -1 2 Mouse 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162654920 180565 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2c(NC(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4754029 180565 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2c(NC(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155535988 172109 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472664 172109 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162674418 183249 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 504 9 1 8 6.2 CCCCN(c1nc2c(-n3cccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796399 183249 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 504 9 1 8 6.2 CCCCN(c1nc2c(-n3cccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155518713 170280 0 None 2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4446260 170280 0 None 2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155538284 172399 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4476545 172399 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155550367 174290 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 10.1016/j.bmc.2019.115091
CHEMBL4549880 174290 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 10.1016/j.bmc.2019.115091
155554828 174620 0 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 174620 0 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162649458 180063 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 9 2 7 6.3 CCCCN(c1nc2c(C(C)(C)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4747865 180063 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 9 2 7 6.3 CCCCN(c1nc2c(C(C)(C)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155550204 173851 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 426 8 1 7 4.3 COCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4539132 173851 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 426 8 1 7 4.3 COCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
162645029 179463 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(Cl)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4740735 179463 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(Cl)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155544237 173367 0 None 3 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 173367 0 None 3 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519352 170441 3 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 170441 3 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168276231 190422 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 626 12 2 7 6.3 CCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5177967 190422 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 626 12 2 7 6.3 CCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
155564611 175525 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 482 9 1 8 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4578235 175525 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 482 9 1 8 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
155538662 172417 0 None 2 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 172417 0 None 2 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155563693 175394 0 None 36 2 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 175394 0 None 36 2 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155544237 173367 0 None -3 2 Mouse 6.3 pIC50 = 6.3 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 173367 0 None -3 2 Mouse 6.3 pIC50 = 6.3 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168286341 191691 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 682 16 2 7 7.9 CCCCCCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5196772 191691 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 682 16 2 7 7.9 CCCCCCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
162668192 182430 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4786002 182430 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162653225 180401 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(F)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4752019 180401 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(F)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162647018 179535 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 523 10 1 7 6.1 CCCCN(c1nc2c(C(=O)N(C)CC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4741497 179535 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 523 10 1 7 6.1 CCCCN(c1nc2c(C(=O)N(C)CC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162672104 182858 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791613 182858 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162648558 179907 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746011 179907 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155525712 171075 0 None 1 2 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4457246 171075 0 None 1 2 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155516007 170031 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4442745 170031 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162675068 183275 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(OC)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796678 183275 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(OC)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168294228 192224 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1263 36 3 18 8.8 CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc([C@@H](C)N(CC4CC4)c4nc(C(=O)NS(=O)(=O)C5CC5)c(C5CC5)s4)cc3)c2-c2ccccc21 10.1016/j.bmc.2021.116587
CHEMBL5204898 192224 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1263 36 3 18 8.8 CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc([C@@H](C)N(CC4CC4)c4nc(C(=O)NS(=O)(=O)C5CC5)c(C5CC5)s4)cc3)c2-c2ccccc21 10.1016/j.bmc.2021.116587
155563693 175394 0 None -36 2 Mouse 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 175394 0 None -36 2 Mouse 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155535518 172068 0 None 4 2 Human 6.0 pIC50 = 6.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472121 172068 0 None 4 2 Human 6.0 pIC50 = 6.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
2945 908 0 None -14 2 Human 8.0 pEC50 = 8.0 Functional
In a β-arrestin recruitment assay.In a β-arrestin recruitment assay.
Guide to Pharmacology None None None None 25437209
2945 908 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14530373
2945 908 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
2945 908 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
2945 908 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23396314
1518 368 2 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
9781 368 2 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
CHEMBL1358898 368 2 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
12979 3439 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Determined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisationDetermined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisation
Guide to Pharmacology 570 9 2 5 7.9 C[C@@H](CC(O)=O)C1=CC=C(OCC2=CC3=C(C(=NN3C4CCCC4)C5=CC(Cl)=C(CO)C(Cl)=C5)C(F)=C2)C=C1 37883692
169422750 3439 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Determined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisationDetermined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisation
Guide to Pharmacology 570 9 2 5 7.9 C[C@@H](CC(O)=O)C1=CC=C(OCC2=CC3=C(C(=NN3C4CCCC4)C5=CC(Cl)=C(CO)C(Cl)=C5)C(F)=C2)C=C1 37883692
12980 2289 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 442 8 1 5 5.6 CC(C)N1N=C(C2=C1C=C(COC3=CC=C(C=C3)[C@H](C)C(=O)C(O)=O)C=C2)C4=CC=CC=C4 37883692
169422751 2289 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 442 8 1 5 5.6 CC(C)N1N=C(C2=C1C=C(COC3=CC=C(C=C3)[C@H](C)C(=O)C(O)=O)C=C2)C4=CC=CC=C4 37883692
11936 988 5 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894
162679547 988 5 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894
CHEMBL5180985 988 5 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

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weight		 Rot
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 DOI
162649940 179995 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746987 179995 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
155519352 170441 3 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 170441 3 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162641724 182257 5 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
CHEMBL4783675 182257 5 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
9784 3787 0 None - 0 Human 8.3 pIC50 ~ 8.3 Binding
Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.
Guide to Pharmacology None None None None 14530373
9784 3787 0 None - 0 Human 8.3 pIC50 ~ 8.3 Binding
Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.
Guide to Pharmacology None None None None 24659779
11332190 909 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
11332190 909 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
156598973 909 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
156598973 909 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
3422 909 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
3422 909 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
CHEMBL5081975 909 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
CHEMBL5081975 909 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
10473088 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
10473088 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
10473088 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
3333 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
3333 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
3333 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
CHEMBL1742483 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
CHEMBL1742483 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
CHEMBL1742483 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
DB13105 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
DB13105 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
DB13105 3319 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
2945 908 0 None 1 2 Human 8.3 pKd = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312