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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	11272103	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.03.065
	CHEMBL363840	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.03.065
	11272103	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.11.087
	CHEMBL363840	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.11.087
	11272103	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nMAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nM	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.11.087
	CHEMBL363840	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nMAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nM	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.11.087
	11272103	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.11.067
	CHEMBL363840	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.11.067
	11272103	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm049530m
	CHEMBL363840	124442	None	0	Human	Functional	pIC50	=	11	11.0	-37	8	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm049530m
	44455820	95495	None	0	Human	Functional	pIC50	=	11.0	11.0	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	551	11	3	7	4.9	CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1	10.1016/j.bmcl.2007.11.067
	CHEMBL257074	95495	None	0	Human	Functional	pIC50	=	11.0	11.0	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	551	11	3	7	4.9	CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1	10.1016/j.bmcl.2007.11.067
	10458976	95064	None	0	Human	Functional	pIC50	=	10.9	10.9	-	1	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil	ChEMBL	509	9	3	7	3.4	CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	CHEMBL254930	95064	None	0	Human	Functional	pIC50	=	10.9	10.9	-	1	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil	ChEMBL	509	9	3	7	3.4	CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	44455711	168836	None	0	Human	Functional	pIC50	=	10.9	10.9	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	509	9	3	7	3.8	CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	CHEMBL437031	168836	None	0	Human	Functional	pIC50	=	10.9	10.9	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	509	9	3	7	3.8	CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	11340670	127301	None	0	Human	Functional	pIC50	=	10.8	10.8	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	483	7	2	3	5.8	CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F	10.1021/jm049530m
	CHEMBL365820	127301	None	0	Human	Functional	pIC50	=	10.8	10.8	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	483	7	2	3	5.8	CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F	10.1021/jm049530m
	11328714	79029	None	0	Human	Functional	pIC50	=	10.8	10.8	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	462	6	3	2	5.9	O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1021/jm049530m
	CHEMBL2113074	79029	None	0	Human	Functional	pIC50	=	10.8	10.8	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	462	6	3	2	5.9	O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1021/jm049530m
	44455686	95545	None	0	Human	Functional	pIC50	=	10.7	10.7	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	523	9	3	7	4.3	CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	CHEMBL257293	95545	None	0	Human	Functional	pIC50	=	10.7	10.7	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	523	9	3	7	4.3	CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	44455869	97598	None	0	Human	Functional	pIC50	=	10.7	10.7	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	507	9	2	7	4.1	CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	CHEMBL270582	97598	None	0	Human	Functional	pIC50	=	10.7	10.7	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	507	9	2	7	4.1	CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	44455509	166521	None	0	Human	Functional	pIC50	=	10.7	10.7	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	493	9	2	6	4.4	CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	CHEMBL427728	166521	None	0	Human	Functional	pIC50	=	10.7	10.7	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	493	9	2	6	4.4	CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	44455485	155588	None	0	Human	Functional	pIC50	=	10.7	10.7	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	507	9	2	6	5.0	CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	CHEMBL404122	155588	None	0	Human	Functional	pIC50	=	10.7	10.7	-	1	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	507	9	2	6	5.0	CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.067
	11329244	71140	None	6	Human	Functional	pIC50	=	10.5	10.5	20	7	Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils	ChEMBL	486	7	2	5	5.4	CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C	10.1016/j.bmcl.2007.03.065
	CHEMBL195433	71140	None	6	Human	Functional	pIC50	=	10.5	10.5	20	7	Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils	ChEMBL	486	7	2	5	5.4	CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C	10.1016/j.bmcl.2007.03.065
	11329244	71140	None	6	Human	Functional	pIC50	=	10.5	10.5	20	7	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	486	7	2	5	5.4	CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C	10.1021/jm049530m
	CHEMBL195433	71140	None	6	Human	Functional	pIC50	=	10.5	10.5	20	7	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	486	7	2	5	5.4	CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C	10.1021/jm049530m
	11227406	94398	None	2	Human	Functional	pIC50	=	10.5	10.5	107	4	Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.03.065
	CHEMBL250689	94398	None	2	Human	Functional	pIC50	=	10.5	10.5	107	4	Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.03.065
	11227406	94398	None	2	Human	Functional	pIC50	=	10.5	10.5	107	4	Antagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assay	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm300682j
	CHEMBL250689	94398	None	2	Human	Functional	pIC50	=	10.5	10.5	107	4	Antagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assay	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm300682j
	11227406	94398	None	2	Human	Functional	pIC50	=	10.5	10.5	107	4	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.11.067
	CHEMBL250689	94398	None	2	Human	Functional	pIC50	=	10.5	10.5	107	4	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1016/j.bmcl.2007.11.067
	11227406	94398	None	2	Human	Functional	pIC50	=	10.5	10.5	107	4	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm049530m
	CHEMBL250689	94398	None	2	Human	Functional	pIC50	=	10.5	10.5	107	4	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm049530m
	10050884	154742	None	15	Human	Functional	pIC50	=	10.4	10.4	-1	3	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2007.11.087
	CHEMBL399495	154742	None	15	Human	Functional	pIC50	=	10.4	10.4	-1	3	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2007.11.087
	11227406	94398	None	2	Human	Functional	pIC50	=	10.4	10.4	107	4	Inhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophilsInhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophils	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm049530m
	CHEMBL250689	94398	None	2	Human	Functional	pIC50	=	10.4	10.4	107	4	Inhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophilsInhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophils	ChEMBL	465	7	2	3	5.7	CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm049530m
	10050884	154742	None	15	Human	Functional	pIC50	=	10.4	10.4	-1	3	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2007.11.067
	CHEMBL399495	154742	None	15	Human	Functional	pIC50	=	10.4	10.4	-1	3	Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2007.11.067
	11169258	140984	None	0	Human	Functional	pIC50	=	10.4	10.4	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	587	8	2	10	3.8	Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1021/jm049530m
	CHEMBL382108	140984	None	0	Human	Functional	pIC50	=	10.4	10.4	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	587	8	2	10	3.8	Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1	10.1021/jm049530m
	11488078	79032	None	0	Human	Functional	pIC50	=	10.4	10.4	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	463	6	3	3	5.3	O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1021/jm049530m
	CHEMBL2113077	79032	None	0	Human	Functional	pIC50	=	10.4	10.4	-	1	Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils	ChEMBL	463	6	3	3	5.3	O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1021/jm049530m

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	38347547	146543	None	8	Human	Binding	pEC50	=	5.9	5.9	-	0	Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay	ChEMBL	430	11	0	7	4.5	C=CCc1cc(OC)c(O[C@@H](C)[C@H](OC(C)=O)c2ccc(OC)c(OC)c2)c(OC)c1	10.1021/acs.jnatprod.6b00262
	CHEMBL3922119	146543	None	8	Human	Binding	pEC50	=	5.9	5.9	-	0	Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay	ChEMBL	430	11	0	7	4.5	C=CCc1cc(OC)c(O[C@@H](C)[C@H](OC(C)=O)c2ccc(OC)c(OC)c2)c(OC)c1	10.1021/acs.jnatprod.6b00262
	25751147	150048	None	3	Human	Binding	pEC50	=	5.8	5.8	-	0	Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay	ChEMBL	404	10	2	7	3.7	C=CCc1cc(OC)c(O[C@H](C)[C@@H](O)c2cc(OC)c(O)c(OC)c2)c(OC)c1	10.1021/acs.jnatprod.6b00262
	CHEMBL3949874	150048	None	3	Human	Binding	pEC50	=	5.8	5.8	-	0	Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay	ChEMBL	404	10	2	7	3.7	C=CCc1cc(OC)c(O[C@H](C)[C@@H](O)c2cc(OC)c(O)c(OC)c2)c(OC)c1	10.1021/acs.jnatprod.6b00262
	124396489	144552	None	10	Human	Binding	pEC50	=	5.8	5.8	-	0	Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay	ChEMBL	356	5	1	5	4.7	C/C=C/c1cc(OC)c2c(c1)[C@@H](C)[C@H](c1cc(OC)c(O)c(OC)c1)O2	10.1021/acs.jnatprod.6b00262
	CHEMBL3906647	144552	None	10	Human	Binding	pEC50	=	5.8	5.8	-	0	Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay	ChEMBL	356	5	1	5	4.7	C/C=C/c1cc(OC)c2c(c1)[C@@H](C)[C@H](c1cc(OC)c(O)c(OC)c1)O2	10.1021/acs.jnatprod.6b00262
	10474776	113721	None	32	Human	Binding	pEC50	=	6.1	6.1	-	0	Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay	ChEMBL	378	6	1	5	3.3	COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12	10.1021/acs.jnatprod.6b00262
	CHEMBL33227	113721	None	32	Human	Binding	pEC50	=	6.1	6.1	-	0	Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay	ChEMBL	378	6	1	5	3.3	COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12	10.1021/acs.jnatprod.6b00262
	11272103	124442	None	0	Rat	Binding	pIC50	=	11	11.0	-	0	Inhibition of eotaxin-induced chemotaxis of rat eosinophilsInhibition of eotaxin-induced chemotaxis of rat eosinophils	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm049530m
	CHEMBL363840	124442	None	0	Rat	Binding	pIC50	=	11	11.0	-	0	Inhibition of eotaxin-induced chemotaxis of rat eosinophilsInhibition of eotaxin-induced chemotaxis of rat eosinophils	ChEMBL	505	7	2	6	4.7	Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1	10.1021/jm049530m
	44570583	191051	None	0	Human	Binding	pIC50	=	9.9	9.9	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	550	7	2	8	3.3	CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O	10.1016/j.bmcl.2008.11.002
	CHEMBL505914	191051	None	0	Human	Binding	pIC50	=	9.9	9.9	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	550	7	2	8	3.3	CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O	10.1016/j.bmcl.2008.11.002
	CHEMBL518571	191051	None	0	Human	Binding	pIC50	=	9.9	9.9	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	550	7	2	8	3.3	CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O	10.1016/j.bmcl.2008.11.002
	44570583	191051	None	0	Human	Binding	pIC50	=	9.8	9.8	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	550	7	2	8	3.3	CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O	10.1016/j.bmcl.2008.11.002
	CHEMBL505914	191051	None	0	Human	Binding	pIC50	=	9.8	9.8	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	550	7	2	8	3.3	CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O	10.1016/j.bmcl.2008.11.002
	CHEMBL518571	191051	None	0	Human	Binding	pIC50	=	9.8	9.8	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	550	7	2	8	3.3	CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O	10.1016/j.bmcl.2008.11.002
	44593547	176971	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	538	10	2	8	3.3	CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1	10.1016/j.bmcl.2008.11.002
	CHEMBL461445	176971	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	538	10	2	8	3.3	CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1	10.1016/j.bmcl.2008.11.002
	44447136	94605	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	469	11	3	7	2.8	CCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	CHEMBL251837	94605	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	469	11	3	7	2.8	CCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	44447381	94944	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	511	12	3	7	3.8	CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)CCc2ccc(F)cc2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	CHEMBL254095	94944	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	511	12	3	7	3.8	CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)CCc2ccc(F)cc2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	44447137	154242	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	483	12	3	7	3.2	CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	CHEMBL398548	154242	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	483	12	3	7	3.2	CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	44570537	178264	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	536	7	2	8	2.9	CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O	10.1016/j.bmcl.2008.11.002
	CHEMBL464902	178264	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	536	7	2	8	2.9	CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O	10.1016/j.bmcl.2008.11.002
	10050884	154742	None	15	Human	Binding	pIC50	=	9.5	9.5	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2008.11.002
	CHEMBL399495	154742	None	15	Human	Binding	pIC50	=	9.5	9.5	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2008.11.002
	44447143	94641	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	469	11	4	7	2.7	CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CNCCCc2ccc(F)cc2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	CHEMBL252035	94641	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	469	11	4	7	2.7	CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CNCCCc2ccc(F)cc2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	10050884	154742	None	15	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2007.11.087
	CHEMBL399495	154742	None	15	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2007.11.087
	44447144	168875	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	483	11	3	7	3.0	CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	CHEMBL437396	168875	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	483	11	3	7	3.0	CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	10050884	154742	None	15	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2007.11.067
	CHEMBL399495	154742	None	15	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells	ChEMBL	481	8	3	7	2.8	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2007.11.067
	44455658	167369	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells	ChEMBL	479	8	3	5	4.4	C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1	10.1016/j.bmcl.2007.11.067
	CHEMBL429323	167369	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells	ChEMBL	479	8	3	5	4.4	C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1	10.1016/j.bmcl.2007.11.067
	11488078	79032	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells	ChEMBL	463	6	3	3	5.3	O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1021/jm049530m
	CHEMBL2113077	79032	None	0	Human	Binding	pIC50	=	9.5	9.5	-	0	Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells	ChEMBL	463	6	3	3	5.3	O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1	10.1021/jm049530m
	44593553	178472	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	489	6	2	6	3.9	Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1	10.1016/j.bmcl.2008.11.002
	CHEMBL465272	178472	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor	ChEMBL	489	6	2	6	3.9	Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1	10.1016/j.bmcl.2008.11.002
	44447139	94606	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	495	12	3	7	3.2	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC1CC1	10.1016/j.bmcl.2007.11.087
	CHEMBL251838	94606	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	495	12	3	7	3.2	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC1CC1	10.1016/j.bmcl.2007.11.087
	44447135	94729	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	455	10	3	7	2.5	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)CCCc1ccc(F)cc1	10.1016/j.bmcl.2007.11.087
	CHEMBL252631	94729	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	455	10	3	7	2.5	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)CCCc1ccc(F)cc1	10.1016/j.bmcl.2007.11.087
	44447361	95006	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	453	9	4	8	1.8	C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	CHEMBL254503	95006	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	453	9	4	8	1.8	C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1	10.1016/j.bmcl.2007.11.087
	44447138	154907	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	481	11	3	7	3.0	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CC1	10.1016/j.bmcl.2007.11.087
	CHEMBL400378	154907	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL	481	11	3	7	3.0	C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CC1	10.1016/j.bmcl.2007.11.087

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Ligand source activities (1 row/activity)