Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 9827294 | 73865 | 3 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL2018953 | 73865 | 3 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.ejmech.2016.02.058 | ||
| 127046612 | 139750 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL3798452 | 139750 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| 127046614 | 139926 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 442 | 6 | 2 | 6 | 3.4 | Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL3799578 | 139926 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 442 | 6 | 2 | 6 | 3.4 | Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| 127047356 | 139634 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 488 | 6 | 1 | 6 | 4.5 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL3797662 | 139634 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 488 | 6 | 1 | 6 | 4.5 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | ||
| 44288958 | 168727 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 624 | 11 | 2 | 5 | 5.6 | Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | ||
| CHEMBL43698 | 168727 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 624 | 11 | 2 | 5 | 5.6 | Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | ||
| 127047440 | 139607 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 542 | 7 | 2 | 8 | 4.4 | COc1cc2nc(N3CCC(N(C)C(=O)[C@H]4CCCN4)CC3)nc(Nc3ccc(Cl)cc3F)c2cc1OC | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL3797462 | 139607 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 542 | 7 | 2 | 8 | 4.4 | COc1cc2nc(N3CCC(N(C)C(=O)[C@H]4CCCN4)CC3)nc(Nc3ccc(Cl)cc3F)c2cc1OC | 10.1016/j.ejmech.2016.02.058 | ||
| 127047612 | 139892 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL3799393 | 139892 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| 44288959 | 165307 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 640 | 11 | 2 | 5 | 6.3 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | ||
| CHEMBL42334 | 165307 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 640 | 11 | 2 | 5 | 6.3 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | ||
| 10238794 | 162835 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 473 | 7 | 2 | 6 | 4.3 | O=S(=O)(Nc1ncc(Cl)nc1OCc1ccccc1CO)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4172769 | 162835 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 473 | 7 | 2 | 6 | 4.3 | O=S(=O)(Nc1ncc(Cl)nc1OCc1ccccc1CO)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 10195057 | 162497 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 444 | 6 | 1 | 6 | 4.2 | O=S(=O)(Nc1ncc(Cl)nc1OCc1cccnc1)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4167445 | 162497 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 444 | 6 | 1 | 6 | 4.2 | O=S(=O)(Nc1ncc(Cl)nc1OCc1cccnc1)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 23585443 | 542 | 12 | None | 3 | 3 | Mouse | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9679 | 542 | 12 | None | 3 | 3 | Mouse | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4172635 | 542 | 12 | None | 3 | 3 | Mouse | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 145959198 | 162173 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 369 | 4 | 1 | 5 | 2.9 | COc1nc(F)c(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4162364 | 162173 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 369 | 4 | 1 | 5 | 2.9 | COc1nc(F)c(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 10308720 | 545 | 42 | None | 2 | 3 | Mouse | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9678 | 545 | 42 | None | 2 | 3 | Mouse | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4169247 | 545 | 42 | None | 2 | 3 | Mouse | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 10309893 | 162688 | 2 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4170431 | 162688 | 2 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 11525206 | 135228 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | ||
| CHEMBL372399 | 135228 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | ||
| 44581043 | 187834 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 511 | 7 | 1 | 8 | 5.1 | COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496152 | 187834 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 511 | 7 | 1 | 8 | 5.1 | COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 44581068 | 187924 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 513 | 7 | 2 | 9 | 3.7 | COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496787 | 187924 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 513 | 7 | 2 | 9 | 3.7 | COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 25212472 | 192646 | 0 | None | -2 | 2 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 497 | 7 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL521737 | 192646 | 0 | None | -2 | 2 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 497 | 7 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 59456023 | 87156 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 516 | 8 | 2 | 7 | 4.4 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)=O)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326612 | 87156 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 516 | 8 | 2 | 7 | 4.4 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)=O)cccc32)c1 | 10.1021/jm301572h | ||
| 59456042 | 87158 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 532 | 8 | 3 | 7 | 4.5 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)(C)O)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326614 | 87158 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 532 | 8 | 3 | 7 | 4.5 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)(C)O)cccc32)c1 | 10.1021/jm301572h | ||
| 59456012 | 87159 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 524 | 8 | 2 | 6 | 5.2 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326615 | 87159 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 524 | 8 | 2 | 6 | 5.2 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1 | 10.1021/jm301572h | ||
| 71584536 | 87173 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 505 | 8 | 2 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccnc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326628 | 87173 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 505 | 8 | 2 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccnc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| 59168189 | 162427 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 377 | 4 | 1 | 5 | 2.7 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4166246 | 162427 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 377 | 4 | 1 | 5 | 2.7 | COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1 | 10.1021/acsmedchemlett.7b00315 | ||
| 118706823 | 112976 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 429 | 5 | 2 | 5 | 4.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(C)C | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310832 | 112976 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 429 | 5 | 2 | 5 | 4.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(C)C | 10.1016/j.bmc.2014.05.021 | ||
| 10309983 | 162113 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 417 | 4 | 1 | 6 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)c(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4161268 | 162113 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 417 | 4 | 1 | 6 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)c(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| 145949792 | 162706 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 425 | 5 | 1 | 6 | 3.8 | COc1nc(Br)cnc1NS(=O)(=O)c1sccc1-c1ccccc1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4170786 | 162706 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 425 | 5 | 1 | 6 | 3.8 | COc1nc(Br)cnc1NS(=O)(=O)c1sccc1-c1ccccc1 | 10.1021/acsmedchemlett.7b00315 | ||
| 137642528 | 158264 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.7 | COc1ccc2c(cnn2C)c1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4088688 | 158264 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.7 | COc1ccc2c(cnn2C)c1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2017.07.052 | ||
| 137659242 | 159167 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 458 | 6 | 2 | 9 | 2.3 | COc1nn(C)c2nc(NC3COC3)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4098333 | 159167 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 458 | 6 | 2 | 9 | 2.3 | COc1nn(C)c2nc(NC3COC3)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 145955299 | 162589 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 368 | 4 | 1 | 6 | 2.6 | COc1nc(Cl)cnc1NS(=O)(=O)c1ccnc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4168920 | 162589 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 368 | 4 | 1 | 6 | 2.6 | COc1nc(Cl)cnc1NS(=O)(=O)c1ccnc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 155520262 | 170468 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 578 | 7 | 0 | 8 | 5.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(C)(=O)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4448901 | 170468 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 578 | 7 | 0 | 8 | 5.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(C)(=O)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 71461546 | 84341 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 640 | 11 | 2 | 5 | 6.3 | C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmc.2012.03.069 | ||
| CHEMBL2216810 | 84341 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 640 | 11 | 2 | 5 | 6.3 | C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmc.2012.03.069 | ||
| 25141301 | 185888 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL486840 | 185888 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 25141301 | 185888 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL486840 | 185888 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 118706824 | 112977 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 443 | 5 | 2 | 6 | 3.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1COC1 | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310833 | 112977 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 443 | 5 | 2 | 6 | 3.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1COC1 | 10.1016/j.bmc.2014.05.021 | ||
| 59456067 | 73881 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 534 | 9 | 3 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018968 | 73881 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 534 | 9 | 3 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 136116031 | 86802 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 3.9 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2321924 | 86802 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 3.9 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1 | 10.1021/jm301572h | ||
| 59456019 | 87175 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326630 | 87175 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| 10195081 | 162160 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 445 | 6 | 1 | 7 | 3.6 | O=S(=O)(Nc1ncc(Cl)nc1OCc1cncnc1)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4162097 | 162160 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 445 | 6 | 1 | 7 | 3.6 | O=S(=O)(Nc1ncc(Cl)nc1OCc1cncnc1)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 10309206 | 162406 | 5 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 367 | 4 | 1 | 5 | 3.2 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4165939 | 162406 | 5 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 367 | 4 | 1 | 5 | 3.2 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 59168214 | 163037 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 377 | 6 | 1 | 6 | 3.0 | CCOc1cnc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(OC)n1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4175972 | 163037 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 377 | 6 | 1 | 6 | 3.0 | CCOc1cnc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(OC)n1 | 10.1021/acsmedchemlett.7b00315 | ||
| 134210781 | 178208 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 551 | 7 | 1 | 8 | 3.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(C4CCCN(CCS(N)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4649666 | 178208 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 551 | 7 | 1 | 8 | 3.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(C4CCCN(CCS(N)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 71584537 | 87174 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 505 | 8 | 2 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)n1 | 10.1021/jm301572h | ||
| CHEMBL2326629 | 87174 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 505 | 8 | 2 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)n1 | 10.1021/jm301572h | ||
| 10150948 | 161975 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4159115 | 161975 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 10287210 | 163091 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 377 | 4 | 1 | 5 | 2.7 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4176859 | 163091 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 377 | 4 | 1 | 5 | 2.7 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1021/acsmedchemlett.7b00315 | ||
| 137652824 | 158761 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 357 | 3 | 1 | 6 | 2.5 | Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4093994 | 158761 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 357 | 3 | 1 | 6 | 2.5 | Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21 | 10.1016/j.bmc.2017.07.052 | ||
| 10126022 | 162774 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 2.1 | COc1nc(Br)cnc1NS(=O)(=O)c1ccsc1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4171873 | 162774 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 2.1 | COc1nc(Br)cnc1NS(=O)(=O)c1ccsc1 | 10.1021/acsmedchemlett.7b00315 | ||
| 137632634 | 156392 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 356 | 3 | 1 | 5 | 3.1 | Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ccnc21 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4066451 | 156392 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 356 | 3 | 1 | 5 | 3.1 | Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ccnc21 | 10.1016/j.bmc.2017.07.052 | ||
| 155543648 | 173193 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn(C(C)c2ccc(Cl)cc2Cl)c2nc(N3CCC(N4CCCCC4)C(C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4522547 | 173193 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn(C(C)c2ccc(Cl)cc2Cl)c2nc(N3CCC(N4CCCCC4)C(C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 70685474 | 73878 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 518 | 8 | 1 | 7 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN(C)C(C)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018965 | 73878 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 518 | 8 | 1 | 7 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN(C)C(C)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 44561334 | 176223 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 423 | 5 | 1 | 6 | 4.8 | COc1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1 | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL459464 | 176223 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 423 | 5 | 1 | 6 | 4.8 | COc1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1 | 10.1016/j.bmc.2008.05.036 | ||
| 44561260 | 189044 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 384 | 6 | 2 | 6 | 5.1 | COc1cc2nc(NC3CCCC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL509396 | 189044 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 384 | 6 | 2 | 6 | 5.1 | COc1cc2nc(NC3CCCC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 44562238 | 186755 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 524 | 8 | 1 | 8 | 5.0 | COc1cc2nc(N3CCCN(CCN4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL488855 | 186755 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 524 | 8 | 1 | 8 | 5.0 | COc1cc2nc(N3CCCN(CCN4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 25141301 | 185888 | 0 | None | -1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL486840 | 185888 | 0 | None | -1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 16724339 | 186437 | 0 | None | -1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL487635 | 186437 | 0 | None | -1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 25141301 | 185888 | 0 | None | -1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL486840 | 185888 | 0 | None | -1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 16724339 | 186437 | 0 | None | -1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL487635 | 186437 | 0 | None | -1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 156013953 | 177207 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 418 | 5 | 0 | 6 | 4.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(CN(C)C)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4635359 | 177207 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 418 | 5 | 0 | 6 | 4.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(CN(C)C)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 10416 | 1879 | 30 | None | 309 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.bmcl.2012.02.104 | ||
| 46861584 | 1879 | 30 | None | 309 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018969 | 1879 | 30 | None | 309 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.bmcl.2012.02.104 | ||
| 44288958 | 168727 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 624 | 11 | 2 | 5 | 5.6 | Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O | 10.1016/j.bmc.2012.03.069 | ||
| CHEMBL43698 | 168727 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 624 | 11 | 2 | 5 | 5.6 | Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O | 10.1016/j.bmc.2012.03.069 | ||
| 25141190 | 1146 | 28 | None | -1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.11.020 | ||
| 9478 | 1146 | 28 | None | -1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL508207 | 1146 | 28 | None | -1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.11.020 | ||
| 44581102 | 187772 | 0 | None | 1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 525 | 8 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL495736 | 187772 | 0 | None | 1 | 2 | Mouse | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 525 | 8 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 156017568 | 177821 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 494 | 5 | 0 | 8 | 4.3 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC#N)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4643839 | 177821 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 494 | 5 | 0 | 8 | 4.3 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC#N)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| 59455988 | 87165 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 547 | 10 | 3 | 8 | 3.8 | CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326620 | 87165 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 547 | 10 | 3 | 8 | 3.8 | CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1021/jm301572h | ||
| 59456014 | 87166 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 547 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1 | 10.1021/jm301572h | ||
| CHEMBL2326621 | 87166 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 547 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1 | 10.1021/jm301572h | ||
| 59456103 | 87167 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 573 | 9 | 3 | 8 | 4.4 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1 | 10.1021/jm301572h | ||
| CHEMBL2326622 | 87167 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 573 | 9 | 3 | 8 | 4.4 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1 | 10.1021/jm301572h | ||
| 58054368 | 87169 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 575 | 9 | 3 | 9 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1 | 10.1021/jm301572h | ||
| CHEMBL2326624 | 87169 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 575 | 9 | 3 | 9 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1 | 10.1021/jm301572h | ||
| 59456058 | 87178 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 566 | 9 | 3 | 8 | 4.1 | COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326633 | 87178 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 566 | 9 | 3 | 8 | 4.1 | COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| 56849395 | 87190 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 540 | 9 | 3 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326926 | 87190 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 540 | 9 | 3 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| 10308720 | 545 | 42 | None | -4 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9678 | 545 | 42 | None | -4 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4169247 | 545 | 42 | None | -4 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 10308963 | 162185 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(F)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4162555 | 162185 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(F)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 145951541 | 162710 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 409 | 6 | 1 | 5 | 4.3 | CC(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4170833 | 162710 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 409 | 6 | 1 | 5 | 4.3 | CC(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 44562237 | 186728 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 510 | 8 | 1 | 8 | 4.7 | COc1cc2nc(N3CCCN(CCN4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL488691 | 186728 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 510 | 8 | 1 | 8 | 4.7 | COc1cc2nc(N3CCCN(CCN4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 71525425 | 132812 | 0 | None | -446 | 5 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 509 | 8 | 3 | 9 | 2.7 | Cc1ccc(C(Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N(C)C)c3O)c(=O)c2=O)C2(C)COC2)o1 | nan | ||
| CHEMBL3701196 | 132812 | 0 | None | -446 | 5 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 509 | 8 | 3 | 9 | 2.7 | Cc1ccc(C(Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N(C)C)c3O)c(=O)c2=O)C2(C)COC2)o1 | nan | ||
| 59455992 | 73869 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 463 | 7 | 1 | 7 | 4.6 | COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018957 | 73869 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 463 | 7 | 1 | 7 | 4.6 | COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 23585443 | 542 | 12 | None | -16 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9679 | 542 | 12 | None | -16 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4172635 | 542 | 12 | None | -16 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 71584535 | 87172 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 505 | 8 | 2 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cc(CNC(C)=O)ccn1 | 10.1021/jm301572h | ||
| CHEMBL2326627 | 87172 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 505 | 8 | 2 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cc(CNC(C)=O)ccn1 | 10.1021/jm301572h | ||
| 137633709 | 156619 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 373 | 4 | 2 | 6 | 2.5 | COc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4069103 | 156619 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 373 | 4 | 2 | 6 | 2.5 | COc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 145955692 | 162495 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 377 | 4 | 1 | 5 | 2.7 | COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4167390 | 162495 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 377 | 4 | 1 | 5 | 2.7 | COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 145971718 | 163068 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 453 | 7 | 1 | 5 | 4.5 | CCCCOc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4176441 | 163068 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 453 | 7 | 1 | 5 | 4.5 | CCCCOc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 118706827 | 112980 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 461 | 7 | 4 | 7 | 2.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(CO)CO | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310836 | 112980 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 461 | 7 | 4 | 7 | 2.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(CO)CO | 10.1016/j.bmc.2014.05.021 | ||
| 137643503 | 158408 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 359 | 3 | 3 | 6 | 2.2 | O=S(=O)(Nc1ncnc2[nH]nc(O)c12)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4090166 | 158408 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 359 | 3 | 3 | 6 | 2.2 | O=S(=O)(Nc1ncnc2[nH]nc(O)c12)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2017.07.052 | ||
| 155561858 | 175755 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 515 | 5 | 1 | 7 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(N)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4583503 | 175755 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 515 | 5 | 1 | 7 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(N)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 134325276 | 175475 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@@H]4C)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4577319 | 175475 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@@H]4C)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 134211225 | 177925 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 557 | 8 | 1 | 7 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4645325 | 177925 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 557 | 8 | 1 | 7 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 25141190 | 1146 | 28 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.11.020 | ||
| 9478 | 1146 | 28 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL508207 | 1146 | 28 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.11.020 | ||
| 25141190 | 1146 | 28 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.05.036 | ||
| 9478 | 1146 | 28 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL508207 | 1146 | 28 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.05.036 | ||
| 44561294 | 172980 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 7 | 1 | 7 | 5.6 | COc1cc2nc(N3CCC(N(C)C4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL451783 | 172980 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 7 | 1 | 7 | 5.6 | COc1cc2nc(N3CCC(N(C)C4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 44581121 | 188263 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 553 | 10 | 2 | 8 | 5.0 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL499852 | 188263 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 553 | 10 | 2 | 8 | 5.0 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 16724339 | 186437 | 0 | None | 1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL487635 | 186437 | 0 | None | 1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 16724339 | 186437 | 0 | None | 1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL487635 | 186437 | 0 | None | 1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 25212379 | 187862 | 1 | None | 2 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 511 | 7 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496356 | 187862 | 1 | None | 2 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 511 | 7 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 16724339 | 186437 | 0 | None | 1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL487635 | 186437 | 0 | None | 1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 25212472 | 192646 | 0 | None | 2 | 2 | Mouse | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 497 | 7 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL521737 | 192646 | 0 | None | 2 | 2 | Mouse | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 497 | 7 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 59455975 | 87157 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 518 | 8 | 3 | 7 | 4.3 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326613 | 87157 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 518 | 8 | 3 | 7 | 4.3 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1 | 10.1021/jm301572h | ||
| 71583488 | 87160 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 546 | 9 | 2 | 8 | 3.9 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1 | 10.1021/jm301572h | ||
| CHEMBL2326616 | 87160 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 546 | 9 | 2 | 8 | 3.9 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1 | 10.1021/jm301572h | ||
| 11244702 | 162333 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 339 | 4 | 1 | 6 | 2.7 | COc1nccnc1NS(=O)(=O)c1scc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4164738 | 162333 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 339 | 4 | 1 | 6 | 2.7 | COc1nccnc1NS(=O)(=O)c1scc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 59168158 | 162551 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 347 | 4 | 1 | 5 | 2.9 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4168237 | 162551 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 347 | 4 | 1 | 5 | 2.9 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C | 10.1021/acsmedchemlett.7b00315 | ||
| 10215932 | 73127 | 1 | None | -22 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 383 | 4 | 1 | 6 | 2.8 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL2011441 | 73127 | 1 | None | -22 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 383 | 4 | 1 | 6 | 2.8 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| 118706818 | 112972 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 401 | 4 | 2 | 5 | 3.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310827 | 112972 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 401 | 4 | 2 | 5 | 3.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C | 10.1016/j.bmc.2014.05.021 | ||
| 118706829 | 112982 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 484 | 5 | 2 | 6 | 2.8 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CN(C(C)=O)C1 | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310838 | 112982 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 484 | 5 | 2 | 6 | 2.8 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CN(C(C)=O)C1 | 10.1016/j.bmc.2014.05.021 | ||
| 137643926 | 158225 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 431 | 6 | 2 | 8 | 2.0 | COc1nn(CC(=O)O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4088207 | 158225 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 431 | 6 | 2 | 8 | 2.0 | COc1nn(CC(=O)O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 10194488 | 162178 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4162503 | 162178 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/acsmedchemlett.7b00315 | ||
| 10194274 | 162383 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 397 | 5 | 1 | 6 | 3.2 | CCOc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4165500 | 162383 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 397 | 5 | 1 | 6 | 3.2 | CCOc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| 118706820 | 112974 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 415 | 4 | 1 | 6 | 3.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)n(C)c(=O)n2C | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310829 | 112974 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 415 | 4 | 1 | 6 | 3.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)n(C)c(=O)n2C | 10.1016/j.bmc.2014.05.021 | ||
| 118706826 | 112979 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 458 | 7 | 2 | 6 | 3.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CCN(C)C | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310835 | 112979 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 458 | 7 | 2 | 6 | 3.0 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CCN(C)C | 10.1016/j.bmc.2014.05.021 | ||
| 137661320 | 159081 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 355 | 3 | 1 | 4 | 3.7 | Cn1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2ccccc21 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4097341 | 159081 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 355 | 3 | 1 | 4 | 3.7 | Cn1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2ccccc21 | 10.1016/j.bmc.2017.07.052 | ||
| 118706819 | 112973 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 401 | 4 | 2 | 5 | 3.0 | COc1cc2[nH]c(=O)n(C)c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310828 | 112973 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 401 | 4 | 2 | 5 | 3.0 | COc1cc2[nH]c(=O)n(C)c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| 23585443 | 542 | 12 | None | -16 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9679 | 542 | 12 | None | -16 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4172635 | 542 | 12 | None | -16 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 59168181 | 162046 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 391 | 5 | 1 | 5 | 3.3 | C#CCOc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4160218 | 162046 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 391 | 5 | 1 | 5 | 3.3 | C#CCOc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 16724339 | 186437 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL487635 | 186437 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 16724339 | 186437 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL487635 | 186437 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 44561335 | 176225 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 393 | 4 | 1 | 5 | 4.8 | c1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1 | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL459465 | 176225 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 393 | 4 | 1 | 5 | 4.8 | c1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1 | 10.1016/j.bmc.2008.05.036 | ||
| 44561588 | 194553 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL529664 | 194553 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 134210933 | 177506 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 535 | 6 | 1 | 8 | 4.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4639600 | 177506 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 535 | 6 | 1 | 8 | 4.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| 134225255 | 177325 | 10 | None | 1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4637143 | 177325 | 10 | None | 1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| 134211098 | 178044 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 564 | 8 | 0 | 8 | 4.6 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4647117 | 178044 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 564 | 8 | 0 | 8 | 4.6 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 58054516 | 73871 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 493 | 8 | 1 | 8 | 4.6 | COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018959 | 73871 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 493 | 8 | 1 | 8 | 4.6 | COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC | 10.1016/j.bmcl.2012.02.104 | ||
| 44562156 | 186729 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 511 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL488704 | 186729 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 511 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 44561217 | 189116 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 427 | 6 | 1 | 7 | 4.3 | COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL510375 | 189116 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 427 | 6 | 1 | 7 | 4.3 | COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 134324821 | 171102 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 515 | 5 | 1 | 7 | 4.5 | CC1CN(c2cnc3c(C(N)=O)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4457732 | 171102 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 515 | 5 | 1 | 7 | 4.5 | CC1CN(c2cnc3c(C(N)=O)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1 | 10.1021/acs.jmedchem.9b00506 | ||
| 134324770 | 170943 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 509 | 5 | 1 | 7 | 5.2 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4455432 | 170943 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 509 | 5 | 1 | 7 | 5.2 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN | 10.1021/acs.jmedchem.9b00506 | ||
| 134225247 | 177663 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 545 | 7 | 1 | 8 | 4.6 | COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4641595 | 177663 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 545 | 7 | 1 | 8 | 4.6 | COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | ||
| 134325106 | 171251 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 500 | 4 | 0 | 6 | 6.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4460062 | 171251 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 500 | 4 | 0 | 6 | 6.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 25212379 | 187862 | 1 | None | 2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 511 | 7 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496356 | 187862 | 1 | None | 2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 511 | 7 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 44581044 | 193448 | 0 | None | -3 | 2 | Mouse | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 525 | 8 | 1 | 8 | 5.4 | COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1 | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL526474 | 193448 | 0 | None | -3 | 2 | Mouse | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 525 | 8 | 1 | 8 | 5.4 | COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1 | 10.1016/j.bmc.2008.11.020 | ||
| 134325169 | 172409 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 472 | 4 | 0 | 6 | 5.4 | CC1CN(c2cnc3cnn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4476671 | 172409 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 472 | 4 | 0 | 6 | 5.4 | CC1CN(c2cnc3cnn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1 | 10.1021/acs.jmedchem.9b00506 | ||
| 134211185 | 177153 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 488 | 6 | 1 | 7 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4634054 | 177153 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 488 | 6 | 1 | 7 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 25141301 | 185888 | 0 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL486840 | 185888 | 0 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 25141301 | 185888 | 0 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL486840 | 185888 | 0 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 156010350 | 177082 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 531 | 7 | 2 | 8 | 3.2 | CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4633133 | 177082 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 531 | 7 | 2 | 8 | 3.2 | CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 44562155 | 186631 | 0 | None | 19 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.7 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL488018 | 186631 | 0 | None | 19 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.7 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 102143549 | 112983 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 388 | 4 | 3 | 5 | 2.4 | COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310839 | 112983 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 388 | 4 | 3 | 5 | 2.4 | COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| 58054475 | 87168 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 575 | 9 | 3 | 9 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1 | 10.1021/jm301572h | ||
| CHEMBL2326623 | 87168 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 575 | 9 | 3 | 9 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1 | 10.1021/jm301572h | ||
| 58597374 | 162580 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 363 | 5 | 2 | 6 | 2.1 | COc1nc(CO)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4168775 | 162580 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 363 | 5 | 2 | 6 | 2.1 | COc1nc(CO)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 134335265 | 174976 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 497 | 4 | 0 | 7 | 5.3 | CC1CN(c2cnc3c(C#N)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4566241 | 174976 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 497 | 4 | 0 | 7 | 5.3 | CC1CN(c2cnc3c(C#N)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1 | 10.1021/acs.jmedchem.9b00506 | ||
| 71583704 | 87171 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 518 | 9 | 2 | 8 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC2COC2)c1 | 10.1021/jm301572h | ||
| CHEMBL2326626 | 87171 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 518 | 9 | 2 | 8 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC2COC2)c1 | 10.1021/jm301572h | ||
| 71583039 | 87191 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 474 | 7 | 2 | 6 | 4.2 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3ccccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326927 | 87191 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 474 | 7 | 2 | 6 | 4.2 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3ccccc32)c1 | 10.1021/jm301572h | ||
| 137647817 | 157557 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 429 | 5 | 1 | 8 | 2.5 | COc1nn(C2COC2)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4080352 | 157557 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 429 | 5 | 1 | 8 | 2.5 | COc1nn(C2COC2)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 137653647 | 159044 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 430 | 6 | 2 | 8 | 2.9 | CCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4096860 | 159044 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 430 | 6 | 2 | 8 | 2.9 | CCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1 | 10.1016/j.bmc.2017.07.052 | ||
| 137661613 | 159222 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 415 | 5 | 1 | 7 | 3.5 | COc1nn(C(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4098813 | 159222 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 415 | 5 | 1 | 7 | 3.5 | COc1nn(C(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 155518637 | 170322 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 458 | 4 | 0 | 6 | 5.2 | CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(N3CCC(N4CCCCC4)CC3)nc21 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4446924 | 170322 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 458 | 4 | 0 | 6 | 5.2 | CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(N3CCC(N4CCCCC4)CC3)nc21 | 10.1021/acs.jmedchem.9b00506 | ||
| 44561137 | 186719 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 6 | 1 | 7 | 4.3 | COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL488640 | 186719 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 6 | 1 | 7 | 4.3 | COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 134325016 | 174653 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 513 | 5 | 1 | 8 | 4.3 | C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4558456 | 174653 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 513 | 5 | 1 | 8 | 4.3 | C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO | 10.1021/acs.jmedchem.9b00506 | ||
| 59456051 | 73880 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 520 | 9 | 3 | 8 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018967 | 73880 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 520 | 9 | 3 | 8 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 142450222 | 169674 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 484 | 4 | 1 | 6 | 4.5 | CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(C3=CCN(C(=O)[C@H]4CCCCN4)CC3)nc21 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4437594 | 169674 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 484 | 4 | 1 | 6 | 4.5 | CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(C3=CCN(C(=O)[C@H]4CCCCN4)CC3)nc21 | 10.1021/acs.jmedchem.9b00506 | ||
| 156010372 | 177108 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 508 | 6 | 0 | 8 | 4.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4633494 | 177108 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 508 | 6 | 0 | 8 | 4.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| 44562191 | 186756 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 485 | 9 | 2 | 8 | 4.3 | COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL488857 | 186756 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 485 | 9 | 2 | 8 | 4.3 | COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 58834906 | 92644 | 0 | None | -467 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 604 | 8 | 1 | 6 | 6.2 | Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 | 10.1021/jm401101p | ||
| CHEMBL2435853 | 92644 | 0 | None | -467 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 604 | 8 | 1 | 6 | 6.2 | Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 | 10.1021/jm401101p | ||
| 134210845 | 178049 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 565 | 8 | 1 | 8 | 3.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4647188 | 178049 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 565 | 8 | 1 | 8 | 3.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 44430312 | 87260 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2006.10.091 | ||
| CHEMBL233046 | 87260 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2006.10.091 | ||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmc.2014.05.021 | ||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmcl.2012.02.104 | ||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmc.2017.07.052 | ||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1021/jm301572h | ||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1021/jm301572h | ||
| 23585443 | 542 | 12 | None | -16 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9679 | 542 | 12 | None | -16 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4172635 | 542 | 12 | None | -16 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 59168106 | 162084 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 397 | 5 | 2 | 6 | 2.7 | COc1nc(CO)c(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4160846 | 162084 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 397 | 5 | 2 | 6 | 2.7 | COc1nc(CO)c(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 23585446 | 162856 | 1 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1ncc(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4173046 | 162856 | 1 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1ncc(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 59168165 | 162991 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 521 | 6 | 1 | 5 | 5.6 | O=S(=O)(Nc1ncc(Cl)nc1OCc1cccc(Br)c1)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4175323 | 162991 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 521 | 6 | 1 | 5 | 5.6 | O=S(=O)(Nc1ncc(Cl)nc1OCc1cccc(Br)c1)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 25212472 | 192646 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 497 | 7 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL521737 | 192646 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 497 | 7 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 134210626 | 177305 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 593 | 9 | 1 | 8 | 4.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4636749 | 177305 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 593 | 9 | 1 | 8 | 4.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 44562189 | 186575 | 0 | None | 7 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 451 | 6 | 1 | 7 | 4.6 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL487835 | 186575 | 0 | None | 7 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 451 | 6 | 1 | 7 | 4.6 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 44561333 | 189878 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 423 | 5 | 1 | 6 | 4.8 | COc1ccc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2c1 | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL516936 | 189878 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 423 | 5 | 1 | 6 | 4.8 | COc1ccc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2c1 | 10.1016/j.bmc.2008.05.036 | ||
| 10308720 | 545 | 42 | None | -4 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9678 | 545 | 42 | None | -4 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4169247 | 545 | 42 | None | -4 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 59456102 | 73877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018964 | 73877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 59456102 | 73877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| CHEMBL2018964 | 73877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| 58054384 | 87151 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 7 | 2 | 6 | 4.9 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326608 | 87151 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 7 | 2 | 6 | 4.9 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1 | 10.1021/jm301572h | ||
| 71583489 | 87161 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 546 | 9 | 2 | 8 | 4.0 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCO2)c1 | 10.1021/jm301572h | ||
| CHEMBL2326617 | 87161 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 546 | 9 | 2 | 8 | 4.0 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCO2)c1 | 10.1021/jm301572h | ||
| 59456010 | 87163 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 574 | 9 | 2 | 8 | 4.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1 | 10.1021/jm301572h | ||
| CHEMBL2326619 | 87163 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 574 | 9 | 2 | 8 | 4.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1 | 10.1021/jm301572h | ||
| 118706817 | 112971 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 387 | 4 | 3 | 4 | 3.0 | COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310826 | 112971 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 387 | 4 | 3 | 4 | 3.0 | COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| 23585443 | 542 | 12 | None | -16 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9679 | 542 | 12 | None | -16 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4172635 | 542 | 12 | None | -16 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 59456021 | 87154 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 499 | 7 | 2 | 7 | 4.1 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C#N)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326610 | 87154 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 499 | 7 | 2 | 7 | 4.1 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C#N)cccc32)c1 | 10.1021/jm301572h | ||
| 137632888 | 156533 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 431 | 7 | 1 | 8 | 2.6 | COCCn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4068045 | 156533 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 431 | 7 | 1 | 8 | 2.6 | COCCn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21 | 10.1016/j.bmc.2017.07.052 | ||
| 137644457 | 158315 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 402 | 4 | 2 | 8 | 2.1 | COc1nn(C)c2nc(N)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4089151 | 158315 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 402 | 4 | 2 | 8 | 2.1 | COc1nn(C)c2nc(N)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 137632974 | 156347 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 444 | 6 | 2 | 8 | 3.3 | COc1nn(C)c2nc(NC(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4065904 | 156347 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 444 | 6 | 2 | 8 | 3.3 | COc1nn(C)c2nc(NC(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 137652382 | 157394 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 355 | 3 | 1 | 4 | 3.7 | Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)cccc21 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4078359 | 157394 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 355 | 3 | 1 | 4 | 3.7 | Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)cccc21 | 10.1016/j.bmc.2017.07.052 | ||
| 10173173 | 162247 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)ccc1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4163571 | 162247 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)ccc1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 145950145 | 162881 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 279 | 6 | 1 | 5 | 1.7 | CCCCS(=O)(=O)Nc1ncc(Cl)nc1OC | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4173424 | 162881 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 279 | 6 | 1 | 5 | 1.7 | CCCCS(=O)(=O)Nc1ncc(Cl)nc1OC | 10.1021/acsmedchemlett.7b00315 | ||
| 145950218 | 162965 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 399 | 4 | 1 | 6 | 3.5 | CSc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4174872 | 162965 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 399 | 4 | 1 | 6 | 3.5 | CSc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| 134325076 | 172185 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 579 | 7 | 1 | 8 | 4.4 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4473604 | 172185 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 579 | 7 | 1 | 8 | 4.4 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 134325041 | 175032 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 502 | 5 | 1 | 7 | 4.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4567398 | 175032 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 502 | 5 | 1 | 7 | 4.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 44561172 | 173710 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 485 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCC(F)CC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL453594 | 173710 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 485 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCC(F)CC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 70685473 | 73863 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018951 | 73863 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 44562189 | 186575 | 0 | None | 7 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 451 | 6 | 1 | 7 | 4.6 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL487835 | 186575 | 0 | None | 7 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 451 | 6 | 1 | 7 | 4.6 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 70681287 | 73873 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018960 | 73873 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO | 10.1016/j.bmcl.2012.02.104 | ||
| 134335394 | 172342 | 0 | None | 8 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 494 | 4 | 0 | 6 | 6.3 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4475665 | 172342 | 0 | None | 8 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 494 | 4 | 0 | 6 | 6.3 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C | 10.1021/acs.jmedchem.9b00506 | ||
| 156018849 | 177907 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 513 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4645037 | 177907 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 513 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| 134335393 | 170112 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 499 | 5 | 1 | 6 | 5.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4443688 | 170112 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 499 | 5 | 1 | 6 | 5.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 44562192 | 185777 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 499 | 10 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL486656 | 185777 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 499 | 10 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 134211221 | 177688 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 7 | 1 | 7 | 4.6 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4641873 | 177688 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 7 | 1 | 7 | 4.6 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 134325003 | 175382 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 543 | 7 | 1 | 7 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4575089 | 175382 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 543 | 7 | 1 | 7 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 156015374 | 177615 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 551 | 6 | 0 | 7 | 5.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4640909 | 177615 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 551 | 6 | 0 | 7 | 5.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| 16041411 | 92576 | 0 | None | -4168 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 572 | 8 | 1 | 6 | 5.6 | O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1 | 10.1021/jm401101p | ||
| CHEMBL2434978 | 92576 | 0 | None | -4168 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 572 | 8 | 1 | 6 | 5.6 | O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1 | 10.1021/jm401101p | ||
| 11525206 | 135228 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | ||
| CHEMBL372399 | 135228 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | ||
| 155557193 | 174525 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 538 | 5 | 1 | 7 | 6.0 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4555534 | 174525 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 538 | 5 | 1 | 7 | 6.0 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O | 10.1021/acs.jmedchem.9b00506 | ||
| 70689680 | 73867 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 433 | 6 | 1 | 6 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018955 | 73867 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 433 | 6 | 1 | 6 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1 | 10.1016/j.bmcl.2012.02.104 | ||
| 25141190 | 1146 | 28 | None | 1 | 2 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.11.020 | ||
| 9478 | 1146 | 28 | None | 1 | 2 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL508207 | 1146 | 28 | None | 1 | 2 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.11.020 | ||
| 10416 | 1879 | 30 | None | 309 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1021/jm301572h | ||
| 46861584 | 1879 | 30 | None | 309 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1021/jm301572h | ||
| CHEMBL2018969 | 1879 | 30 | None | 309 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1021/jm301572h | ||
| 59456111 | 87162 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 560 | 9 | 2 | 8 | 4.4 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1 | 10.1021/jm301572h | ||
| CHEMBL2326618 | 87162 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 560 | 9 | 2 | 8 | 4.4 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1 | 10.1021/jm301572h | ||
| 59456026 | 87176 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 566 | 9 | 3 | 8 | 4.1 | COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326631 | 87176 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 566 | 9 | 3 | 8 | 4.1 | COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| 59455990 | 87177 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326632 | 87177 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| 10288569 | 162040 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 461 | 4 | 1 | 6 | 3.5 | COc1nc(Br)cnc1NS(=O)(=O)c1sc(Cl)cc1Br | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4160139 | 162040 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 461 | 4 | 1 | 6 | 3.5 | COc1nc(Br)cnc1NS(=O)(=O)c1sc(Cl)cc1Br | 10.1021/acsmedchemlett.7b00315 | ||
| 10287192 | 162056 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 377 | 5 | 2 | 6 | 2.4 | COc1nc(CO)c(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4160463 | 162056 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 377 | 5 | 2 | 6 | 2.4 | COc1nc(CO)c(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 10193586 | 162822 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 347 | 4 | 1 | 5 | 2.9 | COc1nc(C)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4172568 | 162822 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 347 | 4 | 1 | 5 | 2.9 | COc1nc(C)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 44581103 | 187773 | 0 | None | -6 | 2 | Mouse | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 539 | 9 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL495737 | 187773 | 0 | None | -6 | 2 | Mouse | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 539 | 9 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 118706828 | 112981 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 442 | 5 | 3 | 6 | 2.6 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CNC1 | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310837 | 112981 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 442 | 5 | 3 | 6 | 2.6 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CNC1 | 10.1016/j.bmc.2014.05.021 | ||
| 56848673 | 87187 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 576 | 9 | 3 | 7 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326923 | 87187 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 576 | 9 | 3 | 7 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| 56848670 | 87189 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 576 | 9 | 3 | 7 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326925 | 87189 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 576 | 9 | 3 | 7 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| 118706825 | 112978 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 429 | 6 | 2 | 5 | 3.9 | CCCn1c(=O)[nH]c2cc(NS(=O)(=O)c3cccc(Cl)c3Cl)c(OC)cc21 | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310834 | 112978 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 429 | 6 | 2 | 5 | 3.9 | CCCn1c(=O)[nH]c2cc(NS(=O)(=O)c3cccc(Cl)c3Cl)c(OC)cc21 | 10.1016/j.bmc.2014.05.021 | ||
| 137656805 | 159726 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 444 | 7 | 1 | 8 | 2.5 | COc1nn(CCN(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4104585 | 159726 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 444 | 7 | 1 | 8 | 2.5 | COc1nn(CCN(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 10417 | 1069 | 9 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 10.1021/acs.jmedchem.9b00506 | ||
| 134324842 | 1069 | 9 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4459231 | 1069 | 9 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 10.1021/acs.jmedchem.9b00506 | ||
| 155541406 | 172995 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 525 | 6 | 0 | 7 | 6.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4518040 | 172995 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 525 | 6 | 0 | 7 | 6.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 58054487 | 73876 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 504 | 7 | 1 | 7 | 4.3 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018963 | 73876 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 504 | 7 | 1 | 7 | 4.3 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 134211126 | 177569 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 4.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4640439 | 177569 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 4.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 155531126 | 171607 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4465359 | 171607 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 44581043 | 187834 | 0 | None | -1 | 2 | Mouse | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 511 | 7 | 1 | 8 | 5.1 | COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496152 | 187834 | 0 | None | -1 | 2 | Mouse | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 511 | 7 | 1 | 8 | 5.1 | COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 44562191 | 186756 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 485 | 9 | 2 | 8 | 4.3 | COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL488857 | 186756 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 485 | 9 | 2 | 8 | 4.3 | COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 44581042 | 187833 | 0 | None | -6 | 2 | Mouse | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 497 | 6 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496151 | 187833 | 0 | None | -6 | 2 | Mouse | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 497 | 6 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 44581102 | 187772 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 525 | 8 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL495736 | 187772 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 525 | 8 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 71555361 | 133324 | 0 | None | -234 | 5 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 564 | 8 | 3 | 10 | 2.4 | Cc1ccc([C@H](Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N4CCN(C)CC4)c3O)c(=O)c2=O)C2(C)COC2)o1 | nan | ||
| CHEMBL3704573 | 133324 | 0 | None | -234 | 5 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 564 | 8 | 3 | 10 | 2.4 | Cc1ccc([C@H](Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N4CCN(C)CC4)c3O)c(=O)c2=O)C2(C)COC2)o1 | nan | ||
| 134210778 | 177702 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 551 | 7 | 1 | 8 | 3.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4642090 | 177702 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 551 | 7 | 1 | 8 | 3.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 118706821 | 112975 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 444 | 6 | 3 | 6 | 1.9 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CC(N)=O | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310830 | 112975 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 444 | 6 | 3 | 6 | 1.9 | COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CC(N)=O | 10.1016/j.bmc.2014.05.021 | ||
| 134336138 | 177495 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 527 | 7 | 1 | 8 | 4.2 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4639418 | 177495 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 527 | 7 | 1 | 8 | 4.2 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| 134324973 | 170387 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4447900 | 170387 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 70693879 | 73421 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2016602 | 73421 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1 | 10.1016/j.bmcl.2012.02.104 | ||
| 44581042 | 187833 | 0 | None | 6 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 497 | 6 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496151 | 187833 | 0 | None | 6 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 497 | 6 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 44561561 | 179001 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 439 | 6 | 1 | 7 | 4.5 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL470962 | 179001 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 439 | 6 | 1 | 7 | 4.5 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 10215932 | 73127 | 1 | None | 22 | 2 | Mouse | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 383 | 4 | 1 | 6 | 2.8 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL2011441 | 73127 | 1 | None | 22 | 2 | Mouse | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 383 | 4 | 1 | 6 | 2.8 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| 9827294 | 73865 | 3 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL2018953 | 73865 | 3 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmc.2014.05.021 | ||
| 9827294 | 73865 | 3 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018953 | 73865 | 3 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2012.02.104 | ||
| 9827294 | 73865 | 3 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmc.2017.07.052 | ||
| 9827294 | 73865 | 3 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1021/jm301572h | ||
| CHEMBL2018953 | 73865 | 3 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL2018953 | 73865 | 3 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1021/jm301572h | ||
| 118706831 | 112985 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 389 | 4 | 3 | 6 | 1.8 | COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310841 | 112985 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 389 | 4 | 3 | 6 | 1.8 | COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| 56848674 | 87188 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 542 | 9 | 3 | 7 | 3.9 | COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326924 | 87188 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 542 | 9 | 3 | 7 | 3.9 | COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | ||
| 59168115 | 162296 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 347 | 4 | 1 | 5 | 2.9 | COc1ncc(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4164247 | 162296 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 347 | 4 | 1 | 5 | 2.9 | COc1ncc(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 44430315 | 11866 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | ||
| CHEMBL1182360 | 11866 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | ||
| CHEMBL233047 | 11866 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | ||
| 11223594 | 71084 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | ||
| CHEMBL195298 | 71084 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | ||
| 10308720 | 545 | 42 | None | -4 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9678 | 545 | 42 | None | -4 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4169247 | 545 | 42 | None | -4 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 10308720 | 545 | 42 | None | -4 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 9678 | 545 | 42 | None | -4 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4169247 | 545 | 42 | None | -4 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 137638825 | 156870 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 430 | 6 | 2 | 8 | 1.4 | COc1nn(CC(N)=O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4071815 | 156870 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 430 | 6 | 2 | 8 | 1.4 | COc1nn(CC(N)=O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 59168213 | 162151 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 411 | 5 | 1 | 7 | 2.0 | COc1nc(S(C)(=O)=O)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4161922 | 162151 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 411 | 5 | 1 | 7 | 2.0 | COc1nc(S(C)(=O)=O)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 145955410 | 162397 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 381 | 4 | 1 | 5 | 3.3 | CCc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4165828 | 162397 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 381 | 4 | 1 | 5 | 3.3 | CCc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| 10309892 | 162466 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4167021 | 162466 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/acsmedchemlett.7b00315 | ||
| 156018931 | 177869 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 540 | 6 | 0 | 6 | 6.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4644412 | 177869 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 540 | 6 | 0 | 6 | 6.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 44581043 | 187834 | 0 | None | 1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 511 | 7 | 1 | 8 | 5.1 | COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496152 | 187834 | 0 | None | 1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 511 | 7 | 1 | 8 | 5.1 | COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 44561363 | 189684 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 6.3 | COc1cc2nc(C3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL515355 | 189684 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 6.3 | COc1cc2nc(C3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 44581044 | 193448 | 0 | None | 3 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 525 | 8 | 1 | 8 | 5.4 | COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1 | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL526474 | 193448 | 0 | None | 3 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 525 | 8 | 1 | 8 | 5.4 | COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1 | 10.1016/j.bmc.2008.11.020 | ||
| 11496063 | 77119 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 447 | 8 | 1 | 4 | 8.0 | c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1 | 10.1016/j.bmcl.2006.01.126 | ||
| CHEMBL207642 | 77119 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 447 | 8 | 1 | 4 | 8.0 | c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1 | 10.1016/j.bmcl.2006.01.126 | ||
| 155540774 | 172514 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 523 | 5 | 1 | 7 | 4.7 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4483537 | 172514 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 523 | 5 | 1 | 7 | 4.7 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00506 | ||
| 155543069 | 173188 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 459 | 5 | 2 | 5 | 4.7 | C[C@@H](Nc1cncc(C2=CCN(C(=O)[C@H]3CCCCN3)CC2)n1)c1ccc(Cl)cc1Cl | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4522437 | 173188 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 459 | 5 | 2 | 5 | 4.7 | C[C@@H](Nc1cncc(C2=CCN(C(=O)[C@H]3CCCCN3)CC2)n1)c1ccc(Cl)cc1Cl | 10.1021/acs.jmedchem.9b00506 | ||
| 59456003 | 73864 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 476 | 7 | 2 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018952 | 73864 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 476 | 7 | 2 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 44562235 | 186460 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 495 | 6 | 1 | 7 | 5.9 | COc1cc2nc(N3CCCN(C4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL487665 | 186460 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 495 | 6 | 1 | 7 | 5.9 | COc1cc2nc(N3CCCN(C4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 44561332 | 176222 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| CHEMBL459463 | 176222 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | ||
| 58835024 | 92643 | 0 | None | -398 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 570 | 8 | 1 | 6 | 5.5 | Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | ||
| CHEMBL2435852 | 92643 | 0 | None | -398 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 570 | 8 | 1 | 6 | 5.5 | Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | ||
| 134324891 | 174567 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 458 | 4 | 0 | 6 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4556507 | 174567 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 458 | 4 | 0 | 6 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 25212379 | 187862 | 1 | None | -2 | 2 | Mouse | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 511 | 7 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496356 | 187862 | 1 | None | -2 | 2 | Mouse | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 511 | 7 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 134210775 | 177776 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 530 | 7 | 0 | 8 | 4.8 | CCOC(=O)CN1CCCC(C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4643066 | 177776 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 530 | 7 | 0 | 8 | 4.8 | CCOC(=O)CN1CCCC(C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | ||
| 134211057 | 177625 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 529 | 7 | 1 | 7 | 4.3 | CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4641127 | 177625 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 529 | 7 | 1 | 7 | 4.3 | CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | ||
| 59455976 | 87155 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 504 | 8 | 3 | 7 | 3.7 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326611 | 87155 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 504 | 8 | 3 | 7 | 3.7 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1 | 10.1021/jm301572h | ||
| 59456050 | 87170 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 589 | 9 | 2 | 9 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1 | 10.1021/jm301572h | ||
| CHEMBL2326625 | 87170 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 589 | 9 | 2 | 9 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1 | 10.1021/jm301572h | ||
| 118706816 | 112970 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310825 | 112970 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C | 10.1016/j.bmc.2014.05.021 | ||
| 118706816 | 112970 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL3310825 | 112970 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C | 10.1016/j.bmc.2017.07.052 | ||
| 44562192 | 185777 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 499 | 10 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL486656 | 185777 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 499 | 10 | 2 | 8 | 4.7 | COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 44581103 | 187773 | 0 | None | 6 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 539 | 9 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL495737 | 187773 | 0 | None | 6 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 539 | 9 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 44581068 | 187924 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 513 | 7 | 2 | 9 | 3.7 | COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496787 | 187924 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 513 | 7 | 2 | 9 | 3.7 | COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 137636569 | 155874 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 387 | 4 | 1 | 7 | 2.5 | COc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4060413 | 155874 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 387 | 4 | 1 | 7 | 2.5 | COc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 10215932 | 73127 | 1 | None | -22 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 383 | 4 | 1 | 6 | 2.8 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL2011441 | 73127 | 1 | None | -22 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 383 | 4 | 1 | 6 | 2.8 | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1021/acsmedchemlett.7b00315 | ||
| 145958908 | 162090 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 401 | 4 | 1 | 5 | 3.6 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(C(F)(F)F)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4160965 | 162090 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 401 | 4 | 1 | 5 | 3.6 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(C(F)(F)F)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 145951136 | 162752 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 358 | 4 | 1 | 6 | 2.5 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C#N | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4171579 | 162752 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 358 | 4 | 1 | 6 | 2.5 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C#N | 10.1021/acsmedchemlett.7b00315 | ||
| 137632086 | 156437 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 401 | 4 | 1 | 7 | 2.8 | COc1nn(C)c2nc(C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4066934 | 156437 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 401 | 4 | 1 | 7 | 2.8 | COc1nn(C)c2nc(C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 137654717 | 158732 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 430 | 5 | 1 | 8 | 2.5 | COc1nn(C)c2nc(N(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4093509 | 158732 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 430 | 5 | 1 | 8 | 2.5 | COc1nn(C)c2nc(N(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 137652889 | 158905 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 444 | 6 | 2 | 8 | 1.7 | CNC(=O)Cn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4095437 | 158905 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 444 | 6 | 2 | 8 | 1.7 | CNC(=O)Cn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21 | 10.1016/j.bmc.2017.07.052 | ||
| 145951247 | 162928 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1c(Cl)cccc1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4174254 | 162928 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 411 | 4 | 1 | 5 | 3.4 | COc1nc(Br)cnc1NS(=O)(=O)c1c(Cl)cccc1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 10193603 | 162943 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 2.1 | COc1nc(Br)cnc1NS(=O)(=O)c1cccs1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4174488 | 162943 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 2.1 | COc1nc(Br)cnc1NS(=O)(=O)c1cccs1 | 10.1021/acsmedchemlett.7b00315 | ||
| 44581044 | 193448 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 525 | 8 | 1 | 8 | 5.4 | COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1 | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL526474 | 193448 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 525 | 8 | 1 | 8 | 5.4 | COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1 | 10.1016/j.bmc.2008.11.020 | ||
| 692856 | 141363 | 19 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 240 | 2 | 1 | 3 | 4.3 | Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | ||
| CHEMBL383736 | 141363 | 19 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 240 | 2 | 1 | 3 | 4.3 | Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | ||
| 134325269 | 170691 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 516 | 5 | 1 | 7 | 4.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(=O)O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4451802 | 170691 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 516 | 5 | 1 | 7 | 4.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(=O)O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 134210768 | 177454 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 530 | 8 | 1 | 7 | 5.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4638846 | 177454 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 530 | 8 | 1 | 7 | 5.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 134325215 | 174978 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 472 | 4 | 0 | 6 | 5.4 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4566304 | 174978 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 472 | 4 | 0 | 6 | 5.4 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 44562155 | 186631 | 0 | None | 19 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.7 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL488018 | 186631 | 0 | None | 19 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.7 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 44430312 | 87260 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2006.10.091 | ||
| CHEMBL233046 | 87260 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2006.10.091 | ||
| 11525206 | 135228 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL372399 | 135228 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.ejmech.2016.02.058 | ||
| 127047356 | 139634 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 488 | 6 | 1 | 6 | 4.5 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL3797662 | 139634 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 488 | 6 | 1 | 6 | 4.5 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | ||
| 127045756 | 139869 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL3799266 | 139869 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| 127046614 | 139926 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 442 | 6 | 2 | 6 | 3.4 | Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| CHEMBL3799578 | 139926 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 442 | 6 | 2 | 6 | 3.4 | Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1 | 10.1016/j.ejmech.2016.02.058 | ||
| 10287052 | 162378 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 367 | 4 | 1 | 5 | 3.2 | COc1ncc(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4165356 | 162378 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 367 | 4 | 1 | 5 | 3.2 | COc1ncc(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 11234202 | 162903 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 373 | 4 | 1 | 6 | 3.3 | COc1nc(Cl)cnc1NS(=O)(=O)c1scc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4173861 | 162903 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 373 | 4 | 1 | 6 | 3.3 | COc1nc(Cl)cnc1NS(=O)(=O)c1scc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 44562189 | 186575 | 0 | None | -7 | 2 | Mouse | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 451 | 6 | 1 | 7 | 4.6 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL487835 | 186575 | 0 | None | -7 | 2 | Mouse | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 451 | 6 | 1 | 7 | 4.6 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 156010600 | 177138 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 550 | 7 | 0 | 8 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4633920 | 177138 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 550 | 7 | 0 | 8 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 118706830 | 112984 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 388 | 4 | 3 | 5 | 2.4 | COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| CHEMBL3310840 | 112984 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 388 | 4 | 3 | 5 | 2.4 | COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | ||
| 58054532 | 73875 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 490 | 7 | 2 | 7 | 4.0 | CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018962 | 73875 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 490 | 7 | 2 | 7 | 4.0 | CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 58054387 | 87152 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 492 | 7 | 2 | 6 | 4.4 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1 | 10.1021/jm301572h | ||
| CHEMBL2326609 | 87152 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 492 | 7 | 2 | 6 | 4.4 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1 | 10.1021/jm301572h | ||
| 59456098 | 87179 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1ccc(F)c2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| CHEMBL2326634 | 87179 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1ccc(F)c2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | ||
| 137639968 | 156677 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 416 | 5 | 2 | 8 | 2.5 | CNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4069639 | 156677 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 416 | 5 | 2 | 8 | 2.5 | CNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1 | 10.1016/j.bmc.2017.07.052 | ||
| 137639432 | 156830 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 359 | 4 | 1 | 8 | 1.9 | COc1nn(C)c2ncnc(NS(=O)(=O)c3ccc(Cl)s3)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4071299 | 156830 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 359 | 4 | 1 | 8 | 1.9 | COc1nn(C)c2ncnc(NS(=O)(=O)c3ccc(Cl)s3)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 10308962 | 163043 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1F | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4176082 | 163043 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1F | 10.1021/acsmedchemlett.7b00315 | ||
| 137634526 | 155929 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 417 | 5 | 1 | 8 | 2.5 | COc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4060967 | 155929 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 417 | 5 | 1 | 8 | 2.5 | COc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1 | 10.1016/j.bmc.2017.07.052 | ||
| 137632304 | 156477 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.7 | COc1nn(C)c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4067451 | 156477 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.7 | COc1nn(C)c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 137647898 | 157741 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 431 | 7 | 1 | 8 | 2.5 | COCCOc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4082318 | 157741 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 431 | 7 | 1 | 8 | 2.5 | COCCOc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 137644970 | 158495 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 387 | 5 | 2 | 6 | 2.9 | CCOc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4091069 | 158495 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 387 | 5 | 2 | 6 | 2.9 | CCOc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 | 10.1016/j.bmc.2017.07.052 | ||
| 59168178 | 162984 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 343 | 4 | 1 | 5 | 2.0 | COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1 | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4175259 | 162984 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 343 | 4 | 1 | 5 | 2.0 | COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1 | 10.1021/acsmedchemlett.7b00315 | ||
| 137637450 | 155819 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 460 | 8 | 2 | 9 | 2.5 | COCCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1 | 10.1016/j.bmc.2017.07.052 | ||
| CHEMBL4059913 | 155819 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 460 | 8 | 2 | 9 | 2.5 | COCCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1 | 10.1016/j.bmc.2017.07.052 | ||
| 145955548 | 162612 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 4.7 | CC(C)(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| CHEMBL4169258 | 162612 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 4.7 | CC(C)(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.7b00315 | ||
| 134225259 | 177744 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 517 | 7 | 2 | 8 | 3.0 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4642563 | 177744 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 517 | 7 | 2 | 8 | 3.0 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| 44430315 | 11866 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | ||
| CHEMBL1182360 | 11866 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | ||
| CHEMBL233047 | 11866 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | ||
| 155548141 | 173787 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@@H](N4CCCCC4)[C@@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4537681 | 173787 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@@H](N4CCCCC4)[C@@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | ||
| 44562155 | 186631 | 0 | None | -19 | 2 | Mouse | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.7 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL488018 | 186631 | 0 | None | -19 | 2 | Mouse | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.7 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 134324996 | 171743 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 540 | 4 | 0 | 6 | 6.5 | CC1CN(c2cnc3c(C(F)(F)F)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1 | 10.1021/acs.jmedchem.9b00506 | ||
| CHEMBL4467274 | 171743 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 540 | 4 | 0 | 6 | 6.5 | CC1CN(c2cnc3c(C(F)(F)F)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1 | 10.1021/acs.jmedchem.9b00506 | ||
| 134210954 | 177810 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 551 | 7 | 1 | 8 | 3.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4643609 | 177810 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 551 | 7 | 1 | 8 | 3.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 44581042 | 187833 | 0 | None | 6 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 497 | 6 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL496151 | 187833 | 0 | None | 6 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 497 | 6 | 2 | 8 | 4.5 | COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 44581102 | 187772 | 0 | None | -1 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 525 | 8 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| CHEMBL495736 | 187772 | 0 | None | -1 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 525 | 8 | 2 | 8 | 4.6 | COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.11.020 | ||
| 156012782 | 177364 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 545 | 7 | 1 | 8 | 3.6 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4637695 | 177364 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 545 | 7 | 1 | 8 | 3.6 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | ||
| 134210898 | 177783 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 516 | 7 | 1 | 7 | 4.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| CHEMBL4643158 | 177783 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 516 | 7 | 1 | 7 | 4.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | ||
| 59455974 | 73874 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 462 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018961 | 73874 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 462 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 44562236 | 186727 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 512 | 10 | 1 | 8 | 4.9 | CCN(CC)CCN1CCCN(c2nc(Nc3ccc(Cl)cc3)c3cc(OC)c(OC)cc3n2)CC1 | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL488690 | 186727 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 512 | 10 | 1 | 8 | 4.9 | CCN(CC)CCN1CCCN(c2nc(Nc3ccc(Cl)cc3)c3cc(OC)c(OC)cc3n2)CC1 | 10.1016/j.bmc.2008.07.062 | ||
| 44562190 | 186576 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 471 | 8 | 2 | 8 | 3.9 | COc1cc2nc(N3CCC(N(C)CCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| CHEMBL487836 | 186576 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 471 | 8 | 2 | 8 | 3.9 | COc1cc2nc(N3CCC(N(C)CCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | ||
| 59455974 | 73874 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Functional | ChEMBL | 462 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018961 | 73874 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Functional | ChEMBL | 462 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 59456102 | 73877 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018964 | 73877 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 59456003 | 73864 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 476 | 7 | 2 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018952 | 73864 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 476 | 7 | 2 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 59456051 | 73880 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 520 | 9 | 3 | 8 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018967 | 73880 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 520 | 9 | 3 | 8 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmcl.2012.02.104 | ||
| 58054516 | 73871 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 493 | 8 | 1 | 8 | 4.6 | COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018959 | 73871 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 493 | 8 | 1 | 8 | 4.6 | COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC | 10.1016/j.bmcl.2012.02.104 | ||
| 9827294 | 73865 | 3 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018953 | 73865 | 3 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2012.02.104 | ||
| 10416 | 1879 | 30 | None | 309 | 2 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.bmcl.2012.02.104 | ||
| 46861584 | 1879 | 30 | None | 309 | 2 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018969 | 1879 | 30 | None | 309 | 2 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.bmcl.2012.02.104 | ||
| 59456067 | 73881 | 0 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 534 | 9 | 3 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018968 | 73881 | 0 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 534 | 9 | 3 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 70685473 | 73863 | 0 | None | - | 1 | Human | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018951 | 73863 | 0 | None | - | 1 | Human | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1 | 10.1016/j.bmcl.2012.02.104 | ||
| 70689680 | 73867 | 0 | None | - | 1 | Human | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | 433 | 6 | 1 | 6 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1 | 10.1016/j.bmcl.2012.02.104 | ||
| CHEMBL2018955 | 73867 | 0 | None | - | 1 | Human | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | 433 | 6 | 1 | 6 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1 | 10.1016/j.bmcl.2012.02.104 | ||
| 49798461 | 10693 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | ||
| CHEMBL1170725 | 10693 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | ||
| 49798437 | 10559 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 515 | 8 | 3 | 6 | 4.4 | O=C(NCCO)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | ||
| CHEMBL1169660 | 10559 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 515 | 8 | 3 | 6 | 4.4 | O=C(NCCO)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | ||
| 49798349 | 10791 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | ||
| CHEMBL1171786 | 10791 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | ||
| 16124598 | 10729 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | ||
| CHEMBL1171008 | 10729 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | ||
| 12893 | 4140 | 0 | None | - | 1 | Human | 7.0 | pIC50 | < | 7 | Functional | Guide to Pharmacology | 565 | 7 | 2 | 6 | 6.3 | CC1=C(C(=NC(=N1)N2CC(C2)[C@H]3CCCN(C3)C4CC(C4)(C)C(=O)O)N[C@H](C)C5=C(C=C(C=C5)Cl)Cl)Cl | None | ||
| 139344142 | 4140 | 0 | None | - | 1 | Human | 7.0 | pIC50 | < | 7 | Functional | Guide to Pharmacology | 565 | 7 | 2 | 6 | 6.3 | CC1=C(C(=NC(=N1)N2CC(C2)[C@H]3CCCN(C3)C4CC(C4)(C)C(=O)O)N[C@H](C)C5=C(C=C(C=C5)Cl)Cl)Cl | None | ||
| 5280343 | 188275 | 124 | None | -16 | 12 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
| CHEMBL1520590 | 188275 | 124 | None | -16 | 12 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
| CHEMBL50 | 188275 | 124 | None | -16 | 12 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
| 2812 | 4779 | 101 | None | 3 | 44 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| CHEMBL104 | 4779 | 101 | None | 3 | 44 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| 4410 | 3137 | 106 | None | -18 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| 65015 | 3137 | 106 | None | -18 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| 844 | 3137 | 106 | None | -18 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| CHEMBL18442 | 3137 | 106 | None | -18 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| DB06809 | 3137 | 106 | None | -18 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| 3793 | 203209 | 77 | None | -1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | None | ||
| 45039617 | 203209 | 77 | None | -1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | None | ||
| CHEMBL64391 | 203209 | 77 | None | -1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | None | ||
| 12153 | 1665 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | Guide to Pharmacology | 542 | 6 | 1 | 7 | 4.9 | C[C@H](c1c(cc(cc1)Cl)Cl)n1c2nc(cnc2c(n1)C(F)(F)F)N1CC(C1)[C@H]1CCCN(C1)CCO | None | ||
| 134210715 | 1665 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | Guide to Pharmacology | 542 | 6 | 1 | 7 | 4.9 | C[C@H](c1c(cc(cc1)Cl)Cl)n1c2nc(cnc2c(n1)C(F)(F)F)N1CC(C1)[C@H]1CCCN(C1)CCO | None | ||
| 10417 | 1069 | 9 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 31259550 | ||
| 134324842 | 1069 | 9 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 31259550 | ||
| CHEMBL4459231 | 1069 | 9 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 31259550 | ||
| 10308720 | 545 | 42 | None | -2 | 3 | Dog | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 9678 | 545 | 42 | None | -2 | 3 | Dog | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| CHEMBL4169247 | 545 | 42 | None | -2 | 3 | Dog | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 25141190 | 1146 | 28 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 19081254 | ||
| 9478 | 1146 | 28 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 19081254 | ||
| CHEMBL508207 | 1146 | 28 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 19081254 | ||
| 10308720 | 545 | 42 | None | -4 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Functional | Guide to Pharmacology | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 9678 | 545 | 42 | None | -4 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Functional | Guide to Pharmacology | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| CHEMBL4169247 | 545 | 42 | None | -4 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Functional | Guide to Pharmacology | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 10308720 | 545 | 42 | None | 2 | 3 | Mouse | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 9678 | 545 | 42 | None | 2 | 3 | Mouse | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| CHEMBL4169247 | 545 | 42 | None | 2 | 3 | Mouse | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 23585443 | 542 | 12 | None | -3 | 3 | Dog | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 9679 | 542 | 12 | None | -3 | 3 | Dog | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| CHEMBL4172635 | 542 | 12 | None | -3 | 3 | Dog | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 23585443 | 542 | 12 | None | -16 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 9679 | 542 | 12 | None | -16 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| CHEMBL4172635 | 542 | 12 | None | -16 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 797 | 832 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9430724 | ||||
| 23585443 | 542 | 12 | None | 3 | 3 | Mouse | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 9679 | 542 | 12 | None | 3 | 3 | Mouse | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| CHEMBL4172635 | 542 | 12 | None | 3 | 3 | Mouse | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 28947948 | ||
| 798 | 846 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 9430724 | ||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 44410965 | 77059 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 283 | 5 | 2 | 4 | 4.1 | CCNCc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL207290 | 77059 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 283 | 5 | 2 | 4 | 4.1 | CCNCc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44406335 | 73934 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | |||
| CHEMBL202085 | 73934 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | |||
| 44288732 | 101169 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 596 | 11 | 2 | 6 | 3.6 | O=C(C[C@H]1S[C@H](c2ccc(F)cc2F)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL295560 | 101169 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 596 | 11 | 2 | 6 | 3.6 | O=C(C[C@H]1S[C@H](c2ccc(F)cc2F)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288854 | 165061 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.5 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42266 | 165061 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.5 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288730 | 165972 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 612 | 11 | 2 | 6 | 4.1 | O=C(C[C@H]1S[C@H](c2ccc(F)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42523 | 165972 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 612 | 11 | 2 | 6 | 4.1 | O=C(C[C@H]1S[C@H](c2ccc(F)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289282 | 169776 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 617 | 11 | 3 | 6 | 4.0 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc2[nH]ccc2c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44390 | 169776 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 617 | 11 | 3 | 6 | 4.0 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc2[nH]ccc2c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 5481702 | 205823 | 1 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 5.3 | CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00639-9 | |||
| CHEMBL83338 | 205823 | 1 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 5.3 | CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00639-9 | |||
| 5280343 | 188275 | 124 | None | - | 32 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/jm301749y | |||
| CHEMBL1520590 | 188275 | 124 | None | - | 32 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/jm301749y | |||
| CHEMBL50 | 188275 | 124 | None | - | 32 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/jm301749y | |||
| 71720517 | 87007 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| CHEMBL2324200 | 87007 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| 44288960 | 163796 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 612 | 11 | 2 | 6 | 4.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42060 | 163796 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 612 | 11 | 2 | 6 | 4.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 44400830 | 71235 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 376 | 10 | 1 | 4 | 5.1 | CCN(CC)CCCC(C)Nc1nc(Cc2ccccc2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL195665 | 71235 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 376 | 10 | 1 | 4 | 5.1 | CCN(CC)CCCC(C)Nc1nc(Cc2ccccc2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| 5280343 | 188275 | 124 | None | - | 32 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/jm301749y | |||
| CHEMBL1520590 | 188275 | 124 | None | - | 32 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/jm301749y | |||
| CHEMBL50 | 188275 | 124 | None | - | 32 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/jm301749y | |||
| 44288899 | 101265 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 588 | 13 | 2 | 6 | 3.6 | O=C(C[C@H]1S[C@H](CCc2ccccc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL296245 | 101265 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 588 | 13 | 2 | 6 | 3.6 | O=C(C[C@H]1S[C@H](CCc2ccccc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288863 | 162071 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 566 | 11 | 2 | 6 | 3.5 | O=C(C[C@H]1S[C@H](C2CCCCC2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL416069 | 162071 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 566 | 11 | 2 | 6 | 3.5 | O=C(C[C@H]1S[C@H](C2CCCCC2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289207 | 168191 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 633 | 9 | 1 | 5 | 6.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(Cc2cccc(CN3CCOCC3)c2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43330 | 168191 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 633 | 9 | 1 | 5 | 6.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(Cc2cccc(CN3CCOCC3)c2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288557 | 170284 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 550 | 11 | 2 | 7 | 2.9 | O=C(C[C@H]1S[C@H](c2ccoc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44463 | 170284 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 550 | 11 | 2 | 7 | 2.9 | O=C(C[C@H]1S[C@H](c2ccoc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 5280343 | 188275 | 124 | None | - | 32 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/jm301749y | |||
| CHEMBL1520590 | 188275 | 124 | None | - | 32 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/jm301749y | |||
| CHEMBL50 | 188275 | 124 | None | - | 32 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/jm301749y | |||
| 134211221 | 177688 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 502 | 7 | 1 | 7 | 4.6 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4641873 | 177688 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 502 | 7 | 1 | 7 | 4.6 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 45104526 | 200709 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 479 | 3 | 3 | 7 | 3.8 | Cc1c(N2CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL599995 | 200709 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 479 | 3 | 3 | 7 | 3.8 | Cc1c(N2CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 44288959 | 165307 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 640 | 11 | 2 | 5 | 6.3 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42334 | 165307 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 640 | 11 | 2 | 5 | 6.3 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44430304 | 152122 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 477 | 12 | 2 | 7 | 5.7 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2c(ncn2CC)n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL396786 | 152122 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 477 | 12 | 2 | 7 | 5.7 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2c(ncn2CC)n1 | 10.1016/j.bmcl.2006.10.091 | |||
| 11285792 | 879 | 34 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
| 801 | 879 | 34 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
| CHEMBL2110727 | 879 | 34 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
| DB11758 | 879 | 34 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
| 44288962 | 100474 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 572 | 10 | 2 | 5 | 4.5 | CN(C)CC(=O)NCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL290845 | 100474 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 572 | 10 | 2 | 5 | 4.5 | CN(C)CC(=O)NCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 44288985 | 155542 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 668 | 14 | 2 | 9 | 3.5 | COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1OC | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL40427 | 155542 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 668 | 14 | 2 | 9 | 3.5 | COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1OC | 10.1016/j.bmcl.2004.01.072 | |||
| 44288961 | 155631 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 3.8 | Cc1ccccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL40468 | 155631 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 3.8 | Cc1ccccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| 44289214 | 157303 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(C[C@H]1S[C@H](c2ccccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL40771 | 157303 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(C[C@H]1S[C@H](c2ccccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288776 | 166319 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 571 | 10 | 2 | 8 | 3.3 | O=C(CN1C(=O)[C@@H](CC(=O)Nc2nccs2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42722 | 166319 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 571 | 10 | 2 | 8 | 3.3 | O=C(CN1C(=O)[C@@H](CC(=O)Nc2nccs2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288731 | 170339 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 588 | 11 | 2 | 6 | 3.9 | Cc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(C)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44472 | 170339 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 588 | 11 | 2 | 6 | 3.9 | Cc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(C)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288963 | 170980 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 584 | 11 | 2 | 7 | 3.5 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccs1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44561 | 170980 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 584 | 11 | 2 | 7 | 3.5 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccs1 | 10.1016/j.bmcl.2004.01.072 | |||
| 45104751 | 200918 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 288 | 1 | 1 | 5 | 1.9 | Cc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| CHEMBL601651 | 200918 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 288 | 1 | 1 | 5 | 1.9 | Cc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| 3793 | 203209 | 77 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 45039617 | 203209 | 77 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| CHEMBL64391 | 203209 | 77 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 134210626 | 177305 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 593 | 9 | 1 | 8 | 4.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4636749 | 177305 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 593 | 9 | 1 | 8 | 4.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 155557193 | 174525 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 538 | 5 | 1 | 7 | 6.0 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4555534 | 174525 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 538 | 5 | 1 | 7 | 6.0 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O | 10.1021/acs.jmedchem.9b00506 | |||
| 44561588 | 194553 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| CHEMBL529664 | 194553 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| 44406247 | 141197 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 463 | 5 | 0 | 6 | 3.4 | CN1CCCC(C(=O)N2CCN(c3nccc(OCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.bmcl.2005.09.022 | |||
| CHEMBL382826 | 141197 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 463 | 5 | 0 | 6 | 3.4 | CN1CCCC(C(=O)N2CCN(c3nccc(OCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.bmcl.2005.09.022 | |||
| 71454500 | 78992 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 409 | 11 | 1 | 4 | 5.9 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2Cl)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL2113068 | 78992 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 409 | 11 | 1 | 4 | 5.9 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2Cl)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| 44289275 | 101513 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 4.0 | C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL298035 | 101513 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 4.0 | C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289277 | 163503 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2cc(Cl)ccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42021 | 163503 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2cc(Cl)ccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289072 | 169340 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.3 | O=C(C[C@H]1S[C@H](c2cccc(C(F)(F)F)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44187 | 169340 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.3 | O=C(C[C@H]1S[C@H](c2cccc(C(F)(F)F)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44411038 | 76800 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 7.6 | Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)no2)c1C | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL206921 | 76800 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 7.6 | Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)no2)c1C | 10.1016/j.bmcl.2006.01.126 | |||
| 3793 | 203209 | 77 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 45039617 | 203209 | 77 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| CHEMBL64391 | 203209 | 77 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 44289062 | 163659 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 654 | 12 | 2 | 6 | 5.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(-c2ccccc2)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42044 | 163659 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 654 | 12 | 2 | 6 | 5.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(-c2ccccc2)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289064 | 170931 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 660 | 12 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCCc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44553 | 170931 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 660 | 12 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCCc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 45104634 | 200736 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 304 | 2 | 2 | 6 | 1.7 | CCN1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1 | 10.1021/jm901652p | |||
| CHEMBL600196 | 200736 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 304 | 2 | 2 | 6 | 1.7 | CCN1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1 | 10.1021/jm901652p | |||
| 45104523 | 201711 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 437 | 3 | 3 | 6 | 4.0 | Cc1c(N2CCN(C(=O)Nc3ccc(C(C)C)cc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL606421 | 201711 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 437 | 3 | 3 | 6 | 4.0 | Cc1c(N2CCN(C(=O)Nc3ccc(C(C)C)cc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 134225247 | 177663 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 545 | 7 | 1 | 8 | 4.6 | COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4641595 | 177663 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 545 | 7 | 1 | 8 | 4.6 | COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | |||
| 134210845 | 178049 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 565 | 8 | 1 | 8 | 3.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4647188 | 178049 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 565 | 8 | 1 | 8 | 3.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 155540774 | 172514 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 5 | 1 | 7 | 4.7 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4483537 | 172514 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 5 | 1 | 7 | 4.7 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O | 10.1021/acs.jmedchem.9b00506 | |||
| 44411321 | 138425 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 509 | 8 | 1 | 4 | 8.6 | FC(F)(F)c1ccccc1CN(Cc1csc(Nc2cccc3ccccc23)n1)CC1CCCCC1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL377421 | 138425 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 509 | 8 | 1 | 4 | 8.6 | FC(F)(F)c1ccccc1CN(Cc1csc(Nc2cccc3ccccc23)n1)CC1CCCCC1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44430311 | 152380 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 11 | 2 | 6 | 5.9 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2cccnc2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL397028 | 152380 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 11 | 2 | 6 | 5.9 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2cccnc2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| 44288958 | 168727 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 624 | 11 | 2 | 5 | 5.6 | Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43698 | 168727 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 624 | 11 | 2 | 5 | 5.6 | Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| 44288981 | 165557 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 570 | 7 | 2 | 5 | 4.2 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42419 | 165557 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 570 | 7 | 2 | 5 | 4.2 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 25141301 | 185888 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | |||
| CHEMBL486840 | 185888 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 5.1 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | |||
| 156015374 | 177615 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 551 | 6 | 0 | 7 | 5.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4640909 | 177615 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 551 | 6 | 0 | 7 | 5.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 44411492 | 138896 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 283 | 2 | 1 | 4 | 4.7 | CC(C)(C)c1csc(Nc2cccc3cnccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL378272 | 138896 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 283 | 2 | 1 | 4 | 4.7 | CC(C)(C)c1csc(Nc2cccc3cnccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44288943 | 164629 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)cc(Cl)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42162 | 164629 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)cc(Cl)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288913 | 169290 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 596 | 11 | 2 | 6 | 3.6 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(F)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44143 | 169290 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 596 | 11 | 2 | 6 | 3.6 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(F)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44401027 | 70552 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 410 | 11 | 1 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL194775 | 70552 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 410 | 11 | 1 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| 134325041 | 175032 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 5 | 1 | 7 | 4.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4567398 | 175032 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 5 | 1 | 7 | 4.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| 45104946 | 200720 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.3 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCC3)ccc12 | 10.1021/jm901652p | |||
| CHEMBL600018 | 200720 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.3 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCC3)ccc12 | 10.1021/jm901652p | |||
| 45104635 | 200737 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 420 | 2 | 2 | 6 | 3.9 | Cc1c(N2CCN(c3cccc(C(F)(F)F)c3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL600197 | 200737 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 420 | 2 | 2 | 6 | 3.9 | Cc1c(N2CCN(c3cccc(C(F)(F)F)c3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 45104422 | 201232 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 406 | 3 | 2 | 6 | 2.9 | Cc1c(N2CCN(C(=O)/C=C/c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL603701 | 201232 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 406 | 3 | 2 | 6 | 2.9 | Cc1c(N2CCN(C(=O)/C=C/c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 45104527 | 200710 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 409 | 3 | 3 | 6 | 2.5 | Cc1c(N2CCN(C(=O)NCc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL599996 | 200710 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 409 | 3 | 3 | 6 | 2.5 | Cc1c(N2CCN(C(=O)NCc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 2812 | 4779 | 101 | None | - | 34 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1021/jm301749y | |||
| CHEMBL104 | 4779 | 101 | None | - | 34 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1021/jm301749y | |||
| 71720517 | 87007 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| CHEMBL2324200 | 87007 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| 45104848 | 201095 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 302 | 3 | 0 | 5 | 2.3 | CCOc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| CHEMBL602887 | 201095 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 302 | 3 | 0 | 5 | 2.3 | CCOc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| 10417 | 1069 | 9 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 10.1021/acs.jmedchem.9b00506 | |||
| 134324842 | 1069 | 9 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4459231 | 1069 | 9 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 10.1021/acs.jmedchem.9b00506 | |||
| 9814022 | 77111 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 268 | 3 | 1 | 3 | 5.2 | CC(C)c1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL207589 | 77111 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 268 | 3 | 1 | 3 | 5.2 | CC(C)c1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 692856 | 141363 | 19 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 240 | 2 | 1 | 3 | 4.3 | Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL383736 | 141363 | 19 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 240 | 2 | 1 | 3 | 4.3 | Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 71461653 | 78990 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 375 | 11 | 1 | 4 | 5.2 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccccc2Cl)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL2113066 | 78990 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 375 | 11 | 1 | 4 | 5.2 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccccc2Cl)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| 134335393 | 170112 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 499 | 5 | 1 | 6 | 5.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4443688 | 170112 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 499 | 5 | 1 | 6 | 5.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| 11496063 | 77119 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 447 | 8 | 1 | 4 | 8.0 | c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL207642 | 77119 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 447 | 8 | 1 | 4 | 8.0 | c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44288978 | 168736 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 585 | 10 | 1 | 5 | 5.9 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43706 | 168736 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 585 | 10 | 1 | 5 | 5.9 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288827 | 168801 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2cccc(Cl)c2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43758 | 168801 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2cccc(Cl)c2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 71458049 | 78999 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 359 | 11 | 1 | 4 | 4.7 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL2113075 | 78999 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 359 | 11 | 1 | 4 | 4.7 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| 44561561 | 179001 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 439 | 6 | 1 | 7 | 4.5 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| CHEMBL470962 | 179001 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 439 | 6 | 1 | 7 | 4.5 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| 44288791 | 100196 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 558 | 12 | 2 | 6 | 3.3 | CC(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL288256 | 100196 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 558 | 12 | 2 | 6 | 3.3 | CC(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| 44430309 | 87224 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 459 | 11 | 2 | 5 | 6.5 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ccccc12 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL232841 | 87224 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 459 | 11 | 2 | 5 | 6.5 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ccccc12 | 10.1016/j.bmcl.2006.10.091 | |||
| 134325106 | 171251 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 500 | 4 | 0 | 6 | 6.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4460062 | 171251 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 500 | 4 | 0 | 6 | 6.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| 45104945 | 200719 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 5 | 0 | 6 | 2.7 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCCC3)ccc12 | 10.1021/jm901652p | |||
| CHEMBL600017 | 200719 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 5 | 0 | 6 | 2.7 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCCC3)ccc12 | 10.1021/jm901652p | |||
| 44430312 | 87260 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL233046 | 87260 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2006.10.091 | |||
| 44288880 | 101558 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 626 | 11 | 2 | 5 | 5.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL298454 | 101558 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 626 | 11 | 2 | 5 | 5.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 3793 | 203209 | 77 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 45039617 | 203209 | 77 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| CHEMBL64391 | 203209 | 77 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 44411325 | 168878 | 1 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 246 | 2 | 1 | 3 | 4.5 | Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL438248 | 168878 | 1 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 246 | 2 | 1 | 3 | 4.5 | Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44288879 | 169343 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44188 | 169343 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 44400833 | 70707 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 392 | 11 | 1 | 5 | 5.1 | CCN(CC)CCCC(C)Nc1nc(COc2ccccc2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL195061 | 70707 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 392 | 11 | 1 | 5 | 5.1 | CCN(CC)CCCC(C)Nc1nc(COc2ccccc2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| 44401066 | 126415 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 382 | 10 | 1 | 5 | 4.5 | CN(C)CCCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL365155 | 126415 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 382 | 10 | 1 | 5 | 4.5 | CN(C)CCCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| 44289208 | 163846 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 584 | 7 | 1 | 5 | 4.6 | CN1CCN(C(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42065 | 163846 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 584 | 7 | 1 | 5 | 4.6 | CN1CCN(C(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1 | 10.1016/j.bmcl.2004.01.072 | |||
| 71452724 | 78996 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 375 | 11 | 1 | 4 | 5.2 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL2113072 | 78996 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 375 | 11 | 1 | 4 | 5.2 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| 45104633 | 200401 | 22 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 290 | 1 | 2 | 6 | 1.3 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL598070 | 200401 | 22 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 290 | 1 | 2 | 6 | 1.3 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 9943773 | 77304 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 286 | 2 | 1 | 3 | 5.1 | CC(C)(C)c1csc(Nc2cccc3c2CCCC3)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL208249 | 77304 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 286 | 2 | 1 | 3 | 5.1 | CC(C)(C)c1csc(Nc2cccc3c2CCCC3)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44411033 | 77349 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 299 | 3 | 1 | 4 | 5.2 | CCn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL208458 | 77349 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 299 | 3 | 1 | 4 | 5.2 | CCn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21 | 10.1016/j.bmcl.2006.01.126 | |||
| 44430302 | 87118 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 449 | 11 | 3 | 6 | 5.2 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2nc[nH]c12 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL232639 | 87118 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 449 | 11 | 3 | 6 | 5.2 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2nc[nH]c12 | 10.1016/j.bmcl.2006.10.091 | |||
| 44289116 | 169280 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 572 | 11 | 2 | 6 | 3.7 | CC(C)(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44134 | 169280 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 572 | 11 | 2 | 6 | 3.7 | CC(C)(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| 176 | 398 | 66 | None | -6 | 31 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 2157 | 398 | 66 | None | -6 | 31 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 2566 | 398 | 66 | None | -6 | 31 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| CHEMBL633 | 398 | 66 | None | -6 | 31 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| DB01118 | 398 | 66 | None | -6 | 31 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 134324891 | 174567 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 4 | 0 | 6 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4556507 | 174567 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 458 | 4 | 0 | 6 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| 9922232 | 165759 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 296 | 3 | 1 | 3 | 5.6 | CC(C)(C)Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL424689 | 165759 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 296 | 3 | 1 | 3 | 5.6 | CC(C)(C)Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44289186 | 165082 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 3.8 | Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42270 | 165082 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 3.8 | Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289105 | 98432 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 656 | 13 | 2 | 6 | 5.4 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL275593 | 98432 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 656 | 13 | 2 | 6 | 5.4 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288818 | 155412 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL40366 | 155412 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44400899 | 70583 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 390 | 11 | 1 | 4 | 5.3 | CCN(CC)CCCC(C)Nc1nc(CCc2ccccc2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL194930 | 70583 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 390 | 11 | 1 | 4 | 5.3 | CCN(CC)CCCC(C)Nc1nc(CCc2ccccc2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| 44288912 | 166085 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 678 | 13 | 2 | 7 | 4.4 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCNS(=O)(=O)CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42586 | 166085 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 678 | 13 | 2 | 7 | 4.4 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCNS(=O)(=O)CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 134211126 | 177569 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 4.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4640439 | 177569 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 4.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 10308720 | 545 | 42 | None | - | 0 | Dog | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | |||
| 9678 | 545 | 42 | None | - | 0 | Dog | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | |||
| CHEMBL4169247 | 545 | 42 | None | - | 0 | Dog | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 333 | 4 | 1 | 5 | 2.6 | COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | |||
| 44289241 | 100414 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 642 | 11 | 2 | 6 | 5.2 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL290201 | 100414 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 642 | 11 | 2 | 6 | 5.2 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288996 | 169360 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 4.0 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44198 | 169360 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 4.0 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289039 | 100243 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 654 | 12 | 2 | 6 | 5.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL288655 | 100243 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 654 | 12 | 2 | 6 | 5.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289340 | 101247 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 664 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1F | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL296152 | 101247 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 664 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1F | 10.1016/j.bmcl.2004.01.072 | |||
| 44288911 | 167924 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 595 | 11 | 2 | 7 | 3.1 | Cc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)n1C | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43143 | 167924 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 595 | 11 | 2 | 7 | 3.1 | Cc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)n1C | 10.1016/j.bmcl.2004.01.072 | |||
| 44400829 | 71317 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 412 | 9 | 1 | 4 | 6.4 | CCN(CC)CCCC(C)Nc1nc(-c2ccc3ccccc3c2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL195751 | 71317 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 412 | 9 | 1 | 4 | 6.4 | CCN(CC)CCCC(C)Nc1nc(-c2ccc3ccccc3c2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| 44400922 | 68650 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 376 | 11 | 1 | 5 | 4.6 | CCN(CC)CCCC(C)Nc1ccnc(COc2cccc(Cl)c2)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL191915 | 68650 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 376 | 11 | 1 | 5 | 4.6 | CCN(CC)CCCC(C)Nc1ccnc(COc2cccc(Cl)c2)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| 44400881 | 71405 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 410 | 11 | 1 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1ccnc(COc2cc(Cl)cc(Cl)c2)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL195893 | 71405 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 410 | 11 | 1 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1ccnc(COc2cc(Cl)cc(Cl)c2)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| 45104427 | 200849 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 473 | 4 | 3 | 8 | 2.0 | CC(=O)Nc1ccc(S(=O)(=O)N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)cc1 | 10.1021/jm901652p | |||
| CHEMBL601217 | 200849 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 473 | 4 | 3 | 8 | 2.0 | CC(=O)Nc1ccc(S(=O)(=O)N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)cc1 | 10.1021/jm901652p | |||
| 134325076 | 172185 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 579 | 7 | 1 | 8 | 4.4 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4473604 | 172185 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 579 | 7 | 1 | 8 | 4.4 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| 134211098 | 178044 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 564 | 8 | 0 | 8 | 4.6 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4647117 | 178044 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 564 | 8 | 0 | 8 | 4.6 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 9856506 | 76758 | 4 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 260 | 2 | 1 | 3 | 4.8 | Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1C | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL206789 | 76758 | 4 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 260 | 2 | 1 | 3 | 4.8 | Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1C | 10.1016/j.bmcl.2006.01.126 | |||
| 44430305 | 87121 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 477 | 12 | 2 | 7 | 5.7 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ncn(CC)c12 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL232641 | 87121 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 477 | 12 | 2 | 7 | 5.7 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ncn(CC)c12 | 10.1016/j.bmcl.2006.10.091 | |||
| 11223594 | 71084 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL195298 | 71084 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| 44430315 | 11866 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL1182360 | 11866 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL233047 | 11866 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 409 | 11 | 2 | 5 | 5.3 | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | |||
| 44430308 | 152125 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 433 | 10 | 1 | 5 | 5.7 | CCN(CC)CCCC(C)Nc1ccc2cnn(Cc3ccc(Cl)cc3Cl)c2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL396787 | 152125 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 433 | 10 | 1 | 5 | 5.7 | CCN(CC)CCCC(C)Nc1ccc2cnn(Cc3ccc(Cl)cc3Cl)c2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| 44401007 | 70840 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 410 | 11 | 1 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1ccnc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL195103 | 70840 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 410 | 11 | 1 | 5 | 5.3 | CCN(CC)CCCC(C)Nc1ccnc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| 44289401 | 163445 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 604 | 10 | 2 | 6 | 4.0 | O=C(CN1C(=O)[C@@H](CC(=O)N[C@@H]2CCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL41983 | 163445 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 604 | 10 | 2 | 6 | 4.0 | O=C(CN1C(=O)[C@@H](CC(=O)N[C@@H]2CCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289082 | 166572 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 550 | 11 | 2 | 7 | 2.9 | O=C(C[C@H]1S[C@H](c2ccco2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42799 | 166572 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 550 | 11 | 2 | 7 | 2.9 | O=C(C[C@H]1S[C@H](c2ccco2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 23585443 | 542 | 12 | None | - | 0 | Dog | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | |||
| 9679 | 542 | 12 | None | - | 0 | Dog | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | |||
| CHEMBL4172635 | 542 | 12 | None | - | 0 | Dog | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 351 | 4 | 1 | 5 | 2.7 | COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl | 10.1021/acsmedchemlett.7b00315 | |||
| 9900444 | 77161 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 283 | 2 | 1 | 4 | 4.7 | CC(C)(C)c1csc(Nc2cccc3ncccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL207857 | 77161 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 283 | 2 | 1 | 4 | 4.7 | CC(C)(C)c1csc(Nc2cccc3ncccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44406309 | 133536 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 462 | 5 | 1 | 6 | 3.4 | CN1CCCC(C(=O)N2CCN(c3ccnc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.bmcl.2005.09.022 | |||
| CHEMBL370861 | 133536 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 462 | 5 | 1 | 6 | 3.4 | CN1CCCC(C(=O)N2CCN(c3ccnc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.bmcl.2005.09.022 | |||
| 692856 | 141363 | 19 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 240 | 2 | 1 | 3 | 4.3 | Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL383736 | 141363 | 19 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 240 | 2 | 1 | 3 | 4.3 | Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44288879 | 169343 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44188 | 169343 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 44400947 | 71322 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 396 | 11 | 1 | 5 | 4.9 | CCN(CC)CCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL195764 | 71322 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 396 | 11 | 1 | 5 | 4.9 | CCN(CC)CCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| 11496063 | 77119 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 447 | 8 | 1 | 4 | 8.0 | c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL207642 | 77119 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 447 | 8 | 1 | 4 | 8.0 | c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44288903 | 166381 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 612 | 11 | 2 | 5 | 5.4 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42757 | 166381 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 612 | 11 | 2 | 5 | 5.4 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 45104849 | 202523 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 384 | 4 | 0 | 5 | 4.2 | CCC1CCC(Oc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)CC1 | 10.1021/jm901652p | |||
| CHEMBL611508 | 202523 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 384 | 4 | 0 | 5 | 4.2 | CCC1CCC(Oc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)CC1 | 10.1021/jm901652p | |||
| 45104748 | 201037 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 380 | 2 | 2 | 6 | 3.5 | Cc1cccc(N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)c1C | 10.1021/jm901652p | |||
| CHEMBL602474 | 201037 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 380 | 2 | 2 | 6 | 3.5 | Cc1cccc(N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)c1C | 10.1021/jm901652p | |||
| 44289098 | 101386 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 638 | 13 | 2 | 8 | 3.5 | COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL297173 | 101386 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 638 | 13 | 2 | 8 | 3.5 | COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 134335394 | 172342 | 0 | None | - | 0 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 494 | 4 | 0 | 6 | 6.3 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4475665 | 172342 | 0 | None | - | 0 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 494 | 4 | 0 | 6 | 6.3 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C | 10.1021/acs.jmedchem.9b00506 | |||
| 134225255 | 177325 | 10 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4637143 | 177325 | 10 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 44289027 | 101232 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 652 | 8 | 1 | 5 | 6.3 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCCC3)CC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL296067 | 101232 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 652 | 8 | 1 | 5 | 6.3 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCCC3)CC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288779 | 101413 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 571 | 9 | 1 | 5 | 5.5 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL297335 | 101413 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 571 | 9 | 1 | 5 | 5.5 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289036 | 163106 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 566 | 11 | 2 | 7 | 3.4 | O=C(C[C@H]1S[C@H](c2cccs2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL417712 | 163106 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 566 | 11 | 2 | 7 | 3.4 | O=C(C[C@H]1S[C@H](c2cccs2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289106 | 165526 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 620 | 13 | 2 | 8 | 3.3 | COc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(OC)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42411 | 165526 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 620 | 13 | 2 | 8 | 3.3 | COc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(OC)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 21866580 | 77146 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 8 | 1 | 3 | 8.0 | Cc1cccc(Nc2cccc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)n2)c1C | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL207780 | 77146 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 8 | 1 | 3 | 8.0 | Cc1cccc(Nc2cccc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)n2)c1C | 10.1016/j.bmcl.2006.01.126 | |||
| 44289276 | 167926 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 11 | 2 | 7 | 4.7 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1csc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43144 | 167926 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 11 | 2 | 7 | 4.7 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1csc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288726 | 169439 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 561 | 11 | 2 | 7 | 2.7 | O=C(C[C@H]1S[C@H](c2ccncc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44262 | 169439 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 561 | 11 | 2 | 7 | 2.7 | O=C(C[C@H]1S[C@H](c2ccncc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 71720517 | 87007 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| CHEMBL2324200 | 87007 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| 44289235 | 101380 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 584 | 8 | 2 | 5 | 4.6 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL297145 | 101380 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 584 | 8 | 2 | 5 | 4.6 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289204 | 169849 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 614 | 10 | 2 | 6 | 4.2 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44401 | 169849 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 614 | 10 | 2 | 6 | 4.2 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 134325003 | 175382 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4575089 | 175382 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| 134225259 | 177744 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 7 | 2 | 8 | 3.0 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4642563 | 177744 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 7 | 2 | 8 | 3.0 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 44288904 | 164668 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 5 | 4.9 | CN(C)CCCNC(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42168 | 164668 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 586 | 11 | 2 | 5 | 4.9 | CN(C)CCCNC(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 44289227 | 169435 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 600 | 11 | 1 | 5 | 5.2 | CN(C)CCCN(C)C(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44259 | 169435 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 600 | 11 | 1 | 5 | 5.2 | CN(C)CCCN(C)C(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 44430317 | 87342 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 439 | 12 | 3 | 7 | 4.8 | CCN(CC)CCCC(C)Nc1nc(NC)nc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL233261 | 87342 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 439 | 12 | 3 | 7 | 4.8 | CCN(CC)CCCC(C)Nc1nc(NC)nc(NCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | |||
| 44288898 | 168688 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 515 | 8 | 1 | 4 | 5.4 | CN(C)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43661 | 168688 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 515 | 8 | 1 | 4 | 5.4 | CN(C)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 155531126 | 171607 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4465359 | 171607 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| 21866577 | 75965 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 285 | 2 | 1 | 4 | 4.7 | Cn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL205279 | 75965 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 285 | 2 | 1 | 4 | 4.7 | Cn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21 | 10.1016/j.bmcl.2006.01.126 | |||
| 134210898 | 177783 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 516 | 7 | 1 | 7 | 4.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4643158 | 177783 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 516 | 7 | 1 | 7 | 4.7 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 44411191 | 140239 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 484 | 8 | 1 | 4 | 7.4 | Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)nn2C)c1C | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL380537 | 140239 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 484 | 8 | 1 | 4 | 7.4 | Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)nn2C)c1C | 10.1016/j.bmcl.2006.01.126 | |||
| 156012782 | 177364 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 545 | 7 | 1 | 8 | 3.6 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4637695 | 177364 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 545 | 7 | 1 | 8 | 3.6 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 44289203 | 170534 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 642 | 12 | 2 | 6 | 5.0 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44498 | 170534 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 642 | 12 | 2 | 6 | 5.0 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 134324973 | 170387 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4447900 | 170387 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 4 | 0 | 6 | 5.8 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| 45104844 | 200920 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 304 | 2 | 1 | 6 | 1.6 | COc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| CHEMBL601653 | 200920 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 304 | 2 | 1 | 6 | 1.6 | COc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| 134225255 | 177325 | 10 | None | - | 0 | Mouse | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4637143 | 177325 | 10 | None | - | 0 | Mouse | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 71720517 | 87007 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| CHEMBL2324200 | 87007 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| 134211057 | 177625 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 4.3 | CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4641127 | 177625 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 4.3 | CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1 | 10.1021/acs.jmedchem.0c00988 | |||
| 44289341 | 163473 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 626 | 11 | 2 | 6 | 4.4 | Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42001 | 163473 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 626 | 11 | 2 | 6 | 4.4 | Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O | 10.1016/j.bmcl.2004.01.072 | |||
| 44288923 | 163668 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)ccc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42046 | 163668 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)ccc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 44288683 | 169070 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 578 | 11 | 2 | 6 | 3.5 | O=C(C[C@H]1S[C@H](c2ccc(F)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43969 | 169070 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 578 | 11 | 2 | 6 | 3.5 | O=C(C[C@H]1S[C@H](c2ccc(F)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 71449124 | 78993 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 409 | 11 | 1 | 4 | 5.9 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL2113069 | 78993 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 409 | 11 | 1 | 4 | 5.9 | CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2005.02.084 | |||
| 134336138 | 177495 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 527 | 7 | 1 | 8 | 4.2 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4639418 | 177495 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 527 | 7 | 1 | 8 | 4.2 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 45104752 | 201583 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 302 | 1 | 0 | 6 | 1.6 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc3c(cc12)OCO3 | 10.1021/jm901652p | |||
| CHEMBL605581 | 201583 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 302 | 1 | 0 | 6 | 1.6 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc3c(cc12)OCO3 | 10.1021/jm901652p | |||
| 45104423 | 200919 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 330 | 2 | 2 | 6 | 1.3 | C=CC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1 | 10.1021/jm901652p | |||
| CHEMBL601652 | 200919 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 330 | 2 | 2 | 6 | 1.3 | C=CC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1 | 10.1021/jm901652p | |||
| 45104321 | 200721 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 276 | 1 | 3 | 6 | 0.9 | Cc1c(N2CCNCC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL600019 | 200721 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 276 | 1 | 3 | 6 | 0.9 | Cc1c(N2CCNCC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 45104425 | 200879 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 380 | 2 | 2 | 6 | 2.5 | Cc1c(N2CCN(C(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL601424 | 200879 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 380 | 2 | 2 | 6 | 2.5 | Cc1c(N2CCN(C(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 134335394 | 172342 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 494 | 4 | 0 | 6 | 6.3 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4475665 | 172342 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 494 | 4 | 0 | 6 | 6.3 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C | 10.1021/acs.jmedchem.9b00506 | |||
| 44411266 | 76757 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 5.3 | CC(C)c1ccccc1Nc1nc(C(C)(C)C)cs1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL206788 | 76757 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 5.3 | CC(C)c1ccccc1Nc1nc(C(C)(C)C)cs1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44289342 | 166112 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 606 | 11 | 2 | 6 | 4.1 | Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1C | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42600 | 166112 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 606 | 11 | 2 | 6 | 4.1 | Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1C | 10.1016/j.bmcl.2004.01.072 | |||
| 156010350 | 177082 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 531 | 7 | 2 | 8 | 3.2 | CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4633133 | 177082 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 531 | 7 | 2 | 8 | 3.2 | CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 10133595 | 77068 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 367 | 8 | 1 | 4 | 6.2 | CC(C)CN(Cc1csc(Nc2cccc3ccccc23)n1)CC(C)C | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL207320 | 77068 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 367 | 8 | 1 | 4 | 6.2 | CC(C)CN(Cc1csc(Nc2cccc3ccccc23)n1)CC(C)C | 10.1016/j.bmcl.2006.01.126 | |||
| 9899450 | 76539 | 1 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 232 | 2 | 1 | 3 | 4.2 | CC(C)(C)c1csc(Nc2ccccc2)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL206103 | 76539 | 1 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 232 | 2 | 1 | 3 | 4.2 | CC(C)(C)c1csc(Nc2ccccc2)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 45104846 | 200762 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 301 | 2 | 0 | 5 | 1.9 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(N(C)C)ccc12 | 10.1021/jm901652p | |||
| CHEMBL600409 | 200762 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 301 | 2 | 0 | 5 | 1.9 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(N(C)C)ccc12 | 10.1021/jm901652p | |||
| 45104845 | 199174 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 318 | 3 | 0 | 6 | 1.9 | COc1cc(OC)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| CHEMBL589521 | 199174 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 318 | 3 | 0 | 6 | 1.9 | COc1cc(OC)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| 21866574 | 77090 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 271 | 2 | 2 | 3 | 4.7 | CC(C)(C)c1csc(Nc2cccc3[nH]ccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL207479 | 77090 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 271 | 2 | 2 | 3 | 4.7 | CC(C)(C)c1csc(Nc2cccc3[nH]ccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44430303 | 87120 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 449 | 11 | 3 | 6 | 5.2 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2[nH]cnc2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL232640 | 87120 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 449 | 11 | 3 | 6 | 5.2 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2[nH]cnc2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| 134225255 | 177325 | 10 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4637143 | 177325 | 10 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 11525206 | 135228 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL372399 | 135228 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2006.10.091 | |||
| 11525206 | 135228 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | |||
| CHEMBL372399 | 135228 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | |||
| 44430310 | 87259 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 11 | 2 | 5 | 6.5 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2ccccc2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL233045 | 87259 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 11 | 2 | 5 | 6.5 | CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2ccccc2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| 3793 | 203209 | 77 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 45039617 | 203209 | 77 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| CHEMBL64391 | 203209 | 77 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 3793 | 203209 | 77 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 45039617 | 203209 | 77 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| CHEMBL64391 | 203209 | 77 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 44562156 | 186729 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 511 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | |||
| CHEMBL488704 | 186729 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 511 | 6 | 1 | 7 | 5.2 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | |||
| 45104847 | 200436 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 288 | 2 | 0 | 5 | 1.9 | COc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| CHEMBL598339 | 200436 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 288 | 2 | 0 | 5 | 1.9 | COc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1 | 10.1021/jm901652p | |||
| 156010372 | 177108 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 508 | 6 | 0 | 8 | 4.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4633494 | 177108 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 508 | 6 | 0 | 8 | 4.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 45104943 | 201124 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 384 | 5 | 0 | 6 | 3.5 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCc3cccs3)ccc12 | 10.1021/jm901652p | |||
| CHEMBL603104 | 201124 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 384 | 5 | 0 | 6 | 3.5 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCc3cccs3)ccc12 | 10.1021/jm901652p | |||
| 45104524 | 200808 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 417 | 7 | 3 | 6 | 3.3 | CCCCCCCNC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1 | 10.1021/jm901652p | |||
| CHEMBL600805 | 200808 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 417 | 7 | 3 | 6 | 3.3 | CCCCCCCNC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1 | 10.1021/jm901652p | |||
| 4015979 | 77347 | 3 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 302 | 3 | 1 | 3 | 5.7 | c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL208452 | 77347 | 3 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 302 | 3 | 1 | 3 | 5.7 | c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1 | 10.1016/j.bmcl.2006.01.126 | |||
| 134210768 | 177454 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 530 | 8 | 1 | 7 | 5.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4638846 | 177454 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 530 | 8 | 1 | 7 | 5.1 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 44406246 | 73026 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.3 | CC(C)[C@@H](CNc1nccc(OCc2ccc(Cl)cc2Cl)n1)NC(=O)C1CCCN(C)C1 | 10.1016/j.bmcl.2005.09.022 | |||
| CHEMBL200966 | 73026 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.3 | CC(C)[C@@H](CNc1nccc(OCc2ccc(Cl)cc2Cl)n1)NC(=O)C1CCCN(C)C1 | 10.1016/j.bmcl.2005.09.022 | |||
| 44288897 | 101486 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 529 | 9 | 1 | 4 | 5.7 | CN(C)CCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL297854 | 101486 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 529 | 9 | 1 | 4 | 5.7 | CN(C)CCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 44288663 | 100260 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 641 | 11 | 2 | 6 | 4.5 | CN1CCN(CCCNC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL288800 | 100260 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 641 | 11 | 2 | 6 | 4.5 | CN1CCN(CCCNC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1 | 10.1016/j.bmcl.2004.01.072 | |||
| 156010600 | 177138 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 550 | 7 | 0 | 8 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4633920 | 177138 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 550 | 7 | 0 | 8 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 134325016 | 174653 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 513 | 5 | 1 | 8 | 4.3 | C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4558456 | 174653 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 513 | 5 | 1 | 8 | 4.3 | C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO | 10.1021/acs.jmedchem.9b00506 | |||
| 45104747 | 201015 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 370 | 2 | 2 | 6 | 3.0 | Cc1c(N2CCN(c3ccc(F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL602269 | 201015 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 370 | 2 | 2 | 6 | 3.0 | Cc1c(N2CCN(c3ccc(F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 134211225 | 177925 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 557 | 8 | 1 | 7 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4645325 | 177925 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 557 | 8 | 1 | 7 | 5.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 44406338 | 72922 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 5 | 2 | 6 | 2.8 | O=C([C@H]1CCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | |||
| CHEMBL200465 | 72922 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 5 | 2 | 6 | 2.8 | O=C([C@H]1CCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | |||
| 44288972 | 166432 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 638 | 8 | 1 | 5 | 5.9 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCC3)CC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42774 | 166432 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 638 | 8 | 1 | 5 | 5.9 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCC3)CC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 45104525 | 201342 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 487 | 4 | 3 | 7 | 4.7 | Cc1c(N2CCN(C(=O)Nc3ccccc3Oc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL604330 | 201342 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 487 | 4 | 3 | 7 | 4.7 | Cc1c(N2CCN(C(=O)Nc3ccccc3Oc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 44289283 | 101254 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 654 | 12 | 2 | 6 | 5.1 | O=C(CN1C(=O)[C@@H](CC(=O)NC(c2ccccc2)c2ccccc2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL296192 | 101254 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 654 | 12 | 2 | 6 | 5.1 | O=C(CN1C(=O)[C@@H](CC(=O)NC(c2ccccc2)c2ccccc2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289063 | 161971 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 654 | 12 | 2 | 6 | 5.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL415902 | 161971 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 654 | 12 | 2 | 6 | 5.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289097 | 178625 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 680 | 11 | 2 | 6 | 5.2 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL46748 | 178625 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 680 | 11 | 2 | 6 | 5.2 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 45104426 | 201854 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 416 | 3 | 2 | 7 | 2.0 | Cc1c(N2CCN(S(=O)(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL607137 | 201854 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 416 | 3 | 2 | 7 | 2.0 | Cc1c(N2CCN(S(=O)(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 44401118 | 71070 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 388 | 10 | 1 | 4 | 5.7 | CCN(CC)CCCC(C)Nc1nc(/C=C/c2ccccc2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL195203 | 71070 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 388 | 10 | 1 | 4 | 5.7 | CCN(CC)CCCC(C)Nc1nc(/C=C/c2ccccc2)nc2ccccc12 | 10.1016/j.bmcl.2005.02.084 | |||
| 134324770 | 170943 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 509 | 5 | 1 | 7 | 5.2 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4455432 | 170943 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 509 | 5 | 1 | 7 | 5.2 | C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN | 10.1021/acs.jmedchem.9b00506 | |||
| 134225255 | 177325 | 10 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4637143 | 177325 | 10 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 499 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 44561217 | 189116 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 427 | 6 | 1 | 7 | 4.3 | COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| CHEMBL510375 | 189116 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 427 | 6 | 1 | 7 | 4.3 | COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| 44289057 | 165342 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 566 | 11 | 2 | 7 | 3.4 | O=C(C[C@H]1S[C@H](c2ccsc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42360 | 165342 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 566 | 11 | 2 | 7 | 3.4 | O=C(C[C@H]1S[C@H](c2ccsc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289281 | 101103 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 618 | 10 | 2 | 6 | 4.4 | O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL295057 | 101103 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 618 | 10 | 2 | 6 | 4.4 | O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| 45104944 | 200718 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 387 | 5 | 0 | 7 | 1.6 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCOCC3)ccc12 | 10.1021/jm901652p | |||
| CHEMBL600016 | 200718 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 387 | 5 | 0 | 7 | 1.6 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCOCC3)ccc12 | 10.1021/jm901652p | |||
| 44288799 | 101532 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL298230 | 101532 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 10417 | 1069 | 9 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 10.1021/acs.jmedchem.9b00506 | |||
| 134324842 | 1069 | 9 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4459231 | 1069 | 9 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 510 | 5 | 1 | 7 | 5.3 | OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C | 10.1021/acs.jmedchem.9b00506 | |||
| 16724339 | 186437 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | |||
| CHEMBL487635 | 186437 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.07.062 | |||
| 16724339 | 186437 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| CHEMBL487635 | 186437 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 6 | 1 | 7 | 4.8 | COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| 44406282 | 72704 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 462 | 5 | 1 | 6 | 3.4 | CN1CCCC(C(=O)N2CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.bmcl.2005.09.022 | |||
| CHEMBL199733 | 72704 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 462 | 5 | 1 | 6 | 3.4 | CN1CCCC(C(=O)N2CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.bmcl.2005.09.022 | |||
| 44289055 | 100360 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 568 | 11 | 2 | 7 | 3.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccco1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL289661 | 100360 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 568 | 11 | 2 | 7 | 3.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccco1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288575 | 155182 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 570 | 10 | 2 | 6 | 3.6 | O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCCC2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL40238 | 155182 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 570 | 10 | 2 | 6 | 3.6 | O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCCC2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288698 | 169093 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(C[C@H]1S[C@H](c2cccc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43988 | 169093 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(C[C@H]1S[C@H](c2cccc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 134210954 | 177810 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 551 | 7 | 1 | 8 | 3.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4643609 | 177810 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 551 | 7 | 1 | 8 | 3.5 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 3793 | 203209 | 77 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 45039617 | 203209 | 77 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| CHEMBL64391 | 203209 | 77 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 25141190 | 1146 | 28 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.05.036 | |||
| 9478 | 1146 | 28 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.05.036 | |||
| CHEMBL508207 | 1146 | 28 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 5.2 | COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1 | 10.1016/j.bmc.2008.05.036 | |||
| 44561137 | 186719 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 427 | 6 | 1 | 7 | 4.3 | COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| CHEMBL488640 | 186719 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 427 | 6 | 1 | 7 | 4.3 | COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC | 10.1016/j.bmc.2008.05.036 | |||
| 45104850 | 201096 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 394 | 5 | 0 | 6 | 3.4 | COc1ccc(COc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)cc1 | 10.1021/jm901652p | |||
| CHEMBL602888 | 201096 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 394 | 5 | 0 | 6 | 3.4 | COc1ccc(COc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)cc1 | 10.1021/jm901652p | |||
| 134211185 | 177153 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4634054 | 177153 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 4.2 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12 | 10.1021/acs.jmedchem.0c00988 | |||
| 156018849 | 177907 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4645037 | 177907 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 6 | 1 | 8 | 3.8 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 45104750 | 200917 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 274 | 1 | 1 | 5 | 1.6 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)ccc12 | 10.1021/jm901652p | |||
| CHEMBL601650 | 200917 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 274 | 1 | 1 | 5 | 1.6 | Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)ccc12 | 10.1021/jm901652p | |||
| 44289343 | 165861 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42491 | 165861 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 646 | 11 | 2 | 6 | 4.8 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 3793 | 203209 | 77 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 45039617 | 203209 | 77 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| CHEMBL64391 | 203209 | 77 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 704 | 11 | 0 | 12 | 5.6 | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O | 10.1021/jm301749y | |||
| 44430313 | 149801 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 485 | 5 | 2 | 7 | 3.3 | O=C([C@@H]1CCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL394859 | 149801 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 485 | 5 | 2 | 7 | 3.3 | O=C([C@@H]1CCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2006.10.091 | |||
| 44411037 | 76783 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 266 | 2 | 1 | 3 | 4.9 | CC(C)(C)c1coc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL206878 | 76783 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 266 | 2 | 1 | 3 | 4.9 | CC(C)(C)c1coc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 9814340 | 139509 | 1 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 282 | 2 | 1 | 3 | 5.3 | CC(C)(C)c1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL379460 | 139509 | 1 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 282 | 2 | 1 | 3 | 5.3 | CC(C)(C)c1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44410966 | 169042 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 311 | 6 | 1 | 4 | 4.9 | CCN(CC)Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL439518 | 169042 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 311 | 6 | 1 | 4 | 4.9 | CCN(CC)Cc1csc(Nc2cccc3ccccc23)n1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44406355 | 72764 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.0 | O=C(C1CCCNC1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | |||
| CHEMBL199913 | 72764 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.0 | O=C(C1CCCNC1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.bmcl.2005.09.022 | |||
| 44288828 | 100458 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2c(Cl)cccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL290678 | 100458 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2c(Cl)cccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289242 | 155435 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 642 | 11 | 2 | 6 | 5.2 | C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL40377 | 155435 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 642 | 11 | 2 | 6 | 5.2 | C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44289205 | 163170 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 598 | 8 | 2 | 5 | 5.0 | CN1CCC(NC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL418072 | 163170 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 598 | 8 | 2 | 5 | 5.0 | CN1CCC(NC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288996 | 169360 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 4.0 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL44198 | 169360 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 592 | 11 | 2 | 6 | 4.0 | C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1 | 10.1016/j.bmcl.2004.01.072 | |||
| 44401087 | 71126 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 382 | 10 | 1 | 5 | 4.5 | CCN(CC)CCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL195484 | 71126 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 382 | 10 | 1 | 5 | 4.5 | CCN(CC)CCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| 44430306 | 87222 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 434 | 10 | 1 | 6 | 5.1 | CCN(CC)CCCC(C)Nc1ncc2ncn(Cc3ccc(Cl)cc3Cl)c2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL232839 | 87222 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 434 | 10 | 1 | 6 | 5.1 | CCN(CC)CCCC(C)Nc1ncc2ncn(Cc3ccc(Cl)cc3Cl)c2n1 | 10.1016/j.bmcl.2006.10.091 | |||
| 44430307 | 87223 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 434 | 10 | 1 | 6 | 5.1 | CCN(CC)CCCC(C)Nc1ncc2c(ncn2Cc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | |||
| CHEMBL232840 | 87223 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 434 | 10 | 1 | 6 | 5.1 | CCN(CC)CCCC(C)Nc1ncc2c(ncn2Cc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2006.10.091 | |||
| 44288818 | 155412 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL40366 | 155412 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288682 | 166084 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42585 | 166084 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 594 | 11 | 2 | 6 | 4.0 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 3117 | 207841 | 103 | None | -4 | 16 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
| CHEMBL964 | 207841 | 103 | None | -4 | 16 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
| 45104424 | 201307 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 352 | 2 | 2 | 6 | 1.4 | Cc1c(N2CCN(C(=O)CCl)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| CHEMBL604130 | 201307 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 352 | 2 | 2 | 6 | 1.4 | Cc1c(N2CCN(C(=O)CCl)CC2)c(=O)oc2cc(O)cc(O)c12 | 10.1021/jm901652p | |||
| 155541406 | 172995 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 525 | 6 | 0 | 7 | 6.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| CHEMBL4518040 | 172995 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 525 | 6 | 0 | 7 | 6.0 | Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12 | 10.1021/acs.jmedchem.9b00506 | |||
| 5071677 | 76000 | 19 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 358 | 3 | 1 | 3 | 7.0 | CC(C)(C)c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL205490 | 76000 | 19 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 358 | 3 | 1 | 3 | 7.0 | CC(C)(C)c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44411322 | 140915 | 1 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 246 | 2 | 1 | 3 | 4.5 | Cc1ccccc1Nc1nc(C(C)(C)C)cs1 | 10.1016/j.bmcl.2006.01.126 | |||
| CHEMBL382244 | 140915 | 1 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 246 | 2 | 1 | 3 | 4.5 | Cc1ccccc1Nc1nc(C(C)(C)C)cs1 | 10.1016/j.bmcl.2006.01.126 | |||
| 44288481 | 101151 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 557 | 8 | 1 | 5 | 5.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL295405 | 101151 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 557 | 8 | 1 | 5 | 5.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44288998 | 166500 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 558 | 10 | 3 | 5 | 4.3 | NCCNC(=O)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42786 | 166500 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 558 | 10 | 3 | 5 | 4.3 | NCCNC(=O)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2004.01.072 | |||
| 44289278 | 167850 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2cc(Cl)cc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL43092 | 167850 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 628 | 11 | 2 | 6 | 4.6 | O=C(C[C@H]1S[C@H](c2cc(Cl)cc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12 | 10.1016/j.bmcl.2004.01.072 | |||
| 44401153 | 135282 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 368 | 9 | 1 | 5 | 4.1 | CCN(CC)CCNc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| CHEMBL372670 | 135282 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 368 | 9 | 1 | 5 | 4.1 | CCN(CC)CCNc1nccc(OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2005.02.084 | |||
| 44288964 | 164904 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 612 | 11 | 2 | 6 | 4.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| CHEMBL42226 | 164904 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 612 | 11 | 2 | 6 | 4.1 | O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1 | 10.1016/j.bmcl.2004.01.072 | |||
| 134210933 | 177506 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 535 | 6 | 1 | 8 | 4.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| CHEMBL4639600 | 177506 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 535 | 6 | 1 | 8 | 4.7 | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21 | 10.1021/acs.jmedchem.0c00988 | |||
| 71720517 | 87007 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| CHEMBL2324200 | 87007 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 822 | 2 | 2 | 4 | 6.0 | O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21 | 10.1021/jm301749y | |||
| 127047356 | 139634 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 488 | 6 | 1 | 6 | 4.5 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3797662 | 139634 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 488 | 6 | 1 | 6 | 4.5 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | |||
| 59456102 | 73877 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | |||
| CHEMBL2018964 | 73877 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | |||
| 59455976 | 87155 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 504 | 8 | 3 | 7 | 3.7 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1 | 10.1021/jm301572h | |||
| CHEMBL2326611 | 87155 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 504 | 8 | 3 | 7 | 3.7 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1 | 10.1021/jm301572h | |||
| 71583488 | 87160 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 546 | 9 | 2 | 8 | 3.9 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1 | 10.1021/jm301572h | |||
| CHEMBL2326616 | 87160 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 546 | 9 | 2 | 8 | 3.9 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1 | 10.1021/jm301572h | |||
| 59455990 | 87177 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | |||
| CHEMBL2326632 | 87177 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6 | Binding | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | |||
| 59456103 | 87167 | 0 | None | - | 1 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 573 | 9 | 3 | 8 | 4.4 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1 | 10.1021/jm301572h | |||
| CHEMBL2326622 | 87167 | 0 | None | - | 1 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 573 | 9 | 3 | 8 | 4.4 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1 | 10.1021/jm301572h | |||
| 56849395 | 87190 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 540 | 9 | 3 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | |||
| CHEMBL2326926 | 87190 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 540 | 9 | 3 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | |||
| 59456014 | 87166 | 0 | None | - | 1 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 547 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1 | 10.1021/jm301572h | |||
| CHEMBL2326621 | 87166 | 0 | None | - | 1 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 547 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1 | 10.1021/jm301572h | |||
| 11525206 | 135228 | 0 | None | - | 1 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL372399 | 135228 | 0 | None | - | 1 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127045756 | 139869 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3799266 | 139869 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| 59455988 | 87165 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 547 | 10 | 3 | 8 | 3.8 | CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1021/jm301572h | |||
| CHEMBL2326620 | 87165 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 547 | 10 | 3 | 8 | 3.8 | CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1021/jm301572h | |||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.ejmech.2016.02.058 | |||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmc.2014.05.021 | |||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmc.2014.05.021 | |||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1021/jm301572h | |||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1021/jm301572h | |||
| 59456050 | 87170 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 589 | 9 | 2 | 9 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1 | 10.1021/jm301572h | |||
| CHEMBL2326625 | 87170 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 589 | 9 | 2 | 9 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1 | 10.1021/jm301572h | |||
| 118706830 | 112984 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 388 | 4 | 3 | 5 | 2.4 | COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | |||
| CHEMBL3310840 | 112984 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 388 | 4 | 3 | 5 | 2.4 | COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | |||
| 59456019 | 87175 | 0 | None | - | 1 | Human | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | |||
| CHEMBL2326630 | 87175 | 0 | None | - | 1 | Human | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 522 | 8 | 2 | 7 | 4.4 | COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1021/jm301572h | |||
| 9827294 | 73865 | 3 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmc.2014.05.021 | |||
| CHEMBL2018953 | 73865 | 3 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmc.2014.05.021 | |||
| 9827294 | 73865 | 3 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1021/jm301572h | |||
| CHEMBL2018953 | 73865 | 3 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1021/jm301572h | |||
| 59455975 | 87157 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 518 | 8 | 3 | 7 | 4.3 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1 | 10.1021/jm301572h | |||
| CHEMBL2326613 | 87157 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 518 | 8 | 3 | 7 | 4.3 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1 | 10.1021/jm301572h | |||
| 59456010 | 87163 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 574 | 9 | 2 | 8 | 4.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1 | 10.1021/jm301572h | |||
| CHEMBL2326619 | 87163 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 574 | 9 | 2 | 8 | 4.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1 | 10.1021/jm301572h | |||
| 118706817 | 112971 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 387 | 4 | 3 | 4 | 3.0 | COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | |||
| CHEMBL3310826 | 112971 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 387 | 4 | 3 | 4 | 3.0 | COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | |||
| 58054387 | 87152 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 492 | 7 | 2 | 6 | 4.4 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1 | 10.1021/jm301572h | |||
| CHEMBL2326609 | 87152 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 492 | 7 | 2 | 6 | 4.4 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1 | 10.1021/jm301572h | |||
| 58054475 | 87168 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 575 | 9 | 3 | 9 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1 | 10.1021/jm301572h | |||
| CHEMBL2326623 | 87168 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 575 | 9 | 3 | 9 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1 | 10.1021/jm301572h | |||
| 10416 | 1879 | 30 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.ejmech.2016.02.058 | |||
| 46861584 | 1879 | 30 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL2018969 | 1879 | 30 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.ejmech.2016.02.058 | |||
| 10416 | 1879 | 30 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1021/jm301572h | |||
| 46861584 | 1879 | 30 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1021/jm301572h | |||
| CHEMBL2018969 | 1879 | 30 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1021/jm301572h | |||
| 59456026 | 87176 | 0 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 566 | 9 | 3 | 8 | 4.1 | COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | |||
| CHEMBL2326631 | 87176 | 0 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 566 | 9 | 3 | 8 | 4.1 | COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | |||
| 59456058 | 87178 | 0 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 566 | 9 | 3 | 8 | 4.1 | COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | |||
| CHEMBL2326633 | 87178 | 0 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 566 | 9 | 3 | 8 | 4.1 | COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1 | 10.1021/jm301572h | |||
| 118706831 | 112985 | 0 | None | - | 1 | Human | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 389 | 4 | 3 | 6 | 1.8 | COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | |||
| CHEMBL3310841 | 112985 | 0 | None | - | 1 | Human | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 389 | 4 | 3 | 6 | 1.8 | COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | |||
| 58054384 | 87151 | 0 | None | - | 1 | Human | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 508 | 7 | 2 | 6 | 4.9 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1 | 10.1021/jm301572h | |||
| CHEMBL2326608 | 87151 | 0 | None | - | 1 | Human | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 508 | 7 | 2 | 6 | 4.9 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1 | 10.1021/jm301572h | |||
| 58054368 | 87169 | 0 | None | - | 1 | Human | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 575 | 9 | 3 | 9 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1 | 10.1021/jm301572h | |||
| CHEMBL2326624 | 87169 | 0 | None | - | 1 | Human | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 575 | 9 | 3 | 9 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1 | 10.1021/jm301572h | |||
| 102143549 | 112983 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 388 | 4 | 3 | 5 | 2.4 | COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | |||
| CHEMBL3310839 | 112983 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 388 | 4 | 3 | 5 | 2.4 | COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmc.2014.05.021 | |||
| 136116031 | 86802 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 490 | 7 | 3 | 7 | 3.9 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1 | 10.1021/jm301572h | |||
| CHEMBL2321924 | 86802 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 490 | 7 | 3 | 7 | 3.9 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1 | 10.1021/jm301572h | |||
| 59456111 | 87162 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 560 | 9 | 2 | 8 | 4.4 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1 | 10.1021/jm301572h | |||
| CHEMBL2326618 | 87162 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 560 | 9 | 2 | 8 | 4.4 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1 | 10.1021/jm301572h | |||
| 59456012 | 87159 | 0 | None | - | 1 | Human | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 524 | 8 | 2 | 6 | 5.2 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1 | 10.1021/jm301572h | |||
| CHEMBL2326615 | 87159 | 0 | None | - | 1 | Human | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 524 | 8 | 2 | 6 | 5.2 | CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1 | 10.1021/jm301572h | |||
| 9827294 | 73865 | 3 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018953 | 73865 | 3 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 499 | 5 | 2 | 7 | 3.7 | O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1 | 10.1016/j.bmcl.2012.02.104 | |||
| 127047356 | 139634 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 488 | 6 | 1 | 6 | 4.5 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3797662 | 139634 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 488 | 6 | 1 | 6 | 4.5 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127045756 | 139869 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3799266 | 139869 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| 71462571 | 82570 | 3 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 506 | 8 | 3 | 8 | 3.5 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(NC(=O)CO)c1 | 10.1021/jm300682j | |||
| CHEMBL2178575 | 82570 | 3 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 506 | 8 | 3 | 8 | 3.5 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(NC(=O)CO)c1 | 10.1021/jm300682j | |||
| 10416 | 1879 | 30 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.bmcl.2012.02.104 | |||
| 46861584 | 1879 | 30 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018969 | 1879 | 30 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1016/j.bmcl.2012.02.104 | |||
| 127047973 | 139765 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 496 | 5 | 1 | 6 | 4.9 | O=C(c1ccccn1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3798539 | 139765 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 496 | 5 | 1 | 6 | 4.9 | O=C(c1ccccn1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127045977 | 139983 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 488 | 5 | 2 | 6 | 4.0 | O=C([C@@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3799904 | 139983 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 488 | 5 | 2 | 6 | 4.0 | O=C([C@@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 59455974 | 73874 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 462 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018961 | 73874 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 462 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| 16747697 | 93528 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 539 | 7 | 0 | 4 | 4.8 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL246334 | 93528 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 539 | 7 | 0 | 4 | 4.8 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 71457815 | 83985 | 0 | None | -19 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.8 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207091 | 83985 | 0 | None | -19 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.8 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71214976 | 83996 | 0 | None | -79 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 4.5 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207101 | 83996 | 0 | None | -79 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 4.5 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 44440045 | 93592 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 443 | 6 | 1 | 4 | 3.2 | CC(C)CN1CCC(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL246584 | 93592 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 443 | 6 | 1 | 4 | 3.2 | CC(C)CN1CCC(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440043 | 166867 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 469 | 7 | 1 | 4 | 3.7 | CC(C)c1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NC2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL428576 | 166867 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 469 | 7 | 1 | 4 | 3.7 | CC(C)c1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NC2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2007.03.030 | |||
| 176 | 398 | 66 | None | -6 | 31 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 2157 | 398 | 66 | None | -6 | 31 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 2566 | 398 | 66 | None | -6 | 31 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| CHEMBL633 | 398 | 66 | None | -6 | 31 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| DB01118 | 398 | 66 | None | -6 | 31 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
| 59456102 | 73877 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018964 | 73877 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| 127046413 | 140116 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 462 | 6 | 2 | 6 | 3.4 | CNCC(=O)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3797946 | 140116 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 462 | 6 | 2 | 6 | 3.4 | CNCC(=O)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3800702 | 140116 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 462 | 6 | 2 | 6 | 3.4 | CNCC(=O)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 59455992 | 73869 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 463 | 7 | 1 | 7 | 4.6 | COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018957 | 73869 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 463 | 7 | 1 | 7 | 4.6 | COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| 71461439 | 83981 | 0 | None | -12 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207087 | 83981 | 0 | None | -12 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71452487 | 83982 | 0 | None | -12 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207088 | 83982 | 0 | None | -12 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 58054487 | 73876 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 504 | 7 | 1 | 7 | 4.3 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018963 | 73876 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 504 | 7 | 1 | 7 | 4.3 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| 44440051 | 149615 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 491 | 6 | 0 | 4 | 4.1 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL394714 | 149615 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 491 | 6 | 0 | 4 | 4.1 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 127045976 | 139831 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 488 | 5 | 2 | 6 | 4.0 | O=C([C@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3799025 | 139831 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 488 | 5 | 2 | 6 | 4.0 | O=C([C@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 59456051 | 73880 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 9 | 3 | 8 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018967 | 73880 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 520 | 9 | 3 | 8 | 3.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| 16747697 | 93528 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 539 | 7 | 0 | 4 | 4.8 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL246334 | 93528 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 539 | 7 | 0 | 4 | 4.8 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440041 | 93536 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 441 | 7 | 1 | 4 | 2.8 | O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)Cc1ccccc1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL246384 | 93536 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 441 | 7 | 1 | 4 | 2.8 | O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)Cc1ccccc1 | 10.1016/j.bmcl.2007.03.030 | |||
| 71450658 | 83992 | 0 | None | -15 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 4.7 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207098 | 83992 | 0 | None | -15 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 4.7 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 59455973 | 73868 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 463 | 7 | 1 | 7 | 4.6 | COc1ccccc1Cn1nc(NS(=O)(=O)c2ccc(Cl)s2)c2c(OC)cccc21 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018956 | 73868 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 463 | 7 | 1 | 7 | 4.6 | COc1ccccc1Cn1nc(NS(=O)(=O)c2ccc(Cl)s2)c2c(OC)cccc21 | 10.1016/j.bmcl.2012.02.104 | |||
| 58054491 | 73879 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CNC(C)=O)cc1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018966 | 73879 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 4.2 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CNC(C)=O)cc1 | 10.1016/j.bmcl.2012.02.104 | |||
| 127046189 | 139621 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 502 | 5 | 2 | 6 | 4.4 | O=C([C@@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3797567 | 139621 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 502 | 5 | 2 | 6 | 4.4 | O=C([C@@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 58054516 | 73871 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 493 | 8 | 1 | 8 | 4.6 | COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018959 | 73871 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 493 | 8 | 1 | 8 | 4.6 | COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC | 10.1016/j.bmcl.2012.02.104 | |||
| 15604497 | 83993 | 0 | None | -79 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 432 | 5 | 1 | 7 | 3.0 | Cn1nnnc1Cc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207099 | 83993 | 0 | None | -79 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 432 | 5 | 1 | 7 | 3.0 | Cn1nnnc1Cc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 11525206 | 135228 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL372399 | 135228 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 448 | 5 | 2 | 6 | 3.2 | O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127046247 | 139616 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 488 | 6 | 2 | 6 | 4.8 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3797537 | 139616 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 488 | 6 | 2 | 6 | 4.8 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| 44440135 | 93335 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 477 | 6 | 1 | 4 | 3.8 | O=C(NC1CCN(Cc2ccccc2)CC1)[C@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL245319 | 93335 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 477 | 6 | 1 | 4 | 3.8 | O=C(NC1CCN(Cc2ccccc2)CC1)[C@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440081 | 93397 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 582 | 8 | 1 | 5 | 3.9 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(N)=O)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL245730 | 93397 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 582 | 8 | 1 | 5 | 3.9 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(N)=O)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 127045978 | 139682 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 502 | 5 | 2 | 6 | 4.4 | O=C([C@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3797980 | 139682 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 502 | 5 | 2 | 6 | 4.4 | O=C([C@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127045975 | 139730 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 488 | 5 | 2 | 6 | 4.0 | O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3798263 | 139730 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 488 | 5 | 2 | 6 | 4.0 | O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127046787 | 139916 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 502 | 5 | 1 | 6 | 4.0 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(C(=O)C4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3799514 | 139916 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 502 | 5 | 1 | 6 | 4.0 | CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(C(=O)C4CCCN4)C3)CC2)n1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127046613 | 139973 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 456 | 5 | 2 | 6 | 2.9 | O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(F)cc4F)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3799865 | 139973 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 456 | 5 | 2 | 6 | 2.9 | O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(F)cc4F)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 44440031 | 149503 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 427 | 6 | 1 | 3 | 4.6 | O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1Cc1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL394642 | 149503 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 427 | 6 | 1 | 3 | 4.6 | O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1Cc1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.03.030 | |||
| 70689680 | 73867 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 6 | 1 | 6 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018955 | 73867 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 6 | 1 | 6 | 4.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1 | 10.1016/j.bmcl.2012.02.104 | |||
| 59456072 | 73870 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 463 | 7 | 1 | 7 | 4.6 | COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018958 | 73870 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 463 | 7 | 1 | 7 | 4.6 | COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1 | 10.1016/j.bmcl.2012.02.104 | |||
| 70681287 | 73873 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018960 | 73873 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO | 10.1016/j.bmcl.2012.02.104 | |||
| 71461438 | 83976 | 0 | None | -251 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1cnnc1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207082 | 83976 | 0 | None | -251 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1cnnc1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71461440 | 83991 | 0 | None | -79 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 400 | 5 | 1 | 5 | 3.6 | O=S(=O)(Nc1cc(F)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207097 | 83991 | 0 | None | -79 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 400 | 5 | 1 | 5 | 3.6 | O=S(=O)(Nc1cc(F)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 44440072 | 93529 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 557 | 7 | 0 | 4 | 5.0 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2F)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL246335 | 93529 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 557 | 7 | 0 | 4 | 5.0 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2F)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440047 | 93593 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 491 | 6 | 0 | 4 | 4.1 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1cccc2ccccc12)C1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL246585 | 93593 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 491 | 6 | 0 | 4 | 4.1 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1cccc2ccccc12)C1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440083 | 150811 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 554 | 7 | 1 | 5 | 4.4 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2N)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL395680 | 150811 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 554 | 7 | 1 | 5 | 4.4 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2N)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440059 | 93524 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 553 | 8 | 0 | 4 | 5.2 | CCN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL246328 | 93524 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 553 | 8 | 0 | 4 | 5.2 | CCN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.ejmech.2016.02.058 | |||
| 127046614 | 139926 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 442 | 6 | 2 | 6 | 3.4 | Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3799578 | 139926 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 442 | 6 | 2 | 6 | 3.4 | Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| 9959269 | 73866 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018954 | 73866 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 550 | 11 | 1 | 8 | 3.9 | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C | 10.1016/j.bmcl.2012.02.104 | |||
| 127046612 | 139750 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3798452 | 139750 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127046412 | 140114 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 391 | 4 | 2 | 5 | 4.0 | Clc1ccc(CNc2ccnc(N3CCC4(CCNC4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3797678 | 140114 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 391 | 4 | 2 | 5 | 4.0 | Clc1ccc(CNc2ccnc(N3CCC4(CCNC4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3800700 | 140114 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 391 | 4 | 2 | 5 | 4.0 | Clc1ccc(CNc2ccnc(N3CCC4(CCNC4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| 58054532 | 73875 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 4.0 | CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018962 | 73875 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 4.0 | CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| 71456007 | 83986 | 0 | None | -1 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 373 | 5 | 1 | 6 | 2.7 | N#Cc1cccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207092 | 83986 | 0 | None | -1 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 373 | 5 | 1 | 6 | 2.7 | N#Cc1cccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71456008 | 83989 | 0 | None | -50 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 404 | 5 | 1 | 6 | 4.0 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1csc2ccccc12 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207095 | 83989 | 0 | None | -50 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 404 | 5 | 1 | 6 | 4.0 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1csc2ccccc12 | 10.1016/j.bmcl.2012.09.020 | |||
| 70685473 | 73863 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018951 | 73863 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| 59456003 | 73864 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 476 | 7 | 2 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018952 | 73864 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 476 | 7 | 2 | 7 | 3.7 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| 15985912 | 83975 | 0 | None | -2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207081 | 83975 | 0 | None | -2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71450657 | 83988 | 0 | None | -15 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cc(Cl)c(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207094 | 83988 | 0 | None | -15 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cc(Cl)c(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71452488 | 83987 | 0 | None | -79 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 388 | 5 | 1 | 6 | 3.5 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207093 | 83987 | 0 | None | -79 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 388 | 5 | 1 | 6 | 3.5 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| 44440076 | 151406 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 573 | 7 | 0 | 4 | 5.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL396166 | 151406 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 573 | 7 | 0 | 4 | 5.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440084 | 93437 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 607 | 7 | 0 | 4 | 5.8 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL245931 | 93437 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 607 | 7 | 0 | 4 | 5.8 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 3117 | 207841 | 103 | None | -4 | 16 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
| CHEMBL964 | 207841 | 103 | None | -4 | 16 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | |||
| 44440075 | 93337 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 573 | 7 | 0 | 4 | 5.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2Cl)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL245331 | 93337 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 573 | 7 | 0 | 4 | 5.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2Cl)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440028 | 93878 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 477 | 6 | 1 | 4 | 3.8 | O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL247976 | 93878 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 477 | 6 | 1 | 4 | 3.8 | O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440079 | 93364 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 569 | 8 | 0 | 5 | 4.8 | COc1cccc(CCN2CCC(N(C)C(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc4c(Cl)cccc4c3)CC2)c1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL245531 | 93364 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 569 | 8 | 0 | 5 | 4.8 | COc1cccc(CCN2CCC(N(C)C(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc4c(Cl)cccc4c3)CC2)c1 | 10.1016/j.bmcl.2007.03.030 | |||
| 127047612 | 139892 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3799393 | 139892 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 4.4 | Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127047970 | 139822 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 502 | 5 | 2 | 6 | 4.2 | O=C(C1CCCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3798949 | 139822 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 502 | 5 | 2 | 6 | 4.2 | O=C(C1CCCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 127046191 | 140115 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 488 | 5 | 2 | 6 | 3.8 | O=C(C1CCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3798941 | 140115 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 488 | 5 | 2 | 6 | 3.8 | O=C(C1CCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3800701 | 140115 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 488 | 5 | 2 | 6 | 3.8 | O=C(C1CCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 70693879 | 73421 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2016602 | 73421 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 463 | 7 | 2 | 7 | 4.1 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1 | 10.1016/j.bmcl.2012.02.104 | |||
| 16747697 | 93528 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 539 | 7 | 0 | 4 | 4.8 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL246334 | 93528 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 539 | 7 | 0 | 4 | 4.8 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 71454246 | 83983 | 0 | None | -1 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 376 | 5 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)cc1C | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207089 | 83983 | 0 | None | -1 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 376 | 5 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)cc1C | 10.1016/j.bmcl.2012.09.020 | |||
| 71454248 | 83995 | 0 | None | -39 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.1 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207100 | 83995 | 0 | None | -39 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.1 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| 44440080 | 153359 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 583 | 8 | 1 | 5 | 4.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(=O)O)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL397848 | 153359 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 583 | 8 | 1 | 5 | 4.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(=O)O)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440054 | 93695 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 505 | 7 | 0 | 4 | 4.2 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL246986 | 93695 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 505 | 7 | 0 | 4 | 4.2 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440055 | 153353 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 519 | 8 | 0 | 4 | 4.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL397845 | 153353 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 519 | 8 | 0 | 4 | 4.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 71214725 | 83977 | 0 | None | -15 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1cncn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207083 | 83977 | 0 | None | -15 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1cncn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71214710 | 83979 | 0 | None | -39 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 431 | 5 | 1 | 6 | 3.6 | Cn1nnnc1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207085 | 83979 | 0 | None | -39 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 431 | 5 | 1 | 6 | 3.6 | Cn1nnnc1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 127047972 | 139620 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 5.8 | O=C(C1CCCCC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| CHEMBL3797555 | 139620 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 5.8 | O=C(C1CCCCC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1 | 10.1016/j.ejmech.2016.02.058 | |||
| 59456067 | 73881 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 534 | 9 | 3 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| CHEMBL2018968 | 73881 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 534 | 9 | 3 | 8 | 3.6 | COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1 | 10.1016/j.bmcl.2012.02.104 | |||
| 44440077 | 93338 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 573 | 7 | 0 | 4 | 5.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL245332 | 93338 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 573 | 7 | 0 | 4 | 5.5 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 44440065 | 93334 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 523 | 7 | 0 | 4 | 4.3 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(F)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| CHEMBL245313 | 93334 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 523 | 7 | 0 | 4 | 4.3 | CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(F)cccc2c1)C1CCN(CCc2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.030 | |||
| 10416 | 1879 | 30 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | Guide to Pharmacology | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 23409871 | |||
| 46861584 | 1879 | 30 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | Guide to Pharmacology | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 23409871 | |||
| CHEMBL2018969 | 1879 | 30 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | Guide to Pharmacology | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 23409871 | |||
| 176 | 398 | 66 | None | -6 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| 2157 | 398 | 66 | None | -6 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| 2566 | 398 | 66 | None | -6 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| CHEMBL633 | 398 | 66 | None | -6 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| DB01118 | 398 | 66 | None | -6 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | |||
| 3117 | 207841 | 103 | None | -4 | 16 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | None | |||
| CHEMBL964 | 207841 | 103 | None | -4 | 16 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | None | |||