Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 172463086 | 196614 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 4 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 330 | 7 | 3 | 7 | 1.9 | C[C@H](CO)Nc1nc(SCCc2ccccc2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5427907 | 196614 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 4 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 330 | 7 | 3 | 7 | 1.9 | C[C@H](CO)Nc1nc(SCCc2ccccc2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172441907 | 194981 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 336 | 7 | 3 | 7 | 2.6 | C[C@H](CO)Nc1nc(SCCC2CCCCC2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5394402 | 194981 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 336 | 7 | 3 | 7 | 2.6 | C[C@H](CO)Nc1nc(SCCC2CCCCC2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 163322282 | 191744 | None | 3 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -478 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 6 | 2 | 7 | 3.0 | C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2oncc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5195797 | 191744 | None | 3 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -478 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 6 | 2 | 7 | 3.0 | C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2oncc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172454542 | 195701 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 7 | 2 | 7 | 2.4 | COCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5409317 | 195701 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 7 | 2 | 7 | 2.4 | COCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 145985766 | 165789 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1862 | 3 | Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay |
ChEMBL | 504 | 6 | 2 | 6 | 4.5 | NC(=O)c1ccc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)cn1 | 10.1016/j.bmcl.2018.07.042 | ||
| CHEMBL4245355 | 165789 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1862 | 3 | Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay |
ChEMBL | 504 | 6 | 2 | 6 | 4.5 | NC(=O)c1ccc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)cn1 | 10.1016/j.bmcl.2018.07.042 | ||
| 172465121 | 196772 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | -4 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 7 | 3 | 7 | 2.1 | OCCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5431899 | 196772 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | -4 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 7 | 3 | 7 | 2.1 | OCCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172467317 | 196928 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 308 | 5 | 3 | 7 | 2.0 | C[C@H](CO)Nc1nc(SC2CCCCC2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5435008 | 196928 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 308 | 5 | 3 | 7 | 2.0 | C[C@H](CO)Nc1nc(SC2CCCCC2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172449533 | 195622 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -5 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 366 | 6 | 3 | 7 | 2.5 | CC(C)(CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5407300 | 195622 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -5 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 366 | 6 | 3 | 7 | 2.5 | CC(C)(CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172445880 | 195146 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -5 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 336 | 6 | 3 | 7 | 1.4 | C[C@H](CO)Nc1nc(OCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5397416 | 195146 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -5 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 336 | 6 | 3 | 7 | 1.4 | C[C@H](CO)Nc1nc(OCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 163322284 | 190266 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -14 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 6 | 3 | 7 | 2.1 | C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5173775 | 190266 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -14 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 6 | 3 | 7 | 2.1 | C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172454278 | 196016 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 312 | 9 | 3 | 8 | 1.1 | CCCOCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5415154 | 196016 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 312 | 9 | 3 | 8 | 1.1 | CCCOCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| 172465276 | 196906 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 322 | 6 | 3 | 7 | 2.2 | C[C@H](CO)Nc1nc(SCC2CCCCC2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5434552 | 196906 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 322 | 6 | 3 | 7 | 2.2 | C[C@H](CO)Nc1nc(SCC2CCCCC2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 170901566 | 197174 | None | 1 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 12 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 310 | 9 | 3 | 7 | 2.2 | CCCCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5440411 | 197174 | None | 1 | Human | Functional | pIC50 | = | 6.4 | 6.4 | 12 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 310 | 9 | 3 | 7 | 2.2 | CCCCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| 8497 | 2737 | None | 41 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -977 | 4 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 397 | 7 | 3 | 7 | 2.9 | CC[C@H](c1ccc(o1)C)NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C | 10.1016/j.ejmech.2023.115240 | ||
| 9865554 | 2737 | None | 41 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -977 | 4 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 397 | 7 | 3 | 7 | 2.9 | CC[C@H](c1ccc(o1)C)NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL216981 | 2737 | None | 41 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -977 | 4 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 397 | 7 | 3 | 7 | 2.9 | CC[C@H](c1ccc(o1)C)NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C | 10.1016/j.ejmech.2023.115240 | ||
| 172450974 | 195735 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 324 | 9 | 3 | 7 | 2.5 | CC(C)CCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5409816 | 195735 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 324 | 9 | 3 | 7 | 2.5 | CC(C)CCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| 172446176 | 195522 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -28 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 366 | 7 | 3 | 7 | 2.5 | CC[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5405321 | 195522 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -28 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 366 | 7 | 3 | 7 | 2.5 | CC[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172450141 | 195840 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -1 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 355 | 6 | 2 | 7 | 2.4 | OCCSc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5411713 | 195840 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -1 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 355 | 6 | 2 | 7 | 2.4 | OCCSc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172450116 | 195812 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 308 | 6 | 3 | 7 | 1.8 | C[C@H](CO)Nc1nc(SCC2CCCC2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5411165 | 195812 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 308 | 6 | 3 | 7 | 1.8 | C[C@H](CO)Nc1nc(SCC2CCCC2)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172461550 | 196824 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 6 | 3 | 7 | 2.1 | C[C@@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5432877 | 196824 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 352 | 6 | 3 | 7 | 2.1 | C[C@@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 172455714 | 196121 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 366 | 7 | 3 | 7 | 2.5 | C[C@H](CCO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5417284 | 196121 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 366 | 7 | 3 | 7 | 2.5 | C[C@H](CCO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 136165388 | 196848 | None | 17 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -1 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 475 | 4 | 3 | 7 | 3.1 | Cc1ccc([C@H](NC2=NS(=O)(=O)N=C2Nc2ccc(C)c(C(=O)N(C)C)c2O)C(C)(C)C)o1 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5433301 | 196848 | None | 17 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -1 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 475 | 4 | 3 | 7 | 3.1 | Cc1ccc([C@H](NC2=NS(=O)(=O)N=C2Nc2ccc(C)c(C(=O)N(C)C)c2O)C(C)(C)C)o1 | 10.1016/j.ejmech.2023.115240 | ||
| 172454055 | 195717 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 310 | 8 | 3 | 7 | 2.1 | CCCC(C)CSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5409489 | 195717 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -3 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 310 | 8 | 3 | 7 | 2.1 | CCCC(C)CSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| 172449877 | 196054 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -2 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 338 | 6 | 3 | 7 | 1.7 | OCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5415857 | 196054 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -2 | 2 | Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay |
ChEMBL | 338 | 6 | 3 | 7 | 1.7 | OCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 | 10.1016/j.ejmech.2023.115240 | ||
| 134817249 | 165922 | None | 19 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -20892 | 3 | Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay |
ChEMBL | 504 | 6 | 2 | 6 | 4.5 | NC(=O)c1cc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)ccn1 | 10.1016/j.bmcl.2018.07.042 | ||
| CHEMBL4248604 | 165922 | None | 19 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -20892 | 3 | Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay |
ChEMBL | 504 | 6 | 2 | 6 | 4.5 | NC(=O)c1cc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)ccn1 | 10.1016/j.bmcl.2018.07.042 | ||
| 8652 | 845 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 16904643 | ||||
Showing 1 to 50 of 54 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 183790 | 3742 | None | 8 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 2 | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/acs.jmedchem.9b01701 | ||
| 783 | 3742 | None | 8 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 2 | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/acs.jmedchem.9b01701 | ||
| CHEMBL1178786 | 3742 | None | 8 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 2 | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/acs.jmedchem.9b01701 | ||
| 170901566 | 197174 | None | 1 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Competitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysisCompetitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysis |
ChEMBL | 310 | 9 | 3 | 7 | 2.2 | CCCCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| CHEMBL5440411 | 197174 | None | 1 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Competitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysisCompetitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysis |
ChEMBL | 310 | 9 | 3 | 7 | 2.2 | CCCCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 | 10.1016/j.ejmech.2023.115240 | ||
| 11285792 | 879 | None | 32 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/acs.jmedchem.9b01701 | ||
| 801 | 879 | None | 32 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/acs.jmedchem.9b01701 | ||
| CHEMBL2110727 | 879 | None | 32 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/acs.jmedchem.9b01701 | ||
| DB11758 | 879 | None | 32 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin) |
ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/acs.jmedchem.9b01701 | ||
| 810 | 834 | None | 0 | Human | Binding | pKd | = | 10 | 10.0 | 39 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 10512740 | ||||
| 8652 | 845 | None | 0 | Human | Binding | pKd | = | 9.9 | 9.9 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 10512740 | ||||
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