Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 14434082 | 83816 | None | 16 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -3 | 3 | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | |||
| CHEMBL2205801 | 83816 | None | 16 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -3 | 3 | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | |||
| 14434082 | 83816 | None | 16 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -3 | 3 | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | |||
| CHEMBL2205801 | 83816 | None | 16 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -3 | 3 | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | |||
| 72791 | 210699 | None | 48 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 2 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| CHEMBL98682 | 210699 | None | 48 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 2 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| 72791 | 210699 | None | 48 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 2 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| CHEMBL98682 | 210699 | None | 48 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 2 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| 77865 | 107342 | None | 51 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 1 | 2 | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| CHEMBL317115 | 107342 | None | 51 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 1 | 2 | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| 14338 | 4369 | None | 74 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 3 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
| CHEMBL101165 | 4369 | None | 74 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 3 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
| 77865 | 107342 | None | 51 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 1 | 2 | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| CHEMBL317115 | 107342 | None | 51 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 1 | 2 | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| 14338 | 4369 | None | 74 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 3 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
| CHEMBL101165 | 4369 | None | 74 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 3 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
| 667748 | 83819 | None | 57 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 3 | 3 | ChEMBL | 267 | 2 | 0 | 3 | 3.9 | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 | 10.1021/jm301121j | |||
| CHEMBL2205805 | 83819 | None | 57 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 3 | 3 | ChEMBL | 267 | 2 | 0 | 3 | 3.9 | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 | 10.1021/jm301121j | |||
| 12425 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| 1318 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| CHEMBL415879 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| DB02365 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| 667748 | 83819 | None | 57 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 3 | 3 | ChEMBL | 267 | 2 | 0 | 3 | 3.9 | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 | 10.1021/jm301121j | |||
| CHEMBL2205805 | 83819 | None | 57 | Human | Functional | pEC50 | = | 6.4 | 6.4 | 3 | 3 | ChEMBL | 267 | 2 | 0 | 3 | 3.9 | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 | 10.1021/jm301121j | |||
| 12425 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| 1318 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| CHEMBL415879 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| DB02365 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| 1474 | 154488 | None | 79 | Human | Functional | pEC50 | = | 4.4 | 4.4 | -1 | 3 | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | |||
| CHEMBL39879 | 154488 | None | 79 | Human | Functional | pEC50 | = | 4.4 | 4.4 | -1 | 3 | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | |||
| 1474 | 154488 | None | 79 | Human | Functional | pEC50 | = | 4.4 | 4.4 | -1 | 3 | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | |||
| CHEMBL39879 | 154488 | None | 79 | Human | Functional | pEC50 | = | 4.4 | 4.4 | -1 | 3 | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | |||
| 74265 | 210806 | None | 69 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 2 | 3 | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | |||
| CHEMBL99384 | 210806 | None | 69 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 2 | 3 | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | |||
| 20445 | 83820 | None | 65 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 2 | 2 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1cccc(-c2cccc(C)n2)n1 | 10.1021/jm301121j | |||
| CHEMBL2205806 | 83820 | None | 65 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 2 | 2 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1cccc(-c2cccc(C)n2)n1 | 10.1021/jm301121j | |||
| 70848 | 209130 | None | 67 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 5 | 3 | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | |||
| CHEMBL89445 | 209130 | None | 67 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 5 | 3 | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | |||
| 72792 | 202179 | None | 52 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 5 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
| CHEMBL593442 | 202179 | None | 52 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 5 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
| 74265 | 210806 | None | 69 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 2 | 3 | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | |||
| CHEMBL99384 | 210806 | None | 69 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 2 | 3 | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | |||
| 20445 | 83820 | None | 65 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 2 | 2 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1cccc(-c2cccc(C)n2)n1 | 10.1021/jm301121j | |||
| CHEMBL2205806 | 83820 | None | 65 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 2 | 2 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1cccc(-c2cccc(C)n2)n1 | 10.1021/jm301121j | |||
| 2733927 | 83822 | None | 59 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 1 | 3 | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | |||
| CHEMBL2205808 | 83822 | None | 59 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 1 | 3 | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | |||
| 70848 | 209130 | None | 67 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 5 | 3 | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | |||
| CHEMBL89445 | 209130 | None | 67 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 5 | 3 | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | |||
| 72792 | 202179 | None | 52 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 5 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
| CHEMBL593442 | 202179 | None | 52 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 5 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
| 2733927 | 83822 | None | 59 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 1 | 3 | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | |||
| CHEMBL2205808 | 83822 | None | 59 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 1 | 3 | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | |||
| 15783796 | 83825 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 1 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | |||
| CHEMBL2205810 | 83825 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 1 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | |||
| 93149 | 107257 | None | 55 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 1 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | |||
| CHEMBL316589 | 107257 | None | 55 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 1 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | |||
| 12987698 | 83823 | None | 3 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -3 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | |||
| CHEMBL2205809 | 83823 | None | 3 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -3 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | |||
| 15783796 | 83825 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 1 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | |||
| CHEMBL2205810 | 83825 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 1 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | |||
| 93149 | 107257 | None | 55 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 1 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | |||
| CHEMBL316589 | 107257 | None | 55 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 1 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | |||
| 12987698 | 83823 | None | 3 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -3 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | |||
| CHEMBL2205809 | 83823 | None | 3 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -3 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | |||
| 15664 | 83821 | None | 63 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -2 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | |||
| CHEMBL2205807 | 83821 | None | 63 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -2 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | |||
| 15664 | 83821 | None | 63 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -2 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | |||
| CHEMBL2205807 | 83821 | None | 63 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -2 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | |||
| 77524 | 55903 | None | 56 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 212 | 0 | 2 | 4 | 2.2 | Oc1ccnc2c1ccc1c(O)ccnc12 | 10.1021/jm301121j | |||
| CHEMBL1623498 | 55903 | None | 56 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 212 | 0 | 2 | 4 | 2.2 | Oc1ccnc2c1ccc1c(O)ccnc12 | 10.1021/jm301121j | |||
| 77524 | 55903 | None | 56 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 212 | 0 | 2 | 4 | 2.2 | Oc1ccnc2c1ccc1c(O)ccnc12 | 10.1021/jm301121j | |||
| CHEMBL1623498 | 55903 | None | 56 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 212 | 0 | 2 | 4 | 2.2 | Oc1ccnc2c1ccc1c(O)ccnc12 | 10.1021/jm301121j | |||
| 10391001 | 137285 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 493 | 7 | 2 | 4 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL374939 | 137285 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 493 | 7 | 2 | 4 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11541506 | 76543 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 575 | 9 | 2 | 5 | 5.7 | CC(C)(C(=O)O)N1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)C1 | 10.1021/jm050965z | |||
| CHEMBL205993 | 76543 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 575 | 9 | 2 | 5 | 5.7 | CC(C)(C(=O)O)N1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)C1 | 10.1021/jm050965z | |||
| 16105860 | 137290 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 507 | 8 | 2 | 4 | 4.7 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(CC)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL374978 | 137290 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 507 | 8 | 2 | 4 | 4.7 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(CC)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105782 | 82737 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 482 | 6 | 2 | 6 | 3.4 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccncc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL217965 | 82737 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 482 | 6 | 2 | 6 | 3.4 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccncc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16112836 | 93418 | None | 3 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 4.9 | COc1ccc2nccc([C@@H]3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL245568 | 93418 | None | 3 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 4.9 | COc1ccc2nccc([C@@H]3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439843 | 91574 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 426 | 4 | 1 | 4 | 4.9 | O=C1OC(c2ccnc3ccccc23)CN1C1CCN(Cc2cc3ccccc3[nH]2)CC1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL240462 | 91574 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 426 | 4 | 1 | 4 | 4.9 | O=C1OC(c2ccnc3ccccc23)CN1C1CCN(Cc2cc3ccccc3[nH]2)CC1 | 10.1016/j.bmcl.2006.12.076 | |||
| 16105780 | 84635 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 481 | 7 | 2 | 6 | 3.0 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cnccn3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL222112 | 84635 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 481 | 7 | 2 | 6 | 3.0 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cnccn3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 44598057 | 199526 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 421 | 6 | 0 | 4 | 4.6 | CC(C)COc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2 | 10.1021/jm900713y | |||
| CHEMBL567419 | 199526 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 421 | 6 | 0 | 4 | 4.6 | CC(C)COc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2 | 10.1021/jm900713y | |||
| 11533398 | 76013 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 499 | 8 | 2 | 5 | 4.9 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3(c4ccccc4)CCNCC3)CC2)c1 | 10.1021/jm050965z | |||
| CHEMBL205447 | 76013 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 499 | 8 | 2 | 5 | 4.9 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3(c4ccccc4)CCNCC3)CC2)c1 | 10.1021/jm050965z | |||
| 44457090 | 97715 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 5.4 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2 | 10.1021/jm900713y | |||
| CHEMBL271128 | 97715 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 5.4 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2 | 10.1021/jm900713y | |||
| 11950828 | 97674 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cc[n+]([O-])cc1)CC2 | 10.1021/jm070543k | |||
| CHEMBL270971 | 97674 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cc[n+]([O-])cc1)CC2 | 10.1021/jm070543k | |||
| 11950828 | 97674 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cc[n+]([O-])cc1)CC2 | 10.1021/jm900713y | |||
| CHEMBL270971 | 97674 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cc[n+]([O-])cc1)CC2 | 10.1021/jm900713y | |||
| 44457090 | 97715 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 5.4 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2 | 10.1021/jm070543k | |||
| CHEMBL271128 | 97715 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 5.4 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2 | 10.1021/jm070543k | |||
| 44457009 | 159100 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 504 | 6 | 0 | 4 | 6.7 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccc(Cl)cc2)CC3)c1 | 10.1021/jm070543k | |||
| CHEMBL409648 | 159100 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 504 | 6 | 0 | 4 | 6.7 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccc(Cl)cc2)CC3)c1 | 10.1021/jm070543k | |||
| 16105857 | 166297 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 479 | 7 | 2 | 4 | 4.2 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL426551 | 166297 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 479 | 7 | 2 | 4 | 4.2 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 10480554 | 150303 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 485 | 5 | 0 | 5 | 5.7 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(Cl)c(Cl)c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL395211 | 150303 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 485 | 5 | 0 | 5 | 5.7 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(Cl)c(Cl)c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439881 | 93853 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 457 | 5 | 0 | 6 | 5.1 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6o5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL247563 | 93853 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 457 | 5 | 0 | 6 | 5.1 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6o5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 10004785 | 93897 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 467 | 5 | 0 | 5 | 5.6 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc6ccccc6c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL247762 | 93897 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 467 | 5 | 0 | 5 | 5.6 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc6ccccc6c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439890 | 93968 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 447 | 6 | 0 | 6 | 4.4 | COc1ccc(CN2CCC(N3CC(c4ccnc5ccc(OC)cc45)OC3=O)CC2)cc1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL248171 | 93968 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 447 | 6 | 0 | 6 | 4.4 | COc1ccc(CN2CCC(N3CC(c4ccnc5ccc(OC)cc45)OC3=O)CC2)cc1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439886 | 93929 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 417 | 5 | 0 | 5 | 4.4 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccccc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL247964 | 93929 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 417 | 5 | 0 | 5 | 4.4 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccccc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439895 | 150554 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 442 | 5 | 0 | 6 | 4.3 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(C#N)cc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL395423 | 150554 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 442 | 5 | 0 | 6 | 4.3 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(C#N)cc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 16065425 | 199684 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 405 | 3 | 0 | 4 | 3.9 | CC1Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccncc3)CC4)c2O1 | 10.1021/jm900713y | |||
| CHEMBL568296 | 199684 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 405 | 3 | 0 | 4 | 3.9 | CC1Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccncc3)CC4)c2O1 | 10.1021/jm900713y | |||
| 16105885 | 82805 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 580 | 11 | 2 | 6 | 5.0 | CCN(CC)CCCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL217984 | 82805 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 580 | 11 | 2 | 6 | 5.0 | CCN(CC)CCCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 44598821 | 200394 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 472 | 6 | 0 | 6 | 4.8 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncn1)CC2 | 10.1021/jm900713y | |||
| CHEMBL573216 | 200394 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 472 | 6 | 0 | 6 | 4.8 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncn1)CC2 | 10.1021/jm900713y | |||
| 44598059 | 199468 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 442 | 5 | 0 | 5 | 4.8 | O=C(c1ccncn1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1 | 10.1021/jm900713y | |||
| CHEMBL566974 | 199468 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 442 | 5 | 0 | 5 | 4.8 | O=C(c1ccncn1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1 | 10.1021/jm900713y | |||
| 44598769 | 199555 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 422 | 6 | 0 | 5 | 4.0 | CC(C)COc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncn1)CC2 | 10.1021/jm900713y | |||
| CHEMBL567620 | 199555 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 422 | 6 | 0 | 5 | 4.0 | CC(C)COc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncn1)CC2 | 10.1021/jm900713y | |||
| 16105854 | 83946 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 485 | 8 | 2 | 4 | 4.4 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)CC3CCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL220650 | 83946 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 485 | 8 | 2 | 4 | 4.4 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)CC3CCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16065428 | 200314 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 391 | 3 | 0 | 4 | 3.5 | O=C(c1ccncc1)N1CCC2(CCN(Cc3cccc4c3OCC4)CC2)CC1 | 10.1021/jm900713y | |||
| CHEMBL572537 | 200314 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 391 | 3 | 0 | 4 | 3.5 | O=C(c1ccncc1)N1CCC2(CCN(Cc3cccc4c3OCC4)CC2)CC1 | 10.1021/jm900713y | |||
| 16105774 | 84358 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 535 | 10 | 2 | 4 | 5.5 | CCCCc1ccc(C(=O)Nc2ccc(S(=O)(=O)NC3CCN(C(=O)CCC)CC3)c3ccccc23)cc1 | 10.1021/jm061118e | |||
| CHEMBL221601 | 84358 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 535 | 10 | 2 | 4 | 5.5 | CCCCc1ccc(C(=O)Nc2ccc(S(=O)(=O)NC3CCN(C(=O)CCC)CC3)c3ccccc23)cc1 | 10.1021/jm061118e | |||
| 3384970 | 161375 | None | 6 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 432 | 6 | 2 | 4 | 4.9 | COc1ccc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)cc1 | 10.1021/jm061118e | |||
| CHEMBL412116 | 161375 | None | 6 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 432 | 6 | 2 | 4 | 4.9 | COc1ccc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)cc1 | 10.1021/jm061118e | |||
| 16105862 | 83421 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 469 | 7 | 2 | 5 | 3.8 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccoc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL219432 | 83421 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 469 | 7 | 2 | 5 | 3.8 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccoc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 44439837 | 148065 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 430 | 8 | 2 | 5 | 4.4 | COc1ccc2nccc(C3CN(CCCNCc4cc5ccccc5[nH]4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL393411 | 148065 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 430 | 8 | 2 | 5 | 4.4 | COc1ccc2nccc(C3CN(CCCNCc4cc5ccccc5[nH]4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44457089 | 97714 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 5.4 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccccn1)CC2 | 10.1021/jm070543k | |||
| CHEMBL271127 | 97714 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 471 | 6 | 0 | 5 | 5.4 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccccn1)CC2 | 10.1021/jm070543k | |||
| 11950826 | 159282 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 457 | 5 | 0 | 4 | 4.6 | O=C(c1cc[n+]([O-])cc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm070543k | |||
| CHEMBL409849 | 159282 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 457 | 5 | 0 | 4 | 4.6 | O=C(c1cc[n+]([O-])cc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm070543k | |||
| 44456993 | 97840 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 441 | 5 | 0 | 4 | 5.4 | O=C(c1ccncc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm900713y | |||
| CHEMBL271801 | 97840 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 441 | 5 | 0 | 4 | 5.4 | O=C(c1ccncc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm900713y | |||
| 44456993 | 97840 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 441 | 5 | 0 | 4 | 5.4 | O=C(c1ccncc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm070543k | |||
| CHEMBL271801 | 97840 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 441 | 5 | 0 | 4 | 5.4 | O=C(c1ccncc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm070543k | |||
| 44598060 | 199722 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 434 | 3 | 0 | 5 | 4.1 | CC1(C)CCc2cc(CN3CCC4(CC3)CCN(C(=O)c3ccncn3)CC4)ccc2O1 | 10.1021/jm900713y | |||
| CHEMBL568503 | 199722 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 434 | 3 | 0 | 5 | 4.1 | CC1(C)CCc2cc(CN3CCC4(CC3)CCN(C(=O)c3ccncn3)CC4)ccc2O1 | 10.1021/jm900713y | |||
| 44457046 | 167431 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 474 | 5 | 0 | 3 | 6.7 | O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm070543k | |||
| CHEMBL429436 | 167431 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 474 | 5 | 0 | 3 | 6.7 | O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm070543k | |||
| 44457046 | 167431 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 474 | 5 | 0 | 3 | 6.7 | O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm900713y | |||
| CHEMBL429436 | 167431 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 474 | 5 | 0 | 3 | 6.7 | O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm900713y | |||
| 16105772 | 83405 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 497 | 7 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3F)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL219380 | 83405 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 497 | 7 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3F)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105819 | 84524 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 622 | 9 | 2 | 7 | 4.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)OCCCN3CC(C)OC(C)C3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL222020 | 84524 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 622 | 9 | 2 | 7 | 4.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)OCCCN3CC(C)OC(C)C3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16112836 | 93418 | None | 3 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 4.9 | COc1ccc2nccc([C@@H]3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL245568 | 93418 | None | 3 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 4.9 | COc1ccc2nccc([C@@H]3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 45483901 | 199525 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 476 | 6 | 1 | 5 | 5.1 | CCCC1(CC)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| CHEMBL567417 | 199525 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 476 | 6 | 1 | 5 | 5.1 | CCCC1(CC)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| 16064872 | 199727 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 434 | 3 | 1 | 5 | 3.9 | CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)c2O1 | 10.1021/jm900713y | |||
| CHEMBL568523 | 199727 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 434 | 3 | 1 | 5 | 3.9 | CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)c2O1 | 10.1021/jm900713y | |||
| 44598124 | 201094 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 470 | 3 | 1 | 5 | 4.4 | CC1(C)Oc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2C1(F)F | 10.1021/jm900713y | |||
| CHEMBL579072 | 201094 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 470 | 3 | 1 | 5 | 4.4 | CC1(C)Oc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2C1(F)F | 10.1021/jm900713y | |||
| 45483880 | 199683 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 476 | 3 | 1 | 5 | 4.9 | CC(C)(C)C1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| CHEMBL568294 | 199683 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 476 | 3 | 1 | 5 | 4.9 | CC(C)(C)C1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| 16105859 | 84363 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 497 | 7 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cccc(F)c3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221639 | 84363 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 497 | 7 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cccc(F)c3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105864 | 84398 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 483 | 7 | 2 | 6 | 2.9 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3nccn3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221842 | 84398 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 483 | 7 | 2 | 6 | 2.9 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3nccn3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105855 | 83175 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 487 | 7 | 2 | 5 | 3.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CCOCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL218209 | 83175 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 487 | 7 | 2 | 5 | 3.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CCOCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11584004 | 140785 | None | 1 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 489 | 7 | 2 | 4 | 5.1 | O=C(NC1CCN(Cc2cccc(Oc3ccccc3Cl)c2)CC1)C1(c2ccccc2)CCNC1 | 10.1021/jm050965z | |||
| CHEMBL381619 | 140785 | None | 1 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 489 | 7 | 2 | 4 | 5.1 | O=C(NC1CCN(Cc2cccc(Oc3ccccc3Cl)c2)CC1)C1(c2ccccc2)CCNC1 | 10.1021/jm050965z | |||
| 45483913 | 199385 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 434 | 3 | 1 | 5 | 3.9 | CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ncccc3N)CC4)c2O1 | 10.1021/jm900713y | |||
| CHEMBL566324 | 199385 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 434 | 3 | 1 | 5 | 3.9 | CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ncccc3N)CC4)c2O1 | 10.1021/jm900713y | |||
| 44598121 | 199556 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 434 | 3 | 1 | 5 | 3.9 | CC1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccnc(N)c3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| CHEMBL567627 | 199556 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 434 | 3 | 1 | 5 | 3.9 | CC1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccnc(N)c3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| 16105777 | 137046 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 535 | 7 | 2 | 5 | 5.4 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cc4ccccc4s3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL374414 | 137046 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 535 | 7 | 2 | 5 | 5.4 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cc4ccccc4s3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 166926318 | 195613 | None | 9 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 429 | 6 | 2 | 4 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5407071 | 195613 | None | 9 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 429 | 6 | 2 | 4 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 16105776 | 137022 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 585 | 10 | 2 | 5 | 5.7 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(OCc4ccccc4)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL374274 | 137022 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 585 | 10 | 2 | 5 | 5.7 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(OCc4ccccc4)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 9911916 | 91713 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 4.9 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL240848 | 91713 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 4.9 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 10433657 | 93930 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 445 | 7 | 0 | 5 | 4.8 | COc1ccc2nccc(C3CN(C4CCN(CCCc5ccccc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL247965 | 93930 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 445 | 7 | 0 | 5 | 4.8 | COc1ccc2nccc(C3CN(C4CCN(CCCc5ccccc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 11842667 | 161140 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2cccc[n+]2[O-])CC3)c1 | 10.1021/jm070543k | |||
| CHEMBL411651 | 161140 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2cccc[n+]2[O-])CC3)c1 | 10.1021/jm070543k | |||
| 44456948 | 160211 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 442 | 5 | 0 | 5 | 4.8 | O=C(c1ccncn1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm070543k | |||
| CHEMBL410885 | 160211 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 442 | 5 | 0 | 5 | 4.8 | O=C(c1ccncn1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm070543k | |||
| 44456948 | 160211 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 442 | 5 | 0 | 5 | 4.8 | O=C(c1ccncn1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm900713y | |||
| CHEMBL410885 | 160211 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 442 | 5 | 0 | 5 | 4.8 | O=C(c1ccncn1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1 | 10.1021/jm900713y | |||
| 16105887 | 84381 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 640 | 9 | 2 | 6 | 5.7 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)OCCCN3CCc4ccccc4C3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL221712 | 84381 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 640 | 9 | 2 | 6 | 5.7 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)OCCCN3CCc4ccccc4C3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105865 | 169444 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 494 | 7 | 2 | 5 | 3.9 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cccnc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL441870 | 169444 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 494 | 7 | 2 | 5 | 3.9 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cccnc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16065567 | 201282 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 419 | 3 | 0 | 4 | 4.3 | CC1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccncc3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| CHEMBL583621 | 201282 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 419 | 3 | 0 | 4 | 4.3 | CC1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccncc3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| 10479253 | 91573 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 457 | 5 | 1 | 6 | 4.3 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2n1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL240461 | 91573 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 457 | 5 | 1 | 6 | 4.3 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2n1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439883 | 93896 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 468 | 5 | 0 | 6 | 5.0 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc6ccccc6n5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL247761 | 93896 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 468 | 5 | 0 | 6 | 5.0 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc6ccccc6n5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 10412437 | 151418 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 470 | 5 | 0 | 6 | 4.9 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6n5C)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL396102 | 151418 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 470 | 5 | 0 | 6 | 4.9 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6n5C)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 11951000 | 97875 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2cc[n+]([O-])cc2)CC3)c1 | 10.1021/jm900713y | |||
| CHEMBL272022 | 97875 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2cc[n+]([O-])cc2)CC3)c1 | 10.1021/jm900713y | |||
| 44457093 | 97831 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 441 | 5 | 0 | 4 | 5.4 | O=C(c1ccncc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1 | 10.1021/jm070543k | |||
| CHEMBL271768 | 97831 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 441 | 5 | 0 | 4 | 5.4 | O=C(c1ccncc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1 | 10.1021/jm070543k | |||
| 11951000 | 97875 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2cc[n+]([O-])cc2)CC3)c1 | 10.1021/jm070543k | |||
| CHEMBL272022 | 97875 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2cc[n+]([O-])cc2)CC3)c1 | 10.1021/jm070543k | |||
| 44457105 | 158706 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 504 | 6 | 0 | 4 | 6.7 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc(Cl)cc1)CC2 | 10.1021/jm070543k | |||
| CHEMBL409224 | 158706 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 504 | 6 | 0 | 4 | 6.7 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc(Cl)cc1)CC2 | 10.1021/jm070543k | |||
| 44457105 | 158706 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 504 | 6 | 0 | 4 | 6.7 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc(Cl)cc1)CC2 | 10.1021/jm900713y | |||
| CHEMBL409224 | 158706 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 504 | 6 | 0 | 4 | 6.7 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc(Cl)cc1)CC2 | 10.1021/jm900713y | |||
| 16105775 | 83420 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 549 | 11 | 2 | 4 | 5.9 | CCCCCc1ccc(C(=O)Nc2ccc(S(=O)(=O)NC3CCN(C(=O)CCC)CC3)c3ccccc23)cc1 | 10.1021/jm061118e | |||
| CHEMBL219431 | 83420 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 549 | 11 | 2 | 4 | 5.9 | CCCCCc1ccc(C(=O)Nc2ccc(S(=O)(=O)NC3CCN(C(=O)CCC)CC3)c3ccccc23)cc1 | 10.1021/jm061118e | |||
| 16105868 | 138128 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 471 | 7 | 2 | 4 | 4.0 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL376517 | 138128 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 471 | 7 | 2 | 4 | 4.0 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105867 | 137953 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 443 | 7 | 2 | 4 | 3.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL376071 | 137953 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 443 | 7 | 2 | 4 | 3.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105863 | 84365 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 539 | 7 | 2 | 6 | 4.2 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cc(C(C)(C)C)nn3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221650 | 84365 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 539 | 7 | 2 | 6 | 4.2 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cc(C(C)(C)C)nn3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 10003657 | 152919 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 445 | 5 | 0 | 5 | 5.0 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(C)c(C)c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL397395 | 152919 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 445 | 5 | 0 | 5 | 5.0 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(C)c(C)c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 11685733 | 140289 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 589 | 9 | 2 | 5 | 6.1 | CC(C)(C(=O)O)N1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| CHEMBL380492 | 140289 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 589 | 9 | 2 | 5 | 6.1 | CC(C)(C(=O)O)N1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| 16105817 | 137059 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 578 | 9 | 2 | 6 | 4.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)OCCCN3CCCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL374527 | 137059 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 578 | 9 | 2 | 6 | 4.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)OCCCN3CCCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 44598058 | 200588 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 472 | 6 | 0 | 6 | 4.8 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccncn2)CC3)c1 | 10.1021/jm900713y | |||
| CHEMBL574655 | 200588 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 472 | 6 | 0 | 6 | 4.8 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccncn2)CC3)c1 | 10.1021/jm900713y | |||
| 16105781 | 83192 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 480 | 7 | 2 | 5 | 3.6 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccn3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL218298 | 83192 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 480 | 7 | 2 | 5 | 3.6 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccn3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11526626 | 75569 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 531 | 8 | 1 | 4 | 6.3 | CCN1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| CHEMBL204419 | 75569 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 531 | 8 | 1 | 4 | 6.3 | CCN1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| 16105779 | 137288 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 528 | 7 | 2 | 5 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cc(C)nc(Cl)c3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL374964 | 137288 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 528 | 7 | 2 | 5 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cc(C)nc(Cl)c3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105778 | 82629 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 551 | 7 | 2 | 5 | 5.1 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cc(C)oc3C(F)(F)F)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL217909 | 82629 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 551 | 7 | 2 | 5 | 5.1 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cc(C)oc3C(F)(F)F)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105858 | 84394 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 493 | 7 | 2 | 4 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cccc(C)c3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221790 | 84394 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 493 | 7 | 2 | 4 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cccc(C)c3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 44598062 | 199726 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 446 | 3 | 1 | 5 | 4.4 | CC1(C)C=Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccnc(N)c3)CC4)c2O1 | 10.1021/jm900713y | |||
| CHEMBL568522 | 199726 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 446 | 3 | 1 | 5 | 4.4 | CC1(C)C=Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccnc(N)c3)CC4)c2O1 | 10.1021/jm900713y | |||
| 10255258 | 150556 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 495 | 5 | 0 | 5 | 5.2 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(Br)cc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL395424 | 150556 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 495 | 5 | 0 | 5 | 5.2 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(Br)cc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 16112836 | 93418 | None | 3 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 4.9 | COc1ccc2nccc([C@@H]3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL245568 | 93418 | None | 3 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 4.9 | COc1ccc2nccc([C@@H]3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 10409369 | 169608 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 411 | 8 | 0 | 5 | 4.8 | CCCCCCN1CCC(N2CC(c3ccnc4ccc(OC)cc34)OC2=O)CC1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL443315 | 169608 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 411 | 8 | 0 | 5 | 4.8 | CCCCCCN1CCC(N2CC(c3ccnc4ccc(OC)cc34)OC2=O)CC1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44598820 | 201237 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 465 | 6 | 0 | 4 | 4.8 | O=C(c1ccncc1)N1CCC2(CCN(Cc3ccccc3OC(F)(F)C(F)F)CC2)CC1 | 10.1021/jm900713y | |||
| CHEMBL583212 | 201237 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 465 | 6 | 0 | 4 | 4.8 | O=C(c1ccncc1)N1CCC2(CCN(Cc3ccccc3OC(F)(F)C(F)F)CC2)CC1 | 10.1021/jm900713y | |||
| 11965686 | 201311 | None | 3 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 487 | 6 | 1 | 5 | 4.7 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc[nH]c1=O)CC2 | 10.1021/jm900713y | |||
| CHEMBL583843 | 201311 | None | 3 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 487 | 6 | 1 | 5 | 4.7 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc[nH]c1=O)CC2 | 10.1021/jm900713y | |||
| 11539239 | 78155 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 430 | 8 | 1 | 4 | 4.8 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)Cc3ccccc3)CC2)c1 | 10.1021/jm050965z | |||
| CHEMBL210322 | 78155 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 430 | 8 | 1 | 4 | 4.8 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)Cc3ccccc3)CC2)c1 | 10.1021/jm050965z | |||
| 11519336 | 77905 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 527 | 9 | 1 | 5 | 5.6 | CCN1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4OC)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| CHEMBL209350 | 77905 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 527 | 9 | 1 | 5 | 5.6 | CCN1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4OC)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| 16105783 | 83243 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 457 | 7 | 2 | 4 | 3.6 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL218554 | 83243 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 457 | 7 | 2 | 4 | 3.6 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105773 | 84444 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 497 | 7 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(F)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221978 | 84444 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 497 | 7 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(F)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105784 | 84354 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 485 | 7 | 2 | 4 | 4.4 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CCCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221586 | 84354 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 485 | 7 | 2 | 4 | 4.4 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C3CCCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16065704 | 201329 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 436 | 3 | 1 | 6 | 3.7 | CC1(C)Oc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccnc(N)c3)CC4)c2O1 | 10.1021/jm900713y | |||
| CHEMBL584087 | 201329 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 436 | 3 | 1 | 6 | 3.7 | CC1(C)Oc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccnc(N)c3)CC4)c2O1 | 10.1021/jm900713y | |||
| 16105861 | 83191 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 535 | 7 | 2 | 4 | 5.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(C(C)(C)C)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL218297 | 83191 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 535 | 7 | 2 | 4 | 5.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(C(C)(C)C)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105787 | 83947 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 473 | 7 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)CC(C)(C)C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL220651 | 83947 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 473 | 7 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)CC(C)(C)C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 10343818 | 151447 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 451 | 5 | 0 | 5 | 5.1 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(Cl)cc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL396124 | 151447 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 451 | 5 | 0 | 5 | 5.1 | COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(Cl)cc5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439838 | 91397 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 444 | 8 | 1 | 5 | 4.7 | COc1ccc2nccc(C3CN(CCCN(C)Cc4cc5ccccc5[nH]4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL240249 | 91397 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 444 | 8 | 1 | 5 | 4.7 | COc1ccc2nccc(C3CN(CCCN(C)Cc4cc5ccccc5[nH]4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439887 | 93967 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 451 | 5 | 0 | 5 | 5.1 | COc1ccc2nccc(C3CN(C4CCN(Cc5cccc(Cl)c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL248169 | 93967 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 451 | 5 | 0 | 5 | 5.1 | COc1ccc2nccc(C3CN(C4CCN(Cc5cccc(Cl)c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439909 | 167627 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 499 | 4 | 0 | 5 | 5.3 | COc1ccc2nccc(C3CN(C4CCN(C(=O)c5ccc(Cl)c(Cl)c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL430012 | 167627 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 499 | 4 | 0 | 5 | 5.3 | COc1ccc2nccc(C3CN(C4CCN(C(=O)c5ccc(Cl)c(Cl)c5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 16105786 | 141794 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 473 | 9 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C(CC)CC)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL385654 | 141794 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 473 | 9 | 2 | 4 | 4.3 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C(CC)CC)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105856 | 83948 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 521 | 9 | 2 | 4 | 5.0 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C(CC)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL220652 | 83948 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 521 | 9 | 2 | 4 | 5.0 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)C(CC)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 44598819 | 199448 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 419 | 6 | 0 | 4 | 4.6 | C=C(C)COc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2 | 10.1021/jm900713y | |||
| CHEMBL566759 | 199448 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 419 | 6 | 0 | 4 | 4.6 | C=C(C)COc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2 | 10.1021/jm900713y | |||
| 11950827 | 97673 | None | 2 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cccc[n+]1[O-])CC2 | 10.1021/jm070543k | |||
| CHEMBL270969 | 97673 | None | 2 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 487 | 6 | 0 | 5 | 4.6 | COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cccc[n+]1[O-])CC2 | 10.1021/jm070543k | |||
| 10412573 | 93854 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 473 | 5 | 0 | 6 | 5.6 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6s5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL247564 | 93854 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 473 | 5 | 0 | 6 | 5.6 | COc1ccc2nccc(C3CN(C4CCN(Cc5cc6ccccc6s5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 44439885 | 93928 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 423 | 5 | 0 | 5 | 4.8 | COc1ccc2nccc(C3CN(C4CCN(CC5CCCCC5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| CHEMBL247963 | 93928 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 423 | 5 | 0 | 5 | 4.8 | COc1ccc2nccc(C3CN(C4CCN(CC5CCCCC5)CC4)C(=O)O3)c2c1 | 10.1016/j.bmcl.2006.12.076 | |||
| 16065569 | 199423 | None | 28 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 434 | 3 | 1 | 5 | 3.9 | CC1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| CHEMBL566543 | 199423 | None | 28 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 434 | 3 | 1 | 5 | 3.9 | CC1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2O1 | 10.1021/jm900713y | |||
| 166926318 | 195613 | None | 9 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 429 | 6 | 2 | 4 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5407071 | 195613 | None | 9 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 429 | 6 | 2 | 4 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 11273324 | 95961 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 474 | 5 | 0 | 3 | 6.7 | O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1 | 10.1021/jm070543k | |||
| CHEMBL259243 | 95961 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 474 | 5 | 0 | 3 | 6.7 | O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1 | 10.1021/jm070543k | |||
| 11273324 | 95961 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 474 | 5 | 0 | 3 | 6.7 | O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1 | 10.1021/jm900713y | |||
| CHEMBL259243 | 95961 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 474 | 5 | 0 | 3 | 6.7 | O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1 | 10.1021/jm900713y | |||
| 16105866 | 83244 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 480 | 7 | 2 | 5 | 3.6 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cccnc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL218555 | 83244 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 480 | 7 | 2 | 5 | 3.6 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3cccnc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105771 | 84592 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 493 | 7 | 2 | 4 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(C)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL222062 | 84592 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 493 | 7 | 2 | 4 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccc(C)cc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105815 | 83210 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 552 | 9 | 2 | 6 | 4.2 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)OCCCN(C)C)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL218369 | 83210 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 552 | 9 | 2 | 6 | 4.2 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)OCCCN(C)C)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 44598061 | 199494 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 448 | 3 | 1 | 5 | 4.3 | CC1(C)CCc2cc(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)ccc2O1 | 10.1021/jm900713y | |||
| CHEMBL567202 | 199494 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 448 | 3 | 1 | 5 | 4.3 | CC1(C)CCc2cc(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)ccc2O1 | 10.1021/jm900713y | |||
| 15664 | 83821 | None | 63 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -2 | 3 | Drug Central | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | None | |||
| CHEMBL2205807 | 83821 | None | 63 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -2 | 3 | Drug Central | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | None | |||
| 486830 | 4002 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -10 | 5 | Guide to Pharmacology | None | None | None | None | 10419462 | |||||
| 768 | 4002 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -10 | 5 | Guide to Pharmacology | None | None | None | None | 10419462 | |||||
| 812 | 823 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 10419462 | |||||
| 812 | 823 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 11154210 | |||||
| 812 | 823 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 16221874 | |||||
| 815 | 4001 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 10419462 | |||||
| 815 | 4001 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 11154210 | |||||
| 816 | 4000 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 10419462 | |||||
| 11688990 | 4147 | None | 0 | Human | Functional | pIC50 | None | 5.7 | 5.7 | - | 1 | Guide to Pharmacology | 356 | 9 | 1 | 5 | 2.6 | OCCOCCN1CCN(CC1)Cc1cccc(c1)Oc1ccccc1 | 16221874 | |||
| 813 | 4147 | None | 0 | Human | Functional | pIC50 | None | 5.7 | 5.7 | - | 1 | Guide to Pharmacology | 356 | 9 | 1 | 5 | 2.6 | OCCOCCN1CCN(CC1)Cc1cccc(c1)Oc1ccccc1 | 16221874 | |||
| CHEMBL1883966 | 4147 | None | 0 | Human | Functional | pIC50 | None | 5.7 | 5.7 | - | 1 | Guide to Pharmacology | 356 | 9 | 1 | 5 | 2.6 | OCCOCCN1CCN(CC1)Cc1cccc(c1)Oc1ccccc1 | 16221874 | |||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 163322187 | 196450 | None | 10 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1ccccc1C(=O)Nc1c(C)cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)cc1Cl | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5424187 | 196450 | None | 10 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1ccccc1C(=O)Nc1c(C)cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)cc1Cl | 10.1021/acs.jmedchem.3c00030 | |||
| 172445647 | 195486 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 465 | 6 | 2 | 4 | 4.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5404620 | 195486 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 465 | 6 | 2 | 4 | 4.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| 167339834 | 195156 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1cccc(Cl)c1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5397693 | 195156 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1cccc(Cl)c1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167339722 | 195818 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccc(Cl)cc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5411391 | 195818 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccc(Cl)cc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167339983 | 195897 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1cc(Cl)ccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5412884 | 195897 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1cc(Cl)ccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 91032188 | 193653 | None | 19 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 471 | 8 | 1 | 5 | 4.5 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)C(=O)NCN3CCc2ccccc2)c1 | 10.1021/acs.jmedchem.6b01309 | |||
| CHEMBL5268017 | 193653 | None | 19 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 471 | 8 | 1 | 5 | 4.5 | COc1ccccc1Oc1cccc(CN2CCC3(CC2)C(=O)NCN3CCc2ccccc2)c1 | 10.1021/acs.jmedchem.6b01309 | |||
| 60016664 | 194059 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 527 | 11 | 1 | 5 | 5.8 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C(CCN3CCCC3)c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.6b01309 | |||
| CHEMBL5277802 | 194059 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 527 | 11 | 1 | 5 | 5.8 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C(CCN3CCCC3)c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.6b01309 | |||
| 166926303 | 196807 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 451 | 6 | 3 | 4 | 4.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC(C)C2CCCNC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5432566 | 196807 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 451 | 6 | 3 | 4 | 4.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC(C)C2CCCNC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| 167339714 | 197032 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 487 | 8 | 2 | 6 | 3.1 | COC(=O)CN1CCC([C@@H](C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c(C)c2)CC1 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5437230 | 197032 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 487 | 8 | 2 | 6 | 3.1 | COC(=O)CN1CCC([C@@H](C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c(C)c2)CC1 | 10.1021/acs.jmedchem.3c00030 | |||
| 167339681 | 195313 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 443 | 7 | 2 | 4 | 3.8 | CCc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5400674 | 195313 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 443 | 7 | 2 | 4 | 3.8 | CCc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167339838 | 195319 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 451 | 6 | 3 | 4 | 4.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCNCC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5400852 | 195319 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 451 | 6 | 3 | 4 | 4.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCNCC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| 60016619 | 193840 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 526 | 10 | 2 | 7 | 4.3 | CCNS(=O)(=O)c1ccc(OC)cc1C1(O)CCN(Cc2cccc(Oc3ccccc3OC)c2)CC1 | 10.1021/acs.jmedchem.6b01309 | |||
| CHEMBL5272687 | 193840 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 526 | 10 | 2 | 7 | 4.3 | CCNS(=O)(=O)c1ccc(OC)cc1C1(O)CCN(Cc2cccc(Oc3ccccc3OC)c2)CC1 | 10.1021/acs.jmedchem.6b01309 | |||
| 172465785 | 196955 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(Cl)c1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5435573 | 196955 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(Cl)c1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167339843 | 194979 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 486 | 8 | 3 | 5 | 2.7 | CNC(=O)CN1CCC([C@@H](C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c(C)c2)CC1 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5394357 | 194979 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 486 | 8 | 3 | 5 | 2.7 | CNC(=O)CN1CCC([C@@H](C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c(C)c2)CC1 | 10.1021/acs.jmedchem.3c00030 | |||
| 166926318 | 195613 | None | 9 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 429 | 6 | 2 | 4 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5407071 | 195613 | None | 9 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 429 | 6 | 2 | 4 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167339691 | 196801 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 415 | 6 | 2 | 4 | 3.2 | Cc1cc(S(=O)(=O)NCC2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5432453 | 196801 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 415 | 6 | 2 | 4 | 3.2 | Cc1cc(S(=O)(=O)NCC2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167339944 | 196917 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 457 | 8 | 2 | 4 | 4.3 | CCCN1CCC([C@@H](C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c(C)c2)CC1 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5434812 | 196917 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 457 | 8 | 2 | 4 | 4.3 | CCCN1CCC([C@@H](C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c(C)c2)CC1 | 10.1021/acs.jmedchem.3c00030 | |||
| 167339894 | 195283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 449 | 6 | 2 | 4 | 3.9 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)cc1Cl | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5400080 | 195283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 449 | 6 | 2 | 4 | 3.9 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)cc1Cl | 10.1021/acs.jmedchem.3c00030 | |||
| 167339899 | 195872 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 435 | 6 | 2 | 4 | 3.9 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)C1CCCCCC1 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5412408 | 195872 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 435 | 6 | 2 | 4 | 3.9 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)C1CCCCCC1 | 10.1021/acs.jmedchem.3c00030 | |||
| 166926032 | 195241 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 451 | 6 | 3 | 4 | 4.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC(C)C2CCNCC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5399315 | 195241 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 451 | 6 | 3 | 4 | 4.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC(C)C2CCNCC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| 172457962 | 196476 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 477 | 6 | 2 | 4 | 4.6 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C23CCN(CC2)CC3)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5424675 | 196476 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 477 | 6 | 2 | 4 | 4.6 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C23CCN(CC2)CC3)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| 60016473 | 193727 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 433 | 7 | 2 | 5 | 4.7 | COc1ccccc1Oc1cccc(CN2CCC(O)(c3ccccc3C(=O)O)CC2)c1 | 10.1021/acs.jmedchem.6b01309 | |||
| CHEMBL5270110 | 193727 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 433 | 7 | 2 | 5 | 4.7 | COc1ccccc1Oc1cccc(CN2CCC(O)(c3ccccc3C(=O)O)CC2)c1 | 10.1021/acs.jmedchem.6b01309 | |||
| 167339928 | 195750 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 435 | 6 | 2 | 5 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccsc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5410064 | 195750 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 435 | 6 | 2 | 5 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccsc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167529305 | 197035 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 440 | 6 | 2 | 5 | 3.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)cc1C#N | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5437244 | 197035 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 440 | 6 | 2 | 5 | 3.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)cc1C#N | 10.1021/acs.jmedchem.3c00030 | |||
| 166926318 | 195613 | None | 9 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 429 | 6 | 2 | 4 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5407071 | 195613 | None | 9 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 429 | 6 | 2 | 4 | 3.6 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167339720 | 195392 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1c(C)cccc1Cl | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5402712 | 195392 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1c(C)cccc1Cl | 10.1021/acs.jmedchem.3c00030 | |||
| 16105824 | 84304 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 549 | 5 | 2 | 5 | 3.5 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCN(C)CC3)CC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL221251 | 84304 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 549 | 5 | 2 | 5 | 3.5 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCN(C)CC3)CC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| 167340022 | 195278 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 443 | 6 | 2 | 4 | 3.9 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(C)cc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5399936 | 195278 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 443 | 6 | 2 | 4 | 3.9 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(C)cc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 166925926 | 195130 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 483 | 6 | 2 | 4 | 4.3 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C(F)(F)F | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5397155 | 195130 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 483 | 6 | 2 | 4 | 4.3 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C(F)(F)F | 10.1021/acs.jmedchem.3c00030 | |||
| 60016644 | 193875 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 485 | 7 | 2 | 5 | 4.7 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3CC(=O)Nc4ccccc43)CC2)c1 | 10.1021/acs.jmedchem.6b01309 | |||
| CHEMBL5273480 | 193875 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 485 | 7 | 2 | 5 | 4.7 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3CC(=O)Nc4ccccc43)CC2)c1 | 10.1021/acs.jmedchem.6b01309 | |||
| 166926335 | 196047 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 521 | 8 | 2 | 4 | 5.1 | CCCC(=O)N1CCCC(C(C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)C1 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5415778 | 196047 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 521 | 8 | 2 | 4 | 5.1 | CCCC(=O)N1CCCC(C(C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)C1 | 10.1021/acs.jmedchem.3c00030 | |||
| 155557362 | 174747 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 560 | 6 | 1 | 6 | 5.4 | CC[C@]12C=C(C(=O)OC)n3c(c(CCNC(=O)c4ccc(Br)cc4)c4ccccc43)[C@H]1N(C#N)CCC2 | 10.1021/acs.jmedchem.9b01924 | |||
| CHEMBL4558185 | 174747 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 560 | 6 | 1 | 6 | 5.4 | CC[C@]12C=C(C(=O)OC)n3c(c(CCNC(=O)c4ccc(Br)cc4)c4ccccc43)[C@H]1N(C#N)CCC2 | 10.1021/acs.jmedchem.9b01924 | |||
| 167339879 | 195469 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 447 | 6 | 2 | 4 | 3.7 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(F)cc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5404280 | 195469 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 447 | 6 | 2 | 4 | 3.7 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(F)cc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 166926153 | 195857 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(Cl)cc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5412094 | 195857 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 463 | 6 | 2 | 4 | 4.2 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C)CC2)c(Cl)cc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 132072454 | 179830 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 558 | 6 | 2 | 8 | 4.7 | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 | 10.1016/j.bmc.2020.115546 | |||
| CHEMBL4744046 | 179830 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 558 | 6 | 2 | 8 | 4.7 | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 | 10.1016/j.bmc.2020.115546 | |||
| 167339914 | 196028 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 431 | 7 | 3 | 5 | 2.9 | COc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCNCC2)cc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5415309 | 196028 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 431 | 7 | 3 | 5 | 2.9 | COc1ccccc1C(=O)Nc1ccc(S(=O)(=O)N[C@H](C)C2CCNCC2)cc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167339969 | 196880 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 473 | 9 | 2 | 5 | 3.6 | COCCN1CCC([C@@H](C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c(C)c2)CC1 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5434069 | 196880 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 473 | 9 | 2 | 5 | 3.6 | COCCN1CCC([C@@H](C)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c(C)c2)CC1 | 10.1021/acs.jmedchem.3c00030 | |||
| 166926273 | 195066 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 437 | 6 | 3 | 4 | 3.7 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC(C)C2CCNC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5395905 | 195066 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 437 | 6 | 3 | 4 | 3.7 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC(C)C2CCNC2)c2ccccc12 | 10.1021/acs.jmedchem.3c00030 | |||
| 172461910 | 196786 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 455 | 7 | 2 | 4 | 4.0 | Cc1cc(S(=O)(=O)N[C@H](C2CC2)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5432261 | 196786 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 455 | 7 | 2 | 4 | 4.0 | Cc1cc(S(=O)(=O)N[C@H](C2CC2)C2CCN(C)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 167339997 | 197111 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 471 | 7 | 2 | 5 | 3.3 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C3COC3)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| CHEMBL5438933 | 197111 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 471 | 7 | 2 | 5 | 3.3 | Cc1cc(S(=O)(=O)N[C@H](C)C2CCN(C3COC3)CC2)ccc1NC(=O)c1ccccc1C | 10.1021/acs.jmedchem.3c00030 | |||
| 10367938 | 83211 | None | 0 | Human | Binding | pKi | = | 9.8 | 9.8 | - | 1 | ChEMBL | 481 | 6 | 2 | 5 | 4.0 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL218374 | 83211 | None | 0 | Human | Binding | pKi | = | 9.8 | 9.8 | - | 1 | ChEMBL | 481 | 6 | 2 | 5 | 4.0 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 10391001 | 137285 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 493 | 7 | 2 | 4 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL374939 | 137285 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 493 | 7 | 2 | 4 | 4.5 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11754900 | 84400 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 480 | 5 | 3 | 4 | 3.5 | CNC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221865 | 84400 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 480 | 5 | 3 | 4 | 3.5 | CNC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 10006907 | 141901 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 520 | 6 | 3 | 5 | 3.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)[C@@H]3CCCN3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL386308 | 141901 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 520 | 6 | 3 | 5 | 3.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)[C@@H]3CCCN3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 10006907 | 141901 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 520 | 6 | 3 | 5 | 3.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)[C@@H]3CCCN3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL386308 | 141901 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 520 | 6 | 3 | 5 | 3.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)[C@@H]3CCCN3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 9984180 | 136636 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 520 | 5 | 2 | 4 | 4.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL373739 | 136636 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 520 | 5 | 2 | 4 | 4.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105811 | 137756 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 506 | 6 | 3 | 5 | 2.9 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)C3CNC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL375854 | 137756 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 506 | 6 | 3 | 5 | 2.9 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)C3CNC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105788 | 83212 | None | 11 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 6 | 2 | 5 | 4.3 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL218375 | 83212 | None | 11 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 6 | 2 | 5 | 4.3 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105880 | 84402 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 508 | 8 | 3 | 5 | 3.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CCCN)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL221867 | 84402 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 508 | 8 | 3 | 5 | 3.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CCCN)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105822 | 138246 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 494 | 5 | 2 | 4 | 3.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N(C)C)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL376910 | 138246 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 494 | 5 | 2 | 4 | 3.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N(C)C)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105890 | 142033 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 542 | 6 | 3 | 4 | 5.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)Nc3ccccc3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL387161 | 142033 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 542 | 6 | 3 | 4 | 5.4 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)Nc3ccccc3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 11519336 | 77905 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 527 | 9 | 1 | 5 | 5.6 | CCN1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4OC)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| CHEMBL209350 | 77905 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 527 | 9 | 1 | 5 | 5.6 | CCN1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4OC)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| 16105807 | 84006 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 494 | 7 | 3 | 5 | 3.0 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CCN)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL220703 | 84006 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 494 | 7 | 3 | 5 | 3.0 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CCN)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105813 | 84279 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 570 | 7 | 2 | 5 | 5.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL221078 | 84279 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 570 | 7 | 2 | 5 | 5.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105831 | 83446 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 488 | 5 | 2 | 5 | 3.8 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)N3CCCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL219589 | 83446 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 488 | 5 | 2 | 5 | 3.8 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)N3CCCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11502217 | 76062 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 400 | 7 | 1 | 3 | 4.8 | O=C(Cc1ccccc1)NC1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 | 10.1021/jm050965z | |||
| CHEMBL205692 | 76062 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 400 | 7 | 1 | 3 | 4.8 | O=C(Cc1ccccc1)NC1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 | 10.1021/jm050965z | |||
| 11526626 | 75569 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 531 | 8 | 1 | 4 | 6.3 | CCN1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| CHEMBL204419 | 75569 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 531 | 8 | 1 | 4 | 6.3 | CCN1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| 16105760 | 137954 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 509 | 5 | 2 | 5 | 4.8 | CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL376076 | 137954 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 509 | 5 | 2 | 5 | 4.8 | CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105805 | 84438 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 495 | 7 | 2 | 5 | 3.3 | COCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221961 | 84438 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 495 | 7 | 2 | 5 | 3.3 | COCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105799 | 166241 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 482 | 6 | 1 | 6 | 4.0 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(OC(=O)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL426207 | 166241 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 482 | 6 | 1 | 6 | 4.0 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(OC(=O)c3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11774008 | 84633 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 402 | 5 | 2 | 3 | 4.9 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| CHEMBL222110 | 84633 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 402 | 5 | 2 | 3 | 4.9 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| 16105809 | 84362 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 522 | 9 | 3 | 5 | 3.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CCCCN)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL221638 | 84362 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 522 | 9 | 3 | 5 | 3.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CCCCN)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105889 | 84005 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 494 | 6 | 3 | 4 | 3.9 | CCNC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL220701 | 84005 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 494 | 6 | 3 | 4 | 3.9 | CCNC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 9982672 | 82857 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 481 | 6 | 2 | 5 | 4.0 | CCOC(=O)N1CCC(NS(=O)(=O)c2cccc3c(NC(=O)c4ccccc4)cccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL218037 | 82857 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 481 | 6 | 2 | 5 | 4.0 | CCOC(=O)N1CCC(NS(=O)(=O)c2cccc3c(NC(=O)c4ccccc4)cccc23)CC1 | 10.1021/jm061118e | |||
| 16105802 | 84099 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 479 | 6 | 2 | 4 | 4.1 | CCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL220753 | 84099 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 479 | 6 | 2 | 4 | 4.1 | CCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105895 | 142005 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 481 | 6 | 2 | 5 | 4.0 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc3cccc(NC(=O)c4ccccc4)c3c2)CC1 | 10.1021/jm061118e | |||
| CHEMBL386987 | 142005 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 481 | 6 | 2 | 5 | 4.0 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc3cccc(NC(=O)c4ccccc4)c3c2)CC1 | 10.1021/jm061118e | |||
| 11563243 | 168803 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 575 | 9 | 2 | 5 | 5.7 | CCN1CCC(C(=O)NC2(C(=O)O)CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| CHEMBL436753 | 168803 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 575 | 9 | 2 | 5 | 5.7 | CCN1CCC(C(=O)NC2(C(=O)O)CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| 11270007 | 84634 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 416 | 6 | 2 | 3 | 4.6 | O=C(Nc1ccc(S(=O)(=O)NCc2ccccc2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| CHEMBL222111 | 84634 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 416 | 6 | 2 | 3 | 4.6 | O=C(Nc1ccc(S(=O)(=O)NCc2ccccc2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| 16105888 | 136461 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 466 | 5 | 3 | 4 | 3.2 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(N)=O)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL373504 | 136461 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 466 | 5 | 3 | 4 | 3.2 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(N)=O)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 11541073 | 76017 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 532 | 8 | 1 | 4 | 7.1 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3(c4ccc(Cl)cc4)CCCCC3)CC2)c1 | 10.1021/jm050965z | |||
| CHEMBL205457 | 76017 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 532 | 8 | 1 | 4 | 7.1 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3(c4ccc(Cl)cc4)CCCCC3)CC2)c1 | 10.1021/jm050965z | |||
| 11539239 | 78155 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 430 | 8 | 1 | 4 | 4.8 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)Cc3ccccc3)CC2)c1 | 10.1021/jm050965z | |||
| CHEMBL210322 | 78155 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 430 | 8 | 1 | 4 | 4.8 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)Cc3ccccc3)CC2)c1 | 10.1021/jm050965z | |||
| 792361 | 76218 | None | 4 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 339 | 6 | 0 | 4 | 4.3 | CCOC(=O)C1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 | 10.1021/jm050965z | |||
| CHEMBL205808 | 76218 | None | 4 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 339 | 6 | 0 | 4 | 4.3 | CCOC(=O)C1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 | 10.1021/jm050965z | |||
| 11584004 | 140785 | None | 1 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 489 | 7 | 2 | 4 | 5.1 | O=C(NC1CCN(Cc2cccc(Oc3ccccc3Cl)c2)CC1)C1(c2ccccc2)CCNC1 | 10.1021/jm050965z | |||
| CHEMBL381619 | 140785 | None | 1 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 489 | 7 | 2 | 4 | 5.1 | O=C(NC1CCN(Cc2cccc(Oc3ccccc3Cl)c2)CC1)C1(c2ccccc2)CCNC1 | 10.1021/jm050965z | |||
| 16105891 | 84285 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 506 | 5 | 2 | 4 | 4.0 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL221130 | 84285 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 506 | 5 | 2 | 4 | 4.0 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 44419035 | 84315 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 495 | 9 | 2 | 5 | 4.8 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NCCCc3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221345 | 84315 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 495 | 9 | 2 | 5 | 4.8 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NCCCc3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11384528 | 141719 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 417 | 6 | 2 | 4 | 4.0 | O=C(Nc1ccc(S(=O)(=O)NCc2ccncc2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| CHEMBL385287 | 141719 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 417 | 6 | 2 | 4 | 4.0 | O=C(Nc1ccc(S(=O)(=O)NCc2ccncc2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| 16105832 | 83393 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 479 | 7 | 2 | 4 | 4.1 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)C1 | 10.1021/jm061118e | |||
| CHEMBL219327 | 83393 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 479 | 7 | 2 | 4 | 4.1 | CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)C1 | 10.1021/jm061118e | |||
| 44419032 | 84591 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 481 | 8 | 2 | 5 | 4.4 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NCCc3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL222058 | 84591 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 481 | 8 | 2 | 5 | 4.4 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NCCc3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105840 | 84393 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 468 | 7 | 1 | 5 | 4.3 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(OCc3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221789 | 84393 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 468 | 7 | 1 | 5 | 4.3 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(OCc3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 10254576 | 84410 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 480 | 6 | 3 | 5 | 2.6 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CN)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL221904 | 84410 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 480 | 6 | 3 | 5 | 2.6 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CN)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105824 | 84304 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 549 | 5 | 2 | 5 | 3.5 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCN(C)CC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL221251 | 84304 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 549 | 5 | 2 | 5 | 3.5 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCN(C)CC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105892 | 141694 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 534 | 5 | 2 | 4 | 4.7 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCCCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL385108 | 141694 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 534 | 5 | 2 | 4 | 4.7 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCCCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 11452569 | 83233 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 408 | 5 | 2 | 3 | 4.7 | O=C(Nc1ccc(S(=O)(=O)NC2CCCCC2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| CHEMBL218503 | 83233 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 408 | 5 | 2 | 3 | 4.7 | O=C(Nc1ccc(S(=O)(=O)NC2CCCCC2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| 3384970 | 161375 | None | 6 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 432 | 6 | 2 | 4 | 4.9 | COc1ccc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)cc1 | 10.1021/jm061118e | |||
| CHEMBL412116 | 161375 | None | 6 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 432 | 6 | 2 | 4 | 4.9 | COc1ccc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)cc1 | 10.1021/jm061118e | |||
| 44419031 | 137789 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 467 | 7 | 2 | 5 | 4.4 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NCc3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL375880 | 137789 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 467 | 7 | 2 | 5 | 4.4 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(NCc3ccccc3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 10391077 | 137471 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 495 | 6 | 2 | 5 | 4.3 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(C(=O)Nc3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL375315 | 137471 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 495 | 6 | 2 | 5 | 4.3 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(C(=O)Nc3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105877 | 82856 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 481 | 6 | 3 | 5 | 2.7 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CO)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL218036 | 82856 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 481 | 6 | 3 | 5 | 2.7 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CO)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105844 | 82803 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 465 | 7 | 2 | 4 | 3.7 | CCCC(=O)N1CC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)C1 | 10.1021/jm061118e | |||
| CHEMBL217979 | 82803 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 465 | 7 | 2 | 4 | 3.7 | CCCC(=O)N1CC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)C1 | 10.1021/jm061118e | |||
| 16105830 | 83430 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 564 | 11 | 2 | 5 | 4.8 | CCN(CC)CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL219487 | 83430 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 564 | 11 | 2 | 5 | 4.8 | CCN(CC)CCCC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11235229 | 83445 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 409 | 5 | 3 | 4 | 3.1 | O=C(Nc1ccc(S(=O)(=O)NC2CCNCC2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| CHEMBL219588 | 83445 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 409 | 5 | 3 | 4 | 3.1 | O=C(Nc1ccc(S(=O)(=O)NC2CCNCC2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| 11541506 | 76543 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 575 | 9 | 2 | 5 | 5.7 | CC(C)(C(=O)O)N1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)C1 | 10.1021/jm050965z | |||
| CHEMBL205993 | 76543 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 575 | 9 | 2 | 5 | 5.7 | CC(C)(C(=O)O)N1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)C1 | 10.1021/jm050965z | |||
| 16105893 | 83179 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 536 | 5 | 2 | 5 | 3.6 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCOCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL218218 | 83179 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 536 | 5 | 2 | 5 | 3.6 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)N3CCOCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105803 | 84443 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 465 | 5 | 2 | 4 | 3.7 | CC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221977 | 84443 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 465 | 5 | 2 | 4 | 3.7 | CC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11706579 | 139824 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 543 | 9 | 3 | 6 | 4.3 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3(c4ccccc4)CCNCC3)(C(=O)O)CC2)c1 | 10.1021/jm050965z | |||
| CHEMBL379834 | 139824 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 543 | 9 | 3 | 6 | 4.3 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3(c4ccccc4)CCNCC3)(C(=O)O)CC2)c1 | 10.1021/jm050965z | |||
| 11533398 | 76013 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 499 | 8 | 2 | 5 | 4.9 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3(c4ccccc4)CCNCC3)CC2)c1 | 10.1021/jm050965z | |||
| CHEMBL205447 | 76013 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 499 | 8 | 2 | 5 | 4.9 | COc1ccccc1Oc1cccc(CN2CCC(NC(=O)C3(c4ccccc4)CCNCC3)CC2)c1 | 10.1021/jm050965z | |||
| 16105876 | 137291 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 491 | 6 | 2 | 4 | 4.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)C3CC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL374979 | 137291 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 491 | 6 | 2 | 4 | 4.1 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)C3CC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105826 | 83208 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 578 | 9 | 2 | 6 | 3.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CCCN3CCOCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL218366 | 83208 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 578 | 9 | 2 | 6 | 3.8 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)CCCN3CCOCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 16105820 | 141720 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 508 | 7 | 3 | 4 | 4.3 | CCCNC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL385288 | 141720 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 508 | 7 | 3 | 4 | 4.3 | CCCNC(=O)N1CCC(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 16105821 | 83204 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 508 | 6 | 3 | 4 | 4.3 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)NC(C)C)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL218350 | 83204 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 508 | 6 | 3 | 4 | 4.3 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)NC(C)C)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 1099153 | 83174 | None | 6 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 396 | 4 | 1 | 4 | 3.1 | O=C(Nc1ccc(S(=O)(=O)N2CCOCC2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| CHEMBL218207 | 83174 | None | 6 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 396 | 4 | 1 | 4 | 3.1 | O=C(Nc1ccc(S(=O)(=O)N2CCOCC2)c2ccccc12)c1ccccc1 | 10.1021/jm061118e | |||
| 16105882 | 142082 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 527 | 6 | 2 | 4 | 5.0 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)c3ccccc3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL387451 | 142082 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 527 | 6 | 2 | 4 | 5.0 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)c3ccccc3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 11685733 | 140289 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 589 | 9 | 2 | 5 | 6.1 | CC(C)(C(=O)O)N1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| CHEMBL380492 | 140289 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 589 | 9 | 2 | 5 | 6.1 | CC(C)(C(=O)O)N1CCC(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)(c2ccccc2)CC1 | 10.1021/jm050965z | |||
| 16105804 | 83422 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 519 | 6 | 2 | 4 | 4.9 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)C3CCCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| CHEMBL219433 | 83422 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 519 | 6 | 2 | 4 | 4.9 | Cc1ccccc1C(=O)Nc1ccc(S(=O)(=O)NC2CCN(C(=O)C3CCCC3)CC2)c2ccccc12 | 10.1021/jm061118e | |||
| 11329260 | 84273 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 487 | 6 | 2 | 5 | 3.8 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(C(=O)NC3CCCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| CHEMBL221021 | 84273 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 487 | 6 | 2 | 5 | 3.8 | CCOC(=O)N1CCC(NS(=O)(=O)c2ccc(C(=O)NC3CCCCC3)c3ccccc23)CC1 | 10.1021/jm061118e | |||
| 11530171 | 75997 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 338 | 6 | 1 | 3 | 3.8 | CCNC(=O)C1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 | 10.1021/jm050965z | |||
| CHEMBL205304 | 75997 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 338 | 6 | 1 | 3 | 3.8 | CCNC(=O)C1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 | 10.1021/jm050965z | |||
| 11681610 | 140672 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 338 | 6 | 1 | 3 | 4.0 | CCC(=O)NC1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 | 10.1021/jm050965z | |||
| CHEMBL381354 | 140672 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 338 | 6 | 1 | 3 | 4.0 | CCC(=O)NC1CCN(Cc2cccc(Oc3ccccc3)c2)CC1 | 10.1021/jm050965z | |||