Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
156013177 | 177457 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 559 | 7 | 1 | 7 | 5.4 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4638895 | 177457 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 559 | 7 | 1 | 7 | 5.4 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156011084 | 177095 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4633217 | 177095 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156021011 | 178051 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4647206 | 178051 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
71768224 | 177966 | 21 | None | 39 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4645971 | 177966 | 21 | None | 39 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156015010 | 177550 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4640319 | 177550 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156012910 | 177446 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4638791 | 177446 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156019927 | 177949 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 441 | 6 | 2 | 4 | 4.1 | COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4645725 | 177949 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 441 | 6 | 2 | 4 | 4.1 | COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2019.126899 | |
156019169 | 178007 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4646463 | 178007 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | |
156016038 | 177627 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4641144 | 177627 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156013415 | 177473 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 495 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4639114 | 177473 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 495 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156020735 | 178116 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4648121 | 178116 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156021922 | 178191 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4649351 | 178191 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156010556 | 177034 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4632425 | 177034 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156010734 | 177088 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 480 | 7 | 1 | 6 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4633183 | 177088 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 480 | 7 | 1 | 6 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
25303824 | 178125 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4648327 | 178125 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156016810 | 177751 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4642662 | 177751 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156016430 | 177672 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4641681 | 177672 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156019204 | 177954 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4645763 | 177954 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156018695 | 177868 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4644405 | 177868 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156016371 | 177640 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 475 | 7 | 1 | 6 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4641301 | 177640 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 475 | 7 | 1 | 6 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
25303824 | 177396 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4638193 | 177396 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156020287 | 178085 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4647701 | 178085 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156014652 | 177234 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4635707 | 177234 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156012554 | 177346 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 474 | 7 | 1 | 5 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4637473 | 177346 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 474 | 7 | 1 | 5 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
156012971 | 177513 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | |
CHEMBL4639692 | 177513 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 |
Showing 1 to 50 of 82 entries
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
71525976 | 153489 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | Antagonist activity at CXCR6 (unknown origin)Antagonist activity at CXCR6 (unknown origin) |
ChEMBL | 453 | 7 | 3 | 8 | 3.1 | Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 | 10.1021/acs.jmedchem.5b01337 | ||
CHEMBL3979652 | 153489 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | Antagonist activity at CXCR6 (unknown origin)Antagonist activity at CXCR6 (unknown origin) |
ChEMBL | 453 | 7 | 3 | 8 | 3.1 | Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 | 10.1021/acs.jmedchem.5b01337 | ||
156019475 | 177979 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 464 | 7 | 2 | 6 | 3.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646034 | 177979 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 464 | 7 | 2 | 6 | 3.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156010556 | 177034 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4632425 | 177034 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020287 | 178085 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4647701 | 178085 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020779 | 178180 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 509 | 8 | 1 | 8 | 4.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4649243 | 178180 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 509 | 8 | 1 | 8 | 4.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156019227 | 177984 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646120 | 177984 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156019654 | 178013 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646569 | 178013 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
71768224 | 177966 | 21 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645971 | 177966 | 21 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012910 | 177446 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4638791 | 177446 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015439 | 177556 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640388 | 177556 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020329 | 178157 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4648997 | 178157 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156018738 | 177926 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 539 | 10 | 2 | 8 | 3.6 | CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645361 | 177926 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 539 | 10 | 2 | 8 | 3.6 | CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
156016430 | 177672 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4641681 | 177672 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020735 | 178116 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4648121 | 178116 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
71768224 | 177966 | 21 | None | - | 0 | Mouse | 4.8 | pIC50 | = | 4.8 | Binding | Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assayAntagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645971 | 177966 | 21 | None | - | 0 | Mouse | 4.8 | pIC50 | = | 4.8 | Binding | Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assayAntagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
71768225 | 177863 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4644339 | 177863 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 | 10.1016/j.bmcl.2019.126899 | ||
156019169 | 178007 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646463 | 178007 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
156012542 | 177324 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assayInhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay |
ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4637126 | 177324 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assayInhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay |
ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156014218 | 177243 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 463 | 7 | 2 | 5 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4635792 | 177243 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 463 | 7 | 2 | 5 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156018695 | 177868 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4644405 | 177868 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012971 | 177513 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4639692 | 177513 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012383 | 177417 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4638493 | 177417 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015010 | 177550 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640319 | 177550 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156017102 | 177712 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 481 | 7 | 1 | 7 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4642230 | 177712 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 481 | 7 | 1 | 7 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156021011 | 178051 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4647206 | 178051 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 |
Showing 1 to 50 of 99 entries