Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 135907764 | 113020 | None | 15 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -18 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 319 | 4 | 1 | 5 | 3.5 | N#Cc1c(O)nc(SCc2cccc(F)c2F)nc1C1CC1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL3310783 | 113020 | None | 15 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -18 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 319 | 4 | 1 | 5 | 3.5 | N#Cc1c(O)nc(SCc2cccc(F)c2F)nc1C1CC1 | 10.6019/CHEMBL5442687 | ||
| 11316919 | 3068 | None | 31 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -32 | 8 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 451 | 4 | 0 | 4 | 5.3 | Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F | 10.6019/CHEMBL5442687 | ||
| 11693 | 3068 | None | 31 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -32 | 8 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 451 | 4 | 0 | 4 | 5.3 | Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F | 10.6019/CHEMBL5442687 | ||
| CHEMBL484929 | 3068 | None | 31 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -32 | 8 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 451 | 4 | 0 | 4 | 5.3 | Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F | 10.6019/CHEMBL5442687 | ||
| 11858154 | 155430 | None | 19 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -309 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 400 | 6 | 3 | 7 | 3.3 | C[C@H](CO)Nc1nc(SCc2cccc(Cl)c2F)nc2[nH]c(=O)sc12 | 10.6019/CHEMBL5442687 | ||
| CHEMBL403225 | 155430 | None | 19 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -309 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 400 | 6 | 3 | 7 | 3.3 | C[C@H](CO)Nc1nc(SCc2cccc(Cl)c2F)nc2[nH]c(=O)sc12 | 10.6019/CHEMBL5442687 | ||
| 2705 | 3842 | None | 44 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -575 | 12 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 325 | 7 | 1 | 2 | 5.3 | Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O | 10.6019/CHEMBL5442687 | ||
| 360 | 3842 | None | 44 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -575 | 12 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 325 | 7 | 1 | 2 | 5.3 | Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O | 10.6019/CHEMBL5442687 | ||
| 443879 | 3842 | None | 44 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -575 | 12 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 325 | 7 | 1 | 2 | 5.3 | Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O | 10.6019/CHEMBL5442687 | ||
| 443879.0 | 3842 | None | 44 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -575 | 12 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 325 | 7 | 1 | 2 | 5.3 | Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O | 10.6019/CHEMBL5442687 | ||
| CHEMBL1382 | 3842 | None | 44 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -575 | 12 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 325 | 7 | 1 | 2 | 5.3 | Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O | 10.6019/CHEMBL5442687 | ||
| DB01036 | 3842 | None | 44 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -575 | 12 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 325 | 7 | 1 | 2 | 5.3 | Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O | 10.6019/CHEMBL5442687 | ||
| 3036864 | 205211 | None | 16 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -9549 | 13 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL1256645 | 205211 | None | 16 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -9549 | 13 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL1814790 | 205211 | None | 16 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -9549 | 13 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL62 | 205211 | None | 16 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -9549 | 13 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.6019/CHEMBL5442687 | ||
| 9887803 | 140924 | None | 26 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -19 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 409 | 3 | 4 | 4 | 3.6 | NS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(Cl)c2Cl)c1O | 10.6019/CHEMBL5442687 | ||
| CHEMBL3819292 | 140924 | None | 26 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -19 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 409 | 3 | 4 | 4 | 3.6 | NS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(Cl)c2Cl)c1O | 10.6019/CHEMBL5442687 | ||
| 24780598 | 1316 | None | 38 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -85 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 441 | 4 | 4 | 5 | 3.7 | O=C(Nc1cccc(c1C)F)Nc1ccc(c(c1O)S(=O)(=O)[C@H]1CCCNC1)Cl | 10.6019/CHEMBL5442687 | ||
| 8500 | 1316 | None | 38 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -85 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 441 | 4 | 4 | 5 | 3.7 | O=C(Nc1cccc(c1C)F)Nc1ccc(c(c1O)S(=O)(=O)[C@H]1CCCNC1)Cl | 10.6019/CHEMBL5442687 | ||
| CHEMBL3039531 | 1316 | None | 38 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -85 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 441 | 4 | 4 | 5 | 3.7 | O=C(Nc1cccc(c1C)F)Nc1ccc(c(c1O)S(=O)(=O)[C@H]1CCCNC1)Cl | 10.6019/CHEMBL5442687 | ||
| DB11922 | 1316 | None | 38 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -85 | 2 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 441 | 4 | 4 | 5 | 3.7 | O=C(Nc1cccc(c1C)F)Nc1ccc(c(c1O)S(=O)(=O)[C@H]1CCCNC1)Cl | 10.6019/CHEMBL5442687 | ||
| 11250647 | 1545 | None | 35 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -2511 | 7 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| 11250647.0 | 1545 | None | 35 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -2511 | 7 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| 5293 | 1545 | None | 35 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -2511 | 7 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| 8362 | 1545 | None | 35 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -2511 | 7 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| CHEMBL1208155 | 1545 | None | 35 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -2511 | 7 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| DB11979 | 1545 | None | 35 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -2511 | 7 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| 6603703 | 208 | None | 8 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -524 | 18 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442687 | ||
| 9637 | 208 | None | 8 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -524 | 18 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442687 | ||
| CHEMBL291143 | 208 | None | 8 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -524 | 18 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442687 | ||
| 662 | 3680 | None | 7 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 12 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 756 | 14 | 2 | 8 | 6.3 | COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C | 10.6019/CHEMBL5442687 | ||
| 9853583 | 3680 | None | 7 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 12 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 756 | 14 | 2 | 8 | 6.3 | COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C | 10.6019/CHEMBL5442687 | ||
| CHEMBL2021721 | 3680 | None | 7 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 12 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 756 | 14 | 2 | 8 | 6.3 | COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C | 10.6019/CHEMBL5442687 | ||
| 1692 | 2154 | None | 25 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -87 | 18 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 411 | 6 | 2 | 4 | 5.5 | CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C | 10.6019/CHEMBL5442687 | ||
| 5311340 | 2154 | None | 25 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -87 | 18 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 411 | 6 | 2 | 4 | 5.5 | CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C | 10.6019/CHEMBL5442687 | ||
| CHEMBL140979 | 2154 | None | 25 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -87 | 18 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 411 | 6 | 2 | 4 | 5.5 | CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C | 10.6019/CHEMBL5442687 | ||
| 10150497 | 4074 | None | 40 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -457 | 15 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 380 | 4 | 1 | 7 | 2.7 | NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2 | 10.6019/CHEMBL5442687 | ||
| 3240 | 4074 | None | 40 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -457 | 15 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 380 | 4 | 1 | 7 | 2.7 | NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2 | 10.6019/CHEMBL5442687 | ||
| CHEMBL392760 | 4074 | None | 40 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -457 | 15 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 380 | 4 | 1 | 7 | 2.7 | NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2 | 10.6019/CHEMBL5442687 | ||
| 209 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1288 | 25 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | ||
| 2113 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1288 | 25 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | ||
| 4748 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1288 | 25 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | ||
| 4748.0 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1288 | 25 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | ||
| CHEMBL567 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1288 | 25 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | ||
| DB00850 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1288 | 25 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | ||
| 1209 | 1658 | None | 52 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -25 | 25 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| 203 | 1658 | None | 52 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -25 | 25 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| 3386 | 1658 | None | 52 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -25 | 25 | GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1GPCR PRESTO-Tango dose-response in antagonist mode with target: CX3CR1 |
ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | ||
Showing 1 to 50 of 83 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 71293797 | 172400 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 501 | 8 | 2 | 4 | 4.6 | Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCCC3)CC2)C1 | nan | ||
| CHEMBL4475030 | 172400 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 501 | 8 | 2 | 4 | 4.6 | Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCCC3)CC2)C1 | nan | ||
| 71293723 | 170156 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 539 | 9 | 2 | 4 | 5.4 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCCCC2)CC1 | nan | ||
| CHEMBL4442967 | 170156 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 539 | 9 | 2 | 4 | 5.4 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCCCC2)CC1 | nan | ||
| 71293703 | 175051 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 549 | 10 | 2 | 4 | 5.0 | CCCC(F)CN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)(F)F)C[C@@H]2C)CC1 | nan | ||
| CHEMBL4565523 | 175051 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 549 | 10 | 2 | 4 | 5.0 | CCCC(F)CN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)(F)F)C[C@@H]2C)CC1 | nan | ||
| 71293644 | 174481 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 527 | 12 | 2 | 4 | 5.4 | CCCCCCN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)F)C[C@@H]2C)CC1 | nan | ||
| CHEMBL4551880 | 174481 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 527 | 12 | 2 | 4 | 5.4 | CCCCCCN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)F)C[C@@H]2C)CC1 | nan | ||
| 71293790 | 169653 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 523 | 9 | 2 | 4 | 4.9 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 | nan | ||
| CHEMBL4435586 | 169653 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 523 | 9 | 2 | 4 | 4.9 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 | nan | ||
| 71293710 | 170194 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 507 | 8 | 2 | 4 | 4.6 | C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)N[C@H]1CCN(CC2=CCCCC2)C1 | nan | ||
| CHEMBL4443425 | 170194 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 507 | 8 | 2 | 4 | 4.6 | C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)N[C@H]1CCN(CC2=CCCCC2)C1 | nan | ||
| 71293610 | 171105 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 559 | 8 | 2 | 4 | 5.3 | C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCC(F)(F)CC2)CC1 | nan | ||
| CHEMBL4456446 | 171105 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 559 | 8 | 2 | 4 | 5.3 | C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCC(F)(F)CC2)CC1 | nan | ||
| 71293715 | 170470 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 487 | 8 | 2 | 4 | 4.3 | Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCC3)CC2)C1 | nan | ||
| CHEMBL4447653 | 170470 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 487 | 8 | 2 | 4 | 4.3 | Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCC3)CC2)C1 | nan | ||
| 71293692 | 173124 | None | 21 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 555 | 8 | 2 | 4 | 5.4 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 | nan | ||
| CHEMBL4518556 | 173124 | None | 21 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 555 | 8 | 2 | 4 | 5.4 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 | nan | ||
| 71293607 | 173977 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 541 | 8 | 2 | 4 | 5.0 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 | nan | ||
| CHEMBL4539605 | 173977 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 541 | 8 | 2 | 4 | 5.0 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 | nan | ||
| 71293699 | 172327 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 521 | 8 | 2 | 4 | 5.0 | C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 | nan | ||
| CHEMBL4474066 | 172327 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 521 | 8 | 2 | 4 | 5.0 | C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 | nan | ||
| 71293737 | 175566 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 537 | 9 | 2 | 4 | 5.3 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 | nan | ||
| CHEMBL4577003 | 175566 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay |
ChEMBL | 537 | 9 | 2 | 4 | 5.3 | C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 | nan | ||
| 132072454 | 179830 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | Antagonist activity at human CX3CR1 expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human CX3CR1 expressed in CHO-K1 cells by PathHunter beta-arrestin assay |
ChEMBL | 558 | 6 | 2 | 8 | 4.7 | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 | 10.1016/j.bmc.2020.115546 | ||
| CHEMBL4744046 | 179830 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | Antagonist activity at human CX3CR1 expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human CX3CR1 expressed in CHO-K1 cells by PathHunter beta-arrestin assay |
ChEMBL | 558 | 6 | 2 | 8 | 4.7 | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 | 10.1016/j.bmc.2020.115546 | ||
| 69440865 | 88403 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -2 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 426 | 8 | 3 | 7 | 3.8 | CC(C)C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]c(=O)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349306 | 88403 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -2 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 426 | 8 | 3 | 7 | 3.8 | CC(C)C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]c(=O)sc12 | 10.1021/jm3012273 | ||
| 59799570 | 88437 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 5 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 375 | 8 | 3 | 8 | 3.5 | CCC[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349339 | 88437 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 5 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 375 | 8 | 3 | 8 | 3.5 | CCC[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| 71625506 | 88413 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 58 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 481 | 8 | 3 | 8 | 5.1 | CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2Br)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349315 | 88413 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 58 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 481 | 8 | 3 | 8 | 5.1 | CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2Br)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| 71625504 | 88388 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 4 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 417 | 10 | 3 | 8 | 4.2 | CC(C)C[C@H](CO)Nc1nc(SCCCc2ccccc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349183 | 88388 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 4 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 417 | 10 | 3 | 8 | 4.2 | CC(C)C[C@H](CO)Nc1nc(SCCCc2ccccc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| 71624890 | 88389 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 422 | 8 | 3 | 8 | 2.2 | CC(C)C[C@H](CO)Nc1nc(S(=O)(=O)Cc2ccccc2)nc2[nH]c(=O)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349184 | 88389 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 422 | 8 | 3 | 8 | 2.2 | CC(C)C[C@H](CO)Nc1nc(S(=O)(=O)Cc2ccccc2)nc2[nH]c(=O)sc12 | 10.1021/jm3012273 | ||
| 11857680 | 97683 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 347 | 6 | 3 | 8 | 2.8 | C[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| CHEMBL271013 | 97683 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 347 | 6 | 3 | 8 | 2.8 | C[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| 71625274 | 88424 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 33 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 414 | 8 | 3 | 9 | 3.7 | CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2C#N)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349326 | 88424 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 33 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 414 | 8 | 3 | 9 | 3.7 | CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2C#N)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| 71625145 | 88392 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 417 | 8 | 3 | 8 | 4.6 | CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(C)(C)O | 10.1021/jm3012273 | ||
| CHEMBL2349187 | 88392 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 417 | 8 | 3 | 8 | 4.6 | CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(C)(C)O | 10.1021/jm3012273 | ||
| 71625390 | 88429 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 414 | 8 | 3 | 9 | 3.7 | CC(C)C[C@H](CO)Nc1nc(SCc2ccc(C#N)cc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349331 | 88429 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 414 | 8 | 3 | 9 | 3.7 | CC(C)C[C@H](CO)Nc1nc(SCc2ccc(C#N)cc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| 71625505 | 88412 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 204 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 481 | 8 | 3 | 8 | 5.1 | CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2Br)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349314 | 88412 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 204 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 481 | 8 | 3 | 8 | 5.1 | CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2Br)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| 66622526 | 88416 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 64 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 415 | 8 | 3 | 8 | 3.7 | CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cccc(C#N)c2)nc2[nH]c(=O)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349318 | 88416 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 64 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 415 | 8 | 3 | 8 | 3.7 | CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cccc(C#N)c2)nc2[nH]c(=O)sc12 | 10.1021/jm3012273 | ||
| 71625503 | 88387 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 19 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 403 | 9 | 3 | 8 | 3.8 | CC(C)C[C@H](CO)Nc1nc(SCCc2ccccc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
| CHEMBL2349182 | 88387 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 19 | 2 | Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis |
ChEMBL | 403 | 9 | 3 | 8 | 3.8 | CC(C)C[C@H](CO)Nc1nc(SCCc2ccccc2)nc2nc(N)sc12 | 10.1021/jm3012273 | ||
Showing 1 to 50 of 128 entries