Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 10099401 | 101263 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 562 | 15 | 1 | 3 | 6.3 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL295895 | 101263 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 562 | 15 | 1 | 3 | 6.3 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 10120470 | 175564 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 563 | 14 | 2 | 4 | 3.8 | CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL45770 | 175564 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 563 | 14 | 2 | 4 | 3.8 | CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| 44293169 | 183259 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 551 | 14 | 0 | 5 | 5.5 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL47953 | 183259 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 551 | 14 | 0 | 5 | 5.5 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 44293020 | 180337 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 482 | 11 | 0 | 5 | 4.6 | CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL47500 | 180337 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 482 | 11 | 0 | 5 | 4.6 | CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 71224515 | 140518 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assayPositive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 557 | 9 | 2 | 5 | 4.5 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 | 10.1021/acsmedchemlett.6b00082 | ||
| CHEMBL3809148 | 140518 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assayPositive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 557 | 9 | 2 | 5 | 4.5 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 | 10.1021/acsmedchemlett.6b00082 | ||
| 44293287 | 187437 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 510 | 13 | 0 | 5 | 5.3 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL49308 | 187437 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 510 | 13 | 0 | 5 | 5.3 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 44293019 | 162762 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 464 | 11 | 0 | 3 | 5.6 | CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(C)c(OC)c(C)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL417003 | 162762 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 464 | 11 | 0 | 3 | 5.6 | CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(C)c(OC)c(C)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| 53322111 | 57382 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -125 | 2 | Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay |
ChEMBL | 482 | 7 | 4 | 8 | 3.4 | C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 | 10.1021/ml100229v | ||
| CHEMBL1651721 | 57382 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -125 | 2 | Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay |
ChEMBL | 482 | 7 | 4 | 8 | 3.4 | C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 | 10.1021/ml100229v | ||
| 10164519 | 187955 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 510 | 13 | 0 | 5 | 5.3 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL49624 | 187955 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 510 | 13 | 0 | 5 | 5.3 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 44292938 | 179071 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 547 | 15 | 0 | 3 | 6.5 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL47059 | 179071 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 547 | 15 | 0 | 3 | 6.5 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 44292917 | 171775 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 519 | 13 | 0 | 3 | 5.7 | CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL44663 | 171775 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 519 | 13 | 0 | 3 | 5.7 | CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 44292891 | 187831 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 510 | 13 | 0 | 5 | 5.3 | CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL49540 | 187831 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 510 | 13 | 0 | 5 | 5.3 | CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 10030777 | 168288 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 563 | 15 | 0 | 4 | 6.7 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL433263 | 168288 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 563 | 15 | 0 | 4 | 6.7 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 44293324 | 101648 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 482 | 12 | 0 | 5 | 4.6 | CCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL298686 | 101648 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 482 | 12 | 0 | 5 | 4.6 | CCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| 44293289 | 99017 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 496 | 12 | 0 | 5 | 5.0 | CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL279759 | 99017 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 496 | 12 | 0 | 5 | 5.0 | CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 44292945 | 162857 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO) |
ChEMBL | 563 | 15 | 2 | 4 | 4.8 | CCCCCCNC(=O)CN1C(=O)C(Cc2ccc(-c3ccc(CN(CCCC)C(=O)NC)cc3)cc2)N(C)C1=O | 10.1016/j.bmcl.2004.01.042 | ||
| CHEMBL417173 | 162857 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO) |
ChEMBL | 563 | 15 | 2 | 4 | 4.8 | CCCCCCNC(=O)CN1C(=O)C(Cc2ccc(-c3ccc(CN(CCCC)C(=O)NC)cc3)cc2)N(C)C1=O | 10.1016/j.bmcl.2004.01.042 | ||
| 10461880 | 188878 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO) |
ChEMBL | 645 | 13 | 3 | 4 | 5.4 | CCCCN(Cc1cccc(-c2ccc(C(=O)NC3CCCCN(CC(=O)NCCc4ccc(Cl)cc4)C3=O)cc2)c1)C(=O)NC | 10.1016/j.bmcl.2004.01.042 | ||
| CHEMBL50556 | 188878 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO) |
ChEMBL | 645 | 13 | 3 | 4 | 5.4 | CCCCN(Cc1cccc(-c2ccc(C(=O)NC3CCCCN(CC(=O)NCCc4ccc(Cl)cc4)C3=O)cc2)c1)C(=O)NC | 10.1016/j.bmcl.2004.01.042 | ||
| 71234037 | 111202 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay |
ChEMBL | 531 | 9 | 2 | 7 | 3.7 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCOC3=O)cc2NC(=O)c2ccco2)CC1 | 10.1016/j.bmcl.2014.03.018 | ||
| CHEMBL3263689 | 111202 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay |
ChEMBL | 531 | 9 | 2 | 7 | 3.7 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCOC3=O)cc2NC(=O)c2ccco2)CC1 | 10.1016/j.bmcl.2014.03.018 | ||
| 10142987 | 101839 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 525 | 13 | 1 | 6 | 3.3 | CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL300022 | 101839 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 525 | 13 | 1 | 6 | 3.3 | CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| 44292731 | 183786 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 550 | 14 | 1 | 4 | 5.1 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL48030 | 183786 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 550 | 14 | 1 | 4 | 5.1 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 44292995 | 188564 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 468 | 11 | 0 | 5 | 4.2 | CCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL50278 | 188564 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay. |
ChEMBL | 468 | 11 | 0 | 5 | 4.2 | CCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O | 10.1016/j.bmcl.2004.01.043 | ||
| 71233908 | 111199 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay |
ChEMBL | 515 | 8 | 2 | 6 | 3.5 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCN3CCCC3=O)cc2NC(=O)c2ccco2)CC1 | 10.1016/j.bmcl.2014.03.018 | ||
| CHEMBL3263683 | 111199 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay |
ChEMBL | 515 | 8 | 2 | 6 | 3.5 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCN3CCCC3=O)cc2NC(=O)c2ccco2)CC1 | 10.1016/j.bmcl.2014.03.018 | ||
| 10030777 | 168288 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay |
ChEMBL | 563 | 15 | 0 | 4 | 6.7 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL433263 | 168288 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay |
ChEMBL | 563 | 15 | 0 | 4 | 6.7 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 10164519 | 187955 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay |
ChEMBL | 510 | 13 | 0 | 5 | 5.3 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL49624 | 187955 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay |
ChEMBL | 510 | 13 | 0 | 5 | 5.3 | CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| 44293289 | 99017 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayAgonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assay |
ChEMBL | 496 | 12 | 0 | 5 | 5.0 | CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
| CHEMBL279759 | 99017 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayAgonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assay |
ChEMBL | 496 | 12 | 0 | 5 | 5.0 | CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C | 10.1016/j.bmcl.2004.01.043 | ||
Showing 1 to 50 of 159 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 71457922 | 84371 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Allosteric activation of human FSH receptorAllosteric activation of human FSH receptor |
ChEMBL | 653 | 10 | 2 | 6 | 5.8 | COc1ccc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)N(c3ccc(C(N)=O)c(Cl)c3)C2=O)cc1OC | 10.1016/j.bmc.2012.03.069 | ||
| CHEMBL2216803 | 84371 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Allosteric activation of human FSH receptorAllosteric activation of human FSH receptor |
ChEMBL | 653 | 10 | 2 | 6 | 5.8 | COc1ccc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)N(c3ccc(C(N)=O)c(Cl)c3)C2=O)cc1OC | 10.1016/j.bmc.2012.03.069 | ||
| 71233981 | 111198 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay |
ChEMBL | 570 | 10 | 2 | 7 | 4.2 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 | 10.1021/acsmedchemlett.6b00082 | ||
| CHEMBL3263667 | 111198 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay |
ChEMBL | 570 | 10 | 2 | 7 | 4.2 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 | 10.1021/acsmedchemlett.6b00082 | ||
| 71234266 | 111203 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay |
ChEMBL | 555 | 10 | 3 | 9 | 3.3 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 | 10.1021/acsmedchemlett.6b00082 | ||
| CHEMBL3263691 | 111203 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay |
ChEMBL | 555 | 10 | 3 | 9 | 3.3 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 | 10.1021/acsmedchemlett.6b00082 | ||
| 71224515 | 140518 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay |
ChEMBL | 557 | 9 | 2 | 5 | 4.5 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 | 10.1021/acsmedchemlett.6b00082 | ||
| CHEMBL3809148 | 140518 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay |
ChEMBL | 557 | 9 | 2 | 5 | 4.5 | Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 | 10.1021/acsmedchemlett.6b00082 | ||
| 171344021 | 193688 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 410 | 1 | 1 | 5 | 4.4 | CC(=O)N1c2cnc(NC(=O)OC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5268829 | 193688 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 410 | 1 | 1 | 5 | 4.4 | CC(=O)N1c2cnc(NC(=O)OC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171347755 | 194389 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 373 | 3 | 1 | 4 | 4.6 | CC(=O)N1c2cnc(NC(=O)OCC(C)C)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5285143 | 194389 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 373 | 3 | 1 | 4 | 4.6 | CC(=O)N1c2cnc(NC(=O)OCC(C)C)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171346919 | 194422 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 407 | 3 | 1 | 4 | 5.2 | CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5285769 | 194422 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 407 | 3 | 1 | 4 | 5.2 | CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171349352 | 194553 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 374 | 3 | 1 | 5 | 4.0 | CC(=O)N1c2cnc(NC(=O)OCC(C)C)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5288869 | 194553 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 374 | 3 | 1 | 5 | 4.0 | CC(=O)N1c2cnc(NC(=O)OCC(C)C)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171350836 | 193615 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 439 | 4 | 1 | 3 | 5.7 | CC(=O)N1c2ncc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5267037 | 193615 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 439 | 4 | 1 | 3 | 5.7 | CC(=O)N1c2ncc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171350838 | 193617 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 476 | 3 | 1 | 5 | 5.0 | CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5267043 | 193617 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 476 | 3 | 1 | 5 | 5.0 | CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 25207657 | 194216 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Allosteric antagonist activity at human FSHR expressed in CHO cells assessed as inhibition of FSH-induced activity incubated for 4 hrs by CRE-luciferase assayAllosteric antagonist activity at human FSHR expressed in CHO cells assessed as inhibition of FSH-induced activity incubated for 4 hrs by CRE-luciferase assay |
ChEMBL | 480 | 5 | 1 | 2 | 6.3 | CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)CCc3cccc(C(F)(F)F)c3)ccc21 | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5281228 | 194216 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Allosteric antagonist activity at human FSHR expressed in CHO cells assessed as inhibition of FSH-induced activity incubated for 4 hrs by CRE-luciferase assayAllosteric antagonist activity at human FSHR expressed in CHO cells assessed as inhibition of FSH-induced activity incubated for 4 hrs by CRE-luciferase assay |
ChEMBL | 480 | 5 | 1 | 2 | 6.3 | CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)CCc3cccc(C(F)(F)F)c3)ccc21 | 10.1016/j.bmc.2023.117258 | ||
| 171344294 | 193758 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 478 | 3 | 1 | 5 | 5.5 | CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5270771 | 193758 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 478 | 3 | 1 | 5 | 5.5 | CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171348353 | 194459 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 438 | 2 | 1 | 5 | 5.1 | CC(=O)N1c2cnc(NC(=O)O[C@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5286556 | 194459 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 438 | 2 | 1 | 5 | 5.1 | CC(=O)N1c2cnc(NC(=O)O[C@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171344225 | 193735 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 408 | 3 | 1 | 5 | 4.6 | CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5270266 | 193735 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 408 | 3 | 1 | 5 | 4.6 | CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171343167 | 193778 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 386 | 2 | 1 | 3 | 5.6 | CC(=O)N1c2ccc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5271120 | 193778 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 386 | 2 | 1 | 3 | 5.6 | CC(=O)N1c2ccc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171358709 | 194617 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 438 | 2 | 1 | 5 | 5.1 | CC(=O)N1c2cnc(NC(=O)O[C@@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5290721 | 194617 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 438 | 2 | 1 | 5 | 5.1 | CC(=O)N1c2cnc(NC(=O)O[C@@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171346093 | 194319 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 440 | 3 | 1 | 5 | 4.7 | CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5283477 | 194319 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 440 | 3 | 1 | 5 | 4.7 | CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171349123 | 193867 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 424 | 4 | 1 | 2 | 5.9 | CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5273361 | 193867 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 424 | 4 | 1 | 2 | 5.9 | CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1C | 10.1016/j.bmc.2023.117258 | ||
| 171353581 | 193975 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 388 | 2 | 1 | 5 | 4.4 | CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5275619 | 193975 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 388 | 2 | 1 | 5 | 4.4 | CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171348427 | 194498 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 476 | 4 | 1 | 4 | 5.3 | CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5287707 | 194498 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 476 | 4 | 1 | 4 | 5.3 | CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171353769 | 194181 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 438 | 4 | 1 | 2 | 6.3 | CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5280508 | 194181 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 438 | 4 | 1 | 2 | 6.3 | CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171358398 | 194145 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 440 | 4 | 1 | 4 | 5.0 | CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5279687 | 194145 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 440 | 4 | 1 | 4 | 5.0 | CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171343813 | 193677 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 387 | 2 | 1 | 4 | 5.0 | CC(=O)N1c2ncc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5268512 | 193677 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 387 | 2 | 1 | 4 | 5.0 | CC(=O)N1c2ncc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171349897 | 193619 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 440 | 3 | 1 | 3 | 6.4 | CC(=O)N1c2ccc(NC(=O)OCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5267166 | 193619 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 440 | 3 | 1 | 3 | 6.4 | CC(=O)N1c2ccc(NC(=O)OCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| 171355446 | 193949 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 438 | 3 | 1 | 5 | 5.1 | CC(=O)N1c2cnc(NC(=O)OC(C)(C)C(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
| CHEMBL5275140 | 193949 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay |
ChEMBL | 438 | 3 | 1 | 5 | 5.1 | CC(=O)N1c2cnc(NC(=O)OC(C)(C)C(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | 10.1016/j.bmc.2023.117258 | ||
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