Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

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ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
44378315 57465 11 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 332 14 0 3 5.5 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
CHEMBL165682 57465 11 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 332 14 0 3 5.5 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
145962053 161633 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 330 13 0 3 5.3 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
CHEMBL4130040 161633 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 330 13 0 3 5.3 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
3391 155 21 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
3416 155 21 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
5283159 155 21 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
CHEMBL18028 155 21 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
102164179 161435 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 316 13 1 2 5.2 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
CHEMBL4127146 161435 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 316 13 1 2 5.2 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
6167 152 8 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1016/j.bmcl.2011.01.032
6438757 152 8 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1016/j.bmcl.2011.01.032
CHEMBL1682258 152 8 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1016/j.bmcl.2011.01.032
3391 155 21 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
3416 155 21 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
5283159 155 21 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
CHEMBL18028 155 21 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
3391 155 21 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
3416 155 21 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
5283159 155 21 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
CHEMBL18028 155 21 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
122588275 166758 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4283608 166758 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
122588230 166993 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 CC(CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4287941 166993 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 CC(CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
145980814 166638 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4281149 166638 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
122588209 166814 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.5 CC(CC(=O)O)CC(=O)c1c(CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4284672 166814 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.5 CC(CC(=O)O)CC(=O)c1c(CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
49800286 105305 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.3 CCCCCCc1cc2ccccc2n1C(=O)CC(C)(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115781 105305 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.3 CCCCCCc1cc2ccccc2n1C(=O)CC(C)(C)CC(=O)O 10.1021/jm401292m
49802318 156702 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2cccc(C(=O)O)c2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4070005 156702 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2cccc(C(=O)O)c2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49804576 87339 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL2332567 87339 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
71717596 87337 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2cc(Cl)ccc21 10.1021/jm400480j
CHEMBL2332561 87337 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2cc(Cl)ccc21 10.1021/jm400480j
49800562 87336 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cccc2ccn(C(=O)CCCC(=O)O)c12 10.1021/jm400480j
CHEMBL2332560 87336 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cccc2ccn(C(=O)CCCC(=O)O)c12 10.1021/jm400480j
145984927 166427 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.8 CC(CC(=O)O)CC(=O)n1c(CCCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4277299 166427 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.8 CC(CC(=O)O)CC(=O)n1c(CCCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
145984923 166422 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4277207 166422 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
137638047 156777 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CC(C)(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4070795 156777 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CC(C)(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
76336045 105307 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.2 CCCCCCc1c(C)c2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115783 105307 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.2 CCCCCCc1c(C)c2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
137644937 158488 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4090987 158488 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49800561 105318 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 287 7 1 3 3.9 CCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115794 105318 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 287 7 1 3 3.9 CCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
66644017 105309 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2cc(Cl)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115785 105309 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2cc(Cl)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49804576 87339 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm400480j
CHEMBL2332567 87339 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm400480j
66644128 105301 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL3115775 105301 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49800843 105304 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 341 9 1 3 5.0 CCCCCCc1cc2ccccc2n1C(=O)CC1(CC(=O)O)CC1 10.1021/jm401292m
CHEMBL3115780 105304 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 341 9 1 3 5.0 CCCCCCc1cc2ccccc2n1C(=O)CC1(CC(=O)O)CC1 10.1021/jm401292m
49802029 105300 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/acs.jmedchem.8b00154
CHEMBL3115774 105300 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/acs.jmedchem.8b00154
66644128 105301 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
CHEMBL3115775 105301 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
49800564 87334 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2c(ccn2C(=O)CCCC(=O)O)c1 10.1021/jm400480j
CHEMBL2332558 87334 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2c(ccn2C(=O)CCCC(=O)O)c1 10.1021/jm400480j
49802029 105300 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
CHEMBL3115774 105300 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
145986668 167188 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 6.0 CC(CC(=O)O)CC(=O)n1c(CCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4291346 167188 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 6.0 CC(CC(=O)O)CC(=O)n1c(CCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
49800839 87335 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2ccn(C(=O)CCCC(=O)O)c2c1 10.1021/jm400480j
CHEMBL2332559 87335 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2ccn(C(=O)CCCC(=O)O)c2c1 10.1021/jm400480j
118707104 113012 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C/c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
CHEMBL3311229 113012 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C/c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
145979967 166693 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.4 CC(CC(=O)O)CC(=O)n1c(CCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4282356 166693 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.4 CC(CC(=O)O)CC(=O)n1c(CCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
49802316 114895 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)C[C@H](C)CC(=O)O 10.1021/ml500161v
CHEMBL3341973 114895 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)C[C@H](C)CC(=O)O 10.1021/ml500161v
49802026 114893 2 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
CHEMBL3341971 114893 2 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
1051 1455 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
4289 1455 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
445580 1455 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
57417355 1455 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
CHEMBL367149 1455 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
DB03756 1455 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
3174 1570 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
3362 1570 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
446284 1570 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
CHEMBL460026 1570 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
DB00159 1570 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
5312529 173890 31 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CC/C=C\C/C=C\C/C=C\CCCCCCCCCC(=O)O 10.1021/jm401292m
CHEMBL453991 173890 31 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CC/C=C\C/C=C\C/C=C\CCCCCCCCCC(=O)O 10.1021/jm401292m
5280581 178356 44 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O 10.1021/jm401292m
CHEMBL465183 178356 44 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O 10.1021/jm401292m
49804582 87333 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cn(C(=O)CCCC(=O)O)c2ccccc12 10.1021/jm400480j
CHEMBL2332557 87333 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cn(C(=O)CCCC(=O)O)c2ccccc12 10.1021/jm400480j
145979016 166616 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.6 CC(CC(=O)O)CC(=O)n1c(CCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4280693 166616 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.6 CC(CC(=O)O)CC(=O)n1c(CCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
49800284 105319 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 301 8 1 3 4.3 CCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115795 105319 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 301 8 1 3 4.3 CCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
49802029 105300 5 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 105300 5 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
122588268 166970 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 5.7 CC(CC(=O)O)CC(=O)c1c(CCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4287509 166970 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 5.7 CC(CC(=O)O)CC(=O)c1c(CCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
137647550 157974 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 447 15 1 3 7.6 CCCCCCCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4084871 157974 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 447 15 1 3 7.6 CCCCCCCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
122600362 167197 3 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4291464 167197 3 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
10544716 105302 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@H](O)/C=C/C=C/C=C/C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115777 105302 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@H](O)/C=C/C=C/C=C/C(=O)CCCC(=O)O 10.1021/jm401292m
76317856 105317 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 421 10 1 3 5.7 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Br)ccc2n1C 10.1021/jm401292m
CHEMBL3115793 105317 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 421 10 1 3 5.7 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Br)ccc2n1C 10.1021/jm401292m
145993055 166838 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4285167 166838 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
66644128 105301 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 105301 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49802029 105300 5 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 105300 5 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644128 105301 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 105301 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
3391 155 21 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
3416 155 21 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
5283159 155 21 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
CHEMBL18028 155 21 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
76328737 105310 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2ccc(Br)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115786 105310 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2ccc(Br)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49804581 105315 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 10 1 3 5.0 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccccc2n1C 10.1021/jm401292m
CHEMBL3115791 105315 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 10 1 3 5.0 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccccc2n1C 10.1021/jm401292m
76332419 105311 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 359 10 1 4 4.9 CCCCCCc1cc2ccc(OC)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115787 105311 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 359 10 1 4 4.9 CCCCCCc1cc2ccc(OC)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
145982307 166511 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 431 10 1 3 6.2 CC(CC(=O)O)CC(=O)c1c(CCCCCC(F)(F)F)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4278772 166511 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 431 10 1 3 6.2 CC(CC(=O)O)CC(=O)c1c(CCCCCC(F)(F)F)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
122600340 166556 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.1 CC(CC(=O)O)CC(=O)c1c(CCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4279605 166556 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.1 CC(CC(=O)O)CC(=O)c1c(CCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
71720638 87338 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2ccc(Cl)cc21 10.1021/jm400480j
CHEMBL2332562 87338 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2ccc(Cl)cc21 10.1021/jm400480j
66644266 105320 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 313 8 1 3 4.7 CCCC/C=C/c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115796 105320 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 313 8 1 3 4.7 CCCC/C=C/c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137660364 159053 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CCC(C)(C)C(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4096962 159053 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CCC(C)(C)C(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
118707105 113013 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C\c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
CHEMBL3311230 113013 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C\c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
10568747 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1021/jm401292m
6171 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1021/jm401292m
CHEMBL3115778 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1021/jm401292m
3404 12 29 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
5283155 12 29 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
5508 12 29 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
CHEMBL1526258 12 29 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
68036050 105324 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 383 13 1 3 6.7 CCCCCCCCC/C=C\c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115800 105324 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 383 13 1 3 6.7 CCCCCCCCC/C=C\c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137655720 158983 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 365 10 1 4 4.2 CCCCCCc1c(C(=O)COCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4096265 158983 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 365 10 1 4 4.2 CCCCCCc1c(C(=O)COCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49801419 105314 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 10 1 3 5.4 CCCCCCc1c(C(=O)CCCC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115790 105314 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 10 1 3 5.4 CCCCCCc1c(C(=O)CCCC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49800560 105322 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 11 1 3 5.4 CCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115798 105322 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 11 1 3 5.4 CCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137645745 157647 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 389 10 1 3 5.8 CCCCCCc1c(C(=O)CC2(CC(=O)O)CC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4081391 157647 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 389 10 1 3 5.8 CCCCCCc1c(C(=O)CC2(CC(=O)O)CC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
66644128 105301 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 105301 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49778909 114894 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49778909 114894 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
CHEMBL3341972 114894 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL3341972 114894 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
49778909 114894 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
CHEMBL3341972 114894 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
49804580 105313 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 4.7 CCCCCCc1c(C(=O)CCCC(=O)O)c2ccccc2n1C 10.1021/jm401292m
CHEMBL3115789 105313 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 4.7 CCCCCCc1c(C(=O)CCCC(=O)O)c2ccccc2n1C 10.1021/jm401292m
76336046 105308 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2cc(Br)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115784 105308 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2cc(Br)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49802029 105300 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 105300 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49802029 105300 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/ml500161v
CHEMBL3115774 105300 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/ml500161v
53248990 60680 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 372 14 1 2 5.9 O=C(O)CCCC(=O)/C=C/C=C\C/C=C\C/C=C\CCCCC(F)(F)F 10.1016/j.bmcl.2011.02.021
CHEMBL1760545 60680 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 372 14 1 2 5.9 O=C(O)CCCC(=O)/C=C/C=C\C/C=C\C/C=C\CCCCC(F)(F)F 10.1016/j.bmcl.2011.02.021
49800558 105323 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 385 14 1 3 6.6 CCCCCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115799 105323 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 385 14 1 3 6.6 CCCCCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137655326 158561 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 403 10 1 3 6.2 CCCCCCc1c(C(=O)CC2(CC(=O)O)CCC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4091674 158561 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 403 10 1 3 6.2 CCCCCCc1c(C(=O)CC2(CC(=O)O)CCC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49800841 105321 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 5.0 CCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115797 105321 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 5.0 CCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
145989845 167237 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4292357 167237 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
49802589 105316 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccc(Cl)cc2n1C 10.1021/jm401292m
CHEMBL3115792 105316 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccc(Cl)cc2n1C 10.1021/jm401292m
137638887 156685 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)C(C)(C)CCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4069768 156685 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)C(C)(C)CCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49804577 105306 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 9 1 3 4.9 CCCCCCc1cc2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115782 105306 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 9 1 3 4.9 CCCCCCc1cc2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644000 105312 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 10 2 2 4.7 CCCCCCc1[nH]c2ccccc2c1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115788 105312 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 10 2 2 4.7 CCCCCCc1[nH]c2ccccc2c1C(=O)CCCC(=O)O 10.1021/jm401292m
6169 153 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 15 2 3 4.4 OCCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 8598482
73755178 153 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 15 2 3 4.4 OCCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 8598482
3390 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 16039985
3390 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 7803484
3390 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 8387490
5280733 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 16039985
5280733 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 7803484
5280733 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 8387490
CHEMBL164813 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 16039985
CHEMBL164813 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 7803484
CHEMBL164813 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 8387490
2483 159 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 15 2 3 5.7 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO 16039985
5280778 159 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 15 2 3 5.7 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO 16039985
CHEMBL1743204 159 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 15 2 3 5.7 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO 16039985
6167 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7797484
6167 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7803484
6167 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8387490
6167 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8598482
6438757 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7797484
6438757 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7803484
6438757 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8387490
6438757 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8598482
CHEMBL1682258 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7797484
CHEMBL1682258 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7803484
CHEMBL1682258 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8387490
CHEMBL1682258 152 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8598482
3392 154 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 15 1 2 5.6 CCCCCCCC/C=C\C/C=C\C=C/C(=O)CCCC(=O)O 18292294
56947094 154 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 15 1 2 5.6 CCCCCCCC/C=C\C/C=C\C=C/C(=O)CCCC(=O)O 18292294
6164 156 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 14 1 2 5.1 CCCCCCCCC/C=C\C=C\C(=O)CCCC(=O)O 18287092
71751402 156 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 14 1 2 5.1 CCCCCCCCC/C=C\C=C\C(=O)CCCC(=O)O 18287092
3391 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
3391 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
3391 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
3391 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
3391 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
3416 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
3416 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
3416 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
3416 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
3416 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
5283159 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
5283159 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
5283159 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
5283159 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
5283159 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
CHEMBL18028 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
CHEMBL18028 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
CHEMBL18028 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
CHEMBL18028 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
CHEMBL18028 155 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
11073 2085 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.
Guide to Pharmacology 487 12 1 3 7.5 C[C@@H](CC(=O)c1c(CCCCCCc2cccc(c2)Cl)n(c2c1cc(Cl)cc2)C)CC(=O)O 31655025
122588231 2085 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.
Guide to Pharmacology 487 12 1 3 7.5 C[C@@H](CC(=O)c1c(CCCCCCc2cccc(c2)Cl)n(c2c1cc(Cl)cc2)C)CC(=O)O 31655025
10568747 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 9920859
6171 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 9920859
CHEMBL3115778 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 9920859
6174 127 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 349 9 1 3 5.3 CCCCCCc1cc2c(n1C(=O)CCCC(=O)O)cc(cc2)Cl 23581530
71655222 127 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 349 9 1 3 5.3 CCCCCCc1cc2c(n1C(=O)CCCC(=O)O)cc(cc2)Cl 23581530
5066134 1892 0 None - 1 Human 6.0 pIC50 ~ 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 447 5 1 6 6.4 CSc1nc2c(s1)c1sc(nc1cc2)NC(=O)C(c1ccccc1)c1ccccc1 22634634
6173 1892 0 None - 1 Human 6.0 pIC50 ~ 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 447 5 1 6 6.4 CSc1nc2c(s1)c1sc(nc1cc2)NC(=O)C(c1ccccc1)c1ccccc1 22634634
CHEMBL4303495 1892 0 None - 1 Human 6.0 pIC50 ~ 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 447 5 1 6 6.4 CSc1nc2c(s1)c1sc(nc1cc2)NC(=O)C(c1ccccc1)c1ccccc1 22634634


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

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 DOI
49802029 105300 5 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 105300 5 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644128 105301 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 105301 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49802029 105300 5 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 105300 5 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644128 105301 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 105301 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
1051 1455 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
4289 1455 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
445580 1455 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
57417355 1455 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
CHEMBL367149 1455 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
DB03756 1455 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
3174 1570 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
3362 1570 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
446284 1570 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
CHEMBL460026 1570 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
DB00159 1570 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
3391 155 21 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
3416 155 21 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
5283159 155 21 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
CHEMBL18028 155 21 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988