Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 118710197 | 113670 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 470 | 8 | 2 | 5 | 3.0 | O=C(O)c1cc(F)ccc1S(=O)(=O)NCCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| CHEMBL3322513 | 113670 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 470 | 8 | 2 | 5 | 3.0 | O=C(O)c1cc(F)ccc1S(=O)(=O)NCCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| 10468943 | 1457 | None | 3 | Human | Functional | pEC50 | = | 6 | 6.0 | -35 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 282 | 12 | 2 | 2 | 4.1 | CCCCCCCCCCCCOP(=S)(O)O | 10.1021/jm049609r | ||
| 6990 | 1457 | None | 3 | Human | Functional | pEC50 | = | 6 | 6.0 | -35 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 282 | 12 | 2 | 2 | 4.1 | CCCCCCCCCCCCOP(=S)(O)O | 10.1021/jm049609r | ||
| CHEMBL191365 | 1457 | None | 3 | Human | Functional | pEC50 | = | 6 | 6.0 | -35 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 282 | 12 | 2 | 2 | 4.1 | CCCCCCCCCCCCOP(=S)(O)O | 10.1021/jm049609r | ||
| 44343866 | 11096 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -2 | 2 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 433 | 19 | 3 | 3 | 5.4 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(=O)P(O)(O)=S | 10.1016/j.bmcl.2004.04.061 | ||
| CHEMBL117798 | 11096 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -2 | 2 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 433 | 19 | 3 | 3 | 5.4 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(=O)P(O)(O)=S | 10.1016/j.bmcl.2004.04.061 | ||
| 10136738 | 11031 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -5 | 2 | Agonist activity at LPA2 (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at LPA2 (unknown origin) by [35S]GTPgammaS binding assay |
ChEMBL | 417 | 19 | 3 | 3 | 5.2 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(=O)P(=O)(O)O | 10.1021/acs.jmedchem.9b01287 | ||
| CHEMBL117529 | 11031 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -5 | 2 | Agonist activity at LPA2 (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at LPA2 (unknown origin) by [35S]GTPgammaS binding assay |
ChEMBL | 417 | 19 | 3 | 3 | 5.2 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(=O)P(=O)(O)O | 10.1021/acs.jmedchem.9b01287 | ||
| 10136738 | 11031 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -5 | 2 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 417 | 19 | 3 | 3 | 5.2 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(=O)P(=O)(O)O | 10.1016/j.bmcl.2004.04.061 | ||
| CHEMBL117529 | 11031 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -5 | 2 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 417 | 19 | 3 | 3 | 5.2 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(=O)P(=O)(O)O | 10.1016/j.bmcl.2004.04.061 | ||
| 73296092 | 113665 | None | 21 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 452 | 8 | 2 | 5 | 2.9 | O=C(O)c1ccccc1S(=O)(=O)NCCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| CHEMBL3322502 | 113665 | None | 21 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 452 | 8 | 2 | 5 | 2.9 | O=C(O)c1ccccc1S(=O)(=O)NCCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| 73296094 | 113666 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 466 | 9 | 2 | 5 | 3.3 | O=C(O)c1ccccc1S(=O)(=O)NCCCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| CHEMBL3322503 | 113666 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 466 | 9 | 2 | 5 | 3.3 | O=C(O)c1ccccc1S(=O)(=O)NCCCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| 4030 | 1358 | None | 14 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -6 | 2 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 238 | 10 | 2 | 2 | 3.2 | CCCCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| 62532 | 1358 | None | 14 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -6 | 2 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 238 | 10 | 2 | 2 | 3.2 | CCCCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| CHEMBL361255 | 1358 | None | 14 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -6 | 2 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 238 | 10 | 2 | 2 | 3.2 | CCCCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| 44343880 | 11048 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 421 | 19 | 3 | 2 | 6.0 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(F)P(=O)(O)O | 10.1016/j.bmcl.2004.04.061 | ||
| CHEMBL117663 | 11048 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 421 | 19 | 3 | 2 | 6.0 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(F)P(=O)(O)O | 10.1016/j.bmcl.2004.04.061 | ||
| 5311263 | 4157 | None | 20 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 7 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 436 | 20 | 3 | 5 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O | 10.1021/jm5007116 | ||
| CHEMBL117021 | 4157 | None | 20 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 7 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 436 | 20 | 3 | 5 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O | 10.1021/jm5007116 | ||
| 10180382 | 110625 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 2 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 419 | 19 | 4 | 3 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(O)P(=O)(O)O | 10.1016/j.bmcl.2004.04.061 | ||
| CHEMBL325288 | 110625 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 2 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 419 | 19 | 4 | 3 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCC(O)P(=O)(O)O | 10.1016/j.bmcl.2004.04.061 | ||
| 73053706 | 113664 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 438 | 7 | 2 | 5 | 2.5 | O=C(O)c1ccccc1S(=O)(=O)NCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| CHEMBL3322501 | 113664 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 438 | 7 | 2 | 5 | 2.5 | O=C(O)c1ccccc1S(=O)(=O)NCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| 11473989 | 67142 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -1 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 364 | 17 | 2 | 2 | 6.3 | CCCCCCCC/C=C/CCCCCCCCOP(O)(O)=S | 10.1021/jm049609r | ||
| CHEMBL187459 | 67142 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -1 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 364 | 17 | 2 | 2 | 6.3 | CCCCCCCC/C=C/CCCCCCCCOP(O)(O)=S | 10.1021/jm049609r | ||
| 11312936 | 67507 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -15 | 2 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 310 | 14 | 2 | 2 | 4.9 | CCCCCCCCCCCCCCOP(O)(O)=S | 10.1021/jm049609r | ||
| CHEMBL189296 | 67507 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -15 | 2 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 310 | 14 | 2 | 2 | 4.9 | CCCCCCCCCCCCCCOP(O)(O)=S | 10.1021/jm049609r | ||
| 2906 | 2355 | None | 15 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -1 | 12 | Agonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assayAgonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay |
ChEMBL | 436 | 20 | 3 | 5 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O | 10.1021/acs.jmedchem.6b01270 | ||
| 5395 | 2355 | None | 15 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -1 | 12 | Agonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assayAgonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay |
ChEMBL | 436 | 20 | 3 | 5 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O | 10.1021/acs.jmedchem.6b01270 | ||
| 5497152 | 2355 | None | 15 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -1 | 12 | Agonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assayAgonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay |
ChEMBL | 436 | 20 | 3 | 5 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O | 10.1021/acs.jmedchem.6b01270 | ||
| CHEMBL1222042 | 2355 | None | 15 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -1 | 12 | Agonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assayAgonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay |
ChEMBL | 436 | 20 | 3 | 5 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O | 10.1021/acs.jmedchem.6b01270 | ||
| 44343825 | 11065 | None | 23 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 6 | 2 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 405 | 19 | 3 | 3 | 5.2 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCOP(=O)(O)O | 10.1016/j.bmcl.2004.04.061 | ||
| CHEMBL117754 | 11065 | None | 23 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 6 | 2 | Agonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitroAgonistic activity against lysophosphatidic acid receptor 2 using [35S]GTP-gamma-S as radioligand tested in vitro |
ChEMBL | 405 | 19 | 3 | 3 | 5.2 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCOP(=O)(O)O | 10.1016/j.bmcl.2004.04.061 | ||
| 75816 | 67194 | None | 39 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -8 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 266 | 12 | 2 | 2 | 4.0 | CCCCCCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| CHEMBL187711 | 67194 | None | 39 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -8 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 266 | 12 | 2 | 2 | 4.0 | CCCCCCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| 3114900 | 113663 | None | 43 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 1 | 2 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 391 | 6 | 1 | 4 | 4.3 | O=C(O)c1ccccc1SCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| CHEMBL3322500 | 113663 | None | 43 | Human | Functional | pEC50 | = | 5.5 | 5.5 | 1 | 2 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 391 | 6 | 1 | 4 | 4.3 | O=C(O)c1ccccc1SCCCN1C(=O)c2cccc3cccc(c23)C1=O | 10.1021/jm5007116 | ||
| 73296091 | 113669 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 478 | 6 | 1 | 6 | 2.8 | O=C(O)c1ccc2c(c1)S(=O)(=O)N(CCCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O | 10.1021/jm5007116 | ||
| CHEMBL3322509 | 113669 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assayAgonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay |
ChEMBL | 478 | 6 | 1 | 6 | 2.8 | O=C(O)c1ccc2c(c1)S(=O)(=O)N(CCCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O | 10.1021/jm5007116 | ||
| 11447695 | 124433 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -4 | 2 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 236 | 10 | 2 | 2 | 3.0 | C=CCCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| CHEMBL363776 | 124433 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -4 | 2 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 236 | 10 | 2 | 2 | 3.0 | C=CCCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| 11197104 | 67647 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -4 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 292 | 13 | 2 | 2 | 4.6 | CCCC/C=C/CCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| CHEMBL190430 | 67647 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -4 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 292 | 13 | 2 | 2 | 4.6 | CCCC/C=C/CCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| 11312382 | 67378 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -39 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 292 | 13 | 2 | 2 | 4.6 | CC/C=C/CCCCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| CHEMBL188591 | 67378 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -39 | 3 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 292 | 13 | 2 | 2 | 4.6 | CC/C=C/CCCCCCCCCCOP(=O)(O)O | 10.1021/jm049609r | ||
| 11242245 | 67219 | None | 3 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -37 | 2 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 254 | 10 | 2 | 2 | 3.4 | CCCCCCCCCCOP(O)(O)=S | 10.1021/jm049609r | ||
| CHEMBL187795 | 67219 | None | 3 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -37 | 2 | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptorInhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor |
ChEMBL | 254 | 10 | 2 | 2 | 3.4 | CCCCCCCCCCOP(O)(O)=S | 10.1021/jm049609r | ||
Showing 1 to 50 of 347 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 11648176 | 87560 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 454 | 23 | 2 | 4 | 6.5 | CCCCCCCCCCCCCCCCCCOCC(COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2335052 | 87560 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 454 | 23 | 2 | 4 | 6.5 | CCCCCCCCCCCCCCCCCCOCC(COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| 122191542 | 123766 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA2 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay |
ChEMBL | 421 | 19 | 3 | 3 | 5.4 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCOP(O)(O)=S | 10.1039/C4MD00333K | ||
| CHEMBL3621959 | 123766 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assayAgonist activity at human LPA2 receptor transfected in HEK293T cells after 30 mins by GTP[gamma-35S] binding assay |
ChEMBL | 421 | 19 | 3 | 3 | 5.4 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCOP(O)(O)=S | 10.1039/C4MD00333K | ||
| 71720690 | 87558 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 454 | 23 | 2 | 4 | 6.5 | CCCCCCCCCCCCCCCCCCOC[C@@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2335047 | 87558 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 454 | 23 | 2 | 4 | 6.5 | CCCCCCCCCCCCCCCCCCOC[C@@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| 16044834 | 14703 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@@H]1OC[C@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL1206092 | 14703 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@@H]1OC[C@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL199400 | 14703 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@@H]1OC[C@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| 71720690 | 87558 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 454 | 23 | 2 | 4 | 6.5 | CCCCCCCCCCCCCCCCCCOC[C@@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2335047 | 87558 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 454 | 23 | 2 | 4 | 6.5 | CCCCCCCCCCCCCCCCCCOC[C@@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| 10322404 | 121145 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL357053 | 121145 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| 10322404 | 121145 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL357053 | 121145 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| 71569054 | 89102 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 426 | 21 | 2 | 4 | 5.7 | CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2335049 | 89102 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 426 | 21 | 2 | 4 | 5.7 | CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2365070 | 89102 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 426 | 21 | 2 | 4 | 5.7 | CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| 71569054 | 89102 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 426 | 21 | 2 | 4 | 5.7 | CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2335049 | 89102 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 426 | 21 | 2 | 4 | 5.7 | CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2365070 | 89102 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 426 | 21 | 2 | 4 | 5.7 | CCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| 71599962 | 89103 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 440 | 22 | 2 | 4 | 6.1 | CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2335050 | 89103 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 440 | 22 | 2 | 4 | 6.1 | CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2365071 | 89103 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 440 | 22 | 2 | 4 | 6.1 | CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| 71599962 | 89103 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 440 | 22 | 2 | 4 | 6.1 | CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2335050 | 89103 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 440 | 22 | 2 | 4 | 6.1 | CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2365071 | 89103 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 440 | 22 | 2 | 4 | 6.1 | CCCCCCCCCCCCCCCCCOC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| 16044826 | 14704 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCCC1OCC(COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL1206093 | 14704 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCCC1OCC(COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL199472 | 14704 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCCC1OCC(COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| 16044838 | 14822 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 420 | 18 | 2 | 4 | 5.9 | CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@H](COP(=O)(O)O)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL1207240 | 14822 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 420 | 18 | 2 | 4 | 5.9 | CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@H](COP(=O)(O)O)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL371955 | 14822 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 420 | 18 | 2 | 4 | 5.9 | CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@H](COP(=O)(O)O)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| 44406645 | 14881 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL1207670 | 14881 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL427014 | 14881 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| 16044832 | 14880 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL1207662 | 14880 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| CHEMBL425218 | 14880 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@H]1OC[C@@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
| 11496444 | 89093 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2335051 | 89093 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2364959 | 89093 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| 44368508 | 45745 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL153043 | 45745 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| 11496444 | 89093 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2335051 | 89093 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL2364959 | 89093 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC(COC)COP(O)(O)=S | 10.1016/j.bmcl.2013.01.002 | ||
| 44368508 | 45745 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| CHEMBL153043 | 45745 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assayAgonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 468 | 22 | 2 | 5 | 6.0 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC | 10.1016/j.bmcl.2013.01.002 | ||
| 16044830 | 14705 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Activity at LPA2 receptor in RH7777 rat hepatoma cell lineActivity at LPA2 receptor in RH7777 rat hepatoma cell line |
ChEMBL | 436 | 18 | 2 | 4 | 6.0 | CCCCCCC/C=C/CCCCCCCC[C@@H]1OC[C@@H](COP(O)(O)=S)O1 | 10.1016/j.bmcl.2005.08.096 | ||
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